TIMP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TIMP1
Entrez Gene ID	7076
Full Name	TIMP metallopeptidase inhibitor 1
Synonyms	CLGI,EPA,EPO,HCI,TIMP,TIMP-1
General protein information	Preferred Names TIMP metallopeptidase inhibitor 1 Names metalloproteinase inhibitor 1 collagenase inhibitor erythroid potentiating activity fibroblast collagenase inhibitor tissue inhibitor of metalloproteinases 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xp11.3
Summary	This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008].
Disorder MIM:	305370

mRNA and Protein(s)

mRNA	Protein	Name
NM_003254.2	NP_003245.1	metalloproteinase inhibitor 1 precursor
XM_017029766.1	XP_016885255.1	metalloproteinase inhibitor 1 isoform X1
NM_003254.3	NP_003245.1	metalloproteinase inhibitor 1 precursor
XM_017029766.2	XP_016885255.1	metalloproteinase inhibitor 1 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Timp1	NP_446271.1
	TIMP1	NP_001028111.1
Mus musculus (house mouse)	Timp1	NP_035723.2
Canis lupus familiaris (dog)	TIMP1	NP_001003182.1
Bos taurus (cattle)	TIMP1	NP_776896.1
Homo sapiens (human)	TIMP1	NP_003245.1

Gene Ontology
Bibliography

Related articles in PubMed

Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer.
D'Costa Z, Jones K, Azad A, van Stiphout R, Lim SY, Gomes AL, Kinchesh P, Smart SC, Gillies McKenna W, Buffa FM, Sansom OJ, Muschel RJ, O'Neill E, Fokas E
Cancer research77(21)5952-5962(2017 Nov)

MMP-10, MMP-7, TIMP-1 and TIMP-2 mRNA expression in esophageal cancer.
Juchniewicz A, Kowalczuk O, Milewski R, Lauda?ski W, Dzi?gielewski P, Koz?owski M, Nikli?ski J
Acta biochimica Polonica64(2)295-299(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Tissue inhibitor of matrix metalloproteinases 1 (TIMP1) inhibition resensitized tumors to gemcitabine and radiotherapy.
Title: Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer.

This study indicates that in our population, the COL4A3 rs55703767 polymorphism decreased the risk of KC. However, the TIMP-1 rs6609533 polymorphism was associated with an increased risk of KC.
Title: Correlation between the COL4A3, MMP-9, and TIMP-1 polymorphisms and risk of keratoconus.

The present study suggests that scoring of TIMP-1 immunoreactivity is a better choice than measuring of TIMP-1 plasma levels.
Title: Comparative studies of TIMP-1 immunohistochemistry, TIMP-1 FISH analysis and plasma TIMP-1 in glioblastoma patients.

The plasma levels of interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, tissue inhibitor of metalloproteinases (TIMP)-1 are increased in myelofibrosis (MF) patients.
Title: Crucial factors of the inflammatory microenvironment (IL-1?/TNF-?/TIMP-1) promote the maintenance of the malignant hemopoietic clone of myelofibrosis: an in vitro study.

plasma concentrations of MMP-7, MMP-8, -9 and TIMP-1 within 96 h from the onset of acute pancreatitis symptoms are elevated in acute pancreatitis patients compared with healthy controls
Title: Association of Matrix Metalloproteinases -7, -8 and -9 and TIMP -1 with Disease Severity in Acute Pancreatitis. A Cohort Study.

The following TIMP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TIMP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24051	NM_003254.3 Latest version!	Homo sapiens TIMP metallopeptidase inhibitor 1 (TIMP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu54019	XM_017029766.2 Latest version!	Homo sapiens TIMP metallopeptidase inhibitor 1 (TIMP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu24051	NM_003254.2	Homo sapiens TIMP metallopeptidase inhibitor 1 (TIMP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu54019	XM_017029766.1	Homo sapiens TIMP metallopeptidase inhibitor 1 (TIMP1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TIMP1 ( NM_003254.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_003245.1 Homo sapiens TIMP metallopeptidase inhibitor 1 (TIMP1), mRNA.

