DCTPP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DCTPP1
Entrez Gene ID	79077
Full Name	dCTP pyrophosphatase 1
Synonyms	CDA03,RS21C6,XTP3TPA
General protein information	Preferred Names dCTP pyrophosphatase 1 Names dCTP pyrophosphatase 1 XTP3-transactivated gene A protein XTP3-transactivated protein A dCTPase 1 deoxycytidine-triphosphatase 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p11.2
Summary	The protein encoded by this gene is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. The encoded protein also displays weak activity against dTTP and dATP, but none against dGTP. This protein may be responsible for eliminating excess dCTP after DNA synthesis and may prevent overmethylation of CpG islands. Three transcript variants, one protein-coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015].
Disorder MIM:	615840

mRNA and Protein(s)

mRNA	Protein	Name
NM_024096.1	NP_077001.1	dCTP pyrophosphatase 1
NM_024096.2	NP_077001.1	dCTP pyrophosphatase 1

Pathways from BioSystems

Homologies

Oryza sativa (rice)	Os02g0479300	NP_001046848.1
Bos taurus (cattle)	DCTPP1	NP_001033291.1
Mus musculus (house mouse)	Dctpp1	NP_075692.1
Rattus norvegicus (Norway rat)	Dctpp1	NP_620247.1
Homo sapiens (human)	DCTPP1	NP_077001.1
Canis lupus familiaris (dog)	DCTPP1	XP_547022.1
	DCTPP1	XP_001110731.1
Danio rerio (zebrafish)	zgc:73273	NP_957065.1
Xenopus tropicalis (tropical clawed frog)	dctpp1	NP_001007937.2
Pan troglodytes (chimpanzee)	DCTPP1	NP_001230036.1

Gene Ontology
Bibliography

Related articles in PubMed

DCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically.
Xia LL, Tang YB, Song FF, Xu L, Ji P, Wang SJ, Zhu JM, Zhang Y, Zhao GP, Wang Y, Liu TT
Oncotarget7(42)68623-68637(2016 Oct)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation.
Song FF, Xia LL, Ji P, Tang YB, Huang ZM, Zhu L, Zhang J, Wang JQ, Zhao GP, Ge HL, Zhang Y, Wang Y
Oncogenesis4e159(2015 Jun)

The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells.
Requena CE, P?rez-Moreno G, Ruiz-P?rez LM, Vidal AE, Gonz?lez-Pacanowska D
The Biochemical journal459(1)171-80(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DCTPP1 has a central role in the balance of dCTP and the metabolism of deoxycytidine analogues.
Title: The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells.

Human dCTP pyrophosphatase 1 binds and is inhibited by the small molecule triptolide in vitro.
Title: Triptolide directly inhibits dCTP pyrophosphatase.

The following DCTPP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DCTPP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27922	NM_024096.2 Latest version!	Homo sapiens dCTP pyrophosphatase 1 (DCTPP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu27922	NM_024096.1	Homo sapiens dCTP pyrophosphatase 1 (DCTPP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DCTPP1 ( NM_024096.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_077001.1 Homo sapiens dCTP pyrophosphatase 1 (DCTPP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27922
Clone ID Related Accession (Same CDS sequence)	NM_024096.1 , NM_024096.2
Accession Version	NM_024096.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	dCTP pyrophosphatase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC001344.1. Transcript Variant: This variant (1) is the protein-coding transcript. ##Evidence-Data-START## Transcript exon combination :: BC001344.1, AY453409.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTGTGG CCGGTGGGGA GATTCGTGGG GACACGGGGG GAGAGGACAC TGCTGCTCCC 
GGCCGGTTCA GCTTCAGCCC GGAGCCCACG CTCGAGGACA TCCGCCGCCT CCATGCTGAG 
TTTGCTGCGG AACGAGACTG GGAACAGTTC CATCAGCCTC GGAATCTCCT CCTGGCCTTG 
GTTGGGGAAG TGGGGGAGCT GGCAGAACTC TTTCAGTGGA AAACCGATGG GGAACCTGGC 
CCCCAAGGCT GGTCCCCCAG GGAACGGGCA GCCCTTCAAG AGGAGCTTAG TGACGTCCTC 
ATCTACCTGG TGGCATTAGC AGCCCGCTGC CGTGTGGATC TGCCGCTAGC AGTGCTCTCC 
AAAATGGACA TCAACCGGCG ACGCTACCCA GCCCATCTGG CCCGCAGCTC TTCCCGCAAG 
TATACAGAAT TGCCCCATGG GGCCATCTCT GAAGACCAGG CTGTGGGGCC TGCGGACATT 
CCCTGTGACT CCACAGGCCA GACCTCAACC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077001.1
CDS	73..585
Translation	MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLSKMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST

Target ORF information:

RefSeq Version	NM_024096.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dCTP pyrophosphatase 1 (DCTPP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024096.1

ORF Insert Sequence:

