PLA2G12A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PLA2G12A
Entrez Gene ID	81579
Full Name	phospholipase A2 group XIIA
Synonyms	GXII,PLA2G12,ROSSY
General protein information	Preferred Names phospholipase A2 group XIIA Names group XIIA secretory phospholipase A2 GXII sPLA2 group XII secreted phospholipase A2 group XIIA secreted phospholipase A2 phosphatidylcholine 2-acylhydrolase 12A phospholipase A2, group XII sPLA2-XII
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4q25
Summary	Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008].
Disorder MIM:	611652

mRNA and Protein(s)

mRNA	Protein	Name
NM_030821.4	NP_110448.2	group XIIA secretory phospholipase A2 precursor
NM_030821.5	NP_110448.2	group XIIA secretory phospholipase A2 precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PLA2G12A	XP_003310492.1
Gallus gallus (chicken)	PLA2G12A	XP_001235270.2
Xenopus tropicalis (tropical clawed frog)	pla2g12a	NP_001017096.1
Danio rerio (zebrafish)	pla2g12a	NP_001076268.1
	PLA2G12A	XP_002804219.1
Mus musculus (house mouse)	Pla2g12a	NP_075685.2
Homo sapiens (human)	PLA2G12A	NP_110448.2
Canis lupus familiaris (dog)	PLA2G12A	XP_535693.1
Bos taurus (cattle)	PLA2G12A	NP_001091532.1

Gene Ontology
Bibliography

Related articles in PubMed

Association between PLA2G12A Polymorphisms and Schizophrenia in a Han Chinese Population from Northeast China.
Yang G, Xu H, Zhang H, Yu Q, Wu Y, Shi J, Rao W, You Y, Kou C, Yu Y
PloS one11(7)e0159584(2016)

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S,
Diabetes care33(10)2250-3(2010 Oct)

A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J Jr, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP
Human molecular genetics19(12)2497-506(2010 Jun)

Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL, , Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Cort?n M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A
Proceedings of the National Academy of Sciences of the United States of America107(16)7401-6(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The study demonstrated that PLA2G12A SNPs or haplotypes might influence the susceptibility to schizophrenia in the Han Chinese population from Northeast China.
Title: Association between PLA2G12A Polymorphisms and Schizophrenia in a Han Chinese Population from Northeast China.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Observational study of gene-disease association. (HuGE Navigator)
Title: A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.

Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

The following PLA2G12A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PLA2G12A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26567	NM_030821.5 Latest version!	Homo sapiens phospholipase A2 group XIIA (PLA2G12A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu26567	NM_030821.4	Homo sapiens phospholipase A2 group XIIA (PLA2G12A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PLA2G12A ( NM_030821.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_110448.2 Homo sapiens phospholipase A2 group XIIA (PLA2G12A), mRNA.

Price & Availability↑

CloneID	OHu26567
Clone ID Related Accession (Same CDS sequence)	NM_030821.4 , NM_030821.5
Accession Version	NM_030821.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	group XIIA secretory phospholipase A2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI667755.1, BC017218.2 and AC004067.1. On Aug 2, 2008 this sequence version replaced NM_030821.3. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this RefSeq transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.196392.1, SRR1660803.87655.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467150, SAMN03267778 [ECO:0000348] ##Evidence-Data-END##

ATGGCCCTGC TCTCGCGCCC CGCGCTCACC CTCCTGCTCC TCCTCATGGC CGCTGTTGTC 
AGGTGCCAGG AGCAGGCCCA GACCACCGAC TGGAGAGCCA CCCTGAAGAC CATCCGGAAC 
GGCGTTCATA AGATAGACAC GTACCTGAAC GCCGCCTTGG ACCTCCTGGG AGGCGAGGAC 
GGTCTCTGCC AGTATAAATG CAGTGACGGA TCTAAGCCTT TCCCACGTTA TGGTTATAAA 
CCCTCCCCAC CGAATGGATG TGGCTCTCCA CTGTTTGGTG TTCATCTTAA CATTGGTATC 
CCTTCCCTGA CAAAGTGTTG CAACCAACAC GACAGGTGCT ATGAGACCTG TGGCAAAAGC 
AAGAATGACT GTGATGAAGA ATTCCAGTAT TGCCTCTCCA AGATCTGCCG AGATGTACAG 
AAAACACTAG GACTAACTCA GCATGTTCAG GCATGTGAAA CAACAGTGGA GCTCTTGTTT 
GACAGTGTTA TACATTTAGG TTGTAAACCA TATCTGGACA GCCAACGAGC CGCATGCAGG 
TGTCATTATG AAGAAAAAAC TGATCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110448.2
CDS	278..847
Translation	MALLSRPALTLLLLLMAAVVRCQEQAQTTDWRATLKTIRNGVHKIDTYLNAALDLLGGEDGLCQYKCSDGSKPFPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKSKNDCDEEFQYCLSKICRDVQKTLGLTQHVQACETTVELLFDSVIHLGCKPYLDSQRAACRCHYEEKTDL

