ARNT2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ARNT2
Entrez Gene ID	9915
Full Name	aryl hydrocarbon receptor nuclear translocator 2
Synonyms	WEDAS,bHLHe1
General protein information	Preferred Names aryl hydrocarbon receptor nuclear translocator 2 Names aryl hydrocarbon receptor nuclear translocator 2 ARNT protein 2 class E basic helix-loop-helix protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q25.1
Summary	This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting additional roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. [provided by RefSeq, Dec 2013].
Disorder MIM:	606036
Disorder Html:	?Webb-Dattani syndrome, 615926 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_014862.3	NP_055677.3	aryl hydrocarbon receptor nuclear translocator 2
NM_014862.4	NP_055677.3	aryl hydrocarbon receptor nuclear translocator 2

Pathways from BioSystems

Homologies

	ARNT2	XP_001109712.2
Mus musculus (house mouse)	Arnt2	NP_031514.3
Canis lupus familiaris (dog)	ARNT2	XP_005618472.1
Rattus norvegicus (Norway rat)	Arnt2	NP_036913.3
Gallus gallus (chicken)	ARNT2	XP_413854.3
Pan troglodytes (chimpanzee)	ARNT2	XP_001156233.1
Danio rerio (zebrafish)	arnt2	NP_571749.1
Homo sapiens (human)	ARNT2	NP_055677.3
Bos taurus (cattle)	ARNT2	NP_001193634.1
Xenopus tropicalis (tropical clawed frog)	arnt2	NP_001093686.1

Gene Ontology
Bibliography

Related articles in PubMed

Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness.
Bogeas A, Morvan-Dubois G, El-Habr EA, Lejeune FX, Defrance M, Narayanan A, Kuranda K, Burel-Vandenbos F, Sayd S, Delaunay V, Dubois LG, Parrinello H, Rialle S, Fabrega S, Idbaih A, Haiech J, Bi?che I, Virolle T, Goodhardt M, Chneiweiss H, Junier MP
Acta neuropathologica135(2)267-283(2018 Feb)

Emotion recognition associated with polymorphism in oxytocinergic pathway gene ARNT2.
Hovey D, Henningsson S, Cortes DS, B?nziger T, Zettergren A, Melke J, Fischer H, Laukka P, Westberg L
Social cognitive and affective neuroscience(2017 Nov)

ARNT2 is downregulated and serves as a potential tumor suppressor gene in non-small cell lung cancer.
Yang B, Yang E, Liao H, Wang Z, Den Z, Ren H
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(3)2111-9(2015 Mar)

Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.
Sullivan AE, Raimondo A, Schwab TA, Bruning JB, Froguel P, Farooqi IS, Peet DJ, Whitelaw ML
The Biochemical journal461(3)403-12(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Attenuated ARNT2 expression in HCC827 cells greatly promoted tumor growth.
Title: ARNT2 is downregulated and serves as a potential tumor suppressor gene in non-small cell lung cancer.

Data suggest that selected human SIM1 (single-minded homolog 1) variants exhibit poor dimerization with ARNT2 and anomalous intracellular localization; these data were used to predict 'hot-spot' in SIM1/SIM2 (residues 290-326) critical for function.
Title: Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.

These results provide insight into the mechanisms of NPAS4/ARNT dimerisation and transcriptional activation.
Title: Human variants in the neuronal basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) transcription factor complex NPAS4/ARNT2 disrupt function.

nominal associations were found between autism spectrum disorder scores and single-nucleotide polymorphisms in OXT, ARNT2 and CD38
Title: Associations between oxytocin-related genes and autistic-like traits.

mutation of ARNT2 results in absence of detectable levels of ARNT2 transcript and protein from patient fibroblasts compared with controls, consistent with nonsense-mediated decay of the mutant transcript and loss of ARNT2 function.
Title: ARNT2 mutation causes hypopituitarism, post-natal microcephaly, visual and renal anomalies.

The following ARNT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARNT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23149	NM_014862.4 Latest version!	Homo sapiens aryl hydrocarbon receptor nuclear translocator 2 (ARNT2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
View Old Accession Versions >>
OHu23149	NM_014862.3	Homo sapiens aryl hydrocarbon receptor nuclear translocator 2 (ARNT2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$391.30 $559.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ARNT2 ( NM_014862.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055677.3 Homo sapiens aryl hydrocarbon receptor nuclear translocator 2 (ARNT2), mRNA.

