LAPTM4A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LAPTM4A
Entrez Gene ID	9741
Full Name	lysosomal protein transmembrane 4 alpha
Synonyms	HUMORF13,LAPTM4,MBNT,Mtrp
General protein information	Preferred Names lysosomal protein transmembrane 4 alpha Names lysosomal-associated transmembrane protein 4A golgi 4-transmembrane-spanning transporter MTP lysosomal-associated protein transmembrane 4 alpha membrane nucleoside transporter
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p24.1
Summary	This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA	Protein	Name
NM_014713.4	NP_055528.1	lysosomal-associated transmembrane protein 4A
NM_014713.5	NP_055528.1	lysosomal-associated transmembrane protein 4A

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	LAPTM4A	NP_001026263.1
Drosophila melanogaster (fruit fly)	CG14767	NP_652400.3
Pan troglodytes (chimpanzee)	LAPTM4A	XP_003949812.1
	LAPTM4A	XP_001095082.1
Mus musculus (house mouse)	Laptm4a	NP_032666.2
Bos taurus (cattle)	LAPTM4A	NP_991368.1
Homo sapiens (human)	LAPTM4A	NP_055528.1
Canis lupus familiaris (dog)	LAPTM4A	XP_003639626.1
Rattus norvegicus (Norway rat)	Laptm4a	NP_955416.1
Danio rerio (zebrafish)	laptm4a	NP_999850.2
Xenopus tropicalis (tropical clawed frog)	laptm4a	NP_001004797.1

Gene Ontology
Bibliography

Related articles in PubMed

LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment.
Grabner A, Brast S, Sucic S, Bierer S, Hirsch B, Pavenst?dt H, Sitte HH, Schlatter E, Ciarimboli G
Cellular and molecular life sciences : CMLS68(24)4079-90(2011 Dec)

Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples.
Aragam N, Wang KS, Pan Y
Journal of affective disorders133(3)516-21(2011 Oct)

LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV.
Vergarajauregui S, Martina JA, Puertollano R
Journal of cell science124(Pt 3)459-68(2011 Feb)

A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins.
Milkereit R, Rotin D
PloS one6(11)e27478(2011)

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A
Genome research13(10)2265-70(2003 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

hOCT2 interacts with LAPTM4A in lysosomes and late endosomes and regulates endocytotic recruitment.
Title: LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment.

The following LAPTM4A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LAPTM4A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06640	NM_014713.5 Latest version!	Homo sapiens lysosomal protein transmembrane 4 alpha (LAPTM4A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu06640	NM_014713.4	Homo sapiens lysosomal protein transmembrane 4 alpha (LAPTM4A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LAPTM4A ( NM_014713.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055528.1 Homo sapiens lysosomal protein transmembrane 4 alpha (LAPTM4A), mRNA.

Price & Availability↑

CloneID	OHu06640
Clone ID Related Accession (Same CDS sequence)	NM_014713.4 , NM_014713.5
Accession Version	NM_014713.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	lysosomal-associated transmembrane protein 4A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP354016.1, DR156048.1, BC093075.1 and CD679337.1. On Aug 13, 2008 this sequence version replaced NM_014713.3. ##Evidence-Data-START## Transcript exon combination :: BC003158.1, SRR1660805.39989.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2149178 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGTGTCCA TGAGTTTCAA GCGGAACCGC AGTGACCGGT TCTACAGCAC CCGGTGCTGC 
GGCTGTTGCC ATGTCCGCAC CGGGACGATC ATCCTGGGGA CCTGGTACAT GGTAGTAAAC 
CTATTGATGG CAATTTTGCT GACTGTGGAA GTGACTCATC CAAACTCCAT GCCAGCTGTC 
AACATTCAGT ATGAAGTCAT CGGTAATTAC TATTCGTCTG AGAGAATGGC TGATAATGCC 
TGTGTTCTTT TTGCCGTCTC TGTTCTTATG TTTATAATCA GTTCAATGCT GGTTTATGGA 
GCAATTTCTT ATCAAGTGGG TTGGCTGATT CCATTCTTCT GTTACCGACT TTTTGACTTC 
GTCCTCAGTT GCCTGGTTGC TATTAGTTCT CTCACCTATT TGCCAAGAAT CAAAGAATAT 
CTGGATCAAC TACCTGATTT TCCCTACAAA GATGACCTCC TGGCCTTGGA CTCCAGCTGC 
CTCCTGTTCA TTGTTCTTGT GTTCTTTGCC TTATTCATCA TTTTTAAGGC TTATCTAATT 
AACTGTGTTT GGAACTGCTA TAAATACATC AACAACCGAA ACGTGCCGGA GATTGCTGTG 
TACCCTGCCT TTGAAGCACC TCCTCAGTAC GTTTTGCCAA CCTATGAAAT GGCCGTGAAA 
ATGCCTGAAA AAGAACCACC ACCTCCTTAC TTACCTGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055528.1
CDS	509..1210
Translation	MVSMSFKRNRSDRFYSTRCCGCCHVRTGTIILGTWYMVVNLLMAILLTVEVTHPNSMPAVNIQYEVIGNYYSSERMADNACVLFAVSVLMFIISSMLVYGAISYQVGWLIPFFCYRLFDFVLSCLVAISSLTYLPRIKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFALFIIFKAYLINCVWNCYKYINNRNVPEIAVYPAFEAPPQYVLPTYEMAVKMPEKEPPPPYLPA