Price & Availability↑

CloneID	OHu24051
Clone ID Related Accession (Same CDS sequence)	NM_003254.2 , NM_003254.3
Accession Version	NM_003254.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	metalloproteinase inhibitor 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU857950.1, BC000866.1, BC007097.1 and BQ181804.1. This sequence is a reference standard in the RefSeqGene project. On Aug 29, 2005 this sequence version replaced NM_003254.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG476130.1, SRR1163655.140733.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCCCCT TTGAGCCCCT GGCTTCTGGC ATCCTGTTGT TGCTGTGGCT GATAGCCCCC 
AGCAGGGCCT GCACCTGTGT CCCACCCCAC CCACAGACGG CCTTCTGCAA TTCCGACCTC 
GTCATCAGGG CCAAGTTCGT GGGGACACCA GAAGTCAACC AGACCACCTT ATACCAGCGT 
TATGAGATCA AGATGACCAA GATGTATAAA GGGTTCCAAG CCTTAGGGGA TGCCGCTGAC 
ATCCGGTTCG TCTACACCCC CGCCATGGAG AGTGTCTGCG GATACTTCCA CAGGTCCCAC 
AACCGCAGCG AGGAGTTTCT CATTGCTGGA AAACTGCAGG ATGGACTCTT GCACATCACT 
ACCTGCAGTT TTGTGGCTCC CTGGAACAGC CTGAGCTTAG CTCAGCGCCG GGGCTTCACC 
AAGACCTACA CTGTTGGCTG TGAGGAATGC ACAGTGTTTC CCTGTTTATC CATCCCCTGC 
AAACTGCAGA GTGGCACTCA TTGCTTGTGG ACGGACCAGC TCCTCCAAGG CTCTGAAAAG 
GGCTTCCAGT CCCGTCACCT TGCCTGCCTG CCTCGGGAGC CAGGGCTGTG CACCTGGCAG 
TCCCTGCGGT CCCAGATAGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003245.1
CDS	193..816
Translation	MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA

Target ORF information:

RefSeq Version	NM_003254.2
Organism	Homo sapiens(human)
Definition	Homo sapiens TIMP metallopeptidase inhibitor 1 (TIMP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003254.2

ORF Insert Sequence:

ATGGCCCCCT TTGAGCCCCT GGCTTCTGGC ATCCTGTTGT TGCTGTGGCT GATAGCCCCC 
AGCAGGGCCT GCACCTGTGT CCCACCCCAC CCACAGACGG CCTTCTGCAA TTCCGACCTC 
GTCATCAGGG CCAAGTTCGT GGGGACACCA GAAGTCAACC AGACCACCTT ATACCAGCGT 
TATGAGATCA AGATGACCAA GATGTATAAA GGGTTCCAAG CCTTAGGGGA TGCCGCTGAC 
ATCCGGTTCG TCTACACCCC CGCCATGGAG AGTGTCTGCG GATACTTCCA CAGGTCCCAC 
AACCGCAGCG AGGAGTTTCT CATTGCTGGA AAACTGCAGG ATGGACTCTT GCACATCACT 
ACCTGCAGTT TTGTGGCTCC CTGGAACAGC CTGAGCTTAG CTCAGCGCCG GGGCTTCACC 
AAGACCTACA CTGTTGGCTG TGAGGAATGC ACAGTGTTTC CCTGTTTATC CATCCCCTGC 
AAACTGCAGA GTGGCACTCA TTGCTTGTGG ACGGACCAGC TCCTCCAAGG CTCTGAAAAG 
GGCTTCCAGT CCCGTCACCT TGCCTGCCTG CCTCGGGAGC CAGGGCTGTG CACCTGGCAG 
TCCCTGCGGT CCCAGATAGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TIMP1 ( NM_003254.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_003245.1 Homo sapiens TIMP metallopeptidase inhibitor 1 (TIMP1), mRNA.

