ADAMTS4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ADAMTS4
Entrez Gene ID	9507
Full Name	ADAM metallopeptidase with thrombospondin type 1 motif 4
Synonyms	ADAMTS-2,ADAMTS-4,ADMP-1
General protein information	Preferred Names ADAM metallopeptidase with thrombospondin type 1 motif 4 Names A disintegrin and metalloproteinase with thrombospondin motifs 4 ADAM-TS 4 ADAM-TS4 a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4 aggrecanase-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.3
Summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016].
Disorder MIM:	603876

mRNA and Protein(s)

mRNA	Protein	Name
NM_001320336.1	NP_001307265.1	A disintegrin and metalloproteinase with thrombospondin motifs 4 isoform 2 precursor
NM_005099.5	NP_005090.3	A disintegrin and metalloproteinase with thrombospondin motifs 4 isoform 1 preproprotein
NM_005099.6	NP_005090.3	A disintegrin and metalloproteinase with thrombospondin motifs 4 isoform 1 preproprotein
NM_001320336.2	NP_001307265.1	A disintegrin and metalloproteinase with thrombospondin motifs 4 isoform 2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ADAMTS4	XP_513940.2
Canis lupus familiaris (dog)	ADAMTS4	XP_545768.3
Xenopus tropicalis (tropical clawed frog)	adamts4	XP_004919795.1
Rattus norvegicus (Norway rat)	Adamts4	NP_076449.1
Homo sapiens (human)	ADAMTS4	NP_005090.3
	ADAMTS4	XP_002808295.1
Bos taurus (cattle)	ADAMTS4	NP_858053.1
Mus musculus (house mouse)	Adamts4	NP_766433.1

Gene Ontology
Bibliography

Related articles in PubMed

Relationship between ADAMTS4 and carotid atherosclerotic plaque vulnerability in humans.
Dong H, Du T, Premaratne S, Zhao CX, Tian Q, Li Y, Yan S, Zhang WW
Journal of vascular surgery(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ADAMTS-4 protein expression increased in cartilage tissue from spinal tuberculosis patients.
Title: Correlation analysis of ADAMTS-4, VCAM-1, and TAK1 expression in cartilage tissue from spine tuberculosis.

ADAMTS4 and ADAMTS15 were upregulated in symptomatic uterine leiomyomas.
Title: Versican Proteolysis by ADAMTS Proteases and Its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma.

ADAMTS4 expression is significantly upregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.

Using in vitro approaches and cultured breast cancer cell lines authors demonstrate that Fibulin-2 is a better substrate for ADAMTS-5 than it is for ADAMTS-4. Fibulin-2 degradation is associated to an enhancement of the invasive potential of T47D, MCF-7 and SK-BR-3 cells.
Title: Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells.

Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes
Title: Single Nucleotide Variants of Candidate Genes in Aggrecan Metabolic Pathway Are Associated with Lumbar Disc Degeneration and Modic Changes.

The following ADAMTS4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADAMTS4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16366	NM_005099.6 Latest version!	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu34831	NM_001320336.2 Latest version!	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
View Old Accession Versions >>
OHu16366	NM_005099.5	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu34831	NM_001320336.1	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ADAMTS4 ( NM_005099.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005090.3 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16366
Clone ID Related Accession (Same CDS sequence)	NM_005099.5 , NM_005099.6
Accession Version	NM_005099.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2514bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 4 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA098917.1, AF148213.1, BC063293.1, AY358886.1, AB014588.1 and AA603151.1. On Feb 20, 2016 this sequence version replaced NM_005099.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY358886.1, SRR1660805.163035.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCAGA CAGGCTCGCA TCCCGGGAGG GGCTTGGCAG GGCGCTGGCT GTGGGGAGCC 
CAACCCTGCC TCCTGCTCCC CATTGTGCCG CTCTCCTGGC TGGTGTGGCT GCTTCTGCTA 
CTGCTGGCCT CTCTCCTGCC CTCAGCCCGG CTGGCCAGCC CCCTCCCCCG GGAGGAGGAG 
ATCGTGTTTC CAGAGAAGCT CAACGGCAGC GTCCTGCCTG GCTCGGGCGC CCCTGCCAGG 
CTGTTGTGCC GCTTGCAGGC CTTTGGGGAG ACGCTGCTAC TAGAGCTGGA GCAGGACTCC 
GGTGTGCAGG TCGAGGGGCT GACAGTGCAG TACCTGGGCC AGGCGCCTGA GCTGCTGGGT 
GGAGCAGAGC CTGGCACCTA CCTGACTGGC ACCATCAATG GAGATCCGGA GTCGGTGGCA 
TCTCTGCACT GGGATGGGGG AGCCCTGTTA GGCGTGTTAC AATATCGGGG GGCTGAACTC 
CACCTCCAGC CCCTGGAGGG AGGCACCCCT AACTCTGCTG GGGGACCTGG GGCTCACATC 
CTACGCCGGA AGAGTCCTGC CAGCGGTCAA GGTCCCATGT GCAACGTCAA GGCTCCTCTT 
GGAAGCCCCA GCCCCAGACC CCGAAGAGCC AAGCGCTTTG CTTCACTGAG TAGATTTGTG 
GAGACACTGG TGGTGGCAGA TGACAAGATG GCCGCATTCC ACGGTGCGGG GCTAAAGCGC 
TACCTGCTAA CAGTGATGGC AGCAGCAGCC AAGGCCTTCA AGCACCCAAG CATCCGCAAT 
CCTGTCAGCT TGGTGGTGAC TCGGCTAGTG ATCCTGGGGT CAGGCGAGGA GGGGCCCCAA 
GTGGGGCCCA GTGCTGCCCA GACCCTGCGC AGCTTCTGTG CCTGGCAGCG GGGCCTCAAC 
ACCCCTGAGG ACTCGGACCC TGACCACTTT GACACAGCCA TTCTGTTTAC CCGTCAGGAC 
CTGTGTGGAG TCTCCACTTG CGACACGCTG GGTATGGCTG ATGTGGGCAC CGTCTGTGAC 
CCGGCTCGGA GCTGTGCCAT TGTGGAGGAT GATGGGCTCC AGTCAGCCTT CACTGCTGCT 
CATGAACTGG GTCATGTCTT CAACATGCTC CATGACAACT CCAAGCCATG CATCAGTTTG 
AATGGGCCTT TGAGCACCTC TCGCCATGTC ATGGCCCCTG TGATGGCTCA TGTGGATCCT 
GAGGAGCCCT GGTCCCCCTG CAGTGCCCGC TTCATCACTG ACTTCCTGGA CAATGGCTAT 
GGGCACTGTC TCTTAGACAA ACCAGAGGCT CCATTGCATC TGCCTGTGAC TTTCCCTGGC 
AAGGACTATG ATGCTGACCG CCAGTGCCAG CTGACCTTCG GGCCCGACTC ACGCCATTGT 
CCACAGCTGC CGCCGCCCTG TGCTGCCCTC TGGTGCTCTG GCCACCTCAA TGGCCATGCC 
ATGTGCCAGA CCAAACACTC GCCCTGGGCC GATGGCACAC CCTGCGGGCC CGCACAGGCC 
TGCATGGGTG GTCGCTGCCT CCACATGGAC CAGCTCCAGG ACTTCAATAT TCCACAGGCT 
GGTGGCTGGG GTCCTTGGGG ACCATGGGGT GACTGCTCTC GGACCTGTGG GGGTGGTGTC 
CAGTTCTCCT CCCGAGACTG CACGAGGCCT GTCCCCCGGA ATGGTGGCAA GTACTGTGAG 
GGCCGCCGTA CCCGCTTCCG CTCCTGCAAC ACTGAGGACT GCCCAACTGG CTCAGCCCTG 
ACCTTCCGCG AGGAGCAGTG TGCTGCCTAC AACCACCGCA CCGACCTCTT CAAGAGCTTC 
CCAGGGCCCA TGGACTGGGT TCCTCGCTAC ACAGGCGTGG CCCCCCAGGA CCAGTGCAAA 
CTCACCTGCC AGGCCCAGGC ACTGGGCTAC TACTATGTGC TGGAGCCACG GGTGGTAGAT 
GGGACCCCCT GTTCCCCGGA CAGCTCCTCG GTCTGTGTCC AGGGCCGATG CATCCATGCT 
GGCTGTGATC GCATCATTGG CTCCAAGAAG AAGTTTGACA AGTGCATGGT GTGCGGAGGG 
GACGGTTCTG GTTGCAGCAA GCAGTCAGGC TCCTTCAGGA AATTCAGGTA CGGATACAAC 
AATGTGGTCA CTATCCCCGC GGGGGCCACC CACATTCTTG TCCGGCAGCA GGGAAACCCT 
GGCCACCGGA GCATCTACTT GGCCCTGAAG CTGCCAGATG GCTCCTATGC CCTCAATGGT 
GAATACACGC TGATGCCCTC CCCCACAGAT GTGGTACTGC CTGGGGCAGT CAGCTTGCGC 
TACAGCGGGG CCACTGCAGC CTCAGAGACA CTGTCAGGCC ATGGGCCACT GGCCCAGCCT 
TTGACACTGC AAGTCCTAGT GGCTGGCAAC CCCCAGGACA CACGCCTCCG ATACAGCTTC 
TTCGTGCCCC GGCCGACCCC TTCAACGCCA CGCCCCACTC CCCAGGACTG GCTGCACCGA 
AGAGCACAGA TTCTGGAGAT CCTTCGGCGG CGCCCCTGGG CGGGCAGGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005090.3
CDS	427..2940
Translation	MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK

Target ORF information:

RefSeq Version	NM_005099.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005099.5

ORF Insert Sequence:

ATGTCCCAGA CAGGCTCGCA TCCCGGGAGG GGCTTGGCAG GGCGCTGGCT GTGGGGAGCC 
CAACCCTGCC TCCTGCTCCC CATTGTGCCG CTCTCCTGGC TGGTGTGGCT GCTTCTGCTA 
CTGCTGGCCT CTCTCCTGCC CTCAGCCCGG CTGGCCAGCC CCCTCCCCCG GGAGGAGGAG 
ATCGTGTTTC CAGAGAAGCT CAACGGCAGC GTCCTGCCTG GCTCGGGCGC CCCTGCCAGG 
CTGTTGTGCC GCTTGCAGGC CTTTGGGGAG ACGCTGCTAC TAGAGCTGGA GCAGGACTCC 
GGTGTGCAGG TCGAGGGGCT GACAGTGCAG TACCTGGGCC AGGCGCCTGA GCTGCTGGGT 
GGAGCAGAGC CTGGCACCTA CCTGACTGGC ACCATCAATG GAGATCCGGA GTCGGTGGCA 
TCTCTGCACT GGGATGGGGG AGCCCTGTTA GGCGTGTTAC AATATCGGGG GGCTGAACTC 
CACCTCCAGC CCCTGGAGGG AGGCACCCCT AACTCTGCTG GGGGACCTGG GGCTCACATC 
CTACGCCGGA AGAGTCCTGC CAGCGGTCAA GGTCCCATGT GCAACGTCAA GGCTCCTCTT 
GGAAGCCCCA GCCCCAGACC CCGAAGAGCC AAGCGCTTTG CTTCACTGAG TAGATTTGTG 
GAGACACTGG TGGTGGCAGA TGACAAGATG GCCGCATTCC ACGGTGCGGG GCTAAAGCGC 
TACCTGCTAA CAGTGATGGC AGCAGCAGCC AAGGCCTTCA AGCACCCAAG CATCCGCAAT 
CCTGTCAGCT TGGTGGTGAC TCGGCTAGTG ATCCTGGGGT CAGGCGAGGA GGGGCCCCAA 
GTGGGGCCCA GTGCTGCCCA GACCCTGCGC AGCTTCTGTG CCTGGCAGCG GGGCCTCAAC 
ACCCCTGAGG ACTCGGACCC TGACCACTTT GACACAGCCA TTCTGTTTAC CCGTCAGGAC 
CTGTGTGGAG TCTCCACTTG CGACACGCTG GGTATGGCTG ATGTGGGCAC CGTCTGTGAC 
CCGGCTCGGA GCTGTGCCAT TGTGGAGGAT GATGGGCTCC AGTCAGCCTT CACTGCTGCT 
CATGAACTGG GTCATGTCTT CAACATGCTC CATGACAACT CCAAGCCATG CATCAGTTTG 
AATGGGCCTT TGAGCACCTC TCGCCATGTC ATGGCCCCTG TGATGGCTCA TGTGGATCCT 
GAGGAGCCCT GGTCCCCCTG CAGTGCCCGC TTCATCACTG ACTTCCTGGA CAATGGCTAT 
GGGCACTGTC TCTTAGACAA ACCAGAGGCT CCATTGCATC TGCCTGTGAC TTTCCCTGGC 
AAGGACTATG ATGCTGACCG CCAGTGCCAG CTGACCTTCG GGCCCGACTC ACGCCATTGT 
CCACAGCTGC CGCCGCCCTG TGCTGCCCTC TGGTGCTCTG GCCACCTCAA TGGCCATGCC 
ATGTGCCAGA CCAAACACTC GCCCTGGGCC GATGGCACAC CCTGCGGGCC CGCACAGGCC 
TGCATGGGTG GTCGCTGCCT CCACATGGAC CAGCTCCAGG ACTTCAATAT TCCACAGGCT 
GGTGGCTGGG GTCCTTGGGG ACCATGGGGT GACTGCTCTC GGACCTGTGG GGGTGGTGTC 
CAGTTCTCCT CCCGAGACTG CACGAGGCCT GTCCCCCGGA ATGGTGGCAA GTACTGTGAG 
GGCCGCCGTA CCCGCTTCCG CTCCTGCAAC ACTGAGGACT GCCCAACTGG CTCAGCCCTG 
ACCTTCCGCG AGGAGCAGTG TGCTGCCTAC AACCACCGCA CCGACCTCTT CAAGAGCTTC 
CCAGGGCCCA TGGACTGGGT TCCTCGCTAC ACAGGCGTGG CCCCCCAGGA CCAGTGCAAA 
CTCACCTGCC AGGCCCAGGC ACTGGGCTAC TACTATGTGC TGGAGCCACG GGTGGTAGAT 
GGGACCCCCT GTTCCCCGGA CAGCTCCTCG GTCTGTGTCC AGGGCCGATG CATCCATGCT 
GGCTGTGATC GCATCATTGG CTCCAAGAAG AAGTTTGACA AGTGCATGGT GTGCGGAGGG 
GACGGTTCTG GTTGCAGCAA GCAGTCAGGC TCCTTCAGGA AATTCAGGTA CGGATACAAC 
AATGTGGTCA CTATCCCCGC GGGGGCCACC CACATTCTTG TCCGGCAGCA GGGAAACCCT 
GGCCACCGGA GCATCTACTT GGCCCTGAAG CTGCCAGATG GCTCCTATGC CCTCAATGGT 
GAATACACGC TGATGCCCTC CCCCACAGAT GTGGTACTGC CTGGGGCAGT CAGCTTGCGC 
TACAGCGGGG CCACTGCAGC CTCAGAGACA CTGTCAGGCC ATGGGCCACT GGCCCAGCCT 
TTGACACTGC AAGTCCTAGT GGCTGGCAAC CCCCAGGACA CACGCCTCCG ATACAGCTTC 
TTCGTGCCCC GGCCGACCCC TTCAACGCCA CGCCCCACTC CCCAGGACTG GCTGCACCGA 
AGAGCACAGA TTCTGGAGAT CCTTCGGCGG CGCCCCTGGG CGGGCAGGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADAMTS4 ( NM_005099.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_005090.3 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu16366
Clone ID Related Accession (Same CDS sequence)	NM_005099.5 , NM_005099.6