Price & Availability↑

CloneID	OHu23149
Clone ID Related Accession (Same CDS sequence)	NM_014862.3 , NM_014862.4
Accession Version	NM_014862.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2154bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	aryl hydrocarbon receptor nuclear translocator 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC051335.1, BX538026.1, AC108451.9 and BX647212.1. On Jun 29, 2005 this sequence version replaced NM_014862.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX647212.1, SRR1660807.141129.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAACCC CGGCGGCGGT CAACCCTCCG GAAATGGCTT CAGACATACC TGGATCTGTG 
ACGTTGCCCG TTGCCCCCAT GGCGGCCACC GGACAGGTGA GGATGGCGGG GGCCATGCCT 
GCCCGTGGAG GAAAGCGGCG TTCCGGAATG GACTTCGATG ATGAAGATGG TGAAGGCCCC 
AGTAAATTTT CAAGAGAGAA TCATAGTGAA ATCGAAAGGC GCAGACGGAA CAAGATGACT 
CAGTACATCA CGGAGCTCTC CGACATGGTC CCCACATGCA GCGCACTGGC TCGGAAGCCA 
GACAAGCTCA CCATCCTCCG CATGGCCGTC TCGCACATGA AGTCCATGAG GGGTACAGGG 
AACAAGTCCA CCGATGGCGC GTACAAGCCT TCCTTCCTCA CAGAGCAGGA ACTGAAGCAT 
CTCATCCTTG AAGCAGCTGA TGGATTTCTG TTTGTGGTGG CTGCTGAGAC AGGGCGAGTG 
ATTTATGTGT CTGACTCCGT CACCCCTGTT CTGAACCAGC CCCAGTCAGA GTGGTTTGGG 
AGCACACTGT ATGAACAGGT GCATCCTGAT GACGTGGAGA AGCTGAGAGA GCAACTGTGC 
ACCTCAGAAA ACTCAATGAC AGGCCGGATC TTGGACCTGA AGACTGGGAC GGTCAAGAAA 
GAAGGGCAGC AGTCATCCAT GAGGATGTGC ATGGGCTCGC GGCGGTCTTT CATCTGCAGG 
ATGAGGTGTG GAAATGCTCC TTTGGACCAC CTTCCTCTAA ACAGAATAAC CACCATGAGG 
AAAAGGTTCA GGAATGGCCT TGGCCCTGTG AAAGAAGGAG AAGCCCAATA TGCTGTGGTC 
CACTGTACAG GATACATCAA GGCCTGGCCA CCAGCAGGAA TGACCATACC TGAAGAAGAC 
GCTGATGTGG GACAAGGCAG TAAATATTGC CTCGTGGCAA TTGGGAGACT CCAGGTGACC 
AGCTCTCCTG TATGCATGGA CATGAATGGG ATGTCGGTGC CCACAGAGTT CTTATCCCGG 
CATAACTCCG ATGGAATCAT CACATTTGTG GATCCAAGAT GTATCAGTGT GATTGGCTAC 
CAACCCCAGG ATCTTCTGGG AAAGGACATT TTGGAATTCT GCCACCCTGA GGATCAAAGC 
CATCTGCGTG AGAGCTTCCA GCAGGTGGTT AAGCTGAAAG GCCAAGTCCT GTCGGTCATG 
TATCGATTTC GCACCAAGAA CCGGGAGTGG ATGTTGATCC GCACCAGCAG CTTCACATTC 
CAGAATCCCT ATTCTGATGA GATTGAGTAC ATCATCTGCA CCAACACCAA CGTCAAGCAA 
CTTCAGCAAC AGCAGGCAGA ATTGGAAGTG CACCAGAGAG ATGGATTGTC ATCGTATGAC 
TTATCCCAGG TCCCCGTCCC CAACCTACCA GCCGGTGTTC ATGAGGCCGG GAAGTCCGTG 
GAAAAGGCGG ATGCAATCTT CTCCCAGGAA AGAGATCCTC GGTTTGCTGA AATGTTTGCA 
GGAATTAGTG CATCGGAGAA GAAGATGATG AGCTCAGCCT CTGCAGCAGG AACCCAGCAG 
ATCTACTCCC AAGGAAGCCC ATTTCCCTCT GGACACTCCG GGAAGGCCTT CAGCTCTTCA 
GTGGTTCATG TGCCTGGAGT GAATGATATT CAGTCCTCTT CTTCCACGGG CCAGAACATG 
TCCCAAATCT CCCGGCAGCT AAACCAGAGT CAGGTGGCAT GGACAGGGAG TCGTCCGCCC 
TTTCCGGGAC AGCAAATCCC ATCTCAGTCC AGCAAGACTC AGTCATCTCC CTTTGGGATT 
GGAACGAGCC ACACCTACCC GGCAGACCCC TCTTCCTACA GCCCCCTCTC CAGCCCAGCT 
ACCTCCTCGC CAAGTGGGAA TGCCTACTCC AGTCTTGCCA ACAGGACTCC AGGGTTCGCT 
GAAAGTGGAC AAAGTAGCGG GCAGTTCCAA GGGCGGCCCT CGGAAGTCTG GTCGCAGTGG 
CAAAGCCAGC ACCATGGCCA GCAGAGCGGT GAGCAGCACT CCCACCAGCA GCCCGGTCAG 
ACTGAAGTGT TCCAGGACAT GCTGCCCATG CCAGGAGATC CAACCCAGGG GACTGGCAAC 
TATAACATCG AAGACTTTGC CGACCTGGGC ATGTTTCCAC CGTTTTCTGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055677.3
CDS	167..2320
Translation	MATPAAVNPPEMASDIPGSVTLPVAPMAATGQVRMAGAMPARGGKRRSGMDFDDEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSVEKADAIFSQERDPRFAEMFAGISASEKKMMSSASAAGTQQIYSQGSPFPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQNMSQISRQLNQSQVAWTGSRPPFPGQQIPSQSSKTQSSPFGIGTSHTYPADPSSYSPLSSPATSSPSGNAYSSLANRTPGFAESGQSSGQFQGRPSEVWSQWQSQHHGQQSGEQHSHQQPGQTEVFQDMLPMPGDPTQGTGNYNIEDFADLGMFPPFSE