Price & Availability↑

CloneID	OHu24051
Clone ID Related Accession (Same CDS sequence)	NM_003254.2 , NM_003254.3
Accession Version	NM_003254.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 624bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-09
Organism	Homo sapiens(human)
Product	metalloproteinase inhibitor 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC000866.1 and BC007097.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_003254.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000866.1, GQ891504.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000218388.9/ ENSP00000218388.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCCCCT TTGAGCCCCT GGCTTCTGGC ATCCTGTTGT TGCTGTGGCT GATAGCCCCC 
AGCAGGGCCT GCACCTGTGT CCCACCCCAC CCACAGACGG CCTTCTGCAA TTCCGACCTC 
GTCATCAGGG CCAAGTTCGT GGGGACACCA GAAGTCAACC AGACCACCTT ATACCAGCGT 
TATGAGATCA AGATGACCAA GATGTATAAA GGGTTCCAAG CCTTAGGGGA TGCCGCTGAC 
ATCCGGTTCG TCTACACCCC CGCCATGGAG AGTGTCTGCG GATACTTCCA CAGGTCCCAC 
AACCGCAGCG AGGAGTTTCT CATTGCTGGA AAACTGCAGG ATGGACTCTT GCACATCACT 
ACCTGCAGTT TTGTGGCTCC CTGGAACAGC CTGAGCTTAG CTCAGCGCCG GGGCTTCACC 
AAGACCTACA CTGTTGGCTG TGAGGAATGC ACAGTGTTTC CCTGTTTATC CATCCCCTGC 
AAACTGCAGA GTGGCACTCA TTGCTTGTGG ACGGACCAGC TCCTCCAAGG CTCTGAAAAG 
GGCTTCCAGT CCCGTCACCT TGCCTGCCTG CCTCGGGAGC CAGGGCTGTG CACCTGGCAG 
TCCCTGCGGT CCCAGATAGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003245.1
CDS	48..671
Translation	MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA

Target ORF information:

RefSeq Version	NM_003254.3
Organism	Homo sapiens(human)
Definition	Homo sapiens TIMP metallopeptidase inhibitor 1 (TIMP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003254.3

ORF Insert Sequence:

ATGGCCCCCT TTGAGCCCCT GGCTTCTGGC ATCCTGTTGT TGCTGTGGCT GATAGCCCCC 
AGCAGGGCCT GCACCTGTGT CCCACCCCAC CCACAGACGG CCTTCTGCAA TTCCGACCTC 
GTCATCAGGG CCAAGTTCGT GGGGACACCA GAAGTCAACC AGACCACCTT ATACCAGCGT 
TATGAGATCA AGATGACCAA GATGTATAAA GGGTTCCAAG CCTTAGGGGA TGCCGCTGAC 
ATCCGGTTCG TCTACACCCC CGCCATGGAG AGTGTCTGCG GATACTTCCA CAGGTCCCAC 
AACCGCAGCG AGGAGTTTCT CATTGCTGGA AAACTGCAGG ATGGACTCTT GCACATCACT 
ACCTGCAGTT TTGTGGCTCC CTGGAACAGC CTGAGCTTAG CTCAGCGCCG GGGCTTCACC 
AAGACCTACA CTGTTGGCTG TGAGGAATGC ACAGTGTTTC CCTGTTTATC CATCCCCTGC 
AAACTGCAGA GTGGCACTCA TTGCTTGTGG ACGGACCAGC TCCTCCAAGG CTCTGAAAAG 
GGCTTCCAGT CCCGTCACCT TGCCTGCCTG CCTCGGGAGC CAGGGCTGTG CACCTGGCAG 
TCCCTGCGGT CCCAGATAGC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TIMP1 ( XM_017029766.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885255.1 Homo sapiens TIMP metallopeptidase inhibitor 1 (TIMP1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu54019
Clone ID Related Accession (Same CDS sequence)	XM_017029766.1 , XM_017029766.2
Accession Version	XM_017029766.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	metalloproteinase inhibitor 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGCTGA CATCCGGTTC GTCTACACCC CCGCCATGGA GAGTGTCTGC GGATACTTCC 
ACAGGTCCCA CAACCGCAGC GAGGAGTTTC TCATTGCTGG TGAGGCACCG TCCCCGCGCC 
CTGTGCCACA CCAACCAGTC CCTGGGGCGC GGCCTAGCAA CCACGAGGGG GCGAGGCTCT 
GATGGGAATG GTCCCACTGG AAATGGGGAC CACCCCAATT TCAGTCTATC AGAAGGCCGG 
GCCTTTGGCA GCTTGGCAGC TCAGCCAATC ACAAGCTGCT TGTCGGTCCC CGCCCCGCCT 
TTCTCCTTAG GAAAACTGCA GGATGGACTC TTGCACATCA CTACCTGCAG TTTTGTGGCT 
CCCTGGAACA GCCTGAGCTT AGCTCAGCGC CGGGGCTTCA CCAAGACCTA CACTGTTGGC 
TGTGAGGAAT GCACAGTGAG TGCCTGGACC CTGACCTCCA ACGGGAGATC CTTCCCGGGG 
CCATTCCCTA AATCGTGGGC TTGTTTCTTG CTCCCTCTGG CTATTCTGTG TCCCTGTGGC 
TGCTCCCCAA CCCTAAGGGC TGTCCCTGAT CTCTCTTGCT ATTTCCCCAA GCCCGAGACT 
GCTCCCTTAC AAATTCTGGC TGCTCCCTTT CCCTGTGTCC AATACCGTGT GATCACCTGT 
CCCTCCCTGG TCCCTCTAAT TCTCCCTTGT GACTATTCTG TAATCCCACT CCCCGTTCCT 
GAGCCCCCGG GATTGTTTCT TGGTTCCCCA GAATGTTCTC CAAGAACCCA AAGTGCTGTT 
CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885255.1
CDS	376..1161
Translation	MPLTSGSSTPPPWRVSADTSTGPTTAARSFSLLVRHRPRALCHTNQSLGRGLATTRGRGSDGNGPTGNGDHPNFSLSEGRAFGSLAAQPITSCLSVPAPPFSLGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVSAWTLTSNGRSFPGPFPKSWACFLLPLAILCPCGCSPTLRAVPDLSCYFPKPETAPLQILAAPFPCVQYRVITCPSLVPLILPCDYSVIPLPVPEPPGLFLGSPECSPRTQSAVP

