UQCC2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UQCC2
Entrez Gene ID	84300
Full Name	ubiquinol-cytochrome c reductase complex assembly factor 2
Synonyms	C6orf125,C6orf126,Cbp6,M19,MNF1,bA6B20.2
General protein information	Preferred Names ubiquinol-cytochrome c reductase complex assembly factor 2 Names ubiquinol-cytochrome-c reductase complex assembly factor 2 breast cancer-associated protein SGA-81M cytochrome B protein synthesis 6 homolog mitochondrial nucleoid factor 1 mitochondrial protein M19
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.31
Summary	This gene encodes a nucleoid protein localized to the mitochondria inner membrane. The encoded protein affects regulation of insulin secretion, mitochondrial ATP production, and myogenesis through modulation of mitochondrial respiratory chain activity. [provided by RefSeq, Oct 2012].
Disorder MIM:	614461
Disorder Html:	?Mitochondrial complex III deficiency, nuclear type 7, 615824 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_032340.3	NP_115716.1	ubiquinol-cytochrome-c reductase complex assembly factor 2
NM_032340.4	NP_115716.1	ubiquinol-cytochrome-c reductase complex assembly factor 2

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	uqcc2	NP_001072250.1
Homo sapiens (human)	UQCC2	NP_115716.1
Mus musculus (house mouse)	Uqcc2	NP_080339.1
Danio rerio (zebrafish)	zgc:73238	NP_957052.1
Pan troglodytes (chimpanzee)	MNF1	XP_003950852.1
Canis lupus familiaris (dog)	MNF1	XP_003431746.1
	C6orf125	XP_002803745.1
Bos taurus (cattle)	MNF1	NP_001193543.1
Rattus norvegicus (Norway rat)	Uqcc2	NP_001101998.1
Gallus gallus (chicken)	C26H6ORF125	NP_001258541.1

Gene Ontology
Bibliography

Related articles in PubMed

A mutation in the human CBP4 ortholog UQCC3 impairs complex III assembly, activity and cytochrome b stability.
Wanschers BF, Szklarczyk R, van den Brand MA, Jonckheere A, Suijskens J, Smeets R, Rodenburg RJ, Stephan K, Helland IB, Elkamil A, Rootwelt T, Ott M, van den Heuvel L, Nijtmans LG, Huynen MA
Human molecular genetics23(23)6356-65(2014 Dec)

Mutations in the UQCC1-interacting protein, UQCC2, cause human complex III deficiency associated with perturbed cytochrome b protein expression.
Tucker EJ, Wanschers BF, Szklarczyk R, Mountford HS, Wijeyeratne XW, van den Brand MA, Leenders AM, Rodenburg RJ, Relji? B, Compton AG, Frazier AE, Bruno DL, Christodoulou J, Endo H, Ryan MT, Nijtmans LG, Huynen MA, Thorburn DR
PLoS genetics9(12)e1004034(2013)

Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.
Calvo SE, Compton AG, Hershman SG, Lim SC, Lieber DS, Tucker EJ, Laskowski A, Garone C, Liu S, Jaffe DB, Christodoulou J, Fletcher JM, Bruno DL, Goldblatt J, Dimauro S, Thorburn DR, Mootha VK
Science translational medicine4(118)118ra10(2012 Jan)

M19 modulates skeletal muscle differentiation and insulin secretion in pancreatic ?-cells through modulation of respiratory chain activity.
Cambier L, Rassam P, Chabi B, Mezghenna K, Gross R, Eveno E, Auffray C, Wrutniak-Cabello C, Lajoix AD, Pomi?s P
PloS one7(2)e31815(2012)

Association of a novel mitochondrial protein M19 with mitochondrial nucleoids.
Sumitani M, Kasashima K, Ohta E, Kang D, Endo H
Journal of biochemistry146(5)725-32(2009 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

UQCC3 is reduced in cells depleted for the complex III assembly factors UQCC1 and UQCC2. Conversely, absence of UQCC3 in patient cells does not affect UQCC1 and UQCC2.
Title: A mutation in the human CBP4 ortholog UQCC3 impairs complex III assembly, activity and cytochrome b stability.

This work provides insight into human complex III assembly by establishing that UQCC1 and UQCC2 are complex III assembly factors participating in cytochrome b biogenesis.
Title: Mutations in the UQCC1-interacting protein, UQCC2, cause human complex III deficiency associated with perturbed cytochrome b protein expression.