Accession Version	NM_005099.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2514bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 4 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL590714.27, DA098917.1, AF148213.1, BC063293.1, AY358886.1, AB014588.1 and AA603151.1. On Nov 23, 2018 this sequence version replaced NM_005099.5. Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.74836.1, SRR1660805.163035.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367996.6/ ENSP00000356975.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCCAGA CAGGCTCGCA TCCCGGGAGG GGCTTGGCAG GGCGCTGGCT GTGGGGAGCC 
CAACCCTGCC TCCTGCTCCC CATTGTGCCG CTCTCCTGGC TGGTGTGGCT GCTTCTGCTA 
CTGCTGGCCT CTCTCCTGCC CTCAGCCCGG CTGGCCAGCC CCCTCCCCCG GGAGGAGGAG 
ATCGTGTTTC CAGAGAAGCT CAACGGCAGC GTCCTGCCTG GCTCGGGCGC CCCTGCCAGG 
CTGTTGTGCC GCTTGCAGGC CTTTGGGGAG ACGCTGCTAC TAGAGCTGGA GCAGGACTCC 
GGTGTGCAGG TCGAGGGGCT GACAGTGCAG TACCTGGGCC AGGCGCCTGA GCTGCTGGGT 
GGAGCAGAGC CTGGCACCTA CCTGACTGGC ACCATCAATG GAGATCCGGA GTCGGTGGCA 
TCTCTGCACT GGGATGGGGG AGCCCTGTTA GGCGTGTTAC AATATCGGGG GGCTGAACTC 
CACCTCCAGC CCCTGGAGGG AGGCACCCCT AACTCTGCTG GGGGACCTGG GGCTCACATC 
CTACGCCGGA AGAGTCCTGC CAGCGGTCAA GGTCCCATGT GCAACGTCAA GGCTCCTCTT 
GGAAGCCCCA GCCCCAGACC CCGAAGAGCC AAGCGCTTTG CTTCACTGAG TAGATTTGTG 
GAGACACTGG TGGTGGCAGA TGACAAGATG GCCGCATTCC ACGGTGCGGG GCTAAAGCGC 
TACCTGCTAA CAGTGATGGC AGCAGCAGCC AAGGCCTTCA AGCACCCAAG CATCCGCAAT 
CCTGTCAGCT TGGTGGTGAC TCGGCTAGTG ATCCTGGGGT CAGGCGAGGA GGGGCCCCAA 
GTGGGGCCCA GTGCTGCCCA GACCCTGCGC AGCTTCTGTG CCTGGCAGCG GGGCCTCAAC 
ACCCCTGAGG ACTCGGACCC TGACCACTTT GACACAGCCA TTCTGTTTAC CCGTCAGGAC 
CTGTGTGGAG TCTCCACTTG CGACACGCTG GGTATGGCTG ATGTGGGCAC CGTCTGTGAC 
CCGGCTCGGA GCTGTGCCAT TGTGGAGGAT GATGGGCTCC AGTCAGCCTT CACTGCTGCT 
CATGAACTGG GTCATGTCTT CAACATGCTC CATGACAACT CCAAGCCATG CATCAGTTTG 
AATGGGCCTT TGAGCACCTC TCGCCATGTC ATGGCCCCTG TGATGGCTCA TGTGGATCCT 
GAGGAGCCCT GGTCCCCCTG CAGTGCCCGC TTCATCACTG ACTTCCTGGA CAATGGCTAT 
GGGCACTGTC TCTTAGACAA ACCAGAGGCT CCATTGCATC TGCCTGTGAC TTTCCCTGGC 
AAGGACTATG ATGCTGACCG CCAGTGCCAG CTGACCTTCG GGCCCGACTC ACGCCATTGT 
CCACAGCTGC CGCCGCCCTG TGCTGCCCTC TGGTGCTCTG GCCACCTCAA TGGCCATGCC 
ATGTGCCAGA CCAAACACTC GCCCTGGGCC GATGGCACAC CCTGCGGGCC CGCACAGGCC 
TGCATGGGTG GTCGCTGCCT CCACATGGAC CAGCTCCAGG ACTTCAATAT TCCACAGGCT 
GGTGGCTGGG GTCCTTGGGG ACCATGGGGT GACTGCTCTC GGACCTGTGG GGGTGGTGTC 
CAGTTCTCCT CCCGAGACTG CACGAGGCCT GTCCCCCGGA ATGGTGGCAA GTACTGTGAG 
GGCCGCCGTA CCCGCTTCCG CTCCTGCAAC ACTGAGGACT GCCCAACTGG CTCAGCCCTG 
ACCTTCCGCG AGGAGCAGTG TGCTGCCTAC AACCACCGCA CCGACCTCTT CAAGAGCTTC 
CCAGGGCCCA TGGACTGGGT TCCTCGCTAC ACAGGCGTGG CCCCCCAGGA CCAGTGCAAA 
CTCACCTGCC AGGCCCAGGC ACTGGGCTAC TACTATGTGC TGGAGCCACG GGTGGTAGAT 
GGGACCCCCT GTTCCCCGGA CAGCTCCTCG GTCTGTGTCC AGGGCCGATG CATCCATGCT 
GGCTGTGATC GCATCATTGG CTCCAAGAAG AAGTTTGACA AGTGCATGGT GTGCGGAGGG 
GACGGTTCTG GTTGCAGCAA GCAGTCAGGC TCCTTCAGGA AATTCAGGTA CGGATACAAC 
AATGTGGTCA CTATCCCCGC GGGGGCCACC CACATTCTTG TCCGGCAGCA GGGAAACCCT 
GGCCACCGGA GCATCTACTT GGCCCTGAAG CTGCCAGATG GCTCCTATGC CCTCAATGGT 
GAATACACGC TGATGCCCTC CCCCACAGAT GTGGTACTGC CTGGGGCAGT CAGCTTGCGC 
TACAGCGGGG CCACTGCAGC CTCAGAGACA CTGTCAGGCC ATGGGCCACT GGCCCAGCCT 
TTGACACTGC AAGTCCTAGT GGCTGGCAAC CCCCAGGACA CACGCCTCCG ATACAGCTTC 
TTCGTGCCCC GGCCGACCCC TTCAACGCCA CGCCCCACTC CCCAGGACTG GCTGCACCGA 
AGAGCACAGA TTCTGGAGAT CCTTCGGCGG CGCCCCTGGG CGGGCAGGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005090.3
CDS	428..2941
Translation	MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGNPGHRSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSFFVPRPTPSTPRPTPQDWLHRRAQILEILRRRPWAGRK

