VPREB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	VPREB1
Entrez Gene ID	7441
Full Name	V-set pre-B cell surrogate light chain 1
Synonyms	CD179a,IGI,IGVPB,VPREB
General protein information	Preferred Names V-set pre-B cell surrogate light chain 1 Names immunoglobulin iota chain CD179 antigen-like family member A pre-B lymphocyte 1 v(pre)B protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 22 Map Location: 22q11.22
Summary	The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Disorder MIM:	605141

mRNA and Protein(s)

mRNA	Protein	Name
NM_001303509.2	NP_001290438.1	immunoglobulin iota chain isoform 2
NM_007128.4	NP_009059.1	immunoglobulin iota chain isoform 1 precursor
NM_001303509.1	NP_001290438.1	immunoglobulin iota chain isoform 2
NM_007128.3	NP_009059.1	immunoglobulin iota chain isoform 1 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Vpreb2	NP_001128260.1
Mus musculus (house mouse)	Vpreb2	NP_058679.1
Canis lupus familiaris (dog)	VPREB1	XP_543537.2
Mus musculus (house mouse)	Vpreb1	NP_058678.1
Rattus norvegicus (Norway rat)	Vpreb1	NP_001102315.1
Homo sapiens (human)	VPREB1	NP_009059.1
Pan troglodytes (chimpanzee)	VPREB1	XP_515010.2
	VPREB1	XP_001089831.1

Gene Ontology
Bibliography

Related articles in PubMed

The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.
Chen D, Zheng J, Gerasimcik N, Lagerstedt K, Sj?gren H, Abrahamsson J, Fogelstrand L, M?rtensson IL
PloS one11(9)e0162638(2016)

VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.
Mangum DS, Downie J, Mason CC, Jahromi MS, Joshi D, Rodic V, M?schen M, Meeker N, Trede N, Frazer JK, Zhou Y, Cheng C, Jeha S, Pui CH, Willman CL, Harvey RC, Hunger SP, Yang JJ, Barnette P, Mullighan CG, Miles RR, Schiffman JD
Leukemia28(1)216-20(2014 Jan)

The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis.
Yim SH, Chung YJ, Jin EH, Shim SC, Kim JY, Kim YS, Hu HJ, Shin SH, Pae HO, Zouali M, Chung HT
Molecular immunology48(11)1338-43(2011 Jun)

Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation.
Rossi B, Espeli M, Schiff C, Gauthier L
Journal of immunology (Baltimore, Md. : 1950)177(2)796-803(2006 Jul)

Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering.
Gauthier L, Rossi B, Roux F, Termine E, Schiff C
Proceedings of the National Academy of Sciences of the United States of America99(20)13014-9(2002 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Irrespective of subtype, Acute Lymphoblastic Leukemia with high levels of IGHM, IGLL1 and VPREB1 are arrested at the pre-B stage and correlate with good prognosis in high-risk pediatric B-cell precursor acute lymphoblastic leukemia.
Title: The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.

VPREB1 focal deletions are common in B-ALL and occur independent of V(D)J light chain recombination. Focal deletions of VPREB1 correlate with decreased expression levels and high-risk patients with focal deletions tend to have poorer overall survival
Title: VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.

The proportion of the individuals with <2 copies of the VPREB1 gene was significantly higher in the patient group than that in the controls, while that of the individuals with >2 copies was lower in the patient group than that in the controls.
Title: The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

Pre-B cell integrins and their stromal cell ligands together with the pre-B cell receptor and galectin-1 form a homogeneous lattice at the contact area between bone marrow pre-B and stromal cells.
Title: Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation.

The following VPREB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VPREB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18799	NM_007128.4 Latest version!	Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu61315	NM_001303509.2 Latest version!	Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu61315	NM_001303509.1	Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu18799	NM_007128.3	Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