Target ORF information:

RefSeq Version	NM_014862.3
Organism	Homo sapiens(human)
Definition	Homo sapiens aryl hydrocarbon receptor nuclear translocator 2 (ARNT2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014862.3

ORF Insert Sequence:

ATGGCAACCC CGGCGGCGGT CAACCCTCCG GAAATGGCTT CAGACATACC TGGATCTGTG 
ACGTTGCCCG TTGCCCCCAT GGCGGCCACC GGACAGGTGA GGATGGCGGG GGCCATGCCT 
GCCCGTGGAG GAAAGCGGCG TTCCGGAATG GACTTCGATG ATGAAGATGG TGAAGGCCCC 
AGTAAATTTT CAAGAGAGAA TCATAGTGAA ATCGAAAGGC GCAGACGGAA CAAGATGACT 
CAGTACATCA CGGAGCTCTC CGACATGGTC CCCACATGCA GCGCACTGGC TCGGAAGCCA 
GACAAGCTCA CCATCCTCCG CATGGCCGTC TCGCACATGA AGTCCATGAG GGGTACAGGG 
AACAAGTCCA CCGATGGCGC GTACAAGCCT TCCTTCCTCA CAGAGCAGGA ACTGAAGCAT 
CTCATCCTTG AAGCAGCTGA TGGATTTCTG TTTGTGGTGG CTGCTGAGAC AGGGCGAGTG 
ATTTATGTGT CTGACTCCGT CACCCCTGTT CTGAACCAGC CCCAGTCAGA GTGGTTTGGG 
AGCACACTGT ATGAACAGGT GCATCCTGAT GACGTGGAGA AGCTGAGAGA GCAACTGTGC 
ACCTCAGAAA ACTCAATGAC AGGCCGGATC TTGGACCTGA AGACTGGGAC GGTCAAGAAA 
GAAGGGCAGC AGTCATCCAT GAGGATGTGC ATGGGCTCGC GGCGGTCTTT CATCTGCAGG 
ATGAGGTGTG GAAATGCTCC TTTGGACCAC CTTCCTCTAA ACAGAATAAC CACCATGAGG 
AAAAGGTTCA GGAATGGCCT TGGCCCTGTG AAAGAAGGAG AAGCCCAATA TGCTGTGGTC 
CACTGTACAG GATACATCAA GGCCTGGCCA CCAGCAGGAA TGACCATACC TGAAGAAGAC 
GCTGATGTGG GACAAGGCAG TAAATATTGC CTCGTGGCAA TTGGGAGACT CCAGGTGACC 
AGCTCTCCTG TATGCATGGA CATGAATGGG ATGTCGGTGC CCACAGAGTT CTTATCCCGG 
CATAACTCCG ATGGAATCAT CACATTTGTG GATCCAAGAT GTATCAGTGT GATTGGCTAC 
CAACCCCAGG ATCTTCTGGG AAAGGACATT TTGGAATTCT GCCACCCTGA GGATCAAAGC 
CATCTGCGTG AGAGCTTCCA GCAGGTGGTT AAGCTGAAAG GCCAAGTCCT GTCGGTCATG 
TATCGATTTC GCACCAAGAA CCGGGAGTGG ATGTTGATCC GCACCAGCAG CTTCACATTC 
CAGAATCCCT ATTCTGATGA GATTGAGTAC ATCATCTGCA CCAACACCAA CGTCAAGCAA 
CTTCAGCAAC AGCAGGCAGA ATTGGAAGTG CACCAGAGAG ATGGATTGTC ATCGTATGAC 
TTATCCCAGG TCCCCGTCCC CAACCTACCA GCCGGTGTTC ATGAGGCCGG GAAGTCCGTG 
GAAAAGGCGG ATGCAATCTT CTCCCAGGAA AGAGATCCTC GGTTTGCTGA AATGTTTGCA 
GGAATTAGTG CATCGGAGAA GAAGATGATG AGCTCAGCCT CTGCAGCAGG AACCCAGCAG 
ATCTACTCCC AAGGAAGCCC ATTTCCCTCT GGACACTCCG GGAAGGCCTT CAGCTCTTCA 
GTGGTTCATG TGCCTGGAGT GAATGATATT CAGTCCTCTT CTTCCACGGG CCAGAACATG 
TCCCAAATCT CCCGGCAGCT AAACCAGAGT CAGGTGGCAT GGACAGGGAG TCGTCCGCCC 
TTTCCGGGAC AGCAAATCCC ATCTCAGTCC AGCAAGACTC AGTCATCTCC CTTTGGGATT 
GGAACGAGCC ACACCTACCC GGCAGACCCC TCTTCCTACA GCCCCCTCTC CAGCCCAGCT 
ACCTCCTCGC CAAGTGGGAA TGCCTACTCC AGTCTTGCCA ACAGGACTCC AGGGTTCGCT 
GAAAGTGGAC AAAGTAGCGG GCAGTTCCAA GGGCGGCCCT CGGAAGTCTG GTCGCAGTGG 
CAAAGCCAGC ACCATGGCCA GCAGAGCGGT GAGCAGCACT CCCACCAGCA GCCCGGTCAG 
ACTGAAGTGT TCCAGGACAT GCTGCCCATG CCAGGAGATC CAACCCAGGG GACTGGCAAC 
TATAACATCG AAGACTTTGC CGACCTGGGC ATGTTTCCAC CGTTTTCTGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARNT2 ( NM_014862.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055677.3 Homo sapiens aryl hydrocarbon receptor nuclear translocator 2 (ARNT2), mRNA.

