TGM1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TGM1
Entrez Gene ID	7051
Full Name	transglutaminase 1
Synonyms	ARCI1,ICR2,KTG,LI,LI1,TGASE,TGK
General protein information	Preferred Names transglutaminase 1 Names protein-glutamine gamma-glutamyltransferase K K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase TG(K) TGase K TGase-1 epidermal TGase transglutaminase 1 isoform transglutaminase K transglutaminase, keratinocyte
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q12
Summary	The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). [provided by RefSeq, Jul 2008].
Disorder MIM:	190195
Disorder Html:	Ichthyosis, congenital, autosomal recessive 1, 242300 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000359.2	NP_000350.1	protein-glutamine gamma-glutamyltransferase K
NM_000359.3	NP_000350.1	protein-glutamine gamma-glutamyltransferase K

Pathways from BioSystems

Homologies

	TGM1	XP_001113577.1
Canis lupus familiaris (dog)	TGM1	NP_001003079.1
Danio rerio (zebrafish)	LOC793448	XP_001331914.1
Danio rerio (zebrafish)	si:ch1073-138d10.2	XP_005169495.1
Drosophila melanogaster (fruit fly)	Tg	NP_609174.1
Mus musculus (house mouse)	Tgm1	NP_001155187.1
Danio rerio (zebrafish)	tgm1l4	NP_001025267.1
Danio rerio (zebrafish)	LOC100535918	XP_003201279.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP009100	XP_319850.2
Homo sapiens (human)	TGM1	NP_000350.1
Pan troglodytes (chimpanzee)	TGM1	XP_001169496.3
Bos taurus (cattle)	TGM1	NP_001010991.1
Rattus norvegicus (Norway rat)	Tgm1	NP_113847.1
Danio rerio (zebrafish)	LOC100334173	XP_002665624.2
Danio rerio (zebrafish)	tgm1l1	XP_694950.3
Danio rerio (zebrafish)	tgm1l2	XP_001332075.5
Xenopus tropicalis (tropical clawed frog)	tgm1	XP_002939073.1

Gene Ontology
Bibliography

Related articles in PubMed

Expanding the Genotypic Spectrum of Bathing Suit Ichthyosis.
Marukian NV, Hu RH, Craiglow BG, Milstone LM, Zhou J, Theos A, Kaymakcalan H, Akkaya DA, Uitto JJ, Vahidnezhad H, Youssefian L, Bayliss SJ, Paller AS, Boyden LM, Choate KA
JAMA dermatology153(6)537-543(2017 Jun)

Summary of mutations underlying autosomal recessive congenital ichthyoses (ARCI) in Arabs with four novel mutations in ARCI-related genes from the United Arab Emirates.
Bastaki F, Mohamed M, Nair P, Saif F, Mustafa EM, Bizzari S, Al-Ali MT, Hamzeh AR
International journal of dermatology56(5)514-523(2017 May)

Tissue transglutaminase-1 promotes stemness and chemoresistance in gastric cancer cells by regulating Wnt/?-catenin signaling.
Huang H, Chen Z, Ni X
Experimental biology and medicine (Maywood, N.J.)242(2)194-202(2017 01)

Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans.
Russo T, Curr? M, Barbera A, Caccamo D, Antonuccio P, Arena S, Montalto AS, Parisi S, Marseglia L, Gitto E, Ientile R, Impellizzeri P, Romeo C
International journal of molecular sciences17(9)(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Seven of 10 probands with a compound heterozygous TGM1 genotype had a mutation at either arginine 307 or 315, providing evidence that mutations at these sites are temperature sensitive and highlighting the importance of these residues in the pathogenesis of bathing suit ichthyosis
Title: Expanding the Genotypic Spectrum of Bathing Suit Ichthyosis.

A novel TGM1 variant c.1085T>G was found in an Emirati family. The mutation causes a nonsynonymous protein change (p.Leu362Arg) that affects a highly conserved residue in the catalytic core domain of the calcium-dependent transglutaminase-1.
Title: Summary of mutations underlying autosomal recessive congenital ichthyoses (ARCI) in Arabs with four novel mutations in ARCI-related genes from the United Arab Emirates.