VPREB1 ( NM_007128.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_009059.1 Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18799
Clone ID Related Accession (Same CDS sequence)	NM_007128.4 , NM_007128.3
Accession Version	NM_007128.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	immunoglobulin iota chain isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG502270.1, BC017922.1 and AC245060.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_007128.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG531255.1, BC017922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000403807.4/ ENSP00000385361.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCTGGG CTCCTGTCCT GCTCATGCTG TTTGTCTACT GCACAGGTTG TGGTCCTCAG 
CCGGTGCTGC ATCAGCCGCC GGCCATGTCC TCGGCCCTTG GAACCACAAT CCGCCTCACC 
TGCACCCTGA GGAACGACCA TGACATCGGT GTGTACAGCG TCTACTGGTA CCAGCAGAGG 
CCGGGCCACC CTCCCAGGTT CCTGCTGAGA TATTTCTCAC AATCAGACAA GAGCCAGGGC 
CCCCAGGTCC CCCCTCGCTT CTCTGGATCC AAAGATGTGG CCAGGAACAG GGGGTATTTG 
AGCATCTCTG AGCTGCAGCC TGAGGACGAG GCTATGTATT ACTGTGCTAT GGGGGCCCGC 
AGCTCGGAGA AGGAGGAGAG GGAGAGGGAG TGGGAGGAAG AAATGGAACC CACTGCAGCC 
AGGACACGTG TCCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009059.1
CDS	29..466
Translation	MSWAPVLLMLFVYCTGCGPQPVLHQPPAMSSALGTTIRLTCTLRNDHDIGVYSVYWYQQRPGHPPRFLLRYFSQSDKSQGPQVPPRFSGSKDVARNRGYLSISELQPEDEAMYYCAMGARSSEKEEREREWEEEMEPTAARTRVP

Target ORF information:

RefSeq Version	NM_007128.4
Organism	Homo sapiens(human)
Definition	Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007128.4

ORF Insert Sequence:

ATGTCCTGGG CTCCTGTCCT GCTCATGCTG TTTGTCTACT GCACAGGTTG TGGTCCTCAG 
CCGGTGCTGC ATCAGCCGCC GGCCATGTCC TCGGCCCTTG GAACCACAAT CCGCCTCACC 
TGCACCCTGA GGAACGACCA TGACATCGGT GTGTACAGCG TCTACTGGTA CCAGCAGAGG 
CCGGGCCACC CTCCCAGGTT CCTGCTGAGA TATTTCTCAC AATCAGACAA GAGCCAGGGC 
CCCCAGGTCC CCCCTCGCTT CTCTGGATCC AAAGATGTGG CCAGGAACAG GGGGTATTTG 
AGCATCTCTG AGCTGCAGCC TGAGGACGAG GCTATGTATT ACTGTGCTAT GGGGGCCCGC 
AGCTCGGAGA AGGAGGAGAG GGAGAGGGAG TGGGAGGAAG AAATGGAACC CACTGCAGCC 
AGGACACGTG TCCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VPREB1 ( NM_007128.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_009059.1 Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18799
Clone ID Related Accession (Same CDS sequence)	NM_007128.4 , NM_007128.3
Accession Version	NM_007128.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 438bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	immunoglobulin iota chain isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG502270.1, BC017922.1 and AC245060.1. This sequence is a reference standard in the RefSeqGene project. On Jan 13, 2015 this sequence version replaced NM_007128.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG531255.1, BC017922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTCCTGGG CTCCTGTCCT GCTCATGCTG TTTGTCTACT GCACAGGTTG TGGTCCTCAG 
CCGGTGCTGC ATCAGCCGCC GGCCATGTCC TCGGCCCTTG GAACCACAAT CCGCCTCACC 
TGCACCCTGA GGAACGACCA TGACATCGGT GTGTACAGCG TCTACTGGTA CCAGCAGAGG 
CCGGGCCACC CTCCCAGGTT CCTGCTGAGA TATTTCTCAC AATCAGACAA GAGCCAGGGC 
CCCCAGGTCC CCCCTCGCTT CTCTGGATCC AAAGATGTGG CCAGGAACAG GGGGTATTTG 
AGCATCTCTG AGCTGCAGCC TGAGGACGAG GCTATGTATT ACTGTGCTAT GGGGGCCCGC 
AGCTCGGAGA AGGAGGAGAG GGAGAGGGAG TGGGAGGAAG AAATGGAACC CACTGCAGCC 
AGGACACGTG TCCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_009059.1
CDS	35..472
Translation	MSWAPVLLMLFVYCTGCGPQPVLHQPPAMSSALGTTIRLTCTLRNDHDIGVYSVYWYQQRPGHPPRFLLRYFSQSDKSQGPQVPPRFSGSKDVARNRGYLSISELQPEDEAMYYCAMGARSSEKEEREREWEEEMEPTAARTRVP

