PHOX2B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PHOX2B
Entrez Gene ID	8929
Full Name	paired like homeobox 2b
Synonyms	NBLST2,NBPhox,PMX2B
General protein information	Preferred Names paired like homeobox 2b Names paired mesoderm homeobox protein 2B PHOX2B homeodomain protein neuroblastoma Phox neuroblastoma paired-type homeobox protein paired mesoderm homeobox 2b paired-like homeobox 2B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p13
Summary	The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016].
Disorder MIM:	603851
Disorder Html:	Central hypoventilation syndrome, congenital, with or without Hirschsprung disease, 209880 (3); {Neuroblastoma, susceptibility to, 2}, 613013 (3); Neuroblastoma with Hirschsprung disease, 613013 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_003924.3	NP_003915.2	paired mesoderm homeobox protein 2B
NM_003924.4	NP_003915.2	paired mesoderm homeobox protein 2B

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PHOX2B	XP_852840.1
Danio rerio (zebrafish)	phox2bb	NP_001014818.1
Homo sapiens (human)	PHOX2B	NP_003915.2
Xenopus tropicalis (tropical clawed frog)	phox2b	NP_001116492.1
Gallus gallus (chicken)	PHOX2B	XP_001234151.2
Danio rerio (zebrafish)	LOC101885818	XP_005157278.1
Pan troglodytes (chimpanzee)	PHOX2B	XP_001149518.1
	PHOX2B	XP_001098028.1
Mus musculus (house mouse)	Phox2b	NP_032914.1

Gene Ontology

The following PHOX2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PHOX2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26329	NM_003924.4 Latest version!	Homo sapiens paired like homeobox 2B (PHOX2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu26329	NM_003924.3	Homo sapiens paired like homeobox 2B (PHOX2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PHOX2B ( NM_003924.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003915.2 Homo sapiens paired like homeobox 2B (PHOX2B), mRNA.

Price & Availability↑

CloneID	OHu26329
Clone ID Related Accession (Same CDS sequence)	NM_003924.3 , NM_003924.4
Accession Version	NM_003924.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-27
Organism	Homo sapiens(human)
Product	paired mesoderm homeobox protein 2B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D82344.1, BC017199.2, AC105389.3 and AI266171.1. This sequence is a reference standard in the RefSeqGene project. On Apr 4, 2008 this sequence version replaced NM_003924.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D82344.1, BC017199.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTATAAAA TGGAATATTC TTACCTCAAT TCCTCTGCCT ACGAGTCCTG TATGGCTGGG 
ATGGACACCT CGAGCCTGGC TTCAGCCTAT GCTGACTTCA GTTCCTGCAG CCAGGCCAGT 
GGCTTCCAGT ATAACCCGAT AAGGACCACT TTTGGGGCCA CGTCCGGCTG CCCTTCCCTC 
ACGCCGGGAT CCTGCAGCCT GGGCACCCTC AGGGACCACC AGAGCAGTCC GTACGCCGCA 
GTTCCTTACA AACTCTTCAC GGACCACGGC GGCCTCAACG AGAAGCGCAA GCAGCGGCGC 
ATCCGCACCA CTTTCACCAG TGCCCAGCTC AAAGAGCTGG AAAGGGTCTT CGCGGAGACT 
CACTACCCCG ACATCTACAC TCGGGAGGAG CTGGCCCTGA AGATCGACCT CACAGAGGCG 
CGAGTCCAGG TGTGGTTCCA GAACCGCCGC GCCAAGTTTC GCAAGCAGGA GCGCGCAGCG 
GCAGCCGCAG CGGCCGCGGC CAAGAACGGC TCCTCGGGCA AAAAGTCTGA CTCTTCCAGG 
GACGACGAGA GCAAAGAGGC CAAGAGCACT GACCCGGACA GCACTGGGGG CCCAGGTCCC 
AATCCCAACC CCACCCCCAG CTGCGGGGCG AATGGAGGCG GCGGCGGCGG GCCCAGCCCG 
GCTGGAGCTC CGGGGGCGGC GGGGCCCGGG GGCCCGGGAG GCGAACCCGG CAAGGGCGGC 
GCAGCAGCAG CGGCGGCGGC CGCGGCAGCG GCGGCGGCGG CAGCGGCAGC GGCGGCAGCT 
GGAGGCCTGG CTGCGGCTGG GGGCCCTGGA CAAGGCTGGG CTCCCGGCCC CGGCCCCATC 
ACCTCCATCC CGGATTCGCT TGGGGGTCCC TTCGCCAGCG TCCTATCTTC GCTCCAAAGA 
CCCAACGGTG CCAAAGCCGC CTTAGTGAAG AGCAGTATGT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003915.2
CDS	361..1305
Translation	MYKMEYSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSLTPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSRDDESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGGPSPAGAPGAAGPGGPGGEPGKGGAAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGPGPITSIPDSLGGPFASVLSSLQRPNGAKAALVKSSMF