The results strongly supported the participation of TGM1 in the regulation of gastric cancer development. The authors found evidence that the mechanism of action of TGM1 in regulating gastric cancer cell might involve the Wnt signaling pathway, as loss of TGM1 expression in gastric cancer cells led to a significant suppression of Wnt signaling activities.
Title: Tissue transglutaminase-1 promotes stemness and chemoresistance in gastric cancer cells by regulating Wnt/?-catenin signaling.

Data indicate a decrease in transglutaminases TG1 and TG3 transcripts by about 70% in foreskins from patients with balanitis xerotica obliterans (BXO) BXO in comparison with patients without BXO and an increase in transglutaminase TG2 mRNA levels by 2.9 fold.
Title: Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans.

that the up-regulation of molecular signatures for antimicrobial and innate defense responses is characteristic of skin with a transglutaminase 1 deficiency.
Title: Activation of Molecular Signatures for Antimicrobial and Innate Defense Responses in Skin with Transglutaminase 1 Deficiency.

The following TGM1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TGM1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23436	NM_000359.3 Latest version!	Homo sapiens transglutaminase 1 (TGM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu23436	NM_000359.2	Homo sapiens transglutaminase 1 (TGM1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TGM1 ( NM_000359.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000350.1 Homo sapiens transglutaminase 1 (TGM1), mRNA.