Target ORF information:

RefSeq Version	XM_017029766.1
Organism	Homo sapiens(human)
Definition	Homo sapiens TIMP metallopeptidase inhibitor 1 (TIMP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017029766.1

ORF Insert Sequence:

ATGCCGCTGA CATCCGGTTC GTCTACACCC CCGCCATGGA GAGTGTCTGC GGATACTTCC 
ACAGGTCCCA CAACCGCAGC GAGGAGTTTC TCATTGCTGG TGAGGCACCG TCCCCGCGCC 
CTGTGCCACA CCAACCAGTC CCTGGGGCGC GGCCTAGCAA CCACGAGGGG GCGAGGCTCT 
GATGGGAATG GTCCCACTGG AAATGGGGAC CACCCCAATT TCAGTCTATC AGAAGGCCGG 
GCCTTTGGCA GCTTGGCAGC TCAGCCAATC ACAAGCTGCT TGTCGGTCCC CGCCCCGCCT 
TTCTCCTTAG GAAAACTGCA GGATGGACTC TTGCACATCA CTACCTGCAG TTTTGTGGCT 
CCCTGGAACA GCCTGAGCTT AGCTCAGCGC CGGGGCTTCA CCAAGACCTA CACTGTTGGC 
TGTGAGGAAT GCACAGTGAG TGCCTGGACC CTGACCTCCA ACGGGAGATC CTTCCCGGGG 
CCATTCCCTA AATCGTGGGC TTGTTTCTTG CTCCCTCTGG CTATTCTGTG TCCCTGTGGC 
TGCTCCCCAA CCCTAAGGGC TGTCCCTGAT CTCTCTTGCT ATTTCCCCAA GCCCGAGACT 
GCTCCCTTAC AAATTCTGGC TGCTCCCTTT CCCTGTGTCC AATACCGTGT GATCACCTGT 
CCCTCCCTGG TCCCTCTAAT TCTCCCTTGT GACTATTCTG TAATCCCACT CCCCGTTCCT 
GAGCCCCCGG GATTGTTTCT TGGTTCCCCA GAATGTTCTC CAAGAACCCA AAGTGCTGTT 
CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TIMP1 ( XM_017029766.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016885255.1 Homo sapiens TIMP metallopeptidase inhibitor 1 (TIMP1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu54019
Clone ID Related Accession (Same CDS sequence)	XM_017029766.1 , XM_017029766.2
Accession Version	XM_017029766.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 786bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	metalloproteinase inhibitor 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017029766.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCGCTGA CATCCGGTTC GTCTACACCC CCGCCATGGA GAGTGTCTGC GGATACTTCC 
ACAGGTCCCA CAACCGCAGC GAGGAGTTTC TCATTGCTGG TGAGGCACCG TCCCCGCGCC 
CTGTGCCACA CCAACCAGTC CCTGGGGCGC GGCCTAGCAA CCACGAGGGG GCGAGGCTCT 
GATGGGAATG GTCCCACTGG AAATGGGGAC CACCCCAATT TCAGTCTATC AGAAGGCCGG 
GCCTTTGGCA GCTTGGCAGC TCAGCCAATC ACAAGCTGCT TGTCGGTCCC CGCCCCGCCT 
TTCTCCTTAG GAAAACTGCA GGATGGACTC TTGCACATCA CTACCTGCAG TTTTGTGGCT 
CCCTGGAACA GCCTGAGCTT AGCTCAGCGC CGGGGCTTCA CCAAGACCTA CACTGTTGGC 
TGTGAGGAAT GCACAGTGAG TGCCTGGACC CTGACCTCCA ACGGGAGATC CTTCCCGGGG 
CCATTCCCTA AATCGTGGGC TTGTTTCTTG CTCCCTCTGG CTATTCTGTG TCCCTGTGGC 
TGCTCCCCAA CCCTAAGGGC TGTCCCTGAT CTCTCTTGCT ATTTCCCCAA GCCCGAGACT 
GCTCCCTTAC AAATTCTGGC TGCTCCCTTT CCCTGTGTCC AATACCGTGT GATCACCTGT 
CCCTCCCTGG TCCCTCTAAT TCTCCCTTGT GACTATTCTG TAATCCCACT CCCCGTTCCT 
GAGCCCCCGG GATTGTTTCT TGGTTCCCCA GAATGTTCTC CAAGAACCCA AAGTGCTGTT 
CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016885255.1
CDS	305..1090
Translation	MPLTSGSSTPPPWRVSADTSTGPTTAARSFSLLVRHRPRALCHTNQSLGRGLATTRGRGSDGNGPTGNGDHPNFSLSEGRAFGSLAAQPITSCLSVPAPPFSLGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVSAWTLTSNGRSFPGPFPKSWACFLLPLAILCPCGCSPTLRAVPDLSCYFPKPETAPLQILAAPFPCVQYRVITCPSLVPLILPCDYSVIPLPVPEPPGLFLGSPECSPRTQSAVP