Target ORF information:

RefSeq Version	NM_003924.3
Organism	Homo sapiens(human)
Definition	Homo sapiens paired like homeobox 2B (PHOX2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003924.3

ORF Insert Sequence:

ATGTATAAAA TGGAATATTC TTACCTCAAT TCCTCTGCCT ACGAGTCCTG TATGGCTGGG 
ATGGACACCT CGAGCCTGGC TTCAGCCTAT GCTGACTTCA GTTCCTGCAG CCAGGCCAGT 
GGCTTCCAGT ATAACCCGAT AAGGACCACT TTTGGGGCCA CGTCCGGCTG CCCTTCCCTC 
ACGCCGGGAT CCTGCAGCCT GGGCACCCTC AGGGACCACC AGAGCAGTCC GTACGCCGCA 
GTTCCTTACA AACTCTTCAC GGACCACGGC GGCCTCAACG AGAAGCGCAA GCAGCGGCGC 
ATCCGCACCA CTTTCACCAG TGCCCAGCTC AAAGAGCTGG AAAGGGTCTT CGCGGAGACT 
CACTACCCCG ACATCTACAC TCGGGAGGAG CTGGCCCTGA AGATCGACCT CACAGAGGCG 
CGAGTCCAGG TGTGGTTCCA GAACCGCCGC GCCAAGTTTC GCAAGCAGGA GCGCGCAGCG 
GCAGCCGCAG CGGCCGCGGC CAAGAACGGC TCCTCGGGCA AAAAGTCTGA CTCTTCCAGG 
GACGACGAGA GCAAAGAGGC CAAGAGCACT GACCCGGACA GCACTGGGGG CCCAGGTCCC 
AATCCCAACC CCACCCCCAG CTGCGGGGCG AATGGAGGCG GCGGCGGCGG GCCCAGCCCG 
GCTGGAGCTC CGGGGGCGGC GGGGCCCGGG GGCCCGGGAG GCGAACCCGG CAAGGGCGGC 
GCAGCAGCAG CGGCGGCGGC CGCGGCAGCG GCGGCGGCGG CAGCGGCAGC GGCGGCAGCT 
GGAGGCCTGG CTGCGGCTGG GGGCCCTGGA CAAGGCTGGG CTCCCGGCCC CGGCCCCATC 
ACCTCCATCC CGGATTCGCT TGGGGGTCCC TTCGCCAGCG TCCTATCTTC GCTCCAAAGA 
CCCAACGGTG CCAAAGCCGC CTTAGTGAAG AGCAGTATGT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PHOX2B ( NM_003924.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003915.2 Homo sapiens paired like homeobox 2B (PHOX2B), mRNA.

