Gene Symbol | ABCG2 |
Entrez Gene ID | 9429 |
Full Name | ATP binding cassette subfamily G member 2 (Junior blood group) |
Synonyms | ABC15,ABCP,BCRP,BCRP1,BMDP,CD338,CDw338,EST157481,GOUT1,MRX,MXR,MXR-1,MXR1,UAQTL1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]. |
Disorder MIM: | |
Disorder Html: | [Junior blood group system], 614490 (3); [Uric acid concentration, serum, QTL1], 138900 (3) |