NKX2-1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NKX2-1
Entrez Gene ID	7080
Full Name	NK2 homeobox 1
Synonyms	BCH,BHC,NK-2,NKX2.1,NKX2A,NMTC1,T/EBP,TEBP,TITF1,TTF-1,TTF1
General protein information	Preferred Names NK2 homeobox 1 Names homeobox protein Nkx-2.1 NK-2 homolog A homeobox protein NK-2 homolog A thyroid nuclear factor 1 thyroid transcription factor 1 thyroid-specific enhancer-binding protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q13.3
Summary	This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq, Feb 2014].
Disorder MIM:	600635
Disorder Html:	{Thyroid cancer, nonmedullary, 1}, 188550 (3); Chorea, hereditary benign, 118700 (3); Choreoathetosis, hypothyroidism, and neonatal respiratory distress, 610978 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001079668.3	NP_001073136.1	homeobox protein Nkx-2.1 isoform 1
NM_001079668.2	NP_001073136.1	homeobox protein Nkx-2.1 isoform 1
NM_003317.4	NP_003308.1	homeobox protein Nkx-2.1 isoform 2
NM_003317.3	NP_003308.1	homeobox protein Nkx-2.1 isoform 2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Nkx2-1	NP_037225.1
Danio rerio (zebrafish)	nkx2.1b	NP_571851.1
Xenopus tropicalis (tropical clawed frog)	nkx2-1	XP_002935383.1
Homo sapiens (human)	NKX2-1	NP_001073136.1
Pan troglodytes (chimpanzee)	NKX2-1	XP_509911.2
	NKX2-1	XP_001089773.1
Bos taurus (cattle)	LOC613713	NP_001178387.1
Mus musculus (house mouse)	Nkx2-1	NP_001139670.1
Gallus gallus (chicken)	NKX2-1	NP_989947.1

Gene Ontology

The following NKX2-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NKX2-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16274	NM_003317.4 Latest version!	Homo sapiens NK2 homeobox 1 (NKX2-1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu22673	NM_001079668.3 Latest version!	Homo sapiens NK2 homeobox 1 (NKX2-1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu22673	NM_001079668.2	Homo sapiens NK2 homeobox 1 (NKX2-1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu16274	NM_003317.3	Homo sapiens NK2 homeobox 1 (NKX2-1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NKX2-1 ( NM_003317.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003308.1 Homo sapiens NK2 homeobox 1 (NKX2-1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16274
Clone ID Related Accession (Same CDS sequence)	NM_003317.4 , NM_003317.3
Accession Version	NM_003317.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1116bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	homeobox protein Nkx-2.1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U33749.1, BC006221.2 and BM970838.1. On Jun 2, 2019 this sequence version replaced NM_003317.3. Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279835.7804.1, DRR138524.267689.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147920, SAMEA2155770 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGATGA GTCCAAAGCA CACGACTCCG TTCTCAGTGT CTGACATCTT GAGTCCCCTG 
GAGGAAAGCT ACAAGAAAGT GGGCATGGAG GGCGGCGGCC TCGGGGCTCC GCTGGCGGCG 
TACAGGCAGG GCCAGGCGGC ACCGCCAACA GCGGCCATGC AGCAGCACGC CGTGGGGCAC 
CACGGCGCCG TCACCGCCGC CTACCACATG ACGGCGGCGG GGGTGCCCCA GCTCTCGCAC 
TCCGCCGTGG GGGGCTACTG CAACGGCAAC CTGGGCAACA TGAGCGAGCT GCCGCCGTAC 
CAGGACACCA TGAGGAACAG CGCCTCTGGC CCCGGATGGT ACGGCGCCAA CCCAGACCCG 
CGCTTCCCCG CCATCTCCCG CTTCATGGGC CCGGCGAGCG GCATGAACAT GAGCGGCATG 
GGCGGCCTGG GCTCGCTGGG GGACGTGAGC AAGAACATGG CCCCGCTGCC AAGCGCGCCG 
CGCAGGAAGC GCCGGGTGCT CTTCTCGCAG GCGCAGGTGT ACGAGCTGGA GCGACGCTTC 
AAGCAACAGA AGTACCTGTC GGCGCCGGAG CGCGAGCACC TGGCCAGCAT GATCCACCTG 
ACGCCCACGC AGGTCAAGAT CTGGTTCCAG AACCACCGCT ACAAAATGAA GCGCCAGGCC 
AAGGACAAGG CGGCGCAGCA GCAACTGCAG CAGGACAGCG GCGGCGGCGG GGGCGGCGGG 
GGCACCGGGT GCCCGCAGCA GCAACAGGCT CAGCAGCAGT CGCCGCGACG CGTGGCGGTG 
CCGGTCCTGG TGAAAGACGG CAAACCGTGC CAGGCGGGTG CCCCCGCGCC GGGCGCCGCC 
AGCCTACAAG GCCACGCGCA GCAGCAGGCG CAGCACCAGG CGCAGGCCGC GCAGGCGGCG 
GCAGCGGCCA TCTCCGTGGG CAGCGGTGGC GCCGGCCTTG GCGCACACCC GGGCCACCAG 
CCAGGCAGCG CAGGCCAGTC TCCGGACCTG GCGCACCACG CCGCCAGCCC CGCGGCGCTG 
CAGGGCCAGG TATCCAGCCT GTCCCACCTG AACTCCTCGG GCTCGGACTA CGGCACCATG 
TCCTGCTCCA CCTTGCTATA CGGTCGGACC TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003308.1
CDS	200..1315
Translation	MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW

