PRCD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRCD
Entrez Gene ID	768206
Full Name	photoreceptor disc component
Synonyms	RP36
General protein information	Preferred Names photoreceptor disc component Names progressive rod-cone degeneration protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q25.1
Summary	This gene is predominantly expressed in the retina, and mutations in this gene are the cause of autosomal recessive retinal degeneration in both humans and dogs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010].
Disorder MIM:	610598
Disorder Html:	Retinitis pigmentosa 36, 610599 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001077620.3	NP_001071088.1	photoreceptor disk component PRCD precursor
XM_017025013.1	XP_016880502.1	photoreceptor disk component PRCD isoform X1
XM_017025015.1	XP_016880504.1	photoreceptor disk component PRCD isoform X1
NM_001077620.2	NP_001071088.1	progressive rod-cone degeneration protein precursor
XM_017025014.1	XP_016880503.1	photoreceptor disk component PRCD isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PRCD	XP_003953244.1
Homo sapiens (human)	PRCD	NP_001071088.1

Gene Ontology
Bibliography

Related articles in PubMed

Palmitoylation of Progressive Rod-Cone Degeneration (PRCD) Regulates Protein Stability and Localization.
Murphy J, Kolandaivelu S
The Journal of biological chemistry291(44)23036-23046(2016 10)

The progressive rod-cone degeneration (PRCD) protein is secreted through the conventional ER/Golgi-dependent pathway.
Remez L, Zobor D, Kohl S, Ben-Yosef T
Experimental eye research125217-25(2014 Aug)

Identification of a novel mutation in the PRCD gene causing autosomal recessive retinitis pigmentosa in a Turkish family.
Pach J, Kohl S, Gekeler F, Zobor D
Molecular vision191350-5(2013)

Identification of a prevalent founder mutation in an Israeli Muslim Arab village confirms the role of PRCD in the aetiology of retinitis pigmentosa in humans.
Nevet MJ, Shalev SA, Zlotogora J, Mazzawi N, Ben-Yosef T
Journal of medical genetics47(8)533-7(2010 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Disrupting PRCD palmitoylation eliminating the modified cysteine dramatically affects the stability of PRCD.
Title: Palmitoylation of Progressive Rod-Cone Degeneration (PRCD) Regulates Protein Stability and Localization.

The identification of a third mutation in PRCD confirms its role in the pathogenesis of retinitis pigmentosa.
Title: Identification of a novel mutation in the PRCD gene causing autosomal recessive retinitis pigmentosa in a Turkish family.

The identification of a second pathogenic mutation of PRCD in multiple retinitis pigmentosa (RP) patients confirms the role of PRCD in the aetiology of RP in humans.
Title: Identification of a prevalent founder mutation in an Israeli Muslim Arab village confirms the role of PRCD in the aetiology of retinitis pigmentosa in humans.

The following PRCD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRCD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22030	NM_001077620.3 Latest version!	Homo sapiens photoreceptor disc component (PRCD), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu22030	XM_017025015.1 Latest version!	Homo sapiens photoreceptor disc component (PRCD), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu22030	XM_017025014.1 Latest version!	Homo sapiens photoreceptor disc component (PRCD), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu22030	XM_017025013.1 Latest version!	Homo sapiens photoreceptor disc component (PRCD), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu22030	NM_001077620.2	Homo sapiens photoreceptor disc component (PRCD), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRCD ( NM_001077620.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001071088.1 Homo sapiens photoreceptor disc component (PRCD), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22030
Clone ID Related Accession (Same CDS sequence)	NM_001077620.3 , XM_017025013.1 , XM_017025015.1 , NM_001077620.2 , XM_017025014.1
Accession Version	NM_001077620.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 165bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	photoreceptor disk component PRCD precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC015802.21, BC146898.1 and BC043413.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_001077620.2. Transcript Variant: This variant (1) represents the protein coding transcript. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC146898.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000592014.6/ ENSP00000467661.1 NMD candidate :: translation inferred from conservation RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

