Gene Symbol | TUSC3 |
Entrez Gene ID | 7991 |
Full Name | tumor suppressor candidate 3 |
Synonyms | D8S1992,M33,MRT22,MRT7,N33,OST3A |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017]. |
Disorder MIM: | |
Disorder Html: | Mental retardation, autosomal recessive 7, 611093 (3) |