Target ORF information:

RefSeq Version	NM_014713.4
Organism	Homo sapiens(human)
Definition	Homo sapiens lysosomal protein transmembrane 4 alpha (LAPTM4A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014713.4

ORF Insert Sequence:

ATGGTGTCCA TGAGTTTCAA GCGGAACCGC AGTGACCGGT TCTACAGCAC CCGGTGCTGC 
GGCTGTTGCC ATGTCCGCAC CGGGACGATC ATCCTGGGGA CCTGGTACAT GGTAGTAAAC 
CTATTGATGG CAATTTTGCT GACTGTGGAA GTGACTCATC CAAACTCCAT GCCAGCTGTC 
AACATTCAGT ATGAAGTCAT CGGTAATTAC TATTCGTCTG AGAGAATGGC TGATAATGCC 
TGTGTTCTTT TTGCCGTCTC TGTTCTTATG TTTATAATCA GTTCAATGCT GGTTTATGGA 
GCAATTTCTT ATCAAGTGGG TTGGCTGATT CCATTCTTCT GTTACCGACT TTTTGACTTC 
GTCCTCAGTT GCCTGGTTGC TATTAGTTCT CTCACCTATT TGCCAAGAAT CAAAGAATAT 
CTGGATCAAC TACCTGATTT TCCCTACAAA GATGACCTCC TGGCCTTGGA CTCCAGCTGC 
CTCCTGTTCA TTGTTCTTGT GTTCTTTGCC TTATTCATCA TTTTTAAGGC TTATCTAATT 
AACTGTGTTT GGAACTGCTA TAAATACATC AACAACCGAA ACGTGCCGGA GATTGCTGTG 
TACCCTGCCT TTGAAGCACC TCCTCAGTAC GTTTTGCCAA CCTATGAAAT GGCCGTGAAA 
ATGCCTGAAA AAGAACCACC ACCTCCTTAC TTACCTGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LAPTM4A ( NM_014713.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_055528.1 Homo sapiens lysosomal protein transmembrane 4 alpha (LAPTM4A), mRNA.

Price & Availability↑

CloneID	OHu06640
Clone ID Related Accession (Same CDS sequence)	NM_014713.4 , NM_014713.5
Accession Version	NM_014713.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	lysosomal-associated transmembrane protein 4A
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DR156048.1, BC093075.1 and CD679337.1. On Nov 23, 2018 this sequence version replaced NM_014713.4. ##Evidence-Data-START## Transcript exon combination :: ERR279841.1653.1, BC003158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2149178 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000175091.5/ ENSP00000175091.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGTCCA TGAGTTTCAA GCGGAACCGC AGTGACCGGT TCTACAGCAC CCGGTGCTGC 
GGCTGTTGCC ATGTCCGCAC CGGGACGATC ATCCTGGGGA CCTGGTACAT GGTAGTAAAC 
CTATTGATGG CAATTTTGCT GACTGTGGAA GTGACTCATC CAAACTCCAT GCCAGCTGTC 
AACATTCAGT ATGAAGTCAT CGGTAATTAC TATTCGTCTG AGAGAATGGC TGATAATGCC 
TGTGTTCTTT TTGCCGTCTC TGTTCTTATG TTTATAATCA GTTCAATGCT GGTTTATGGA 
GCAATTTCTT ATCAAGTGGG TTGGCTGATT CCATTCTTCT GTTACCGACT TTTTGACTTC 
GTCCTCAGTT GCCTGGTTGC TATTAGTTCT CTCACCTATT TGCCAAGAAT CAAAGAATAT 
CTGGATCAAC TACCTGATTT TCCCTACAAA GATGACCTCC TGGCCTTGGA CTCCAGCTGC 
CTCCTGTTCA TTGTTCTTGT GTTCTTTGCC TTATTCATCA TTTTTAAGGC TTATCTAATT 
AACTGTGTTT GGAACTGCTA TAAATACATC AACAACCGAA ACGTGCCGGA GATTGCTGTG 
TACCCTGCCT TTGAAGCACC TCCTCAGTAC GTTTTGCCAA CCTATGAAAT GGCCGTGAAA 
ATGCCTGAAA AAGAACCACC ACCTCCTTAC TTACCTGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055528.1
CDS	109..810
Translation	MVSMSFKRNRSDRFYSTRCCGCCHVRTGTIILGTWYMVVNLLMAILLTVEVTHPNSMPAVNIQYEVIGNYYSSERMADNACVLFAVSVLMFIISSMLVYGAISYQVGWLIPFFCYRLFDFVLSCLVAISSLTYLPRIKEYLDQLPDFPYKDDLLALDSSCLLFIVLVFFALFIIFKAYLINCVWNCYKYINNRNVPEIAVYPAFEAPPQYVLPTYEMAVKMPEKEPPPPYLPA