Target ORF information:

RefSeq Version	NM_005099.6
Organism	Homo sapiens(human)
Definition	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005099.6

ORF Insert Sequence:

ATGTCCCAGA CAGGCTCGCA TCCCGGGAGG GGCTTGGCAG GGCGCTGGCT GTGGGGAGCC 
CAACCCTGCC TCCTGCTCCC CATTGTGCCG CTCTCCTGGC TGGTGTGGCT GCTTCTGCTA 
CTGCTGGCCT CTCTCCTGCC CTCAGCCCGG CTGGCCAGCC CCCTCCCCCG GGAGGAGGAG 
ATCGTGTTTC CAGAGAAGCT CAACGGCAGC GTCCTGCCTG GCTCGGGCGC CCCTGCCAGG 
CTGTTGTGCC GCTTGCAGGC CTTTGGGGAG ACGCTGCTAC TAGAGCTGGA GCAGGACTCC 
GGTGTGCAGG TCGAGGGGCT GACAGTGCAG TACCTGGGCC AGGCGCCTGA GCTGCTGGGT 
GGAGCAGAGC CTGGCACCTA CCTGACTGGC ACCATCAATG GAGATCCGGA GTCGGTGGCA 
TCTCTGCACT GGGATGGGGG AGCCCTGTTA GGCGTGTTAC AATATCGGGG GGCTGAACTC 
CACCTCCAGC CCCTGGAGGG AGGCACCCCT AACTCTGCTG GGGGACCTGG GGCTCACATC 
CTACGCCGGA AGAGTCCTGC CAGCGGTCAA GGTCCCATGT GCAACGTCAA GGCTCCTCTT 
GGAAGCCCCA GCCCCAGACC CCGAAGAGCC AAGCGCTTTG CTTCACTGAG TAGATTTGTG 
GAGACACTGG TGGTGGCAGA TGACAAGATG GCCGCATTCC ACGGTGCGGG GCTAAAGCGC 
TACCTGCTAA CAGTGATGGC AGCAGCAGCC AAGGCCTTCA AGCACCCAAG CATCCGCAAT 
CCTGTCAGCT TGGTGGTGAC TCGGCTAGTG ATCCTGGGGT CAGGCGAGGA GGGGCCCCAA 
GTGGGGCCCA GTGCTGCCCA GACCCTGCGC AGCTTCTGTG CCTGGCAGCG GGGCCTCAAC 
ACCCCTGAGG ACTCGGACCC TGACCACTTT GACACAGCCA TTCTGTTTAC CCGTCAGGAC 
CTGTGTGGAG TCTCCACTTG CGACACGCTG GGTATGGCTG ATGTGGGCAC CGTCTGTGAC 
CCGGCTCGGA GCTGTGCCAT TGTGGAGGAT GATGGGCTCC AGTCAGCCTT CACTGCTGCT 
CATGAACTGG GTCATGTCTT CAACATGCTC CATGACAACT CCAAGCCATG CATCAGTTTG 
AATGGGCCTT TGAGCACCTC TCGCCATGTC ATGGCCCCTG TGATGGCTCA TGTGGATCCT 
GAGGAGCCCT GGTCCCCCTG CAGTGCCCGC TTCATCACTG ACTTCCTGGA CAATGGCTAT 
GGGCACTGTC TCTTAGACAA ACCAGAGGCT CCATTGCATC TGCCTGTGAC TTTCCCTGGC 
AAGGACTATG ATGCTGACCG CCAGTGCCAG CTGACCTTCG GGCCCGACTC ACGCCATTGT 
CCACAGCTGC CGCCGCCCTG TGCTGCCCTC TGGTGCTCTG GCCACCTCAA TGGCCATGCC 
ATGTGCCAGA CCAAACACTC GCCCTGGGCC GATGGCACAC CCTGCGGGCC CGCACAGGCC 
TGCATGGGTG GTCGCTGCCT CCACATGGAC CAGCTCCAGG ACTTCAATAT TCCACAGGCT 
GGTGGCTGGG GTCCTTGGGG ACCATGGGGT GACTGCTCTC GGACCTGTGG GGGTGGTGTC 
CAGTTCTCCT CCCGAGACTG CACGAGGCCT GTCCCCCGGA ATGGTGGCAA GTACTGTGAG 
GGCCGCCGTA CCCGCTTCCG CTCCTGCAAC ACTGAGGACT GCCCAACTGG CTCAGCCCTG 
ACCTTCCGCG AGGAGCAGTG TGCTGCCTAC AACCACCGCA CCGACCTCTT CAAGAGCTTC 
CCAGGGCCCA TGGACTGGGT TCCTCGCTAC ACAGGCGTGG CCCCCCAGGA CCAGTGCAAA 
CTCACCTGCC AGGCCCAGGC ACTGGGCTAC TACTATGTGC TGGAGCCACG GGTGGTAGAT 
GGGACCCCCT GTTCCCCGGA CAGCTCCTCG GTCTGTGTCC AGGGCCGATG CATCCATGCT 
GGCTGTGATC GCATCATTGG CTCCAAGAAG AAGTTTGACA AGTGCATGGT GTGCGGAGGG 
GACGGTTCTG GTTGCAGCAA GCAGTCAGGC TCCTTCAGGA AATTCAGGTA CGGATACAAC 
AATGTGGTCA CTATCCCCGC GGGGGCCACC CACATTCTTG TCCGGCAGCA GGGAAACCCT 
GGCCACCGGA GCATCTACTT GGCCCTGAAG CTGCCAGATG GCTCCTATGC CCTCAATGGT 
GAATACACGC TGATGCCCTC CCCCACAGAT GTGGTACTGC CTGGGGCAGT CAGCTTGCGC 
TACAGCGGGG CCACTGCAGC CTCAGAGACA CTGTCAGGCC ATGGGCCACT GGCCCAGCCT 
TTGACACTGC AAGTCCTAGT GGCTGGCAAC CCCCAGGACA CACGCCTCCG ATACAGCTTC 
TTCGTGCCCC GGCCGACCCC TTCAACGCCA CGCCCCACTC CCCAGGACTG GCTGCACCGA 
AGAGCACAGA TTCTGGAGAT CCTTCGGCGG CGCCCCTGGG CGGGCAGGAA ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADAMTS4 ( NM_001320336.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307265.1 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu34831
Clone ID Related Accession (Same CDS sequence)	NM_001320336.1 , NM_001320336.2