Target ORF information:

RefSeq Version	NM_007128.3
Organism	Homo sapiens(human)
Definition	Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_007128.3

ORF Insert Sequence:

ATGTCCTGGG CTCCTGTCCT GCTCATGCTG TTTGTCTACT GCACAGGTTG TGGTCCTCAG 
CCGGTGCTGC ATCAGCCGCC GGCCATGTCC TCGGCCCTTG GAACCACAAT CCGCCTCACC 
TGCACCCTGA GGAACGACCA TGACATCGGT GTGTACAGCG TCTACTGGTA CCAGCAGAGG 
CCGGGCCACC CTCCCAGGTT CCTGCTGAGA TATTTCTCAC AATCAGACAA GAGCCAGGGC 
CCCCAGGTCC CCCCTCGCTT CTCTGGATCC AAAGATGTGG CCAGGAACAG GGGGTATTTG 
AGCATCTCTG AGCTGCAGCC TGAGGACGAG GCTATGTATT ACTGTGCTAT GGGGGCCCGC 
AGCTCGGAGA AGGAGGAGAG GGAGAGGGAG TGGGAGGAAG AAATGGAACC CACTGCAGCC 
AGGACACGTG TCCCTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VPREB1 ( NM_001303509.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290438.1 Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu61315
Clone ID Related Accession (Same CDS sequence)	NM_001303509.2 , NM_001303509.1
Accession Version	NM_001303509.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-28
Organism	Homo sapiens(human)
Product	immunoglobulin iota chain isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC245060.1. On Jun 1, 2019 this sequence version replaced NM_001303509.1. Transcript Variant: This variant (2) uses an alternate splice site in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG502270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529, SAMEA2162823 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTCTGCAC CATGTCCTGG GCTCCTGTCC TGCTCATGCT GTTTGTCTAC TGCACAGCCG 
GTGCTGCATC AGCCGCCGGC CATGTCCTCG GCCCTTGGAA CCACAATCCG CCTCACCTGC 
ACCCTGAGGA ACGACCATGA CATCGGTGTG TACAGCGTCT ACTGGTACCA GCAGAGGCCG 
GGCCACCCTC CCAGGTTCCT GCTGAGATAT TTCTCACAAT CAGACAAGAG CCAGGGCCCC 
CAGGTCCCCC CTCGCTTCTC TGGATCCAAA GATGTGGCCA GGAACAGGGG GTATTTGAGC 
ATCTCTGAGC TGCAGCCTGA GGACGAGGCT ATGTATTACT GTGCTATGGG GGCCCGCAGC 
TCGGAGAAGG AGGAGAGGGA GAGGGAGTGG GAGGAAGAAA TGGAACCCAC TGCAGCCAGG 
ACACGTGTCC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290438.1
CDS	18..452
Translation	MSAPCPGLLSCSCCLSTAQPVLHQPPAMSSALGTTIRLTCTLRNDHDIGVYSVYWYQQRPGHPPRFLLRYFSQSDKSQGPQVPPRFSGSKDVARNRGYLSISELQPEDEAMYYCAMGARSSEKEEREREWEEEMEPTAARTRVP

Target ORF information:

RefSeq Version	NM_001303509.2
Organism	Homo sapiens(human)
Definition	Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303509.2

ORF Insert Sequence:

ATGTCTGCAC CATGTCCTGG GCTCCTGTCC TGCTCATGCT GTTTGTCTAC TGCACAGCCG 
GTGCTGCATC AGCCGCCGGC CATGTCCTCG GCCCTTGGAA CCACAATCCG CCTCACCTGC 
ACCCTGAGGA ACGACCATGA CATCGGTGTG TACAGCGTCT ACTGGTACCA GCAGAGGCCG 
GGCCACCCTC CCAGGTTCCT GCTGAGATAT TTCTCACAAT CAGACAAGAG CCAGGGCCCC 
CAGGTCCCCC CTCGCTTCTC TGGATCCAAA GATGTGGCCA GGAACAGGGG GTATTTGAGC 
ATCTCTGAGC TGCAGCCTGA GGACGAGGCT ATGTATTACT GTGCTATGGG GGCCCGCAGC 
TCGGAGAAGG AGGAGAGGGA GAGGGAGTGG GAGGAAGAAA TGGAACCCAC TGCAGCCAGG 
ACACGTGTCC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

