UCHL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UCHL1
Entrez Gene ID	7345
Full Name	ubiquitin C-terminal hydrolase L1
Synonyms	HEL-117,HEL-S-53,NDGOA,PARK5,PGP 9.5,PGP9.5,PGP95,SPG79,Uch-L1
General protein information	Preferred Names ubiquitin C-terminal hydrolase L1 Names ubiquitin carboxyl-terminal hydrolase isozyme L1 epididymis luminal protein 117 epididymis secretory protein Li 53 neuron cytoplasmic protein 9.5 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) ubiquitin thioesterase L1 ubiquitin thiolesterase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p13
Summary	The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009].
Disorder MIM:	191342
Disorder Html:	{?Parkinson disease 5, susceptibility to}, 613643 (3); Spastic paraplegia 79, autosomal recessive, 615491 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_004181.4	NP_004172.2	ubiquitin carboxyl-terminal hydrolase isozyme L1
NM_004181.5	NP_004172.2	ubiquitin carboxyl-terminal hydrolase isozyme L1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	UCHL1	XP_536245.3
Bos taurus (cattle)	UCHL1	NP_001039637.1
Mus musculus (house mouse)	Uchl1	NP_035800.2
Rattus norvegicus (Norway rat)	Uchl1	NP_058933.2
Pan troglodytes (chimpanzee)	UCHL1	XP_517163.2
	LOC701579	XP_001097839.2
Gallus gallus (chicken)	UCHL1	NP_001073681.1
Danio rerio (zebrafish)	uchl1	NP_958885.1
Xenopus tropicalis (tropical clawed frog)	uchl1	NP_001011321.1
Homo sapiens (human)	UCHL1	NP_004172.2

Gene Ontology

The following UCHL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UCHL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19475	NM_004181.5 Latest version!	Homo sapiens ubiquitin C-terminal hydrolase L1 (UCHL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$216.30 $309.00
View Old Accession Versions >>
OHu19475	NM_004181.4	Homo sapiens ubiquitin C-terminal hydrolase L1 (UCHL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UCHL1 ( NM_004181.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004172.2 Homo sapiens ubiquitin C-terminal hydrolase L1 (UCHL1), mRNA.

Price & Availability↑

CloneID	OHu19475
Clone ID Related Accession (Same CDS sequence)	NM_004181.4 , NM_004181.5
Accession Version	NM_004181.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 672bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	ubiquitin carboxyl-terminal hydrolase isozyme L1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP202166.1 and BC000332.2. This sequence is a reference standard in the RefSeqGene project. On Jun 12, 2009 this sequence version replaced NM_004181.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000332.2, SRR1803616.330153.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAGCTCA AGCCGATGGA GATCAACCCC GAGATGCTGA ACAAAGTGCT GTCCCGGCTG 
GGGGTCGCCG GCCAGTGGCG CTTCGTGGAC GTGCTGGGGC TGGAAGAGGA GTCTCTGGGC 
TCGGTGCCAG CGCCTGCCTG CGCGCTGCTG CTGCTGTTTC CCCTCACGGC CCAGCATGAG 
AACTTCAGGA AAAAGCAGAT TGAAGAGCTG AAGGGACAAG AAGTTAGTCC TAAAGTGTAC 
TTCATGAAGC AGACCATTGG GAATTCCTGT GGCACAATCG GACTTATTCA CGCAGTGGCC 
AATAATCAAG ACAAACTGGG ATTTGAGGAT GGATCAGTTC TGAAACAGTT TCTTTCTGAA 
ACAGAGAAAA TGTCCCCTGA AGACAGAGCA AAATGCTTTG AAAAGAATGA GGCCATACAG 
GCAGCCCATG ATGCCGTGGC ACAGGAAGGC CAATGTCGGG TAGATGACAA GGTGAATTTC 
CATTTTATTC TGTTTAACAA CGTGGATGGC CACCTCTATG AACTTGATGG ACGAATGCCT 
TTTCCGGTGA ACCATGGCGC CAGTTCAGAG GACACCCTGC TGAAGGACGC TGCCAAGGTC 
TGCAGAGAAT TCACCGAGCG TGAGCAAGGA GAAGTCCGCT TCTCTGCCGT GGCTCTCTGC 
AAGGCAGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004172.2
CDS	97..768
Translation	MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA

Target ORF information:

RefSeq Version	NM_004181.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin C-terminal hydrolase L1 (UCHL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004181.4

ORF Insert Sequence:

ATGCAGCTCA AGCCGATGGA GATCAACCCC GAGATGCTGA ACAAAGTGCT GTCCCGGCTG 
GGGGTCGCCG GCCAGTGGCG CTTCGTGGAC GTGCTGGGGC TGGAAGAGGA GTCTCTGGGC 
TCGGTGCCAG CGCCTGCCTG CGCGCTGCTG CTGCTGTTTC CCCTCACGGC CCAGCATGAG 
AACTTCAGGA AAAAGCAGAT TGAAGAGCTG AAGGGACAAG AAGTTAGTCC TAAAGTGTAC 
TTCATGAAGC AGACCATTGG GAATTCCTGT GGCACAATCG GACTTATTCA CGCAGTGGCC 
AATAATCAAG ACAAACTGGG ATTTGAGGAT GGATCAGTTC TGAAACAGTT TCTTTCTGAA 
ACAGAGAAAA TGTCCCCTGA AGACAGAGCA AAATGCTTTG AAAAGAATGA GGCCATACAG 
GCAGCCCATG ATGCCGTGGC ACAGGAAGGC CAATGTCGGG TAGATGACAA GGTGAATTTC 
CATTTTATTC TGTTTAACAA CGTGGATGGC CACCTCTATG AACTTGATGG ACGAATGCCT 
TTTCCGGTGA ACCATGGCGC CAGTTCAGAG GACACCCTGC TGAAGGACGC TGCCAAGGTC 
TGCAGAGAAT TCACCGAGCG TGAGCAAGGA GAAGTCCGCT TCTCTGCCGT GGCTCTCTGC 
AAGGCAGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UCHL1 ( NM_004181.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004172.2 Homo sapiens ubiquitin C-terminal hydrolase L1 (UCHL1), mRNA.

Price & Availability↑

CloneID	OHu19475
Clone ID Related Accession (Same CDS sequence)	NM_004181.4 , NM_004181.5
Accession Version	NM_004181.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 672bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	ubiquitin carboxyl-terminal hydrolase isozyme L1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP202166.1, BC000332.2 and AC095043.3. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_004181.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.231640.1, SRR7410570.231655.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000284440.9/ ENSP00000284440.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGCTCA AGCCGATGGA GATCAACCCC GAGATGCTGA ACAAAGTGCT GTCCCGGCTG 
GGGGTCGCCG GCCAGTGGCG CTTCGTGGAC GTGCTGGGGC TGGAAGAGGA GTCTCTGGGC 
TCGGTGCCAG CGCCTGCCTG CGCGCTGCTG CTGCTGTTTC CCCTCACGGC CCAGCATGAG 
AACTTCAGGA AAAAGCAGAT TGAAGAGCTG AAGGGACAAG AAGTTAGTCC TAAAGTGTAC 
TTCATGAAGC AGACCATTGG GAATTCCTGT GGCACAATCG GACTTATTCA CGCAGTGGCC 
AATAATCAAG ACAAACTGGG ATTTGAGGAT GGATCAGTTC TGAAACAGTT TCTTTCTGAA 
ACAGAGAAAA TGTCCCCTGA AGACAGAGCA AAATGCTTTG AAAAGAATGA GGCCATACAG 
GCAGCCCATG ATGCCGTGGC ACAGGAAGGC CAATGTCGGG TAGATGACAA GGTGAATTTC 
CATTTTATTC TGTTTAACAA CGTGGATGGC CACCTCTATG AACTTGATGG ACGAATGCCT 
TTTCCGGTGA ACCATGGCGC CAGTTCAGAG GACACCCTGC TGAAGGACGC TGCCAAGGTC 
TGCAGAGAAT TCACCGAGCG TGAGCAAGGA GAAGTCCGCT TCTCTGCCGT GGCTCTCTGC 
AAGGCAGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004172.2
CDS	50..721
Translation	MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA

Target ORF information:

RefSeq Version	NM_004181.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ubiquitin C-terminal hydrolase L1 (UCHL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004181.5

ORF Insert Sequence:

ATGCAGCTCA AGCCGATGGA GATCAACCCC GAGATGCTGA ACAAAGTGCT GTCCCGGCTG 
GGGGTCGCCG GCCAGTGGCG CTTCGTGGAC GTGCTGGGGC TGGAAGAGGA GTCTCTGGGC 
TCGGTGCCAG CGCCTGCCTG CGCGCTGCTG CTGCTGTTTC CCCTCACGGC CCAGCATGAG 
AACTTCAGGA AAAAGCAGAT TGAAGAGCTG AAGGGACAAG AAGTTAGTCC TAAAGTGTAC 
TTCATGAAGC AGACCATTGG GAATTCCTGT GGCACAATCG GACTTATTCA CGCAGTGGCC 
AATAATCAAG ACAAACTGGG ATTTGAGGAT GGATCAGTTC TGAAACAGTT TCTTTCTGAA 
ACAGAGAAAA TGTCCCCTGA AGACAGAGCA AAATGCTTTG AAAAGAATGA GGCCATACAG 
GCAGCCCATG ATGCCGTGGC ACAGGAAGGC CAATGTCGGG TAGATGACAA GGTGAATTTC 
CATTTTATTC TGTTTAACAA CGTGGATGGC CACCTCTATG AACTTGATGG ACGAATGCCT 
TTTCCGGTGA ACCATGGCGC CAGTTCAGAG GACACCCTGC TGAAGGACGC TGCCAAGGTC 
TGCAGAGAAT TCACCGAGCG TGAGCAAGGA GAAGTCCGCT TCTCTGCCGT GGCTCTCTGC 
AAGGCAGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.