Target ORF information:

RefSeq Version	NM_030821.4
Organism	Homo sapiens(human)
Definition	Homo sapiens phospholipase A2 group XIIA (PLA2G12A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030821.4

ORF Insert Sequence:

ATGGCCCTGC TCTCGCGCCC CGCGCTCACC CTCCTGCTCC TCCTCATGGC CGCTGTTGTC 
AGGTGCCAGG AGCAGGCCCA GACCACCGAC TGGAGAGCCA CCCTGAAGAC CATCCGGAAC 
GGCGTTCATA AGATAGACAC GTACCTGAAC GCCGCCTTGG ACCTCCTGGG AGGCGAGGAC 
GGTCTCTGCC AGTATAAATG CAGTGACGGA TCTAAGCCTT TCCCACGTTA TGGTTATAAA 
CCCTCCCCAC CGAATGGATG TGGCTCTCCA CTGTTTGGTG TTCATCTTAA CATTGGTATC 
CCTTCCCTGA CAAAGTGTTG CAACCAACAC GACAGGTGCT ATGAGACCTG TGGCAAAAGC 
AAGAATGACT GTGATGAAGA ATTCCAGTAT TGCCTCTCCA AGATCTGCCG AGATGTACAG 
AAAACACTAG GACTAACTCA GCATGTTCAG GCATGTGAAA CAACAGTGGA GCTCTTGTTT 
GACAGTGTTA TACATTTAGG TTGTAAACCA TATCTGGACA GCCAACGAGC CGCATGCAGG 
TGTCATTATG AAGAAAAAAC TGATCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PLA2G12A ( NM_030821.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_110448.2 Homo sapiens phospholipase A2 group XIIA (PLA2G12A), mRNA.

Price & Availability↑

CloneID	OHu26567
Clone ID Related Accession (Same CDS sequence)	NM_030821.4 , NM_030821.5
Accession Version	NM_030821.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	group XIIA secretory phospholipase A2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI667755.1, BC017218.2 and AC004067.1. On Nov 22, 2018 this sequence version replaced NM_030821.4. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this RefSeq transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.232034.1, SRR1660809.196392.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467150, SAMN03267778 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000243501.10/ ENSP00000243501.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCTGC TCTCGCGCCC CGCGCTCACC CTCCTGCTCC TCCTCATGGC CGCTGTTGTC 
AGGTGCCAGG AGCAGGCCCA GACCACCGAC TGGAGAGCCA CCCTGAAGAC CATCCGGAAC 
GGCGTTCATA AGATAGACAC GTACCTGAAC GCCGCCTTGG ACCTCCTGGG AGGCGAGGAC 
GGTCTCTGCC AGTATAAATG CAGTGACGGA TCTAAGCCTT TCCCACGTTA TGGTTATAAA 
CCCTCCCCAC CGAATGGATG TGGCTCTCCA CTGTTTGGTG TTCATCTTAA CATTGGTATC 
CCTTCCCTGA CAAAGTGTTG CAACCAACAC GACAGGTGCT ATGAGACCTG TGGCAAAAGC 
AAGAATGACT GTGATGAAGA ATTCCAGTAT TGCCTCTCCA AGATCTGCCG AGATGTACAG 
AAAACACTAG GACTAACTCA GCATGTTCAG GCATGTGAAA CAACAGTGGA GCTCTTGTTT 
GACAGTGTTA TACATTTAGG TTGTAAACCA TATCTGGACA GCCAACGAGC CGCATGCAGG 
TGTCATTATG AAGAAAAAAC TGATCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110448.2
CDS	262..831
Translation	MALLSRPALTLLLLLMAAVVRCQEQAQTTDWRATLKTIRNGVHKIDTYLNAALDLLGGEDGLCQYKCSDGSKPFPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKSKNDCDEEFQYCLSKICRDVQKTLGLTQHVQACETTVELLFDSVIHLGCKPYLDSQRAACRCHYEEKTDL