Price & Availability↑

CloneID	OHu23436
Clone ID Related Accession (Same CDS sequence)	NM_000359.2 , NM_000359.3
Accession Version	NM_000359.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2454bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	protein-glutamine gamma-glutamyltransferase K
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA437895.1, BC034699.1 and AL096870.5. This sequence is a reference standard in the RefSeqGene project. On Jul 20, 2006 this sequence version replaced NM_000359.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034699.1, AK291350.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGGATG GGCCACGTTC CGATGTGGGC CGTTGGGGTG GCAACCCCTT GCAGCCCCCT 
ACCACGCCAT CTCCAGAGCC AGAGCCAGAG CCAGACGGAC GCTCTCGCAG AGGAGGAGGC 
CGTTCCTTCT GGGCTCGCTG CTGTGGCTGC TGTTCATGCC GAAATGCGGC AGATGACGAC 
TGGGGACCTG AACCCTCTGA CTCCAGGGGT CGAGGGTCCA GCTCTGGCAC TCGAAGACCT 
GGCTCCCGGG GCTCAGACTC CCGCCGGCCT GTATCCCGGG GCAGCGGTGT CAATGCAGCT 
GGAGATGGCA CCATCCGAGA GGGCATGCTA GTAGTGAACG GTGTGGACTT GCTGAGCTCG 
CGCTCGGACC AGAACCGCCG AGAGCACCAC ACAGACGAGT ATGAGTACGA CGAGCTGATA 
GTGCGCCGCG GGCAGCCTTT CCATATGCTC CTCCTCCTGT CCCGGACCTA TGAATCCTCT 
GATCGCATCA CCCTTGAGTT ACTCATCGGA AACAACCCCG AGGTGGGCAA GGGCACGCAC 
GTGATCATCC CAGTGGGCAA GGGGGGCAGT GGAGGCTGGA AAGCCCAGGT GGTCAAGGCC 
AGTGGGCAGA ATCTGAACCT GCGGGTCCAC ACTTCCCCCA ACGCCATCAT CGGCAAGTTT 
CAGTTCACAG TCCGCACACA ATCAGACGCT GGGGAGTTCC AGTTGCCCTT TGACCCCCGC 
AATGAGATCT ACATCCTCTT CAACCCCTGG TGCCCAGAGG ACATTGTGTA CGTGGACCAT 
GAGGATTGGC GGCAGGAGTA TGTTCTTAAT GAGTCTGGGA GAATTTACTA CGGGACCGAA 
GCACAGATTG GTGAGCGGAC CTGGAACTAC GGCCAGTTTG ACCACGGGGT GCTGGATGCC 
TGCTTATACA TCCTGGACCG GCGGGGGATG CCATATGGAG GCCGTGGAGA CCCAGTCAAT 
GTCTCCCGGG TCATCTCTGC CATGGTGAAC TCCCTGGATG ACAATGGAGT CCTGATTGGG 
AACTGGTCTG GTGATTACTC CCGAGGCACC AACCCATCAG CGTGGGTGGG CAGCGTGGAG 
ATCCTGCTTA GCTACCTACG CACGGGATAT TCCGTCCCCT ATGGCCAGTG CTGGGTCTTT 
GCTGGCGTGA CCACCACAGT GCTGCGCTGC CTGGGTCTGG CCACCCGTAC TGTCACCAAC 
TTCAACTCCG CCCACGACAC AGACACATCC CTTACCATGG ACATCTACTT CGACGAGAAC 
ATGAAGCCCC TGGAGCACCT GAACCATGAT TCTGTCTGGA ACTTCCATGT GTGGAACGAC 
TGCTGGATGA AGAGGCCGGA TCTGCCCTCG GGCTTTGATG GGTGGCAGGT GGTGGATGCC 
ACACCCCAAG AGACTAGCAG TGGCATCTTC TGCTGCGGCC CCTGCTCTGT GGAGTCCATC 
AAGAATGGCC TGGTCTACAT GAAGTACGAC ACGCCTTTCA TTTTTGCTGA GGTGAATAGT 
GACAAGGTGT ACTGGCAGCG GCAGGATGAT GGCAGCTTCA AGATTGTTTA TGTGGAGGAG 
AAGGCCATCG GCACACTCAT TGTCACAAAG GCCATCAGCT CCAACATGCG GGAGGACATC 
ACCTACCTCT ATAAGCACCC AGAAGGCTCA GACGCAGAGC GGAAGGCAGT AGAGACAGCA 
GCAGCCCACG GCAGCAAACC CAATGTGTAT GCCAACCGGG GCTCAGCGGA GGATGTGGCC 
ATGCAGGTGG AGGCACAGGA CGCGGTGATG GGGCAGGATC TGATGGTCTC TGTGATGCTG 
ATCAATCACA GCAGCAGCCG CCGCACAGTG AAACTGCACC TCTACCTCTC AGTCACTTTC 
TATACTGGTG TCAGTGGTAC CATCTTCAAG GAGACCAAGA AGGAAGTGGA GCTGGCACCA 
GGGGCCTCGG ACCGTGTGAC CATGCCAGTG GCCTACAAGG AATACCGGCC CCATCTTGTG 
GACCAGGGGG CCATGCTGCT CAATGTCTCA GGCCACGTCA AGGAGAGCGG GCAGGTGCTG 
GCCAAGCAGC ACACCTTCCG TCTGCGCACC CCAGACCTCT CCCTCACGTT ACTGGGAGCA 
GCAGTGGTTG GCCAGGAGTG TGAAGTACAG ATTGTCTTCA AGAACCCCCT TCCCGTCACC 
CTCACCAATG TCGTCTTCCG GCTCGAAGGC TCTGGGTTAC AGAGGCCCAA GATCCTCAAC 
GTTGGGGACA TTGGAGGCAA TGAAACAGTG ACACTGCGCC AGTCGTTTGT GCCTGTGCGA 
CCAGGCCCCC GCCAGCTCAT TGCCAGCTTG GACAGCCCAC AGCTCTCCCA GGTGCACGGT 
GTCATCCAGG TGGATGTGGC CCCAGCCCCT GGGGATGGGG GCTTCTTCTC AGACGCTGGA 
GGTGACAGTC ACTTAGGAGA GACCATCCCT ATGGCATCTC GAGGTGGAGC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000350.1
CDS	125..2578
Translation	MMDGPRSDVGRWGGNPLQPPTTPSPEPEPEPDGRSRRGGGRSFWARCCGCCSCRNAADDDWGPEPSDSRGRGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGMLVVNGVDLLSSRSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYESSDRITLELLIGNNPEVGKGTHVIIPVGKGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDACLYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSVEILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESIKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMREDITYLYKHPEGSDAERKAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAVMGQDLMVSVMLINHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLVDQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPVTLTNVVFRLEGSGLQRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHGVIQVDVAPAPGDGGFFSDAGGDSHLGETIPMASRGGA

Target ORF information:

RefSeq Version	NM_000359.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transglutaminase 1 (TGM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000359.2

ORF Insert Sequence:

ATGATGGATG GGCCACGTTC CGATGTGGGC CGTTGGGGTG GCAACCCCTT GCAGCCCCCT 
ACCACGCCAT CTCCAGAGCC AGAGCCAGAG CCAGACGGAC GCTCTCGCAG AGGAGGAGGC 
CGTTCCTTCT GGGCTCGCTG CTGTGGCTGC TGTTCATGCC GAAATGCGGC AGATGACGAC 
TGGGGACCTG AACCCTCTGA CTCCAGGGGT CGAGGGTCCA GCTCTGGCAC TCGAAGACCT 
GGCTCCCGGG GCTCAGACTC CCGCCGGCCT GTATCCCGGG GCAGCGGTGT CAATGCAGCT 
GGAGATGGCA CCATCCGAGA GGGCATGCTA GTAGTGAACG GTGTGGACTT GCTGAGCTCG 
CGCTCGGACC AGAACCGCCG AGAGCACCAC ACAGACGAGT ATGAGTACGA CGAGCTGATA 
GTGCGCCGCG GGCAGCCTTT CCATATGCTC CTCCTCCTGT CCCGGACCTA TGAATCCTCT 
GATCGCATCA CCCTTGAGTT ACTCATCGGA AACAACCCCG AGGTGGGCAA GGGCACGCAC 
GTGATCATCC CAGTGGGCAA GGGGGGCAGT GGAGGCTGGA AAGCCCAGGT GGTCAAGGCC 
AGTGGGCAGA ATCTGAACCT GCGGGTCCAC ACTTCCCCCA ACGCCATCAT CGGCAAGTTT 
CAGTTCACAG TCCGCACACA ATCAGACGCT GGGGAGTTCC AGTTGCCCTT TGACCCCCGC 
AATGAGATCT ACATCCTCTT CAACCCCTGG TGCCCAGAGG ACATTGTGTA CGTGGACCAT 
GAGGATTGGC GGCAGGAGTA TGTTCTTAAT GAGTCTGGGA GAATTTACTA CGGGACCGAA 
GCACAGATTG GTGAGCGGAC CTGGAACTAC GGCCAGTTTG ACCACGGGGT GCTGGATGCC 
TGCTTATACA TCCTGGACCG GCGGGGGATG CCATATGGAG GCCGTGGAGA CCCAGTCAAT 
GTCTCCCGGG TCATCTCTGC CATGGTGAAC TCCCTGGATG ACAATGGAGT CCTGATTGGG 
AACTGGTCTG GTGATTACTC CCGAGGCACC AACCCATCAG CGTGGGTGGG CAGCGTGGAG 
ATCCTGCTTA GCTACCTACG CACGGGATAT TCCGTCCCCT ATGGCCAGTG CTGGGTCTTT 
GCTGGCGTGA CCACCACAGT GCTGCGCTGC CTGGGTCTGG CCACCCGTAC TGTCACCAAC 
TTCAACTCCG CCCACGACAC AGACACATCC CTTACCATGG ACATCTACTT CGACGAGAAC 
ATGAAGCCCC TGGAGCACCT GAACCATGAT TCTGTCTGGA ACTTCCATGT GTGGAACGAC 
TGCTGGATGA AGAGGCCGGA TCTGCCCTCG GGCTTTGATG GGTGGCAGGT GGTGGATGCC 
ACACCCCAAG AGACTAGCAG TGGCATCTTC TGCTGCGGCC CCTGCTCTGT GGAGTCCATC 
AAGAATGGCC TGGTCTACAT GAAGTACGAC ACGCCTTTCA TTTTTGCTGA GGTGAATAGT 
GACAAGGTGT ACTGGCAGCG GCAGGATGAT GGCAGCTTCA AGATTGTTTA TGTGGAGGAG 
AAGGCCATCG GCACACTCAT TGTCACAAAG GCCATCAGCT CCAACATGCG GGAGGACATC 
ACCTACCTCT ATAAGCACCC AGAAGGCTCA GACGCAGAGC GGAAGGCAGT AGAGACAGCA 
GCAGCCCACG GCAGCAAACC CAATGTGTAT GCCAACCGGG GCTCAGCGGA GGATGTGGCC 
ATGCAGGTGG AGGCACAGGA CGCGGTGATG GGGCAGGATC TGATGGTCTC TGTGATGCTG 
ATCAATCACA GCAGCAGCCG CCGCACAGTG AAACTGCACC TCTACCTCTC AGTCACTTTC 
TATACTGGTG TCAGTGGTAC CATCTTCAAG GAGACCAAGA AGGAAGTGGA GCTGGCACCA 
GGGGCCTCGG ACCGTGTGAC CATGCCAGTG GCCTACAAGG AATACCGGCC CCATCTTGTG 
GACCAGGGGG CCATGCTGCT CAATGTCTCA GGCCACGTCA AGGAGAGCGG GCAGGTGCTG 
GCCAAGCAGC ACACCTTCCG TCTGCGCACC CCAGACCTCT CCCTCACGTT ACTGGGAGCA 
GCAGTGGTTG GCCAGGAGTG TGAAGTACAG ATTGTCTTCA AGAACCCCCT TCCCGTCACC 
CTCACCAATG TCGTCTTCCG GCTCGAAGGC TCTGGGTTAC AGAGGCCCAA GATCCTCAAC 
GTTGGGGACA TTGGAGGCAA TGAAACAGTG ACACTGCGCC AGTCGTTTGT GCCTGTGCGA 
CCAGGCCCCC GCCAGCTCAT TGCCAGCTTG GACAGCCCAC AGCTCTCCCA GGTGCACGGT 
GTCATCCAGG TGGATGTGGC CCCAGCCCCT GGGGATGGGG GCTTCTTCTC AGACGCTGGA 
GGTGACAGTC ACTTAGGAGA GACCATCCCT ATGGCATCTC GAGGTGGAGC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TGM1 ( NM_000359.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000350.1 Homo sapiens transglutaminase 1 (TGM1), mRNA.

