GALP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GALP
Entrez Gene ID	85569
Full Name	galanin like peptide
General protein information	Preferred Names galanin like peptide Names galanin-like peptide alarin gal-like peptide
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.43
Summary	This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014].
Disorder MIM:	611178

mRNA and Protein(s)

mRNA	Protein	Name
NM_033106.3	NP_149097.1	galanin-like peptide isoform 1 precursor
NM_033106.4	NP_149097.1	galanin-like peptide isoform 1 precursor
NM_001145546.1	NP_001139018.1	galanin-like peptide isoform 2 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Galp	NP_072155.1
Homo sapiens (human)	GALP	NP_149097.1
Mus musculus (house mouse)	Galp	NP_821171.1
Canis lupus familiaris (dog)	GALP	XP_005616158.1
Pan troglodytes (chimpanzee)	GALP	XP_524495.2
	GALP	XP_001090902.1

Gene Ontology
Bibliography

Related articles in PubMed

Circulating galanin and galanin like peptide concentrations are correlated with increased triglyceride concentration in obese patients.
Fang P, Yu M, Gu X, Shi M, Zhu Y, Zhang Z, Bo P
Clinica chimica acta; international journal of clinical chemistry461126-9(2016 Oct)

Alarin but not its alternative-splicing form, GALP (Galanin-like peptide) has antimicrobial activity.
Wada A, Wong PF, Hojo H, Hasegawa M, Ichinose A, Llanes R, Kubo Y, Senba M, Ichinose Y
Biochemical and biophysical research communications434(2)223-7(2013 May)

Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
Shulman JM, Chibnik LB, Aubin C, Schneider JA, Bennett DA, De Jager PL
PloS one5(6)e11244(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results indicated that obese individuals have higher plasma GAL and GALP concentrations and both peptide concentrations were positively correlative to triglyceride concentrations in obese human
Title: Circulating galanin and galanin like peptide concentrations are correlated with increased triglyceride concentration in obese patients.

One isoform (alarin) of this gene but not the other (galanin-like peptide) displays antimicrobial activity against E. coli.
Title: Alarin but not its alternative-splicing form, GALP (Galanin-like peptide) has antimicrobial activity.

Observational study of gene-disease association. (HuGE Navigator)
Title: Intermediate phenotypes identify divergent pathways to Alzheimer's disease.

Meta-analysis of gene-disease association. (HuGE Navigator)
Title: Assessment of Alzheimer's disease case-control associations using family-based methods.

reports immunostaining of human GALP in the dermal microvasculature.
Title: Alarin is a vasoactive peptide.

The following GALP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GALP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22899	NM_033106.4 Latest version!	Homo sapiens galanin like peptide (GALP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu11657	NM_001145546.1 Latest version!	Homo sapiens galanin like peptide (GALP), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu22899	NM_033106.3	Homo sapiens galanin like peptide (GALP), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GALP ( NM_033106.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_149097.1 Homo sapiens galanin like peptide (GALP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22899
Clone ID Related Accession (Same CDS sequence)	NM_033106.3 , NM_033106.4
Accession Version	NM_033106.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	galanin-like peptide isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC024580.6 and AF188493.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_033106.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF188493.1, AF188492.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2145122, SAMEA2148874 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000357330.7/ ENSP00000349884.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCTC CCTCCGTCCC CCTGGTCCTC CTCCTCGTCC TCTTGCTGAG CCTGGCAGAG 
ACTCCAGCAT CCGCACCTGC CCACCGGGGA CGAGGAGGCT GGACCCTCAA TAGTGCTGGC 
TACCTTCTGG GTCCCGTCCT CCACCTTCCC CAAATGGGTG ACCAAGACGG AAAGAGGGAG 
ACAGCCCTTG AGATCCTAGA CCTGTGGAAG GCCATCGACG GGCTCCCCTA CTCCCACCCT 
CCACAGCCCT CCAAGAGGAA TGTGATGGAG ACGTTTGCCA AACCAGAGAT TGGAGATCTG 
GGCATGCTCA GCATGAAAAT TCCCAAGGAG GAAGATGTCC TGAAGTCATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149097.1
CDS	95..445
Translation	MAPPSVPLVLLLVLLLSLAETPASAPAHRGRGGWTLNSAGYLLGPVLHLPQMGDQDGKRETALEILDLWKAIDGLPYSHPPQPSKRNVMETFAKPEIGDLGMLSMKIPKEEDVLKS

Target ORF information:

RefSeq Version	NM_033106.4
Organism	Homo sapiens(human)
Definition	Homo sapiens galanin like peptide (GALP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033106.4

ORF Insert Sequence:

ATGGCTCCTC CCTCCGTCCC CCTGGTCCTC CTCCTCGTCC TCTTGCTGAG CCTGGCAGAG 
ACTCCAGCAT CCGCACCTGC CCACCGGGGA CGAGGAGGCT GGACCCTCAA TAGTGCTGGC 
TACCTTCTGG GTCCCGTCCT CCACCTTCCC CAAATGGGTG ACCAAGACGG AAAGAGGGAG 
ACAGCCCTTG AGATCCTAGA CCTGTGGAAG GCCATCGACG GGCTCCCCTA CTCCCACCCT 
CCACAGCCCT CCAAGAGGAA TGTGATGGAG ACGTTTGCCA AACCAGAGAT TGGAGATCTG 
GGCATGCTCA GCATGAAAAT TCCCAAGGAG GAAGATGTCC TGAAGTCATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GALP ( NM_001145546.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001139018.1 Homo sapiens galanin like peptide (GALP), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11657
Clone ID Related Accession (Same CDS sequence)	NM_001145546.1
Accession Version	NM_001145546.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 150bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Homo sapiens(human)
Product	galanin-like peptide isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC024580.6 and AF188493.1. On Aug 31, 2013 this sequence version replaced XR_243968.1. Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus compared to isoform 1. This variant, termed alarin, is a candidate for nonsense-mediated mRNA decay (NMD) but is being represented as protein-coding based on evidence supporting the transcript and protein described in PMID 16954604. The exon structure of this variant is based on Figure 1 from PMID 16954604. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AY329637.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA2145122, SAMEA2148874 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: PMID: 16954604, 17535903 Protein has antimicrobial activity :: PMID: 23537644 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGGCTCCTC CCTCCGTCCC CCTGGTCCTC CTCCTCGTCC TCTTGCTGAG CCTGGCAGAG 
ACTCCAGCAT CCGCACCTGC CCACCGGTCC TCCACCTTCC CCAAATGGGT GACCAAGACG 
GAAAGAGGGA GACAGCCCTT GAGATCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001139018.1
CDS	83..232
Translation	MAPPSVPLVLLLVLLLSLAETPASAPAHRSSTFPKWVTKTERGRQPLRS

Target ORF information:

RefSeq Version	NM_001145546.1
Organism	Homo sapiens(human)
Definition	Homo sapiens galanin like peptide (GALP), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001145546.1

ORF Insert Sequence:

1
61
121

ATGGCTCCTC CCTCCGTCCC CCTGGTCCTC CTCCTCGTCC TCTTGCTGAG CCTGGCAGAG 
ACTCCAGCAT CCGCACCTGC CCACCGGTCC TCCACCTTCC CCAAATGGGT GACCAAGACG 
GAAAGAGGGA GACAGCCCTT GAGATCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GALP ( NM_033106.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_149097.1 Homo sapiens galanin like peptide (GALP), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22899
Clone ID Related Accession (Same CDS sequence)	NM_033106.3 , NM_033106.4
Accession Version	NM_033106.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 351bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-26
Organism	Homo sapiens(human)
Product	galanin-like peptide isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC024580.6 and AF188493.1. This sequence is a reference standard in the RefSeqGene project. On Mar 6, 2009 this sequence version replaced NM_033106.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF188492.1, AF188493.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2145122, SAMEA2148874 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCTC CCTCCGTCCC CCTGGTCCTC CTCCTCGTCC TCTTGCTGAG CCTGGCAGAG 
ACTCCAGCAT CCGCACCTGC CCACCGGGGA CGAGGAGGCT GGACCCTCAA TAGTGCTGGC 
TACCTTCTGG GTCCCGTCCT CCACCTTCCC CAAATGGGTG ACCAAGACGG AAAGAGGGAG 
ACAGCCCTTG AGATCCTAGA CCTGTGGAAG GCCATCGACG GGCTCCCCTA CTCCCACCCT 
CCACAGCCCT CCAAGAGGAA TGTGATGGAG ACGTTTGCCA AACCAGAGAT TGGAGATCTG 
GGCATGCTCA GCATGAAAAT TCCCAAGGAG GAAGATGTCC TGAAGTCATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_149097.1
CDS	83..433
Translation	MAPPSVPLVLLLVLLLSLAETPASAPAHRGRGGWTLNSAGYLLGPVLHLPQMGDQDGKRETALEILDLWKAIDGLPYSHPPQPSKRNVMETFAKPEIGDLGMLSMKIPKEEDVLKS

Target ORF information:

RefSeq Version	NM_033106.3
Organism	Homo sapiens(human)
Definition	Homo sapiens galanin like peptide (GALP), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_033106.3

ORF Insert Sequence:

ATGGCTCCTC CCTCCGTCCC CCTGGTCCTC CTCCTCGTCC TCTTGCTGAG CCTGGCAGAG 
ACTCCAGCAT CCGCACCTGC CCACCGGGGA CGAGGAGGCT GGACCCTCAA TAGTGCTGGC 
TACCTTCTGG GTCCCGTCCT CCACCTTCCC CAAATGGGTG ACCAAGACGG AAAGAGGGAG 
ACAGCCCTTG AGATCCTAGA CCTGTGGAAG GCCATCGACG GGCTCCCCTA CTCCCACCCT 
CCACAGCCCT CCAAGAGGAA TGTGATGGAG ACGTTTGCCA AACCAGAGAT TGGAGATCTG 
GGCATGCTCA GCATGAAAAT TCCCAAGGAG GAAGATGTCC TGAAGTCATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Circulating galanin and galanin like peptide concentrations are correlated with increased triglyceride concentration in obese patients.
Clinica chimica acta; international journal of clinical chemistry461126-9(2016 Oct)
Fang P,Yu M,Gu X,Shi M,Zhu Y,Zhang Z,Bo P

Alarin but not its alternative-splicing form, GALP (Galanin-like peptide) has antimicrobial activity.
Biochemical and biophysical research communications434(2)223-7(2013 May)
Wada A,Wong PF,Hojo H,Hasegawa M,Ichinose A,Llanes R,Kubo Y,Senba M,Ichinose Y

Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
PloS one5(6)e11244(2010 Jun)
Shulman JM,Chibnik LB,Aubin C,Schneider JA,Bennett DA,De Jager PL

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GALP cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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