VPREB1 ( NM_001303509.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001290438.1 Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu61315
Clone ID Related Accession (Same CDS sequence)	NM_001303509.2 , NM_001303509.1
Accession Version	NM_001303509.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	immunoglobulin iota chain isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC245060.1. Transcript Variant: This variant (2) uses an alternate splice site in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG502270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529, SAMEA2162823 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTCTGCAC CATGTCCTGG GCTCCTGTCC TGCTCATGCT GTTTGTCTAC TGCACAGCCG 
GTGCTGCATC AGCCGCCGGC CATGTCCTCG GCCCTTGGAA CCACAATCCG CCTCACCTGC 
ACCCTGAGGA ACGACCATGA CATCGGTGTG TACAGCGTCT ACTGGTACCA GCAGAGGCCG 
GGCCACCCTC CCAGGTTCCT GCTGAGATAT TTCTCACAAT CAGACAAGAG CCAGGGCCCC 
CAGGTCCCCC CTCGCTTCTC TGGATCCAAA GATGTGGCCA GGAACAGGGG GTATTTGAGC 
ATCTCTGAGC TGCAGCCTGA GGACGAGGCT ATGTATTACT GTGCTATGGG GGCCCGCAGC 
TCGGAGAAGG AGGAGAGGGA GAGGGAGTGG GAGGAAGAAA TGGAACCCAC TGCAGCCAGG 
ACACGTGTCC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001290438.1
CDS	24..458
Translation	MSAPCPGLLSCSCCLSTAQPVLHQPPAMSSALGTTIRLTCTLRNDHDIGVYSVYWYQQRPGHPPRFLLRYFSQSDKSQGPQVPPRFSGSKDVARNRGYLSISELQPEDEAMYYCAMGARSSEKEEREREWEEEMEPTAARTRVP

Target ORF information:

RefSeq Version	NM_001303509.1
Organism	Homo sapiens(human)
Definition	Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001303509.1

ORF Insert Sequence:

ATGTCTGCAC CATGTCCTGG GCTCCTGTCC TGCTCATGCT GTTTGTCTAC TGCACAGCCG 
GTGCTGCATC AGCCGCCGGC CATGTCCTCG GCCCTTGGAA CCACAATCCG CCTCACCTGC 
ACCCTGAGGA ACGACCATGA CATCGGTGTG TACAGCGTCT ACTGGTACCA GCAGAGGCCG 
GGCCACCCTC CCAGGTTCCT GCTGAGATAT TTCTCACAAT CAGACAAGAG CCAGGGCCCC 
CAGGTCCCCC CTCGCTTCTC TGGATCCAAA GATGTGGCCA GGAACAGGGG GTATTTGAGC 
ATCTCTGAGC TGCAGCCTGA GGACGAGGCT ATGTATTACT GTGCTATGGG GGCCCGCAGC 
TCGGAGAAGG AGGAGAGGGA GAGGGAGTGG GAGGAAGAAA TGGAACCCAC TGCAGCCAGG 
ACACGTGTCC CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.
PloS one11(9)e0162638(2016)
Chen D,Zheng J,Gerasimcik N,Lagerstedt K,Sj?gren H,Abrahamsson J,Fogelstrand L,M?rtensson IL

VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.
Leukemia28(1)216-20(2014 Jan)
Mangum DS,Downie J,Mason CC,Jahromi MS,Joshi D,Rodic V,M?schen M,Meeker N,Trede N,Frazer JK,Zhou Y,Cheng C,Jeha S,Pui CH,Willman CL,Harvey RC,Hunger SP,Yang JJ,Barnette P,Mullighan CG,Miles RR,Schiffman JD

The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis.
Molecular immunology48(11)1338-43(2011 Jun)
Yim SH,Chung YJ,Jin EH,Shim SC,Kim JY,Kim YS,Hu HJ,Shin SH,Pae HO,Zouali M,Chung HT

Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation.
Journal of immunology (Baltimore, Md. : 1950)177(2)796-803(2006 Jul)
Rossi B,Espeli M,Schiff C,Gauthier L

Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering.
Proceedings of the National Academy of Sciences of the United States of America99(20)13014-9(2002 Oct)
Gauthier L,Rossi B,Roux F,Termine E,Schiff C

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VPREB1 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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