Price & Availability↑

CloneID	OHu23436
Clone ID Related Accession (Same CDS sequence)	NM_000359.2 , NM_000359.3
Accession Version	NM_000359.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2454bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-09
Organism	Homo sapiens(human)
Product	protein-glutamine gamma-glutamyltransferase K
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL096870.5. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000359.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC034699.1, AK315819.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000206765.11/ ENSP00000206765.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGGATG GGCCACGTTC CGATGTGGGC CGTTGGGGTG GCAACCCCTT GCAGCCCCCT 
ACCACGCCAT CTCCAGAGCC AGAGCCAGAG CCAGACGGAC GCTCTCGCAG AGGAGGAGGC 
CGTTCCTTCT GGGCTCGCTG CTGTGGCTGC TGTTCATGCC GAAATGCGGC AGATGACGAC 
TGGGGACCTG AACCCTCTGA CTCCAGGGGT CGAGGGTCCA GCTCTGGCAC TCGAAGACCT 
GGCTCCCGGG GCTCAGACTC CCGCCGGCCT GTATCCCGGG GCAGCGGTGT CAATGCAGCT 
GGAGATGGCA CCATCCGAGA GGGCATGCTA GTAGTGAACG GTGTGGACTT GCTGAGCTCG 
CGCTCGGACC AGAACCGCCG AGAGCACCAC ACAGACGAGT ATGAGTACGA CGAGCTGATA 
GTGCGCCGCG GGCAGCCTTT CCATATGCTC CTCCTCCTGT CCCGGACCTA TGAATCCTCT 
GATCGCATCA CCCTTGAGTT ACTCATCGGA AACAACCCCG AGGTGGGCAA GGGCACGCAC 
GTGATCATCC CAGTGGGCAA GGGGGGCAGT GGAGGCTGGA AAGCCCAGGT GGTCAAGGCC 
AGTGGGCAGA ATCTGAACCT GCGGGTCCAC ACTTCCCCCA ACGCCATCAT CGGCAAGTTT 
CAGTTCACAG TCCGCACACA ATCAGACGCT GGGGAGTTCC AGTTGCCCTT TGACCCCCGC 
AATGAGATCT ACATCCTCTT CAACCCCTGG TGCCCAGAGG ACATTGTGTA CGTGGACCAT 
GAGGATTGGC GGCAGGAGTA TGTTCTTAAT GAGTCTGGGA GAATTTACTA CGGGACCGAA 
GCACAGATTG GTGAGCGGAC CTGGAACTAC GGCCAGTTTG ACCACGGGGT GCTGGATGCC 
TGCTTATACA TCCTGGACCG GCGGGGGATG CCATATGGAG GCCGTGGAGA CCCAGTCAAT 
GTCTCCCGGG TCATCTCTGC CATGGTGAAC TCCCTGGATG ACAATGGAGT CCTGATTGGG 
AACTGGTCTG GTGATTACTC CCGAGGCACC AACCCATCAG CGTGGGTGGG CAGCGTGGAG 
ATCCTGCTTA GCTACCTACG CACGGGATAT TCCGTCCCCT ATGGCCAGTG CTGGGTCTTT 
GCTGGCGTGA CCACCACAGT GCTGCGCTGC CTGGGTCTGG CCACCCGTAC TGTCACCAAC 
TTCAACTCCG CCCACGACAC AGACACATCC CTTACCATGG ACATCTACTT CGACGAGAAC 
ATGAAGCCCC TGGAGCACCT GAACCATGAT TCTGTCTGGA ACTTCCATGT GTGGAACGAC 