Price & Availability↑

CloneID	OHu26329
Clone ID Related Accession (Same CDS sequence)	NM_003924.3 , NM_003924.4
Accession Version	NM_003924.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 945bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	paired mesoderm homeobox protein 2B
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D82344.1, BC017199.2, AC105389.3 and AI266171.1. On Aug 31, 2019 this sequence version replaced NM_003924.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D82344.1, BC017199.2 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTATAAAA TGGAATATTC TTACCTCAAT TCCTCTGCCT ACGAGTCCTG TATGGCTGGG 
ATGGACACCT CGAGCCTGGC TTCAGCCTAT GCTGACTTCA GTTCCTGCAG CCAGGCCAGT 
GGCTTCCAGT ATAACCCGAT AAGGACCACT TTTGGGGCCA CGTCCGGCTG CCCTTCCCTC 
ACGCCGGGAT CCTGCAGCCT GGGCACCCTC AGGGACCACC AGAGCAGTCC GTACGCCGCA 
GTTCCTTACA AACTCTTCAC GGACCACGGC GGCCTCAACG AGAAGCGCAA GCAGCGGCGC 
ATCCGCACCA CTTTCACCAG TGCCCAGCTC AAAGAGCTGG AAAGGGTCTT CGCGGAGACT 
CACTACCCCG ACATCTACAC TCGGGAGGAG CTGGCCCTGA AGATCGACCT CACAGAGGCG 
CGAGTCCAGG TGTGGTTCCA GAACCGCCGC GCCAAGTTTC GCAAGCAGGA GCGCGCAGCG 
GCAGCCGCAG CGGCCGCGGC CAAGAACGGC TCCTCGGGCA AAAAGTCTGA CTCTTCCAGG 
GACGACGAGA GCAAAGAGGC CAAGAGCACT GACCCGGACA GCACTGGGGG CCCAGGTCCC 
AATCCCAACC CCACCCCCAG CTGCGGGGCG AATGGAGGCG GCGGCGGCGG GCCCAGCCCG 
GCTGGAGCTC CGGGGGCGGC GGGGCCCGGG GGCCCGGGAG GCGAACCCGG CAAGGGCGGC 
GCAGCAGCAG CGGCGGCGGC CGCGGCAGCG GCGGCGGCGG CAGCGGCAGC GGCGGCAGCT 
GGAGGCCTGG CTGCGGCTGG GGGCCCTGGA CAAGGCTGGG CTCCCGGCCC CGGCCCCATC 
ACCTCCATCC CGGATTCGCT TGGGGGTCCC TTCGCCAGCG TCCTATCTTC GCTCCAAAGA 
CCCAACGGTG CCAAAGCCGC CTTAGTGAAG AGCAGTATGT TCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003915.2
CDS	116..1060
Translation	MYKMEYSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSLTPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSRDDESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGGPSPAGAPGAAGPGGPGGEPGKGGAAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGPGPITSIPDSLGGPFASVLSSLQRPNGAKAALVKSSMF

Target ORF information:

RefSeq Version	NM_003924.4
Organism	Homo sapiens(human)
Definition	Homo sapiens paired like homeobox 2B (PHOX2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003924.4

ORF Insert Sequence:

ATGTATAAAA TGGAATATTC TTACCTCAAT TCCTCTGCCT ACGAGTCCTG TATGGCTGGG 
ATGGACACCT CGAGCCTGGC TTCAGCCTAT GCTGACTTCA GTTCCTGCAG CCAGGCCAGT 
GGCTTCCAGT ATAACCCGAT AAGGACCACT TTTGGGGCCA CGTCCGGCTG CCCTTCCCTC 
ACGCCGGGAT CCTGCAGCCT GGGCACCCTC AGGGACCACC AGAGCAGTCC GTACGCCGCA 
GTTCCTTACA AACTCTTCAC GGACCACGGC GGCCTCAACG AGAAGCGCAA GCAGCGGCGC 
ATCCGCACCA CTTTCACCAG TGCCCAGCTC AAAGAGCTGG AAAGGGTCTT CGCGGAGACT 
CACTACCCCG ACATCTACAC TCGGGAGGAG CTGGCCCTGA AGATCGACCT CACAGAGGCG 
CGAGTCCAGG TGTGGTTCCA GAACCGCCGC GCCAAGTTTC GCAAGCAGGA GCGCGCAGCG 
GCAGCCGCAG CGGCCGCGGC CAAGAACGGC TCCTCGGGCA AAAAGTCTGA CTCTTCCAGG 
GACGACGAGA GCAAAGAGGC CAAGAGCACT GACCCGGACA GCACTGGGGG CCCAGGTCCC 
AATCCCAACC CCACCCCCAG CTGCGGGGCG AATGGAGGCG GCGGCGGCGG GCCCAGCCCG 
GCTGGAGCTC CGGGGGCGGC GGGGCCCGGG GGCCCGGGAG GCGAACCCGG CAAGGGCGGC 
GCAGCAGCAG CGGCGGCGGC CGCGGCAGCG GCGGCGGCGG CAGCGGCAGC GGCGGCAGCT 
GGAGGCCTGG CTGCGGCTGG GGGCCCTGGA CAAGGCTGGG CTCCCGGCCC CGGCCCCATC 
ACCTCCATCC CGGATTCGCT TGGGGGTCCC TTCGCCAGCG TCCTATCTTC GCTCCAAAGA 
CCCAACGGTG CCAAAGCCGC CTTAGTGAAG AGCAGTATGT TCTGA