Accession Version	NM_001320336.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2541bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 4 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA098917.1, AF148213.1, BC063293.1, DQ364570.1, AY358886.1, AB014588.1 and AA603151.1. On Feb 20, 2016 this sequence version replaced XM_006711635.1. Transcript Variant: This variant (2, also known as ADAMTS4_v1) uses an alternate splice site in the 3' coding region resulting in a frameshift compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus compared to isoform 1, but may undergo proteolytic processing similar to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.265503.1, SRR1803611.209294.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCAGA CAGGCTCGCA TCCCGGGAGG GGCTTGGCAG GGCGCTGGCT GTGGGGAGCC 
CAACCCTGCC TCCTGCTCCC CATTGTGCCG CTCTCCTGGC TGGTGTGGCT GCTTCTGCTA 
CTGCTGGCCT CTCTCCTGCC CTCAGCCCGG CTGGCCAGCC CCCTCCCCCG GGAGGAGGAG 
ATCGTGTTTC CAGAGAAGCT CAACGGCAGC GTCCTGCCTG GCTCGGGCGC CCCTGCCAGG 
CTGTTGTGCC GCTTGCAGGC CTTTGGGGAG ACGCTGCTAC TAGAGCTGGA GCAGGACTCC 
GGTGTGCAGG TCGAGGGGCT GACAGTGCAG TACCTGGGCC AGGCGCCTGA GCTGCTGGGT 
GGAGCAGAGC CTGGCACCTA CCTGACTGGC ACCATCAATG GAGATCCGGA GTCGGTGGCA 
TCTCTGCACT GGGATGGGGG AGCCCTGTTA GGCGTGTTAC AATATCGGGG GGCTGAACTC 
CACCTCCAGC CCCTGGAGGG AGGCACCCCT AACTCTGCTG GGGGACCTGG GGCTCACATC 
CTACGCCGGA AGAGTCCTGC CAGCGGTCAA GGTCCCATGT GCAACGTCAA GGCTCCTCTT 
GGAAGCCCCA GCCCCAGACC CCGAAGAGCC AAGCGCTTTG CTTCACTGAG TAGATTTGTG 
GAGACACTGG TGGTGGCAGA TGACAAGATG GCCGCATTCC ACGGTGCGGG GCTAAAGCGC 
TACCTGCTAA CAGTGATGGC AGCAGCAGCC AAGGCCTTCA AGCACCCAAG CATCCGCAAT 
CCTGTCAGCT TGGTGGTGAC TCGGCTAGTG ATCCTGGGGT CAGGCGAGGA GGGGCCCCAA 
GTGGGGCCCA GTGCTGCCCA GACCCTGCGC AGCTTCTGTG CCTGGCAGCG GGGCCTCAAC 
ACCCCTGAGG ACTCGGACCC TGACCACTTT GACACAGCCA TTCTGTTTAC CCGTCAGGAC 
CTGTGTGGAG TCTCCACTTG CGACACGCTG GGTATGGCTG ATGTGGGCAC CGTCTGTGAC 
CCGGCTCGGA GCTGTGCCAT TGTGGAGGAT GATGGGCTCC AGTCAGCCTT CACTGCTGCT 
CATGAACTGG GTCATGTCTT CAACATGCTC CATGACAACT CCAAGCCATG CATCAGTTTG 
AATGGGCCTT TGAGCACCTC TCGCCATGTC ATGGCCCCTG TGATGGCTCA TGTGGATCCT 
GAGGAGCCCT GGTCCCCCTG CAGTGCCCGC TTCATCACTG ACTTCCTGGA CAATGGCTAT 
GGGCACTGTC TCTTAGACAA ACCAGAGGCT CCATTGCATC TGCCTGTGAC TTTCCCTGGC 
AAGGACTATG ATGCTGACCG CCAGTGCCAG CTGACCTTCG GGCCCGACTC ACGCCATTGT 
CCACAGCTGC CGCCGCCCTG TGCTGCCCTC TGGTGCTCTG GCCACCTCAA TGGCCATGCC 
ATGTGCCAGA CCAAACACTC GCCCTGGGCC GATGGCACAC CCTGCGGGCC CGCACAGGCC 
TGCATGGGTG GTCGCTGCCT CCACATGGAC CAGCTCCAGG ACTTCAATAT TCCACAGGCT 
GGTGGCTGGG GTCCTTGGGG ACCATGGGGT GACTGCTCTC GGACCTGTGG GGGTGGTGTC 
CAGTTCTCCT CCCGAGACTG CACGAGGCCT GTCCCCCGGA ATGGTGGCAA GTACTGTGAG 
GGCCGCCGTA CCCGCTTCCG CTCCTGCAAC ACTGAGGACT GCCCAACTGG CTCAGCCCTG 
ACCTTCCGCG AGGAGCAGTG TGCTGCCTAC AACCACCGCA CCGACCTCTT CAAGAGCTTC 
CCAGGGCCCA TGGACTGGGT TCCTCGCTAC ACAGGCGTGG CCCCCCAGGA CCAGTGCAAA 
CTCACCTGCC AGGCCCAGGC ACTGGGCTAC TACTATGTGC TGGAGCCACG GGTGGTAGAT 
GGGACCCCCT GTTCCCCGGA CAGCTCCTCG GTCTGTGTCC AGGGCCGATG CATCCATGCT 
GGCTGTGATC GCATCATTGG CTCCAAGAAG AAGTTTGACA AGTGCATGGT GTGCGGAGGG 
GACGGTTCTG GTTGCAGCAA GCAGTCAGGC TCCTTCAGGA AATTCAGATG TGGTACTGCC 
TGGGGCAGTC AGCTTGCGCT ACAGCGGGGC CACTGCAGCC TCAGAGACAC TGTCAGGCCA 
TGGGCCACTG GCCCAGCCTT TGACACTGCA AGTCCTAGTG GCTGGCAACC CCCAGGACAC 
ACGCCTCCGA TACAGCTTCT TCGTGCCCCG GCCGACCCCT TCAACGCCAC GCCCCACTCC 
CCAGGACTGG CTGCACCGAA GAGCACAGAT TCTGGAGATC CTTCGGCGGC GCCCCTGGGC 
GGGCAGGAAA TAACCTCACT ATCCCGGCTG CCCTTTCTGG GCACCGGGGC CTCGGACTTA 
GCTGGGAGAA AGAGAGAGCT TCTGTTGCTG CCTCATGCTA AGACTCAGTG GGGAGGGGCT 
GTGGGCGTGA GACCTGCCCC TCCTCTCTGC CCTAATGCGC AGGCTGGCCC TGCCCTGGTT 
TCCTGCCCTG GGAGGCAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307265.1
CDS	427..2967
Translation	MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRCGTAWGSQLALQRGHCSLRDTVRPWATGPAFDTASPSGWQPPGHTPPIQLLRAPADPFNATPHSPGLAAPKSTDSGDPSAAPLGGQEITSLSRLPFLGTGASDLAGRKRELLLLPHAKTQWGGAVGVRPAPPLCPNAQAGPALVSCPGRQ