Price & Availability↑

CloneID	OHu23149
Clone ID Related Accession (Same CDS sequence)	NM_014862.3 , NM_014862.4
Accession Version	NM_014862.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2154bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-09
Organism	Homo sapiens(human)
Product	aryl hydrocarbon receptor nuclear translocator 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC051335.1, BX538026.1, AC108451.9 and BX647212.1. On Nov 22, 2018 this sequence version replaced NM_014862.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX538026.1, SRR1660807.141129.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000303329.9/ ENSP00000307479.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAACCC CGGCGGCGGT CAACCCTCCG GAAATGGCTT CAGACATACC TGGATCTGTG 
ACGTTGCCCG TTGCCCCCAT GGCGGCCACC GGACAGGTGA GGATGGCGGG GGCCATGCCT 
GCCCGTGGAG GAAAGCGGCG TTCCGGAATG GACTTCGATG ATGAAGATGG TGAAGGCCCC 
AGTAAATTTT CAAGAGAGAA TCATAGTGAA ATCGAAAGGC GCAGACGGAA CAAGATGACT 
CAGTACATCA CGGAGCTCTC CGACATGGTC CCCACATGCA GCGCACTGGC TCGGAAGCCA 
GACAAGCTCA CCATCCTCCG CATGGCCGTC TCGCACATGA AGTCCATGAG GGGTACAGGG 
AACAAGTCCA CCGATGGCGC GTACAAGCCT TCCTTCCTCA CAGAGCAGGA ACTGAAGCAT 
CTCATCCTTG AAGCAGCTGA TGGATTTCTG TTTGTGGTGG CTGCTGAGAC AGGGCGAGTG 
ATTTATGTGT CTGACTCCGT CACCCCTGTT CTGAACCAGC CCCAGTCAGA GTGGTTTGGG 
AGCACACTGT ATGAACAGGT GCATCCTGAT GACGTGGAGA AGCTGAGAGA GCAACTGTGC 
ACCTCAGAAA ACTCAATGAC AGGCCGGATC TTGGACCTGA AGACTGGGAC GGTCAAGAAA 
GAAGGGCAGC AGTCATCCAT GAGGATGTGC ATGGGCTCGC GGCGGTCTTT CATCTGCAGG 
ATGAGGTGTG GAAATGCTCC TTTGGACCAC CTTCCTCTAA ACAGAATAAC CACCATGAGG 
AAAAGGTTCA GGAATGGCCT TGGCCCTGTG AAAGAAGGAG AAGCCCAATA TGCTGTGGTC 
CACTGTACAG GATACATCAA GGCCTGGCCA CCAGCAGGAA TGACCATACC TGAAGAAGAC 
GCTGATGTGG GACAAGGCAG TAAATATTGC CTCGTGGCAA TTGGGAGACT CCAGGTGACC 
AGCTCTCCTG TATGCATGGA CATGAATGGG ATGTCGGTGC CCACAGAGTT CTTATCCCGG 