Target ORF information:

RefSeq Version	NM_003317.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NK2 homeobox 1 (NKX2-1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003317.4

ORF Insert Sequence:

ATGTCGATGA GTCCAAAGCA CACGACTCCG TTCTCAGTGT CTGACATCTT GAGTCCCCTG 
GAGGAAAGCT ACAAGAAAGT GGGCATGGAG GGCGGCGGCC TCGGGGCTCC GCTGGCGGCG 
TACAGGCAGG GCCAGGCGGC ACCGCCAACA GCGGCCATGC AGCAGCACGC CGTGGGGCAC 
CACGGCGCCG TCACCGCCGC CTACCACATG ACGGCGGCGG GGGTGCCCCA GCTCTCGCAC 
TCCGCCGTGG GGGGCTACTG CAACGGCAAC CTGGGCAACA TGAGCGAGCT GCCGCCGTAC 
CAGGACACCA TGAGGAACAG CGCCTCTGGC CCCGGATGGT ACGGCGCCAA CCCAGACCCG 
CGCTTCCCCG CCATCTCCCG CTTCATGGGC CCGGCGAGCG GCATGAACAT GAGCGGCATG 
GGCGGCCTGG GCTCGCTGGG GGACGTGAGC AAGAACATGG CCCCGCTGCC AAGCGCGCCG 
CGCAGGAAGC GCCGGGTGCT CTTCTCGCAG GCGCAGGTGT ACGAGCTGGA GCGACGCTTC 
AAGCAACAGA AGTACCTGTC GGCGCCGGAG CGCGAGCACC TGGCCAGCAT GATCCACCTG 
ACGCCCACGC AGGTCAAGAT CTGGTTCCAG AACCACCGCT ACAAAATGAA GCGCCAGGCC 
AAGGACAAGG CGGCGCAGCA GCAACTGCAG CAGGACAGCG GCGGCGGCGG GGGCGGCGGG 
GGCACCGGGT GCCCGCAGCA GCAACAGGCT CAGCAGCAGT CGCCGCGACG CGTGGCGGTG 
CCGGTCCTGG TGAAAGACGG CAAACCGTGC CAGGCGGGTG CCCCCGCGCC GGGCGCCGCC 
AGCCTACAAG GCCACGCGCA GCAGCAGGCG CAGCACCAGG CGCAGGCCGC GCAGGCGGCG 
GCAGCGGCCA TCTCCGTGGG CAGCGGTGGC GCCGGCCTTG GCGCACACCC GGGCCACCAG 
CCAGGCAGCG CAGGCCAGTC TCCGGACCTG GCGCACCACG CCGCCAGCCC CGCGGCGCTG 
CAGGGCCAGG TATCCAGCCT GTCCCACCTG AACTCCTCGG GCTCGGACTA CGGCACCATG 
TCCTGCTCCA CCTTGCTATA CGGTCGGACC TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NKX2-1 ( NM_003317.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003308.1 Homo sapiens NK2 homeobox 1 (NKX2-1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu16274
Clone ID Related Accession (Same CDS sequence)	NM_003317.4 , NM_003317.3
Accession Version	NM_003317.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1116bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-11
Organism	Homo sapiens(human)
Product	homeobox protein Nkx-2.1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U33749.1, BC006221.2 and BM970838.1. On or before Jul 8, 2009 this sequence version replaced XM_002344771.1, NM_003317.2. Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U33749.1, ERR279873.1315.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147920, SAMEA2155770 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGATGA GTCCAAAGCA CACGACTCCG TTCTCAGTGT CTGACATCTT GAGTCCCCTG 
GAGGAAAGCT ACAAGAAAGT GGGCATGGAG GGCGGCGGCC TCGGGGCTCC GCTGGCGGCG 
TACAGGCAGG GCCAGGCGGC ACCGCCAACA GCGGCCATGC AGCAGCACGC CGTGGGGCAC 
CACGGCGCCG TCACCGCCGC CTACCACATG ACGGCGGCGG GGGTGCCCCA GCTCTCGCAC 
TCCGCCGTGG GGGGCTACTG CAACGGCAAC CTGGGCAACA TGAGCGAGCT GCCGCCGTAC 
CAGGACACCA TGAGGAACAG CGCCTCTGGC CCCGGATGGT ACGGCGCCAA CCCAGACCCG 
CGCTTCCCCG CCATCTCCCG CTTCATGGGC CCGGCGAGCG GCATGAACAT GAGCGGCATG 
GGCGGCCTGG GCTCGCTGGG GGACGTGAGC AAGAACATGG CCCCGCTGCC AAGCGCGCCG 
CGCAGGAAGC GCCGGGTGCT CTTCTCGCAG GCGCAGGTGT ACGAGCTGGA GCGACGCTTC 
AAGCAACAGA AGTACCTGTC GGCGCCGGAG CGCGAGCACC TGGCCAGCAT GATCCACCTG 
ACGCCCACGC AGGTCAAGAT CTGGTTCCAG AACCACCGCT ACAAAATGAA GCGCCAGGCC 
AAGGACAAGG CGGCGCAGCA GCAACTGCAG CAGGACAGCG GCGGCGGCGG GGGCGGCGGG 
GGCACCGGGT GCCCGCAGCA GCAACAGGCT CAGCAGCAGT CGCCGCGACG CGTGGCGGTG 
CCGGTCCTGG TGAAAGACGG CAAACCGTGC CAGGCGGGTG CCCCCGCGCC GGGCGCCGCC 
AGCCTACAAG GCCACGCGCA GCAGCAGGCG CAGCACCAGG CGCAGGCCGC GCAGGCGGCG 
GCAGCGGCCA TCTCCGTGGG CAGCGGTGGC GCCGGCCTTG GCGCACACCC GGGCCACCAG 
CCAGGCAGCG CAGGCCAGTC TCCGGACCTG GCGCACCACG CCGCCAGCCC CGCGGCGCTG 
CAGGGCCAGG TATCCAGCCT GTCCCACCTG AACTCCTCGG GCTCGGACTA CGGCACCATG 
TCCTGCTCCA CCTTGCTATA CGGTCGGACC TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003308.1
CDS	342..1457
Translation	MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW

Target ORF information:

RefSeq Version	NM_003317.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NK2 homeobox 1 (NKX2-1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003317.3

ORF Insert Sequence:

ATGTCGATGA GTCCAAAGCA CACGACTCCG TTCTCAGTGT CTGACATCTT GAGTCCCCTG 
GAGGAAAGCT ACAAGAAAGT GGGCATGGAG GGCGGCGGCC TCGGGGCTCC GCTGGCGGCG 
TACAGGCAGG GCCAGGCGGC ACCGCCAACA GCGGCCATGC AGCAGCACGC CGTGGGGCAC 
CACGGCGCCG TCACCGCCGC CTACCACATG ACGGCGGCGG GGGTGCCCCA GCTCTCGCAC 
TCCGCCGTGG GGGGCTACTG CAACGGCAAC CTGGGCAACA TGAGCGAGCT GCCGCCGTAC 
CAGGACACCA TGAGGAACAG CGCCTCTGGC CCCGGATGGT ACGGCGCCAA CCCAGACCCG 
CGCTTCCCCG CCATCTCCCG CTTCATGGGC CCGGCGAGCG GCATGAACAT GAGCGGCATG 
GGCGGCCTGG GCTCGCTGGG GGACGTGAGC AAGAACATGG CCCCGCTGCC AAGCGCGCCG 
CGCAGGAAGC GCCGGGTGCT CTTCTCGCAG GCGCAGGTGT ACGAGCTGGA GCGACGCTTC 
AAGCAACAGA AGTACCTGTC GGCGCCGGAG CGCGAGCACC TGGCCAGCAT GATCCACCTG 
ACGCCCACGC AGGTCAAGAT CTGGTTCCAG AACCACCGCT ACAAAATGAA GCGCCAGGCC 
AAGGACAAGG CGGCGCAGCA GCAACTGCAG CAGGACAGCG GCGGCGGCGG GGGCGGCGGG 
GGCACCGGGT GCCCGCAGCA GCAACAGGCT CAGCAGCAGT CGCCGCGACG CGTGGCGGTG 
CCGGTCCTGG TGAAAGACGG CAAACCGTGC CAGGCGGGTG CCCCCGCGCC GGGCGCCGCC 
AGCCTACAAG GCCACGCGCA GCAGCAGGCG CAGCACCAGG CGCAGGCCGC GCAGGCGGCG 
GCAGCGGCCA TCTCCGTGGG CAGCGGTGGC GCCGGCCTTG GCGCACACCC GGGCCACCAG 
CCAGGCAGCG CAGGCCAGTC TCCGGACCTG GCGCACCACG CCGCCAGCCC CGCGGCGCTG 
CAGGGCCAGG TATCCAGCCT GTCCCACCTG AACTCCTCGG GCTCGGACTA CGGCACCATG 
TCCTGCTCCA CCTTGCTATA CGGTCGGACC TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NKX2-1 ( NM_001079668.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001073136.1 Homo sapiens NK2 homeobox 1 (NKX2-1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22673
Clone ID Related Accession (Same CDS sequence)	NM_001079668.3 , NM_001079668.2
Accession Version	NM_001079668.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1206bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	homeobox protein Nkx-2.1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL132857.4, U43203.1 and BM970287.1. This sequence is a reference standard in the RefSeqGene project. On Jun 2, 2019 this sequence version replaced NM_001079668.2. Transcript Variant: This variant (1) encodes the longer protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC006221.2, U43203.