Target ORF information:

RefSeq Version	NM_001320336.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320336.1

ORF Insert Sequence:

ATGTCCCAGA CAGGCTCGCA TCCCGGGAGG GGCTTGGCAG GGCGCTGGCT GTGGGGAGCC 
CAACCCTGCC TCCTGCTCCC CATTGTGCCG CTCTCCTGGC TGGTGTGGCT GCTTCTGCTA 
CTGCTGGCCT CTCTCCTGCC CTCAGCCCGG CTGGCCAGCC CCCTCCCCCG GGAGGAGGAG 
ATCGTGTTTC CAGAGAAGCT CAACGGCAGC GTCCTGCCTG GCTCGGGCGC CCCTGCCAGG 
CTGTTGTGCC GCTTGCAGGC CTTTGGGGAG ACGCTGCTAC TAGAGCTGGA GCAGGACTCC 
GGTGTGCAGG TCGAGGGGCT GACAGTGCAG TACCTGGGCC AGGCGCCTGA GCTGCTGGGT 
GGAGCAGAGC CTGGCACCTA CCTGACTGGC ACCATCAATG GAGATCCGGA GTCGGTGGCA 
TCTCTGCACT GGGATGGGGG AGCCCTGTTA GGCGTGTTAC AATATCGGGG GGCTGAACTC 
CACCTCCAGC CCCTGGAGGG AGGCACCCCT AACTCTGCTG GGGGACCTGG GGCTCACATC 
CTACGCCGGA AGAGTCCTGC CAGCGGTCAA GGTCCCATGT GCAACGTCAA GGCTCCTCTT 
GGAAGCCCCA GCCCCAGACC CCGAAGAGCC AAGCGCTTTG CTTCACTGAG TAGATTTGTG 
GAGACACTGG TGGTGGCAGA TGACAAGATG GCCGCATTCC ACGGTGCGGG GCTAAAGCGC 
TACCTGCTAA CAGTGATGGC AGCAGCAGCC AAGGCCTTCA AGCACCCAAG CATCCGCAAT 
CCTGTCAGCT TGGTGGTGAC TCGGCTAGTG ATCCTGGGGT CAGGCGAGGA GGGGCCCCAA 
GTGGGGCCCA GTGCTGCCCA GACCCTGCGC AGCTTCTGTG CCTGGCAGCG GGGCCTCAAC 
ACCCCTGAGG ACTCGGACCC TGACCACTTT GACACAGCCA TTCTGTTTAC CCGTCAGGAC 
CTGTGTGGAG TCTCCACTTG CGACACGCTG GGTATGGCTG ATGTGGGCAC CGTCTGTGAC 
CCGGCTCGGA GCTGTGCCAT TGTGGAGGAT GATGGGCTCC AGTCAGCCTT CACTGCTGCT 
CATGAACTGG GTCATGTCTT CAACATGCTC CATGACAACT CCAAGCCATG CATCAGTTTG 
AATGGGCCTT TGAGCACCTC TCGCCATGTC ATGGCCCCTG TGATGGCTCA TGTGGATCCT 
GAGGAGCCCT GGTCCCCCTG CAGTGCCCGC TTCATCACTG ACTTCCTGGA CAATGGCTAT 
GGGCACTGTC TCTTAGACAA ACCAGAGGCT CCATTGCATC TGCCTGTGAC TTTCCCTGGC 
AAGGACTATG ATGCTGACCG CCAGTGCCAG CTGACCTTCG GGCCCGACTC ACGCCATTGT 
CCACAGCTGC CGCCGCCCTG TGCTGCCCTC TGGTGCTCTG GCCACCTCAA TGGCCATGCC 
ATGTGCCAGA CCAAACACTC GCCCTGGGCC GATGGCACAC CCTGCGGGCC CGCACAGGCC 
TGCATGGGTG GTCGCTGCCT CCACATGGAC CAGCTCCAGG ACTTCAATAT TCCACAGGCT 
GGTGGCTGGG GTCCTTGGGG ACCATGGGGT GACTGCTCTC GGACCTGTGG GGGTGGTGTC 
CAGTTCTCCT CCCGAGACTG CACGAGGCCT GTCCCCCGGA ATGGTGGCAA GTACTGTGAG 
GGCCGCCGTA CCCGCTTCCG CTCCTGCAAC ACTGAGGACT GCCCAACTGG CTCAGCCCTG 
ACCTTCCGCG AGGAGCAGTG TGCTGCCTAC AACCACCGCA CCGACCTCTT CAAGAGCTTC 
CCAGGGCCCA TGGACTGGGT TCCTCGCTAC ACAGGCGTGG CCCCCCAGGA CCAGTGCAAA 
CTCACCTGCC AGGCCCAGGC ACTGGGCTAC TACTATGTGC TGGAGCCACG GGTGGTAGAT 
GGGACCCCCT GTTCCCCGGA CAGCTCCTCG GTCTGTGTCC AGGGCCGATG CATCCATGCT 
GGCTGTGATC GCATCATTGG CTCCAAGAAG AAGTTTGACA AGTGCATGGT GTGCGGAGGG 
GACGGTTCTG GTTGCAGCAA GCAGTCAGGC TCCTTCAGGA AATTCAGATG TGGTACTGCC 
TGGGGCAGTC AGCTTGCGCT ACAGCGGGGC CACTGCAGCC TCAGAGACAC TGTCAGGCCA 
TGGGCCACTG GCCCAGCCTT TGACACTGCA AGTCCTAGTG GCTGGCAACC CCCAGGACAC 
ACGCCTCCGA TACAGCTTCT TCGTGCCCCG GCCGACCCCT TCAACGCCAC GCCCCACTCC 
CCAGGACTGG CTGCACCGAA GAGCACAGAT TCTGGAGATC CTTCGGCGGC GCCCCTGGGC 
GGGCAGGAAA TAACCTCACT ATCCCGGCTG CCCTTTCTGG GCACCGGGGC CTCGGACTTA 
GCTGGGAGAA AGAGAGAGCT TCTGTTGCTG CCTCATGCTA AGACTCAGTG GGGAGGGGCT 
GTGGGCGTGA GACCTGCCCC TCCTCTCTGC CCTAATGCGC AGGCTGGCCC TGCCCTGGTT 
TCCTGCCCTG GGAGGCAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ADAMTS4 ( NM_001320336.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001307265.1 Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu34831
Clone ID Related Accession (Same CDS sequence)	NM_001320336.1 , NM_001320336.2