CATAACTCCG ATGGAATCAT CACATTTGTG GATCCAAGAT GTATCAGTGT GATTGGCTAC 
CAACCCCAGG ATCTTCTGGG AAAGGACATT TTGGAATTCT GCCACCCTGA GGATCAAAGC 
CATCTGCGTG AGAGCTTCCA GCAGGTGGTT AAGCTGAAAG GCCAAGTCCT GTCGGTCATG 
TATCGATTTC GCACCAAGAA CCGGGAGTGG ATGTTGATCC GCACCAGCAG CTTCACATTC 
CAGAATCCCT ATTCTGATGA GATTGAGTAC ATCATCTGCA CCAACACCAA CGTCAAGCAA 
CTTCAGCAAC AGCAGGCAGA ATTGGAAGTG CACCAGAGAG ATGGATTGTC ATCGTATGAC 
TTATCCCAGG TCCCCGTCCC CAACCTACCA GCCGGTGTTC ATGAGGCCGG GAAGTCCGTG 
GAAAAGGCGG ATGCAATCTT CTCCCAGGAA AGAGATCCTC GGTTTGCTGA AATGTTTGCA 
GGAATTAGTG CATCGGAGAA GAAGATGATG AGCTCAGCCT CTGCAGCAGG AACCCAGCAG 
ATCTACTCCC AAGGAAGCCC ATTTCCCTCT GGACACTCCG GGAAGGCCTT CAGCTCTTCA 
GTGGTTCATG TGCCTGGAGT GAATGATATT CAGTCCTCTT CTTCCACGGG CCAGAACATG 
TCCCAAATCT CCCGGCAGCT AAACCAGAGT CAGGTGGCAT GGACAGGGAG TCGTCCGCCC 
TTTCCGGGAC AGCAAATCCC ATCTCAGTCC AGCAAGACTC AGTCATCTCC CTTTGGGATT 
GGAACGAGCC ACACCTACCC GGCAGACCCC TCTTCCTACA GCCCCCTCTC CAGCCCAGCT 
ACCTCCTCGC CAAGTGGGAA TGCCTACTCC AGTCTTGCCA ACAGGACTCC AGGGTTCGCT 
GAAAGTGGAC AAAGTAGCGG GCAGTTCCAA GGGCGGCCCT CGGAAGTCTG GTCGCAGTGG 
CAAAGCCAGC ACCATGGCCA GCAGAGCGGT GAGCAGCACT CCCACCAGCA GCCCGGTCAG 
ACTGAAGTGT TCCAGGACAT GCTGCCCATG CCAGGAGATC CAACCCAGGG GACTGGCAAC 
TATAACATCG AAGACTTTGC CGACCTGGGC ATGTTTCCAC CGTTTTCTGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055677.3
CDS	135..2288
Translation	MATPAAVNPPEMASDIPGSVTLPVAPMAATGQVRMAGAMPARGGKRRSGMDFDDEDGEGPSKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTGNKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSVEKADAIFSQERDPRFAEMFAGISASEKKMMSSASAAGTQQIYSQGSPFPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQNMSQISRQLNQSQVAWTGSRPPFPGQQIPSQSSKTQSSPFGIGTSHTYPADPSSYSPLSSPATSSPSGNAYSSLANRTPGFAESGQSSGQFQGRPSEVWSQWQSQHHGQQSGEQHSHQQPGQTEVFQDMLPMPGDPTQGTGNYNIEDFADLGMFPPFSE