Strong candidate gene for mitochondrial disease, based on recessive mutations detected in infantile patients
Title: Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.

The function of M19, a novel mitochondrial nucleoid protein, is characterized in muscle and pancreatic beta-cells.
Title: M19 modulates skeletal muscle differentiation and insulin secretion in pancreatic ?-cells through modulation of respiratory chain activity.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following UQCC2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UQCC2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27889	NM_032340.4 Latest version!	Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor 2 (UQCC2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	Quote Price
View Old Accession Versions >>
OHu27889	NM_032340.3	Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor 2 (UQCC2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	Quote Price
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UQCC2 ( NM_032340.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_115716.1 Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor 2 (UQCC2), mRNA.

Price & Availability↑

CloneID	OHu27889
Clone ID Related Accession (Same CDS sequence)	NM_032340.3 , NM_032340.4
Accession Version	NM_032340.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	ubiquinol-cytochrome-c reductase complex assembly factor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA123098.1, BC006007.1, BI604191.1, CN261727.1, AI688269.1 and CB241659.1. This sequence is a reference standard in the RefSeqGene project. On Oct 17, 2012 this sequence version replaced NM_032340.2. ##Evidence-Data-START## Transcript exon combination :: DA123098.1, SRR1803616.185302.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151119, SAMEA2153932 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCA GCCGGTACCG GCGTTTTCTT AAGCTCTGTG AGGAATGGCC AGTGGACGAG 
ACCAAACGGG GCCGGGACTT GGGCGCTTAC CTGCGACAGC GGGTAGCACA GGCCTTTCGG 
GAGGGAGAGA ATACCCAGGT TGCAGAGCCT GAGGCCTGTG ATCAGATGTA CGAGAGCTTA 
GCGCGACTCC ATTCAAACTA CTACAAACAC AAGTACCCTC GCCCCAGAGA CACCAGCTTC 
AGTGGCCTGT CGTTGGAAGA GTACAAGCTG ATCCTGTCCA CAGACACCTT GGAAGAGCTT 
AAGGAAATAG ATAAAGGCAT GTGGAAGAAA CTGCAGGAGA AGTTTGCCCC CAAGGGTCCT 
GAGGAGGATC ATAAGGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115716.1
CDS	66..446
Translation	MAASRYRRFLKLCEEWPVDETKRGRDLGAYLRQRVAQAFREGENTQVAEPEACDQMYESLARLHSNYYKHKYPRPRDTSFSGLSLEEYKLILSTDTLEELKEIDKGMWKKLQEKFAPKGPEEDHKA

Target ORF information:

RefSeq Version	NM_032340.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor 2 (UQCC2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032340.3

ORF Insert Sequence:

ATGGCGGCCA GCCGGTACCG GCGTTTTCTT AAGCTCTGTG AGGAATGGCC AGTGGACGAG 
ACCAAACGGG GCCGGGACTT GGGCGCTTAC CTGCGACAGC GGGTAGCACA GGCCTTTCGG 
GAGGGAGAGA ATACCCAGGT TGCAGAGCCT GAGGCCTGTG ATCAGATGTA CGAGAGCTTA 
GCGCGACTCC ATTCAAACTA CTACAAACAC AAGTACCCTC GCCCCAGAGA CACCAGCTTC 
AGTGGCCTGT CGTTGGAAGA GTACAAGCTG ATCCTGTCCA CAGACACCTT GGAAGAGCTT 
AAGGAAATAG ATAAAGGCAT GTGGAAGAAA CTGCAGGAGA AGTTTGCCCC CAAGGGTCCT 
GAGGAGGATC ATAAGGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UQCC2 ( NM_032340.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_115716.1 Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor 2 (UQCC2), mRNA.