Accession Version	NM_001320336.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2541bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	A disintegrin and metalloproteinase with thrombospondin motifs 4 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL590714.27, DA098917.1, AF148213.1, BC063293.1, DQ364570.1, AY358886.1, AB014588.1 and AA603151.1. On May 31, 2019 this sequence version replaced NM_001320336.1. Transcript Variant: This variant (2, also known as ADAMTS4_v1) uses an alternate splice site in the 3' coding region resulting in a frameshift compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus compared to isoform 1, but may undergo proteolytic processing similar to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.265503.1, SRR1803611.209294.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCCAGA CAGGCTCGCA TCCCGGGAGG GGCTTGGCAG GGCGCTGGCT GTGGGGAGCC 
CAACCCTGCC TCCTGCTCCC CATTGTGCCG CTCTCCTGGC TGGTGTGGCT GCTTCTGCTA 
CTGCTGGCCT CTCTCCTGCC CTCAGCCCGG CTGGCCAGCC CCCTCCCCCG GGAGGAGGAG 
ATCGTGTTTC CAGAGAAGCT CAACGGCAGC GTCCTGCCTG GCTCGGGCGC CCCTGCCAGG 
CTGTTGTGCC GCTTGCAGGC CTTTGGGGAG ACGCTGCTAC TAGAGCTGGA GCAGGACTCC 
GGTGTGCAGG TCGAGGGGCT GACAGTGCAG TACCTGGGCC AGGCGCCTGA GCTGCTGGGT 
GGAGCAGAGC CTGGCACCTA CCTGACTGGC ACCATCAATG GAGATCCGGA GTCGGTGGCA 
TCTCTGCACT GGGATGGGGG AGCCCTGTTA GGCGTGTTAC AATATCGGGG GGCTGAACTC 
CACCTCCAGC CCCTGGAGGG AGGCACCCCT AACTCTGCTG GGGGACCTGG GGCTCACATC 
CTACGCCGGA AGAGTCCTGC CAGCGGTCAA GGTCCCATGT GCAACGTCAA GGCTCCTCTT 
GGAAGCCCCA GCCCCAGACC CCGAAGAGCC AAGCGCTTTG CTTCACTGAG TAGATTTGTG 
GAGACACTGG TGGTGGCAGA TGACAAGATG GCCGCATTCC ACGGTGCGGG GCTAAAGCGC 
TACCTGCTAA CAGTGATGGC AGCAGCAGCC AAGGCCTTCA AGCACCCAAG CATCCGCAAT 
CCTGTCAGCT TGGTGGTGAC TCGGCTAGTG ATCCTGGGGT CAGGCGAGGA GGGGCCCCAA 
GTGGGGCCCA GTGCTGCCCA GACCCTGCGC AGCTTCTGTG CCTGGCAGCG GGGCCTCAAC 
ACCCCTGAGG ACTCGGACCC TGACCACTTT GACACAGCCA TTCTGTTTAC CCGTCAGGAC 
CTGTGTGGAG TCTCCACTTG CGACACGCTG GGTATGGCTG ATGTGGGCAC CGTCTGTGAC 
CCGGCTCGGA GCTGTGCCAT TGTGGAGGAT GATGGGCTCC AGTCAGCCTT CACTGCTGCT 
CATGAACTGG GTCATGTCTT CAACATGCTC CATGACAACT CCAAGCCATG CATCAGTTTG 
AATGGGCCTT TGAGCACCTC TCGCCATGTC ATGGCCCCTG TGATGGCTCA TGTGGATCCT 
GAGGAGCCCT GGTCCCCCTG CAGTGCCCGC TTCATCACTG ACTTCCTGGA CAATGGCTAT 
GGGCACTGTC TCTTAGACAA ACCAGAGGCT CCATTGCATC TGCCTGTGAC TTTCCCTGGC 
AAGGACTATG ATGCTGACCG CCAGTGCCAG CTGACCTTCG GGCCCGACTC ACGCCATTGT 
CCACAGCTGC CGCCGCCCTG TGCTGCCCTC TGGTGCTCTG GCCACCTCAA TGGCCATGCC 
ATGTGCCAGA CCAAACACTC GCCCTGGGCC GATGGCACAC CCTGCGGGCC CGCACAGGCC 
TGCATGGGTG GTCGCTGCCT CCACATGGAC CAGCTCCAGG ACTTCAATAT TCCACAGGCT 
GGTGGCTGGG GTCCTTGGGG ACCATGGGGT GACTGCTCTC GGACCTGTGG GGGTGGTGTC 
CAGTTCTCCT CCCGAGACTG CACGAGGCCT GTCCCCCGGA ATGGTGGCAA GTACTGTGAG 
GGCCGCCGTA CCCGCTTCCG CTCCTGCAAC ACTGAGGACT GCCCAACTGG CTCAGCCCTG 
ACCTTCCGCG AGGAGCAGTG TGCTGCCTAC AACCACCGCA CCGACCTCTT CAAGAGCTTC 
CCAGGGCCCA TGGACTGGGT TCCTCGCTAC ACAGGCGTGG CCCCCCAGGA CCAGTGCAAA 
CTCACCTGCC AGGCCCAGGC ACTGGGCTAC TACTATGTGC TGGAGCCACG GGTGGTAGAT 
GGGACCCCCT GTTCCCCGGA CAGCTCCTCG GTCTGTGTCC AGGGCCGATG CATCCATGCT 
GGCTGTGATC GCATCATTGG CTCCAAGAAG AAGTTTGACA AGTGCATGGT GTGCGGAGGG 
GACGGTTCTG GTTGCAGCAA GCAGTCAGGC TCCTTCAGGA AATTCAGATG TGGTACTGCC 
TGGGGCAGTC AGCTTGCGCT ACAGCGGGGC CACTGCAGCC TCAGAGACAC TGTCAGGCCA 
TGGGCCACTG GCCCAGCCTT TGACACTGCA AGTCCTAGTG GCTGGCAACC CCCAGGACAC 
ACGCCTCCGA TACAGCTTCT TCGTGCCCCG GCCGACCCCT TCAACGCCAC GCCCCACTCC 
CCAGGACTGG CTGCACCGAA GAGCACAGAT TCTGGAGATC CTTCGGCGGC GCCCCTGGGC 
GGGCAGGAAA TAACCTCACT ATCCCGGCTG CCCTTTCTGG GCACCGGGGC CTCGGACTTA 
GCTGGGAGAA AGAGAGAGCT TCTGTTGCTG CCTCATGCTA AGACTCAGTG GGGAGGGGCT 
GTGGGCGTGA GACCTGCCCC TCCTCTCTGC CCTAATGCGC AGGCTGGCCC TGCCCTGGTT 
TCCTGCCCTG GGAGGCAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001307265.1
CDS	428..2968
Translation	MSQTGSHPGRGLAGRWLWGAQPCLLLPIVPLSWLVWLLLLLLASLLPSARLASPLPREEEIVFPEKLNGSVLPGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQGPMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRCGTAWGSQLALQRGHCSLRDTVRPWATGPAFDTASPSGWQPPGHTPPIQLLRAPADPFNATPHSPGLAAPKSTDSGDPSAAPLGGQEITSLSRLPFLGTGASDLAGRKRELLLLPHAKTQWGGAVGVRPAPPLCPNAQAGPALVSCPGRQ