Target ORF information:

RefSeq Version	NM_014713.5
Organism	Homo sapiens(human)
Definition	Homo sapiens lysosomal protein transmembrane 4 alpha (LAPTM4A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014713.5

ORF Insert Sequence:

ATGGTGTCCA TGAGTTTCAA GCGGAACCGC AGTGACCGGT TCTACAGCAC CCGGTGCTGC 
GGCTGTTGCC ATGTCCGCAC CGGGACGATC ATCCTGGGGA CCTGGTACAT GGTAGTAAAC 
CTATTGATGG CAATTTTGCT GACTGTGGAA GTGACTCATC CAAACTCCAT GCCAGCTGTC 
AACATTCAGT ATGAAGTCAT CGGTAATTAC TATTCGTCTG AGAGAATGGC TGATAATGCC 
TGTGTTCTTT TTGCCGTCTC TGTTCTTATG TTTATAATCA GTTCAATGCT GGTTTATGGA 
GCAATTTCTT ATCAAGTGGG TTGGCTGATT CCATTCTTCT GTTACCGACT TTTTGACTTC 
GTCCTCAGTT GCCTGGTTGC TATTAGTTCT CTCACCTATT TGCCAAGAAT CAAAGAATAT 
CTGGATCAAC TACCTGATTT TCCCTACAAA GATGACCTCC TGGCCTTGGA CTCCAGCTGC 
CTCCTGTTCA TTGTTCTTGT GTTCTTTGCC TTATTCATCA TTTTTAAGGC TTATCTAATT 
AACTGTGTTT GGAACTGCTA TAAATACATC AACAACCGAA ACGTGCCGGA GATTGCTGTG 
TACCCTGCCT TTGAAGCACC TCCTCAGTAC GTTTTGCCAA CCTATGAAAT GGCCGTGAAA 
ATGCCTGAAA AAGAACCACC ACCTCCTTAC TTACCTGCCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment.
Cellular and molecular life sciences : CMLS68(24)4079-90(2011 Dec)
Grabner A,Brast S,Sucic S,Bierer S,Hirsch B,Pavenst?dt H,Sitte HH,Schlatter E,Ciarimboli G

Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples.
Journal of affective disorders133(3)516-21(2011 Oct)
Aragam N,Wang KS,Pan Y

LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV.
Journal of cell science124(Pt 3)459-68(2011 Feb)
Vergarajauregui S,Martina JA,Puertollano R

A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins.
PloS one6(11)e27478(2011)
Milkereit R,Rotin D

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.
Genome research13(10)2265-70(2003 Oct)
Clark HF,Gurney AL,Abaya E,Baker K,Baldwin D,Brush J,Chen J,Chow B,Chui C,Crowley C,Currell B,Deuel B,Dowd P,Eaton D,Foster J,Grimaldi C,Gu Q,Hass PE,Heldens S,Huang A,Kim HS,Klimowski L,Jin Y,Johnson S,Lee J,Lewis L,Liao D,Mark M,Robbie E,Sanchez C,Schoenfeld J,Seshagiri S,Simmons L,Singh J,Smith V,Stinson J,Vagts A,Vandlen R,Watanabe C,Wieand D,Woods K,Xie MH,Yansura D,Yi S,Yu G,Yuan J,Zhang M,Zhang Z,Goddard A,Wood WI,Godowski P,Gray A

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LAPTM4A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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