TGCTGGATGA AGAGGCCGGA TCTGCCCTCG GGCTTTGATG GGTGGCAGGT GGTGGATGCC 
ACACCCCAAG AGACTAGCAG TGGCATCTTC TGCTGCGGCC CCTGCTCTGT GGAGTCCATC 
AAGAATGGCC TGGTCTACAT GAAGTACGAC ACGCCTTTCA TTTTTGCTGA GGTGAATAGT 
GACAAGGTGT ACTGGCAGCG GCAGGATGAT GGCAGCTTCA AGATTGTTTA TGTGGAGGAG 
AAGGCCATCG GCACACTCAT TGTCACAAAG GCCATCAGCT CCAACATGCG GGAGGACATC 
ACCTACCTCT ATAAGCACCC AGAAGGCTCA GACGCAGAGC GGAAGGCAGT AGAGACAGCA 
GCAGCCCACG GCAGCAAACC CAATGTGTAT GCCAACCGGG GCTCAGCGGA GGATGTGGCC 
ATGCAGGTGG AGGCACAGGA CGCGGTGATG GGGCAGGATC TGATGGTCTC TGTGATGCTG 
ATCAATCACA GCAGCAGCCG CCGCACAGTG AAACTGCACC TCTACCTCTC AGTCACTTTC 
TATACTGGTG TCAGTGGTAC CATCTTCAAG GAGACCAAGA AGGAAGTGGA GCTGGCACCA 
GGGGCCTCGG ACCGTGTGAC CATGCCAGTG GCCTACAAGG AATACCGGCC CCATCTTGTG 
GACCAGGGGG CCATGCTGCT CAATGTCTCA GGCCACGTCA AGGAGAGCGG GCAGGTGCTG 
GCCAAGCAGC ACACCTTCCG TCTGCGCACC CCAGACCTCT CCCTCACGTT ACTGGGAGCA 
GCAGTGGTTG GCCAGGAGTG TGAAGTACAG ATTGTCTTCA AGAACCCCCT TCCCGTCACC 
CTCACCAATG TCGTCTTCCG GCTCGAAGGC TCTGGGTTAC AGAGGCCCAA GATCCTCAAC 
GTTGGGGACA TTGGAGGCAA TGAAACAGTG ACACTGCGCC AGTCGTTTGT GCCTGTGCGA 
CCAGGCCCCC GCCAGCTCAT TGCCAGCTTG GACAGCCCAC AGCTCTCCCA GGTGCACGGT 
GTCATCCAGG TGGATGTGGC CCCAGCCCCT GGGGATGGGG GCTTCTTCTC AGACGCTGGA 
GGTGACAGTC ACTTAGGAGA GACCATCCCT ATGGCATCTC GAGGTGGAGC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000350.1
CDS	92..2545
Translation	MMDGPRSDVGRWGGNPLQPPTTPSPEPEPEPDGRSRRGGGRSFWARCCGCCSCRNAADDDWGPEPSDSRGRGSSSGTRRPGSRGSDSRRPVSRGSGVNAAGDGTIREGMLVVNGVDLLSSRSDQNRREHHTDEYEYDELIVRRGQPFHMLLLLSRTYESSDRITLELLIGNNPEVGKGTHVIIPVGKGGSGGWKAQVVKASGQNLNLRVHTSPNAIIGKFQFTVRTQSDAGEFQLPFDPRNEIYILFNPWCPEDIVYVDHEDWRQEYVLNESGRIYYGTEAQIGERTWNYGQFDHGVLDACLYILDRRGMPYGGRGDPVNVSRVISAMVNSLDDNGVLIGNWSGDYSRGTNPSAWVGSVEILLSYLRTGYSVPYGQCWVFAGVTTTVLRCLGLATRTVTNFNSAHDTDTSLTMDIYFDENMKPLEHLNHDSVWNFHVWNDCWMKRPDLPSGFDGWQVVDATPQETSSGIFCCGPCSVESIKNGLVYMKYDTPFIFAEVNSDKVYWQRQDDGSFKIVYVEEKAIGTLIVTKAISSNMREDITYLYKHPEGSDAERKAVETAAAHGSKPNVYANRGSAEDVAMQVEAQDAVMGQDLMVSVMLINHSSSRRTVKLHLYLSVTFYTGVSGTIFKETKKEVELAPGASDRVTMPVAYKEYRPHLVDQGAMLLNVSGHVKESGQVLAKQHTFRLRTPDLSLTLLGAAVVGQECEVQIVFKNPLPVTLTNVVFRLEGSGLQRPKILNVGDIGGNETVTLRQSFVPVRPGPRQLIASLDSPQLSQVHGVIQVDVAPAPGDGGFFSDAGGDSHLGETIPMASRGGA