Target ORF information:

RefSeq Version	NM_001320336.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001320336.2

ORF Insert Sequence:

ATGTCCCAGA CAGGCTCGCA TCCCGGGAGG GGCTTGGCAG GGCGCTGGCT GTGGGGAGCC 
CAACCCTGCC TCCTGCTCCC CATTGTGCCG CTCTCCTGGC TGGTGTGGCT GCTTCTGCTA 
CTGCTGGCCT CTCTCCTGCC CTCAGCCCGG CTGGCCAGCC CCCTCCCCCG GGAGGAGGAG 
ATCGTGTTTC CAGAGAAGCT CAACGGCAGC GTCCTGCCTG GCTCGGGCGC CCCTGCCAGG 
CTGTTGTGCC GCTTGCAGGC CTTTGGGGAG ACGCTGCTAC TAGAGCTGGA GCAGGACTCC 
GGTGTGCAGG TCGAGGGGCT GACAGTGCAG TACCTGGGCC AGGCGCCTGA GCTGCTGGGT 
GGAGCAGAGC CTGGCACCTA CCTGACTGGC ACCATCAATG GAGATCCGGA GTCGGTGGCA 
TCTCTGCACT GGGATGGGGG AGCCCTGTTA GGCGTGTTAC AATATCGGGG GGCTGAACTC 
CACCTCCAGC CCCTGGAGGG AGGCACCCCT AACTCTGCTG GGGGACCTGG GGCTCACATC 
CTACGCCGGA AGAGTCCTGC CAGCGGTCAA GGTCCCATGT GCAACGTCAA GGCTCCTCTT 
GGAAGCCCCA GCCCCAGACC CCGAAGAGCC AAGCGCTTTG CTTCACTGAG TAGATTTGTG 
GAGACACTGG TGGTGGCAGA TGACAAGATG GCCGCATTCC ACGGTGCGGG GCTAAAGCGC 
TACCTGCTAA CAGTGATGGC AGCAGCAGCC AAGGCCTTCA AGCACCCAAG CATCCGCAAT 
CCTGTCAGCT TGGTGGTGAC TCGGCTAGTG ATCCTGGGGT CAGGCGAGGA GGGGCCCCAA 
GTGGGGCCCA GTGCTGCCCA GACCCTGCGC AGCTTCTGTG CCTGGCAGCG GGGCCTCAAC 
ACCCCTGAGG ACTCGGACCC TGACCACTTT GACACAGCCA TTCTGTTTAC CCGTCAGGAC 
CTGTGTGGAG TCTCCACTTG CGACACGCTG GGTATGGCTG ATGTGGGCAC CGTCTGTGAC 
CCGGCTCGGA GCTGTGCCAT TGTGGAGGAT GATGGGCTCC AGTCAGCCTT CACTGCTGCT 
CATGAACTGG GTCATGTCTT CAACATGCTC CATGACAACT CCAAGCCATG CATCAGTTTG 
AATGGGCCTT TGAGCACCTC TCGCCATGTC ATGGCCCCTG TGATGGCTCA TGTGGATCCT 
GAGGAGCCCT GGTCCCCCTG CAGTGCCCGC TTCATCACTG ACTTCCTGGA CAATGGCTAT 
GGGCACTGTC TCTTAGACAA ACCAGAGGCT CCATTGCATC TGCCTGTGAC TTTCCCTGGC 
AAGGACTATG ATGCTGACCG CCAGTGCCAG CTGACCTTCG GGCCCGACTC ACGCCATTGT 
CCACAGCTGC CGCCGCCCTG TGCTGCCCTC TGGTGCTCTG GCCACCTCAA TGGCCATGCC 
ATGTGCCAGA CCAAACACTC GCCCTGGGCC GATGGCACAC CCTGCGGGCC CGCACAGGCC 
TGCATGGGTG GTCGCTGCCT CCACATGGAC CAGCTCCAGG ACTTCAATAT TCCACAGGCT 
GGTGGCTGGG GTCCTTGGGG ACCATGGGGT GACTGCTCTC GGACCTGTGG GGGTGGTGTC 
CAGTTCTCCT CCCGAGACTG CACGAGGCCT GTCCCCCGGA ATGGTGGCAA GTACTGTGAG 
GGCCGCCGTA CCCGCTTCCG CTCCTGCAAC ACTGAGGACT GCCCAACTGG CTCAGCCCTG 
ACCTTCCGCG AGGAGCAGTG TGCTGCCTAC AACCACCGCA CCGACCTCTT CAAGAGCTTC 
CCAGGGCCCA TGGACTGGGT TCCTCGCTAC ACAGGCGTGG CCCCCCAGGA CCAGTGCAAA 
CTCACCTGCC AGGCCCAGGC ACTGGGCTAC TACTATGTGC TGGAGCCACG GGTGGTAGAT 
GGGACCCCCT GTTCCCCGGA CAGCTCCTCG GTCTGTGTCC AGGGCCGATG CATCCATGCT 
GGCTGTGATC GCATCATTGG CTCCAAGAAG AAGTTTGACA AGTGCATGGT GTGCGGAGGG 
GACGGTTCTG GTTGCAGCAA GCAGTCAGGC TCCTTCAGGA AATTCAGATG TGGTACTGCC 
TGGGGCAGTC AGCTTGCGCT ACAGCGGGGC CACTGCAGCC TCAGAGACAC TGTCAGGCCA 
TGGGCCACTG GCCCAGCCTT TGACACTGCA AGTCCTAGTG GCTGGCAACC CCCAGGACAC 
ACGCCTCCGA TACAGCTTCT TCGTGCCCCG GCCGACCCCT TCAACGCCAC GCCCCACTCC 
CCAGGACTGG CTGCACCGAA GAGCACAGAT TCTGGAGATC CTTCGGCGGC GCCCCTGGGC 
GGGCAGGAAA TAACCTCACT ATCCCGGCTG CCCTTTCTGG GCACCGGGGC CTCGGACTTA 
GCTGGGAGAA AGAGAGAGCT TCTGTTGCTG CCTCATGCTA AGACTCAGTG GGGAGGGGCT 
GTGGGCGTGA GACCTGCCCC TCCTCTCTGC CCTAATGCGC AGGCTGGCCC TGCCCTGGTT 
TCCTGCCCTG GGAGGCAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Relationship between ADAMTS4 and carotid atherosclerotic plaque vulnerability in humans.
Journal of vascular surgery(2017 Nov)
Dong H,Du T,Premaratne S,Zhao CX,Tian Q,Li Y,Yan S,Zhang WW

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ADAMTS4 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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