Price & Availability↑

CloneID	OHu27889
Clone ID Related Accession (Same CDS sequence)	NM_032340.3 , NM_032340.4
Accession Version	NM_032340.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 381bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	ubiquinol-cytochrome-c reductase complex assembly factor 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC006007.1, BI604191.1, CN261727.1 and AI688269.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_032340.3. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.105486.1, SRR1660803.213719.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151119, SAMEA2153932 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000607484.6/ ENSP00000476140.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCCA GCCGGTACCG GCGTTTTCTT AAGCTCTGTG AGGAATGGCC AGTGGACGAG 
ACCAAACGGG GCCGGGACTT GGGCGCTTAC CTGCGACAGC GGGTAGCACA GGCCTTTCGG 
GAGGGAGAGA ATACCCAGGT TGCAGAGCCT GAGGCCTGTG ATCAGATGTA CGAGAGCTTA 
GCGCGACTCC ATTCAAACTA CTACAAACAC AAGTACCCTC GCCCCAGAGA CACCAGCTTC 
AGTGGCCTGT CGTTGGAAGA GTACAAGCTG ATCCTGTCCA CAGACACCTT GGAAGAGCTT 
AAGGAAATAG ATAAAGGCAT GTGGAAGAAA CTGCAGGAGA AGTTTGCCCC CAAGGGTCCT 
GAGGAGGATC ATAAGGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_115716.1
CDS	15..395
Translation	MAASRYRRFLKLCEEWPVDETKRGRDLGAYLRQRVAQAFREGENTQVAEPEACDQMYESLARLHSNYYKHKYPRPRDTSFSGLSLEEYKLILSTDTLEELKEIDKGMWKKLQEKFAPKGPEEDHKA

Target ORF information:

RefSeq Version	NM_032340.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquinol-cytochrome c reductase complex assembly factor 2 (UQCC2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032340.4

ORF Insert Sequence:

ATGGCGGCCA GCCGGTACCG GCGTTTTCTT AAGCTCTGTG AGGAATGGCC AGTGGACGAG 
ACCAAACGGG GCCGGGACTT GGGCGCTTAC CTGCGACAGC GGGTAGCACA GGCCTTTCGG 
GAGGGAGAGA ATACCCAGGT TGCAGAGCCT GAGGCCTGTG ATCAGATGTA CGAGAGCTTA 
GCGCGACTCC ATTCAAACTA CTACAAACAC AAGTACCCTC GCCCCAGAGA CACCAGCTTC 
AGTGGCCTGT CGTTGGAAGA GTACAAGCTG ATCCTGTCCA CAGACACCTT GGAAGAGCTT 
AAGGAAATAG ATAAAGGCAT GTGGAAGAAA CTGCAGGAGA AGTTTGCCCC CAAGGGTCCT 
GAGGAGGATC ATAAGGCCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A mutation in the human CBP4 ortholog UQCC3 impairs complex III assembly, activity and cytochrome b stability.
Human molecular genetics23(23)6356-65(2014 Dec)
Wanschers BF,Szklarczyk R,van den Brand MA,Jonckheere A,Suijskens J,Smeets R,Rodenburg RJ,Stephan K,Helland IB,Elkamil A,Rootwelt T,Ott M,van den Heuvel L,Nijtmans LG,Huynen MA

Mutations in the UQCC1-interacting protein, UQCC2, cause human complex III deficiency associated with perturbed cytochrome b protein expression.
PLoS genetics9(12)e1004034(2013)
Tucker EJ,Wanschers BF,Szklarczyk R,Mountford HS,Wijeyeratne XW,van den Brand MA,Leenders AM,Rodenburg RJ,Relji? B,Compton AG,Frazier AE,Bruno DL,Christodoulou J,Endo H,Ryan MT,Nijtmans LG,Huynen MA,Thorburn DR

Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing.
Science translational medicine4(118)118ra10(2012 Jan)
Calvo SE,Compton AG,Hershman SG,Lim SC,Lieber DS,Tucker EJ,Laskowski A,Garone C,Liu S,Jaffe DB,Christodoulou J,Fletcher JM,Bruno DL,Goldblatt J,Dimauro S,Thorburn DR,Mootha VK

M19 modulates skeletal muscle differentiation and insulin secretion in pancreatic ?-cells through modulation of respiratory chain activity.
PloS one7(2)e31815(2012)
Cambier L,Rassam P,Chabi B,Mezghenna K,Gross R,Eveno E,Auffray C,Wrutniak-Cabello C,Lajoix AD,Pomi?s P

Association of a novel mitochondrial protein M19 with mitochondrial nucleoids.
Journal of biochemistry146(5)725-32(2009 Nov)
Sumitani M,Kasashima K,Ohta E,Kang D,Endo H

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UQCC2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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見積依頼

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電話

FAX

オンラインフォーム