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147920, SAMEA2155770 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTGGTCCG GAGGCAGTGG GAAGGCGCGG GGCTGGGAGG CCGCGGCGGG AGGGAGGAGC 
AGCCCCGGCA GGCTCAGCCG CCGCCGAATC ATGTCGATGA GTCCAAAGCA CACGACTCCG 
TTCTCAGTGT CTGACATCTT GAGTCCCCTG GAGGAAAGCT ACAAGAAAGT GGGCATGGAG 
GGCGGCGGCC TCGGGGCTCC GCTGGCGGCG TACAGGCAGG GCCAGGCGGC ACCGCCAACA 
GCGGCCATGC AGCAGCACGC CGTGGGGCAC CACGGCGCCG TCACCGCCGC CTACCACATG 
ACGGCGGCGG GGGTGCCCCA GCTCTCGCAC TCCGCCGTGG GGGGCTACTG CAACGGCAAC 
CTGGGCAACA TGAGCGAGCT GCCGCCGTAC CAGGACACCA TGAGGAACAG CGCCTCTGGC 
CCCGGATGGT ACGGCGCCAA CCCAGACCCG CGCTTCCCCG CCATCTCCCG CTTCATGGGC 
CCGGCGAGCG GCATGAACAT GAGCGGCATG GGCGGCCTGG GCTCGCTGGG GGACGTGAGC 
AAGAACATGG CCCCGCTGCC AAGCGCGCCG CGCAGGAAGC GCCGGGTGCT CTTCTCGCAG 
GCGCAGGTGT ACGAGCTGGA GCGACGCTTC AAGCAACAGA AGTACCTGTC GGCGCCGGAG 
CGCGAGCACC TGGCCAGCAT GATCCACCTG ACGCCCACGC AGGTCAAGAT CTGGTTCCAG 
AACCACCGCT ACAAAATGAA GCGCCAGGCC AAGGACAAGG CGGCGCAGCA GCAACTGCAG 
CAGGACAGCG GCGGCGGCGG GGGCGGCGGG GGCACCGGGT GCCCGCAGCA GCAACAGGCT 
CAGCAGCAGT CGCCGCGACG CGTGGCGGTG CCGGTCCTGG TGAAAGACGG CAAACCGTGC 
CAGGCGGGTG CCCCCGCGCC GGGCGCCGCC AGCCTACAAG GCCACGCGCA GCAGCAGGCG 
CAGCACCAGG CGCAGGCCGC GCAGGCGGCG GCAGCGGCCA TCTCCGTGGG CAGCGGTGGC 
GCCGGCCTTG GCGCACACCC GGGCCACCAG CCAGGCAGCG CAGGCCAGTC TCCGGACCTG 
GCGCACCACG CCGCCAGCCC CGCGGCGCTG CAGGGCCAGG TATCCAGCCT GTCCCACCTG 
AACTCCTCGG GCTCGGACTA CGGCACCATG TCCTGCTCCA CCTTGCTATA CGGTCGGACC 
TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001073136.1
CDS	104..1309
Translation	MWSGGSGKARGWEAAAGGRSSPGRLSRRRIMSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW

Target ORF information:

RefSeq Version	NM_001079668.3
Organism	Homo sapiens(human)
Definition	Homo sapiens NK2 homeobox 1 (NKX2-1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001079668.3

ORF Insert Sequence:

ATGTGGTCCG GAGGCAGTGG GAAGGCGCGG GGCTGGGAGG CCGCGGCGGG AGGGAGGAGC 
AGCCCCGGCA GGCTCAGCCG CCGCCGAATC ATGTCGATGA GTCCAAAGCA CACGACTCCG 
TTCTCAGTGT CTGACATCTT GAGTCCCCTG GAGGAAAGCT ACAAGAAAGT GGGCATGGAG 
GGCGGCGGCC TCGGGGCTCC GCTGGCGGCG TACAGGCAGG GCCAGGCGGC ACCGCCAACA 
GCGGCCATGC AGCAGCACGC CGTGGGGCAC CACGGCGCCG TCACCGCCGC CTACCACATG 
ACGGCGGCGG GGGTGCCCCA GCTCTCGCAC TCCGCCGTGG GGGGCTACTG CAACGGCAAC 
CTGGGCAACA TGAGCGAGCT GCCGCCGTAC CAGGACACCA TGAGGAACAG CGCCTCTGGC 
CCCGGATGGT ACGGCGCCAA CCCAGACCCG CGCTTCCCCG CCATCTCCCG CTTCATGGGC 
CCGGCGAGCG GCATGAACAT GAGCGGCATG GGCGGCCTGG GCTCGCTGGG GGACGTGAGC 
AAGAACATGG CCCCGCTGCC AAGCGCGCCG CGCAGGAAGC GCCGGGTGCT CTTCTCGCAG 
GCGCAGGTGT ACGAGCTGGA GCGACGCTTC AAGCAACAGA AGTACCTGTC GGCGCCGGAG 
CGCGAGCACC TGGCCAGCAT GATCCACCTG ACGCCCACGC AGGTCAAGAT CTGGTTCCAG 
AACCACCGCT ACAAAATGAA GCGCCAGGCC AAGGACAAGG CGGCGCAGCA GCAACTGCAG 
CAGGACAGCG GCGGCGGCGG GGGCGGCGGG GGCACCGGGT GCCCGCAGCA GCAACAGGCT 
CAGCAGCAGT CGCCGCGACG CGTGGCGGTG CCGGTCCTGG TGAAAGACGG CAAACCGTGC 
CAGGCGGGTG CCCCCGCGCC GGGCGCCGCC AGCCTACAAG GCCACGCGCA GCAGCAGGCG 
CAGCACCAGG CGCAGGCCGC GCAGGCGGCG GCAGCGGCCA TCTCCGTGGG CAGCGGTGGC 
GCCGGCCTTG GCGCACACCC GGGCCACCAG CCAGGCAGCG CAGGCCAGTC TCCGGACCTG 
GCGCACCACG CCGCCAGCCC CGCGGCGCTG CAGGGCCAGG TATCCAGCCT GTCCCACCTG 
AACTCCTCGG GCTCGGACTA CGGCACCATG TCCTGCTCCA CCTTGCTATA CGGTCGGACC 
TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NKX2-1 ( NM_001079668.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001073136.1 Homo sapiens NK2 homeobox 1 (NKX2-1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22673
Clone ID Related Accession (Same CDS sequence)	NM_001079668.3 , NM_001079668.2
Accession Version	NM_001079668.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1206bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-11
Organism	Homo sapiens(human)