Target ORF information:

RefSeq Version	NM_030821.5
Organism	Homo sapiens(human)
Definition	Homo sapiens phospholipase A2 group XIIA (PLA2G12A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030821.5

ORF Insert Sequence:

ATGGCCCTGC TCTCGCGCCC CGCGCTCACC CTCCTGCTCC TCCTCATGGC CGCTGTTGTC 
AGGTGCCAGG AGCAGGCCCA GACCACCGAC TGGAGAGCCA CCCTGAAGAC CATCCGGAAC 
GGCGTTCATA AGATAGACAC GTACCTGAAC GCCGCCTTGG ACCTCCTGGG AGGCGAGGAC 
GGTCTCTGCC AGTATAAATG CAGTGACGGA TCTAAGCCTT TCCCACGTTA TGGTTATAAA 
CCCTCCCCAC CGAATGGATG TGGCTCTCCA CTGTTTGGTG TTCATCTTAA CATTGGTATC 
CCTTCCCTGA CAAAGTGTTG CAACCAACAC GACAGGTGCT ATGAGACCTG TGGCAAAAGC 
AAGAATGACT GTGATGAAGA ATTCCAGTAT TGCCTCTCCA AGATCTGCCG AGATGTACAG 
AAAACACTAG GACTAACTCA GCATGTTCAG GCATGTGAAA CAACAGTGGA GCTCTTGTTT 
GACAGTGTTA TACATTTAGG TTGTAAACCA TATCTGGACA GCCAACGAGC CGCATGCAGG 
TGTCATTATG AAGAAAAAAC TGATCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association between PLA2G12A Polymorphisms and Schizophrenia in a Han Chinese Population from Northeast China.
PloS one11(7)e0159584(2016)
Yang G,Xu H,Zhang H,Yu Q,Wu Y,Shi J,Rao W,You Y,Kou C,Yu Y

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Diabetes care33(10)2250-3(2010 Oct)
Bailey SD,Xie C,Do R,Montpetit A,Diaz R,Mohan V,Keavney B,Yusuf S,Gerstein HC,Engert JC,Anand S,

A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Human molecular genetics19(12)2497-506(2010 Jun)
Kalsi G,Kuo PH,Aliev F,Alexander J,McMichael O,Patterson DG,Walsh D,Zhao Z,Schuckit M,Nurnberger J Jr,Edenberg H,Kramer J,Hesselbrock V,Tischfield JA,Vladimirov V,Prescott CA,Dick DM,Kendler KS,Riley BP

Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
Proceedings of the National Academy of Sciences of the United States of America107(16)7401-6(2010 Apr)
Chen W,Stambolian D,Edwards AO,Branham KE,Othman M,Jakobsdottir J,Tosakulwong N,Pericak-Vance MA,Campochiaro PA,Klein ML,Tan PL,Conley YP,Kanda A,Kopplin L,Li Y,Augustaitis KJ,Karoukis AJ,Scott WK,Agarwal A,Kovach JL,Schwartz SG,Postel EA,Brooks M,Baratz KH,Brown WL,,Brucker AJ,Orlin A,Brown G,Ho A,Regillo C,Donoso L,Tian L,Kaderli B,Hadley D,Hagstrom SA,Peachey NS,Klein R,Klein BE,Gotoh N,Yamashiro K,Ferris Iii F,Fagerness JA,Reynolds R,Farrer LA,Kim IK,Miller JW,Cort?n M,Carracedo A,Sanchez-Salorio M,Pugh EW,Doheny KF,Brion M,Deangelis MM,Weeks DE,Zack DJ,Chew EY,Heckenlively JR,Yoshimura N,Iyengar SK,Francis PJ,Katsanis N,Seddon JM,Haines JL,Gorin MB,Abecasis GR,Swaroop A

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PLA2G12A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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