Target ORF information:

RefSeq Version	NM_000359.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transglutaminase 1 (TGM1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000359.3

ORF Insert Sequence:

ATGATGGATG GGCCACGTTC CGATGTGGGC CGTTGGGGTG GCAACCCCTT GCAGCCCCCT 
ACCACGCCAT CTCCAGAGCC AGAGCCAGAG CCAGACGGAC GCTCTCGCAG AGGAGGAGGC 
CGTTCCTTCT GGGCTCGCTG CTGTGGCTGC TGTTCATGCC GAAATGCGGC AGATGACGAC 
TGGGGACCTG AACCCTCTGA CTCCAGGGGT CGAGGGTCCA GCTCTGGCAC TCGAAGACCT 
GGCTCCCGGG GCTCAGACTC CCGCCGGCCT GTATCCCGGG GCAGCGGTGT CAATGCAGCT 
GGAGATGGCA CCATCCGAGA GGGCATGCTA GTAGTGAACG GTGTGGACTT GCTGAGCTCG 
CGCTCGGACC AGAACCGCCG AGAGCACCAC ACAGACGAGT ATGAGTACGA CGAGCTGATA 
GTGCGCCGCG GGCAGCCTTT CCATATGCTC CTCCTCCTGT CCCGGACCTA TGAATCCTCT 
GATCGCATCA CCCTTGAGTT ACTCATCGGA AACAACCCCG AGGTGGGCAA GGGCACGCAC 
GTGATCATCC CAGTGGGCAA GGGGGGCAGT GGAGGCTGGA AAGCCCAGGT GGTCAAGGCC 
AGTGGGCAGA ATCTGAACCT GCGGGTCCAC ACTTCCCCCA ACGCCATCAT CGGCAAGTTT 
CAGTTCACAG TCCGCACACA ATCAGACGCT GGGGAGTTCC AGTTGCCCTT TGACCCCCGC 
AATGAGATCT ACATCCTCTT CAACCCCTGG TGCCCAGAGG ACATTGTGTA CGTGGACCAT 
GAGGATTGGC GGCAGGAGTA TGTTCTTAAT GAGTCTGGGA GAATTTACTA CGGGACCGAA 
GCACAGATTG GTGAGCGGAC CTGGAACTAC GGCCAGTTTG ACCACGGGGT GCTGGATGCC 
TGCTTATACA TCCTGGACCG GCGGGGGATG CCATATGGAG GCCGTGGAGA CCCAGTCAAT 
GTCTCCCGGG TCATCTCTGC CATGGTGAAC TCCCTGGATG ACAATGGAGT CCTGATTGGG 
AACTGGTCTG GTGATTACTC CCGAGGCACC AACCCATCAG CGTGGGTGGG CAGCGTGGAG 
ATCCTGCTTA GCTACCTACG CACGGGATAT TCCGTCCCCT ATGGCCAGTG CTGGGTCTTT 
GCTGGCGTGA CCACCACAGT GCTGCGCTGC CTGGGTCTGG CCACCCGTAC TGTCACCAAC 
TTCAACTCCG CCCACGACAC AGACACATCC CTTACCATGG ACATCTACTT CGACGAGAAC 
ATGAAGCCCC TGGAGCACCT GAACCATGAT TCTGTCTGGA ACTTCCATGT GTGGAACGAC 
TGCTGGATGA AGAGGCCGGA TCTGCCCTCG GGCTTTGATG GGTGGCAGGT GGTGGATGCC 
ACACCCCAAG AGACTAGCAG TGGCATCTTC TGCTGCGGCC CCTGCTCTGT GGAGTCCATC 
AAGAATGGCC TGGTCTACAT GAAGTACGAC ACGCCTTTCA TTTTTGCTGA GGTGAATAGT 
GACAAGGTGT ACTGGCAGCG GCAGGATGAT GGCAGCTTCA AGATTGTTTA TGTGGAGGAG 
AAGGCCATCG GCACACTCAT TGTCACAAAG GCCATCAGCT CCAACATGCG GGAGGACATC 
ACCTACCTCT ATAAGCACCC AGAAGGCTCA GACGCAGAGC GGAAGGCAGT AGAGACAGCA 