Product	homeobox protein Nkx-2.1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL132857.4, U43203.1 and BM970287.1. This sequence is a reference standard in the RefSeqGene project. On Oct 10, 2009 this sequence version replaced NM_001079668.1. Transcript Variant: This variant (1) encodes the longer protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U43203.1, BT009773.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147920, SAMEA2155770 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGGTCCG GAGGCAGTGG GAAGGCGCGG GGCTGGGAGG CCGCGGCGGG AGGGAGGAGC 
AGCCCCGGCA GGCTCAGCCG CCGCCGAATC ATGTCGATGA GTCCAAAGCA CACGACTCCG 
TTCTCAGTGT CTGACATCTT GAGTCCCCTG GAGGAAAGCT ACAAGAAAGT GGGCATGGAG 
GGCGGCGGCC TCGGGGCTCC GCTGGCGGCG TACAGGCAGG GCCAGGCGGC ACCGCCAACA 
GCGGCCATGC AGCAGCACGC CGTGGGGCAC CACGGCGCCG TCACCGCCGC CTACCACATG 
ACGGCGGCGG GGGTGCCCCA GCTCTCGCAC TCCGCCGTGG GGGGCTACTG CAACGGCAAC 
CTGGGCAACA TGAGCGAGCT GCCGCCGTAC CAGGACACCA TGAGGAACAG CGCCTCTGGC 
CCCGGATGGT ACGGCGCCAA CCCAGACCCG CGCTTCCCCG CCATCTCCCG CTTCATGGGC 
CCGGCGAGCG GCATGAACAT GAGCGGCATG GGCGGCCTGG GCTCGCTGGG GGACGTGAGC 
AAGAACATGG CCCCGCTGCC AAGCGCGCCG CGCAGGAAGC GCCGGGTGCT CTTCTCGCAG 
GCGCAGGTGT ACGAGCTGGA GCGACGCTTC AAGCAACAGA AGTACCTGTC GGCGCCGGAG 
CGCGAGCACC TGGCCAGCAT GATCCACCTG ACGCCCACGC AGGTCAAGAT CTGGTTCCAG 
AACCACCGCT ACAAAATGAA GCGCCAGGCC AAGGACAAGG CGGCGCAGCA GCAACTGCAG 
CAGGACAGCG GCGGCGGCGG GGGCGGCGGG GGCACCGGGT GCCCGCAGCA GCAACAGGCT 
CAGCAGCAGT CGCCGCGACG CGTGGCGGTG CCGGTCCTGG TGAAAGACGG CAAACCGTGC 
CAGGCGGGTG CCCCCGCGCC GGGCGCCGCC AGCCTACAAG GCCACGCGCA GCAGCAGGCG 
CAGCACCAGG CGCAGGCCGC GCAGGCGGCG GCAGCGGCCA TCTCCGTGGG CAGCGGTGGC 
GCCGGCCTTG GCGCACACCC GGGCCACCAG CCAGGCAGCG CAGGCCAGTC TCCGGACCTG 
GCGCACCACG CCGCCAGCCC CGCGGCGCTG CAGGGCCAGG TATCCAGCCT GTCCCACCTG 
AACTCCTCGG GCTCGGACTA CGGCACCATG TCCTGCTCCA CCTTGCTATA CGGTCGGACC 
TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001073136.1
CDS	97..1302
Translation	MWSGGSGKARGWEAAAGGRSSPGRLSRRRIMSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPTAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGTGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQHQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGTMSCSTLLYGRTW

Target ORF information:

RefSeq Version	NM_001079668.2
Organism	Homo sapiens(human)
Definition	Homo sapiens NK2 homeobox 1 (NKX2-1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001079668.2

ORF Insert Sequence:

ATGTGGTCCG GAGGCAGTGG GAAGGCGCGG GGCTGGGAGG CCGCGGCGGG AGGGAGGAGC 
AGCCCCGGCA GGCTCAGCCG CCGCCGAATC ATGTCGATGA GTCCAAAGCA CACGACTCCG 
TTCTCAGTGT CTGACATCTT GAGTCCCCTG GAGGAAAGCT ACAAGAAAGT GGGCATGGAG 
GGCGGCGGCC TCGGGGCTCC GCTGGCGGCG TACAGGCAGG GCCAGGCGGC ACCGCCAACA 
GCGGCCATGC AGCAGCACGC CGTGGGGCAC CACGGCGCCG TCACCGCCGC CTACCACATG 
ACGGCGGCGG GGGTGCCCCA GCTCTCGCAC TCCGCCGTGG GGGGCTACTG CAACGGCAAC 
CTGGGCAACA TGAGCGAGCT GCCGCCGTAC CAGGACACCA TGAGGAACAG CGCCTCTGGC 
CCCGGATGGT ACGGCGCCAA CCCAGACCCG CGCTTCCCCG CCATCTCCCG CTTCATGGGC 
CCGGCGAGCG GCATGAACAT GAGCGGCATG GGCGGCCTGG GCTCGCTGGG GGACGTGAGC 
AAGAACATGG CCCCGCTGCC AAGCGCGCCG CGCAGGAAGC GCCGGGTGCT CTTCTCGCAG 
GCGCAGGTGT ACGAGCTGGA GCGACGCTTC AAGCAACAGA AGTACCTGTC GGCGCCGGAG 
CGCGAGCACC TGGCCAGCAT GATCCACCTG ACGCCCACGC AGGTCAAGAT CTGGTTCCAG 
AACCACCGCT ACAAAATGAA GCGCCAGGCC AAGGACAAGG CGGCGCAGCA GCAACTGCAG 
CAGGACAGCG GCGGCGGCGG GGGCGGCGGG GGCACCGGGT GCCCGCAGCA GCAACAGGCT 
CAGCAGCAGT CGCCGCGACG CGTGGCGGTG CCGGTCCTGG TGAAAGACGG CAAACCGTGC 
CAGGCGGGTG CCCCCGCGCC GGGCGCCGCC AGCCTACAAG GCCACGCGCA GCAGCAGGCG 
CAGCACCAGG CGCAGGCCGC GCAGGCGGCG GCAGCGGCCA TCTCCGTGGG CAGCGGTGGC 
GCCGGCCTTG GCGCACACCC GGGCCACCAG CCAGGCAGCG CAGGCCAGTC TCCGGACCTG 
GCGCACCACG CCGCCAGCCC CGCGGCGCTG CAGGGCCAGG TATCCAGCCT GTCCCACCTG 
AACTCCTCGG GCTCGGACTA CGGCACCATG TCCTGCTCCA CCTTGCTATA CGGTCGGACC 
TGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

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NKX2-1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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