1
61
121

ATGTGCACCA CCCTTTTCCT GCTCAGCACC CTGGCCATGC TCTGGCGCCG CCGATTTGCC 
AACCGAGTCC AACCAGAGCC CAGCGACGTG GATGGGGCAG CTAGGGGCAG CAGCTTGGAT 
GCGGACCCTC AGTCCTCAGG CAGGGAGAAA GAACCTCTGA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001071088.1
CDS	99..263
Translation	MCTTLFLLSTLAMLWRRRFANRVQPEPSDVDGAARGSSLDADPQSSGREKEPLK

Target ORF information:

RefSeq Version	NM_001077620.3
Organism	Homo sapiens(human)
Definition	Homo sapiens photoreceptor disc component (PRCD), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077620.3

ORF Insert Sequence:

1
61
121

ATGTGCACCA CCCTTTTCCT GCTCAGCACC CTGGCCATGC TCTGGCGCCG CCGATTTGCC 
AACCGAGTCC AACCAGAGCC CAGCGACGTG GATGGGGCAG CTAGGGGCAG CAGCTTGGAT 
GCGGACCCTC AGTCCTCAGG CAGGGAGAAA GAACCTCTGA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRCD ( NM_001077620.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001071088.1 Homo sapiens photoreceptor disc component (PRCD), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22030
Clone ID Related Accession (Same CDS sequence)	NM_001077620.3 , XM_017025013.1 , XM_017025015.1 , NM_001077620.2 , XM_017025014.1
Accession Version	NM_001077620.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 165bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-27
Organism	Homo sapiens(human)
Product	progressive rod-cone degeneration protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC015802.21, BC146898.1 and BC043413.1. This sequence is a reference standard in the RefSeqGene project. On Jul 17, 2009 this sequence version replaced NM_001077620.1. Transcript Variant: This variant (1) represents the protein coding transcript. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC146898.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: translation inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121

ATGTGCACCA CCCTTTTCCT GCTCAGCACC CTGGCCATGC TCTGGCGCCG CCGATTTGCC 
AACCGAGTCC AACCAGAGCC CAGCGACGTG GATGGGGCAG CTAGGGGCAG CAGCTTGGAT 
GCGGACCCTC AGTCCTCAGG CAGGGAGAAA GAACCTCTGA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001071088.1
CDS	104..268
Translation	MCTTLFLLSTLAMLWRRRFANRVQPEPSDVDGAARGSSLDADPQSSGREKEPLK

Target ORF information:

RefSeq Version	NM_001077620.2
Organism	Homo sapiens(human)
Definition	Homo sapiens photoreceptor disc component (PRCD), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001077620.2

ORF Insert Sequence:

1
61
121

ATGTGCACCA CCCTTTTCCT GCTCAGCACC CTGGCCATGC TCTGGCGCCG CCGATTTGCC 
AACCGAGTCC AACCAGAGCC CAGCGACGTG GATGGGGCAG CTAGGGGCAG CAGCTTGGAT 
GCGGACCCTC AGTCCTCAGG CAGGGAGAAA GAACCTCTGA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRCD ( XM_017025013.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880502.1 Homo sapiens photoreceptor disc component (PRCD), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu22030
Clone ID Related Accession (Same CDS sequence)	NM_001077620.3 , XM_017025013.1 , XM_017025015.1 , NM_001077620.2 , XM_017025014.1
Accession Version	XM_017025013.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 165bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	photoreceptor disk component PRCD isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121

ATGTGCACCA CCCTTTTCCT GCTCAGCACC CTGGCCATGC TCTGGCGCCG CCGATTTGCC 
AACCGAGTCC AACCAGAGCC CAGCGACGTG GATGGGGCAG CTAGGGGCAG CAGCTTGGAT 
GCGGACCCTC AGTCCTCAGG CAGGGAGAAA GAACCTCTGA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016880502.1
CDS	2122..2286
Translation	MCTTLFLLSTLAMLWRRRFANRVQPEPSDVDGAARGSSLDADPQSSGREKEPLK

Target ORF information:

RefSeq Version	XM_017025013.1
Organism	Homo sapiens(human)
Definition	Homo sapiens photoreceptor disc component (PRCD), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017025013.1

ORF Insert Sequence:

1
61
121

ATGTGCACCA CCCTTTTCCT GCTCAGCACC CTGGCCATGC TCTGGCGCCG CCGATTTGCC 
AACCGAGTCC AACCAGAGCC CAGCGACGTG GATGGGGCAG CTAGGGGCAG CAGCTTGGAT 
GCGGACCCTC AGTCCTCAGG CAGGGAGAAA GAACCTCTGA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRCD ( XM_017025015.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880504.1 Homo sapiens photoreceptor disc component (PRCD), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu22030
Clone ID Related Accession (Same CDS sequence)	NM_001077620.3 , XM_017025013.1 , XM_017025015.1 , NM_001077620.2 , XM_017025014.1
Accession Version	XM_017025015.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 165bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	photoreceptor disk component PRCD isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121

ATGTGCACCA CCCTTTTCCT GCTCAGCACC CTGGCCATGC TCTGGCGCCG CCGATTTGCC 
AACCGAGTCC AACCAGAGCC CAGCGACGTG GATGGGGCAG CTAGGGGCAG CAGCTTGGAT 
GCGGACCCTC AGTCCTCAGG CAGGGAGAAA GAACCTCTGA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016880504.1
CDS	2122..2286
Translation	MCTTLFLLSTLAMLWRRRFANRVQPEPSDVDGAARGSSLDADPQSSGREKEPLK

Target ORF information:

RefSeq Version	XM_017025015.1
Organism	Homo sapiens(human)
Definition	Homo sapiens photoreceptor disc component (PRCD), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017025015.1

ORF Insert Sequence:

1
61
121

ATGTGCACCA CCCTTTTCCT GCTCAGCACC CTGGCCATGC TCTGGCGCCG CCGATTTGCC 
AACCGAGTCC AACCAGAGCC CAGCGACGTG GATGGGGCAG CTAGGGGCAG CAGCTTGGAT 
GCGGACCCTC AGTCCTCAGG CAGGGAGAAA GAACCTCTGA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRCD ( XM_017025014.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016880503.1 Homo sapiens photoreceptor disc component (PRCD), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu22030
Clone ID Related Accession (Same CDS sequence)	NM_001077620.3 , XM_017025013.1 , XM_017025015.1 , NM_001077620.2 , XM_017025014.1
Accession Version	XM_017025014.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 165bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	photoreceptor disk component PRCD isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121

ATGTGCACCA CCCTTTTCCT GCTCAGCACC CTGGCCATGC TCTGGCGCCG CCGATTTGCC 
AACCGAGTCC AACCAGAGCC CAGCGACGTG GATGGGGCAG CTAGGGGCAG CAGCTTGGAT 
GCGGACCCTC AGTCCTCAGG CAGGGAGAAA GAACCTCTGA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016880503.1
CDS	2122..2286
Translation	MCTTLFLLSTLAMLWRRRFANRVQPEPSDVDGAARGSSLDADPQSSGREKEPLK

Target ORF information:

RefSeq Version	XM_017025014.1
Organism	Homo sapiens(human)
Definition	Homo sapiens photoreceptor disc component (PRCD), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017025014.1

ORF Insert Sequence:

1
61
121

ATGTGCACCA CCCTTTTCCT GCTCAGCACC CTGGCCATGC TCTGGCGCCG CCGATTTGCC 
AACCGAGTCC AACCAGAGCC CAGCGACGTG GATGGGGCAG CTAGGGGCAG CAGCTTGGAT 
GCGGACCCTC AGTCCTCAGG CAGGGAGAAA GAACCTCTGA AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Palmitoylation of Progressive Rod-Cone Degeneration (PRCD) Regulates Protein Stability and Localization.
The Journal of biological chemistry291(44)23036-23046(2016 10)
Murphy J,Kolandaivelu S

The progressive rod-cone degeneration (PRCD) protein is secreted through the conventional ER/Golgi-dependent pathway.
Experimental eye research125217-25(2014 Aug)
Remez L,Zobor D,Kohl S,Ben-Yosef T

Identification of a novel mutation in the PRCD gene causing autosomal recessive retinitis pigmentosa in a Turkish family.
Molecular vision191350-5(2013)
Pach J,Kohl S,Gekeler F,Zobor D

Identification of a prevalent founder mutation in an Israeli Muslim Arab village confirms the role of PRCD in the aetiology of retinitis pigmentosa in humans.
Journal of medical genetics47(8)533-7(2010 Aug)
Nevet MJ,Shalev SA,Zlotogora J,Mazzawi N,Ben-Yosef T

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PRCD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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