SULT1A3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SULT1A3
Entrez Gene ID	6818
Full Name	sulfotransferase family 1A member 3
Synonyms	HAST,HAST3,M-PST,ST1A3,ST1A3/ST1A4,ST1A5,STM,TL-PST
General protein information	Preferred Names sulfotransferase family 1A member 3 Names sulfotransferase 1A3 aryl sulfotransferase 1A3/1A4 catecholamine-sulfating phenol sulfotransferase dopamine-specific sulfotransferase monoamine-sulfating phenosulfotransferase phenol sulfotransferase 1A5 placental estrogen sulfotransferase sulfokinase sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 thermolabile (monoamine, M form) phenol sulfotransferase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p11.2
Summary	Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010].
Disorder MIM:	600641

mRNA and Protein(s)

mRNA	Protein	Name
NM_177552.3	NP_808220.1	sulfotransferase 1A3
NM_177552.4	NP_808220.1	sulfotransferase 1A3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC454364	XP_003953044.1
Homo sapiens (human)	SULT1A3	NP_808220.1
Homo sapiens (human)	SULT1A4	NP_001017390.1

Gene Ontology
Bibliography

Related articles in PubMed

Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma.
Zou J, Li H, Huang Q, Liu X, Qi X, Wang Y, Lu L, Liu Z
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(10)1010428317719272(2017 Oct)

Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation.
Cook I, Wang T, Leyh TS
Proceedings of the National Academy of Sciences of the United States of America114(27)E5317-E5324(2017 Jul)

Sulfotransferase 1A3/4 copy number variation is associated with neurodegenerative disease.
Butcher NJ, Horne MK, Mellick GD, Fowler CJ, Masters CL, , Minchin RF
The pharmacogenomics journal(2017 Apr)

Human Cytosolic Sulfotransferase SULT1A3 Mediates the Sulfation of Dextrorphan.
Yamamoto A, Kurogi K, Schiefer IT, Liu MY, Sakakibara Y, Suiko M, Liu MC
Biological & pharmaceutical bulletin39(9)1432-6(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our results implied that SULT1A3/4 exhibited bidirectional effect on tumor and normal hepatocytes and may thus provide a novel strategy for hepatocellular carcinoma clinical targeting. In addition, SULT1A3/4 re-expression could serve as a biomarker for hepatocellular carcinoma prognosis.
Title: Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma.

The present study revealed SULT1A3 as the major human SULT enzyme capable of sulfating dextrorphan
Title: Human Cytosolic Sulfotransferase SULT1A3 Mediates the Sulfation of Dextrorphan.

A systematic analysis showed that three of the twelve human SULTs, SULT1A1, SULT1A3 and SULT1C4, displayed the strongest sulphating activity towards acetaminophen.
Title: Sulphation of acetaminophen by the human cytosolic sulfotransferases: a systematic analysis.

Sulfate metabolites R-6-S and R-4'-S were generated from raloxifene in SULT293 expression HEK293 cells. Cellular excretion of the raloxifene sulfates was mainly mediated by BCRP and MRP4.
Title: Sulfonation of raloxifene in HEK293 cells overexpressing SULT1A3: Involvement of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated protein 4 (MRP4/ABCC4) in excretion of sulfate metabolites.

This study aimed to establish SULT1A3 stably transfected HEK293 cells, and to determine the contributions of BCRP and MRP transporters to excretion of chrysin and apigenin sulfates.
Title: Efflux transport of chrysin and apigenin sulfates in HEK293 cells overexpressing SULT1A3: The role of multidrug resistance-associated protein 4 (MRP4/ABCC4).

The following SULT1A3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SULT1A3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu14121	NM_177552.4 Latest version!	Homo sapiens sulfotransferase family 1A member 3 (SULT1A3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu14121	NM_177552.3	Homo sapiens sulfotransferase family 1A member 3 (SULT1A3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SULT1A3 ( NM_177552.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_808220.1 Homo sapiens sulfotransferase family 1A member 3 (SULT1A3), mRNA.