ATGTCTGTGG CCGGTGGGGA GATTCGTGGG GACACGGGGG GAGAGGACAC TGCTGCTCCC 
GGCCGGTTCA GCTTCAGCCC GGAGCCCACG CTCGAGGACA TCCGCCGCCT CCATGCTGAG 
TTTGCTGCGG AACGAGACTG GGAACAGTTC CATCAGCCTC GGAATCTCCT CCTGGCCTTG 
GTTGGGGAAG TGGGGGAGCT GGCAGAACTC TTTCAGTGGA AAACCGATGG GGAACCTGGC 
CCCCAAGGCT GGTCCCCCAG GGAACGGGCA GCCCTTCAAG AGGAGCTTAG TGACGTCCTC 
ATCTACCTGG TGGCATTAGC AGCCCGCTGC CGTGTGGATC TGCCGCTAGC AGTGCTCTCC 
AAAATGGACA TCAACCGGCG ACGCTACCCA GCCCATCTGG CCCGCAGCTC TTCCCGCAAG 
TATACAGAAT TGCCCCATGG GGCCATCTCT GAAGACCAGG CTGTGGGGCC TGCGGACATT 
CCCTGTGACT CCACAGGCCA GACCTCAACC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DCTPP1 ( NM_024096.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_077001.1 Homo sapiens dCTP pyrophosphatase 1 (DCTPP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu27922
Clone ID Related Accession (Same CDS sequence)	NM_024096.1 , NM_024096.2
Accession Version	NM_024096.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 513bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	dCTP pyrophosphatase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC001344.1 and AC116348.3. On May 17, 2019 this sequence version replaced NM_024096.1. Transcript Variant: This variant (1) is the protein-coding transcript. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.623808.1, SRR7410570.623803.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000319285.5/ ENSP00000322524.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGTGG CCGGTGGGGA GATTCGTGGG GACACGGGGG GAGAGGACAC TGCTGCTCCC 
GGCCGGTTCA GCTTCAGCCC GGAGCCCACG CTCGAGGACA TCCGCCGCCT CCATGCTGAG 
TTTGCTGCGG AACGAGACTG GGAACAGTTC CATCAGCCTC GGAATCTCCT CCTGGCCTTG 
GTTGGGGAAG TGGGGGAGCT GGCAGAACTC TTTCAGTGGA AAACCGATGG GGAACCTGGC 
CCCCAAGGCT GGTCCCCCAG GGAACGGGCA GCCCTTCAAG AGGAGCTTAG TGACGTCCTC 
ATCTACCTGG TGGCATTAGC AGCCCGCTGC CGTGTGGATC TGCCGCTAGC AGTGCTCTCC 
AAAATGGACA TCAACCGGCG ACGCTACCCA GCCCATCTGG CCCGCAGCTC TTCCCGCAAG 
TATACAGAAT TGCCCCATGG GGCCATCTCT GAAGACCAGG CTGTGGGGCC TGCGGACATT 
CCCTGTGACT CCACAGGCCA GACCTCAACC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077001.1
CDS	51..563
Translation	MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLSKMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST

Target ORF information:

RefSeq Version	NM_024096.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dCTP pyrophosphatase 1 (DCTPP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024096.2

ORF Insert Sequence:

ATGTCTGTGG CCGGTGGGGA GATTCGTGGG GACACGGGGG GAGAGGACAC TGCTGCTCCC 
GGCCGGTTCA GCTTCAGCCC GGAGCCCACG CTCGAGGACA TCCGCCGCCT CCATGCTGAG 
TTTGCTGCGG AACGAGACTG GGAACAGTTC CATCAGCCTC GGAATCTCCT CCTGGCCTTG 
GTTGGGGAAG TGGGGGAGCT GGCAGAACTC TTTCAGTGGA AAACCGATGG GGAACCTGGC 
CCCCAAGGCT GGTCCCCCAG GGAACGGGCA GCCCTTCAAG AGGAGCTTAG TGACGTCCTC 
ATCTACCTGG TGGCATTAGC AGCCCGCTGC CGTGTGGATC TGCCGCTAGC AGTGCTCTCC 
AAAATGGACA TCAACCGGCG ACGCTACCCA GCCCATCTGG CCCGCAGCTC TTCCCGCAAG 
TATACAGAAT TGCCCCATGG GGCCATCTCT GAAGACCAGG CTGTGGGGCC TGCGGACATT 
CCCTGTGACT CCACAGGCCA GACCTCAACC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically.
Oncotarget7(42)68623-68637(2016 Oct)
Xia LL,Tang YB,Song FF,Xu L,Ji P,Wang SJ,Zhu JM,Zhang Y,Zhao GP,Wang Y,Liu TT

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation.
Oncogenesis4e159(2015 Jun)
Song FF,Xia LL,Ji P,Tang YB,Huang ZM,Zhu L,Zhang J,Wang JQ,Zhao GP,Ge HL,Zhang Y,Wang Y

The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells.
The Biochemical journal459(1)171-80(2014 Apr)
Requena CE,P?rez-Moreno G,Ruiz-P?rez LM,Vidal AE,Gonz?lez-Pacanowska D

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DCTPP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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