GCAGCCCACG GCAGCAAACC CAATGTGTAT GCCAACCGGG GCTCAGCGGA GGATGTGGCC 
ATGCAGGTGG AGGCACAGGA CGCGGTGATG GGGCAGGATC TGATGGTCTC TGTGATGCTG 
ATCAATCACA GCAGCAGCCG CCGCACAGTG AAACTGCACC TCTACCTCTC AGTCACTTTC 
TATACTGGTG TCAGTGGTAC CATCTTCAAG GAGACCAAGA AGGAAGTGGA GCTGGCACCA 
GGGGCCTCGG ACCGTGTGAC CATGCCAGTG GCCTACAAGG AATACCGGCC CCATCTTGTG 
GACCAGGGGG CCATGCTGCT CAATGTCTCA GGCCACGTCA AGGAGAGCGG GCAGGTGCTG 
GCCAAGCAGC ACACCTTCCG TCTGCGCACC CCAGACCTCT CCCTCACGTT ACTGGGAGCA 
GCAGTGGTTG GCCAGGAGTG TGAAGTACAG ATTGTCTTCA AGAACCCCCT TCCCGTCACC 
CTCACCAATG TCGTCTTCCG GCTCGAAGGC TCTGGGTTAC AGAGGCCCAA GATCCTCAAC 
GTTGGGGACA TTGGAGGCAA TGAAACAGTG ACACTGCGCC AGTCGTTTGT GCCTGTGCGA 
CCAGGCCCCC GCCAGCTCAT TGCCAGCTTG GACAGCCCAC AGCTCTCCCA GGTGCACGGT 
GTCATCCAGG TGGATGTGGC CCCAGCCCCT GGGGATGGGG GCTTCTTCTC AGACGCTGGA 
GGTGACAGTC ACTTAGGAGA GACCATCCCT ATGGCATCTC GAGGTGGAGC TTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expanding the Genotypic Spectrum of Bathing Suit Ichthyosis.
JAMA dermatology153(6)537-543(2017 Jun)
Marukian NV,Hu RH,Craiglow BG,Milstone LM,Zhou J,Theos A,Kaymakcalan H,Akkaya DA,Uitto JJ,Vahidnezhad H,Youssefian L,Bayliss SJ,Paller AS,Boyden LM,Choate KA

Summary of mutations underlying autosomal recessive congenital ichthyoses (ARCI) in Arabs with four novel mutations in ARCI-related genes from the United Arab Emirates.
International journal of dermatology56(5)514-523(2017 May)
Bastaki F,Mohamed M,Nair P,Saif F,Mustafa EM,Bizzari S,Al-Ali MT,Hamzeh AR

Tissue transglutaminase-1 promotes stemness and chemoresistance in gastric cancer cells by regulating Wnt/?-catenin signaling.
Experimental biology and medicine (Maywood, N.J.)242(2)194-202(2017 01)
Huang H,Chen Z,Ni X

Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans.
International journal of molecular sciences17(9)(2016 Sep)
Russo T,Curr? M,Barbera A,Caccamo D,Antonuccio P,Arena S,Montalto AS,Parisi S,Marseglia L,Gitto E,Ientile R,Impellizzeri P,Romeo C

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TGM1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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