Price & Availability↑

CloneID	OHu14121
Clone ID Related Accession (Same CDS sequence)	NM_177552.3 , NM_177552.4
Accession Version	NM_177552.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	sulfotransferase 1A3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA978913.1, BC144355.1, BC078144.1 and AI672638.1. On Dec 1, 2010 this sequence version replaced NM_177552.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279862.3493.1, L25275.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTGA TCCAGGACAC CTCCCGCCCG CCACTGGAGT ACGTGAAGGG GGTCCCGCTC 
ATCAAGTACT TTGCAGAGGC ACTGGGGCCC CTGCAGAGCT TCCAAGCCCG ACCTGATGAC 
CTGCTCATCA ACACCTACCC CAAGTCTGGC ACCACCTGGG TGAGCCAGAT ACTGGACATG 
ATCTACCAGG GCGGCGACCT AGAGAAGTGT AACCGGGCTC CCATCTACGT ACGGGTGCCC 
TTCCTTGAGG TCAATGATCC AGGGGAACCC TCAGGGCTGG AGACTCTGAA AGACACACCG 
CCCCCACGGC TCATCAAGTC ACACCTGCCC CTGGCTCTGC TCCCTCAGAC TCTGTTGGAT 
CAGAAGGTCA AGGTGGTCTA TGTTGCCCGA AACCCAAAGG ACGTGGCGGT CTCCTACTAC 
CATTTCCACC GTATGGAAAA GGCGCACCCT GAGCCTGGGA CCTGGGACAG CTTCCTGGAA 
AAGTTCATGG CTGGAGAAGT GTCCTACGGG TCCTGGTACC AGCACGTGCA GGAGTGGTGG 
GAGCTGAGCC GCACCCACCC TGTTCTCTAC CTCTTCTATG AAGACATGAA GGAGAACCCC 
AAAAGGGAGA TTCAAAAGAT CCTGGAGTTT GTGGGGCGCT CCCTGCCAGA GGAGACCATG 
GACTTCATGG TTCAGCACAC GTCGTTCAAG GAGATGAAGA AGAACCCTAT GACCAACTAC 
ACCACCGTCC CCCAGGAGCT CATGGACCAC AGCATCTCCC CCTTCATGAG GAAAGGCATG 
GCTGGGGACT GGAAGACCAC CTTCACCGTG GCGCAGAATG AGCGCTTCGA TGCGGACTAT 
GCGGAGAAGA TGGCAGGCTG CAGCCTCAGC TTCCGCTCTG AGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808220.1
CDS	105..992
Translation	MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLINTYPKSGTTWVSQILDMIYQGGDLEKCNRAPIYVRVPFLEVNDPGEPSGLETLKDTPPPRLIKSHLPLALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMVQHTSFKEMKKNPMTNYTTVPQELMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL

Target ORF information:

RefSeq Version	NM_177552.3
Organism	Homo sapiens(human)
Definition	Homo sapiens sulfotransferase family 1A member 3 (SULT1A3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177552.3

ORF Insert Sequence:

ATGGAGCTGA TCCAGGACAC CTCCCGCCCG CCACTGGAGT ACGTGAAGGG GGTCCCGCTC 
ATCAAGTACT TTGCAGAGGC ACTGGGGCCC CTGCAGAGCT TCCAAGCCCG ACCTGATGAC 
CTGCTCATCA ACACCTACCC CAAGTCTGGC ACCACCTGGG TGAGCCAGAT ACTGGACATG 
ATCTACCAGG GCGGCGACCT AGAGAAGTGT AACCGGGCTC CCATCTACGT ACGGGTGCCC 
TTCCTTGAGG TCAATGATCC AGGGGAACCC TCAGGGCTGG AGACTCTGAA AGACACACCG 
CCCCCACGGC TCATCAAGTC ACACCTGCCC CTGGCTCTGC TCCCTCAGAC TCTGTTGGAT 
CAGAAGGTCA AGGTGGTCTA TGTTGCCCGA AACCCAAAGG ACGTGGCGGT CTCCTACTAC 
CATTTCCACC GTATGGAAAA GGCGCACCCT GAGCCTGGGA CCTGGGACAG CTTCCTGGAA 
AAGTTCATGG CTGGAGAAGT GTCCTACGGG TCCTGGTACC AGCACGTGCA GGAGTGGTGG 
GAGCTGAGCC GCACCCACCC TGTTCTCTAC CTCTTCTATG AAGACATGAA GGAGAACCCC 
AAAAGGGAGA TTCAAAAGAT CCTGGAGTTT GTGGGGCGCT CCCTGCCAGA GGAGACCATG 
GACTTCATGG TTCAGCACAC GTCGTTCAAG GAGATGAAGA AGAACCCTAT GACCAACTAC 
ACCACCGTCC CCCAGGAGCT CATGGACCAC AGCATCTCCC CCTTCATGAG GAAAGGCATG 
GCTGGGGACT GGAAGACCAC CTTCACCGTG GCGCAGAATG AGCGCTTCGA TGCGGACTAT 
GCGGAGAAGA TGGCAGGCTG CAGCCTCAGC TTCCGCTCTG AGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SULT1A3 ( NM_177552.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_808220.1 Homo sapiens sulfotransferase family 1A member 3 (SULT1A3), mRNA.