Target ORF information:

RefSeq Version	NM_014862.4
Organism	Homo sapiens(human)
Definition	Homo sapiens aryl hydrocarbon receptor nuclear translocator 2 (ARNT2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014862.4

ORF Insert Sequence:

ATGGCAACCC CGGCGGCGGT CAACCCTCCG GAAATGGCTT CAGACATACC TGGATCTGTG 
ACGTTGCCCG TTGCCCCCAT GGCGGCCACC GGACAGGTGA GGATGGCGGG GGCCATGCCT 
GCCCGTGGAG GAAAGCGGCG TTCCGGAATG GACTTCGATG ATGAAGATGG TGAAGGCCCC 
AGTAAATTTT CAAGAGAGAA TCATAGTGAA ATCGAAAGGC GCAGACGGAA CAAGATGACT 
CAGTACATCA CGGAGCTCTC CGACATGGTC CCCACATGCA GCGCACTGGC TCGGAAGCCA 
GACAAGCTCA CCATCCTCCG CATGGCCGTC TCGCACATGA AGTCCATGAG GGGTACAGGG 
AACAAGTCCA CCGATGGCGC GTACAAGCCT TCCTTCCTCA CAGAGCAGGA ACTGAAGCAT 
CTCATCCTTG AAGCAGCTGA TGGATTTCTG TTTGTGGTGG CTGCTGAGAC AGGGCGAGTG 
ATTTATGTGT CTGACTCCGT CACCCCTGTT CTGAACCAGC CCCAGTCAGA GTGGTTTGGG 
AGCACACTGT ATGAACAGGT GCATCCTGAT GACGTGGAGA AGCTGAGAGA GCAACTGTGC 
ACCTCAGAAA ACTCAATGAC AGGCCGGATC TTGGACCTGA AGACTGGGAC GGTCAAGAAA 
GAAGGGCAGC AGTCATCCAT GAGGATGTGC ATGGGCTCGC GGCGGTCTTT CATCTGCAGG 
ATGAGGTGTG GAAATGCTCC TTTGGACCAC CTTCCTCTAA ACAGAATAAC CACCATGAGG 
AAAAGGTTCA GGAATGGCCT TGGCCCTGTG AAAGAAGGAG AAGCCCAATA TGCTGTGGTC 
CACTGTACAG GATACATCAA GGCCTGGCCA CCAGCAGGAA TGACCATACC TGAAGAAGAC 
GCTGATGTGG GACAAGGCAG TAAATATTGC CTCGTGGCAA TTGGGAGACT CCAGGTGACC 
AGCTCTCCTG TATGCATGGA CATGAATGGG ATGTCGGTGC CCACAGAGTT CTTATCCCGG 
CATAACTCCG ATGGAATCAT CACATTTGTG GATCCAAGAT GTATCAGTGT GATTGGCTAC 
CAACCCCAGG ATCTTCTGGG AAAGGACATT TTGGAATTCT GCCACCCTGA GGATCAAAGC 
CATCTGCGTG AGAGCTTCCA GCAGGTGGTT AAGCTGAAAG GCCAAGTCCT GTCGGTCATG 
TATCGATTTC GCACCAAGAA CCGGGAGTGG ATGTTGATCC GCACCAGCAG CTTCACATTC 
CAGAATCCCT ATTCTGATGA GATTGAGTAC ATCATCTGCA CCAACACCAA CGTCAAGCAA 
CTTCAGCAAC AGCAGGCAGA ATTGGAAGTG CACCAGAGAG ATGGATTGTC ATCGTATGAC 
TTATCCCAGG TCCCCGTCCC CAACCTACCA GCCGGTGTTC ATGAGGCCGG GAAGTCCGTG 
GAAAAGGCGG ATGCAATCTT CTCCCAGGAA AGAGATCCTC GGTTTGCTGA AATGTTTGCA 