Target ORF information:

RefSeq Version	XM_017029766.2
Organism	Homo sapiens(human)
Definition	Homo sapiens TIMP metallopeptidase inhibitor 1 (TIMP1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017029766.2

ORF Insert Sequence:

ATGCCGCTGA CATCCGGTTC GTCTACACCC CCGCCATGGA GAGTGTCTGC GGATACTTCC 
ACAGGTCCCA CAACCGCAGC GAGGAGTTTC TCATTGCTGG TGAGGCACCG TCCCCGCGCC 
CTGTGCCACA CCAACCAGTC CCTGGGGCGC GGCCTAGCAA CCACGAGGGG GCGAGGCTCT 
GATGGGAATG GTCCCACTGG AAATGGGGAC CACCCCAATT TCAGTCTATC AGAAGGCCGG 
GCCTTTGGCA GCTTGGCAGC TCAGCCAATC ACAAGCTGCT TGTCGGTCCC CGCCCCGCCT 
TTCTCCTTAG GAAAACTGCA GGATGGACTC TTGCACATCA CTACCTGCAG TTTTGTGGCT 
CCCTGGAACA GCCTGAGCTT AGCTCAGCGC CGGGGCTTCA CCAAGACCTA CACTGTTGGC 
TGTGAGGAAT GCACAGTGAG TGCCTGGACC CTGACCTCCA ACGGGAGATC CTTCCCGGGG 
CCATTCCCTA AATCGTGGGC TTGTTTCTTG CTCCCTCTGG CTATTCTGTG TCCCTGTGGC 
TGCTCCCCAA CCCTAAGGGC TGTCCCTGAT CTCTCTTGCT ATTTCCCCAA GCCCGAGACT 
GCTCCCTTAC AAATTCTGGC TGCTCCCTTT CCCTGTGTCC AATACCGTGT GATCACCTGT 
CCCTCCCTGG TCCCTCTAAT TCTCCCTTGT GACTATTCTG TAATCCCACT CCCCGTTCCT 
GAGCCCCCGG GATTGTTTCT TGGTTCCCCA GAATGTTCTC CAAGAACCCA AAGTGCTGTT 
CCCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer.
Cancer research77(21)5952-5962(2017 Nov)
D'Costa Z,Jones K,Azad A,van Stiphout R,Lim SY,Gomes AL,Kinchesh P,Smart SC,Gillies McKenna W,Buffa FM,Sansom OJ,Muschel RJ,O'Neill E,Fokas E

MMP-10, MMP-7, TIMP-1 and TIMP-2 mRNA expression in esophageal cancer.
Acta biochimica Polonica64(2)295-299(2017)
Juchniewicz A,Kowalczuk O,Milewski R,Lauda?ski W,Dzi?gielewski P,Koz?owski M,Nikli?ski J

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TIMP1 cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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