GGAATTAGTG CATCGGAGAA GAAGATGATG AGCTCAGCCT CTGCAGCAGG AACCCAGCAG 
ATCTACTCCC AAGGAAGCCC ATTTCCCTCT GGACACTCCG GGAAGGCCTT CAGCTCTTCA 
GTGGTTCATG TGCCTGGAGT GAATGATATT CAGTCCTCTT CTTCCACGGG CCAGAACATG 
TCCCAAATCT CCCGGCAGCT AAACCAGAGT CAGGTGGCAT GGACAGGGAG TCGTCCGCCC 
TTTCCGGGAC AGCAAATCCC ATCTCAGTCC AGCAAGACTC AGTCATCTCC CTTTGGGATT 
GGAACGAGCC ACACCTACCC GGCAGACCCC TCTTCCTACA GCCCCCTCTC CAGCCCAGCT 
ACCTCCTCGC CAAGTGGGAA TGCCTACTCC AGTCTTGCCA ACAGGACTCC AGGGTTCGCT 
GAAAGTGGAC AAAGTAGCGG GCAGTTCCAA GGGCGGCCCT CGGAAGTCTG GTCGCAGTGG 
CAAAGCCAGC ACCATGGCCA GCAGAGCGGT GAGCAGCACT CCCACCAGCA GCCCGGTCAG 
ACTGAAGTGT TCCAGGACAT GCTGCCCATG CCAGGAGATC CAACCCAGGG GACTGGCAAC 
TATAACATCG AAGACTTTGC CGACCTGGGC ATGTTTCCAC CGTTTTCTGA GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness.
Acta neuropathologica135(2)267-283(2018 Feb)
Bogeas A,Morvan-Dubois G,El-Habr EA,Lejeune FX,Defrance M,Narayanan A,Kuranda K,Burel-Vandenbos F,Sayd S,Delaunay V,Dubois LG,Parrinello H,Rialle S,Fabrega S,Idbaih A,Haiech J,Bi?che I,Virolle T,Goodhardt M,Chneiweiss H,Junier MP

Emotion recognition associated with polymorphism in oxytocinergic pathway gene ARNT2.
Social cognitive and affective neuroscience(2017 Nov)
Hovey D,Henningsson S,Cortes DS,B?nziger T,Zettergren A,Melke J,Fischer H,Laukka P,Westberg L

ARNT2 is downregulated and serves as a potential tumor suppressor gene in non-small cell lung cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(3)2111-9(2015 Mar)
Yang B,Yang E,Liao H,Wang Z,Den Z,Ren H

Characterization of human variants in obesity-related SIM1 protein identifies a hot-spot for dimerization with the partner protein ARNT2.
The Biochemical journal461(3)403-12(2014 Aug)
Sullivan AE,Raimondo A,Schwab TA,Bruning JB,Froguel P,Farooqi IS,Peet DJ,Whitelaw ML

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ARNT2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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