Price & Availability↑

CloneID	OHu14121
Clone ID Related Accession (Same CDS sequence)	NM_177552.3 , NM_177552.4
Accession Version	NM_177552.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 888bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	sulfotransferase 1A3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC144355.1 and BC078144.1. On Nov 26, 2019 this sequence version replaced NM_177552.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189658.72478.1, BX342017.2 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTGA TCCAGGACAC CTCCCGCCCG CCACTGGAGT ACGTGAAGGG GGTCCCGCTC 
ATCAAGTACT TTGCAGAGGC ACTGGGGCCC CTGCAGAGCT TCCAAGCCCG ACCTGATGAC 
CTGCTCATCA ACACCTACCC CAAGTCTGGC ACCACCTGGG TGAGCCAGAT ACTGGACATG 
ATCTACCAGG GCGGCGACCT AGAGAAGTGT AACCGGGCTC CCATCTACGT ACGGGTGCCC 
TTCCTTGAGG TCAATGATCC AGGGGAACCC TCAGGGCTGG AGACTCTGAA AGACACACCG 
CCCCCACGGC TCATCAAGTC ACACCTGCCC CTGGCTCTGC TCCCTCAGAC TCTGTTGGAT 
CAGAAGGTCA AGGTGGTCTA TGTTGCCCGA AACCCAAAGG ACGTGGCGGT CTCCTACTAC 
CATTTCCACC GTATGGAAAA GGCGCACCCT GAGCCTGGGA CCTGGGACAG CTTCCTGGAA 
AAGTTCATGG CTGGAGAAGT GTCCTACGGG TCCTGGTACC AGCACGTGCA GGAGTGGTGG 
GAGCTGAGCC GCACCCACCC TGTTCTCTAC CTCTTCTATG AAGACATGAA GGAGAACCCC 
AAAAGGGAGA TTCAAAAGAT CCTGGAGTTT GTGGGGCGCT CCCTGCCAGA GGAGACCATG 
GACTTCATGG TTCAGCACAC GTCGTTCAAG GAGATGAAGA AGAACCCTAT GACCAACTAC 
ACCACCGTCC CCCAGGAGCT CATGGACCAC AGCATCTCCC CCTTCATGAG GAAAGGCATG 
GCTGGGGACT GGAAGACCAC CTTCACCGTG GCGCAGAATG AGCGCTTCGA TGCGGACTAT 
GCGGAGAAGA TGGCAGGCTG CAGCCTCAGC TTCCGCTCTG AGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_808220.1
CDS	78..965
Translation	MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLINTYPKSGTTWVSQILDMIYQGGDLEKCNRAPIYVRVPFLEVNDPGEPSGLETLKDTPPPRLIKSHLPLALLPQTLLDQKVKVVYVARNPKDVAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMVQHTSFKEMKKNPMTNYTTVPQELMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL

Target ORF information:

RefSeq Version	NM_177552.4
Organism	Homo sapiens(human)
Definition	Homo sapiens sulfotransferase family 1A member 3 (SULT1A3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177552.4

ORF Insert Sequence:

ATGGAGCTGA TCCAGGACAC CTCCCGCCCG CCACTGGAGT ACGTGAAGGG GGTCCCGCTC 
ATCAAGTACT TTGCAGAGGC ACTGGGGCCC CTGCAGAGCT TCCAAGCCCG ACCTGATGAC 
CTGCTCATCA ACACCTACCC CAAGTCTGGC ACCACCTGGG TGAGCCAGAT ACTGGACATG 
ATCTACCAGG GCGGCGACCT AGAGAAGTGT AACCGGGCTC CCATCTACGT ACGGGTGCCC 
TTCCTTGAGG TCAATGATCC AGGGGAACCC TCAGGGCTGG AGACTCTGAA AGACACACCG 
CCCCCACGGC TCATCAAGTC ACACCTGCCC CTGGCTCTGC TCCCTCAGAC TCTGTTGGAT 
CAGAAGGTCA AGGTGGTCTA TGTTGCCCGA AACCCAAAGG ACGTGGCGGT CTCCTACTAC 
CATTTCCACC GTATGGAAAA GGCGCACCCT GAGCCTGGGA CCTGGGACAG CTTCCTGGAA 
AAGTTCATGG CTGGAGAAGT GTCCTACGGG TCCTGGTACC AGCACGTGCA GGAGTGGTGG 
GAGCTGAGCC GCACCCACCC TGTTCTCTAC CTCTTCTATG AAGACATGAA GGAGAACCCC 
AAAAGGGAGA TTCAAAAGAT CCTGGAGTTT GTGGGGCGCT CCCTGCCAGA GGAGACCATG 
GACTTCATGG TTCAGCACAC GTCGTTCAAG GAGATGAAGA AGAACCCTAT GACCAACTAC 
ACCACCGTCC CCCAGGAGCT CATGGACCAC AGCATCTCCC CCTTCATGAG GAAAGGCATG 
GCTGGGGACT GGAAGACCAC CTTCACCGTG GCGCAGAATG AGCGCTTCGA TGCGGACTAT 
GCGGAGAAGA TGGCAGGCTG CAGCCTCAGC TTCCGCTCTG AGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dopamine-induced SULT1A3/4 promotes EMT and cancer stemness in hepatocellular carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(10)1010428317719272(2017 Oct)
Zou J,Li H,Huang Q,Liu X,Qi X,Wang Y,Lu L,Liu Z

Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation.
Proceedings of the National Academy of Sciences of the United States of America114(27)E5317-E5324(2017 Jul)
Cook I,Wang T,Leyh TS

Sulfotransferase 1A3/4 copy number variation is associated with neurodegenerative disease.
The pharmacogenomics journal(2017 Apr)
Butcher NJ,Horne MK,Mellick GD,Fowler CJ,Masters CL,,Minchin RF

Human Cytosolic Sulfotransferase SULT1A3 Mediates the Sulfation of Dextrorphan.
Biological & pharmaceutical bulletin39(9)1432-6(2016)
Yamamoto A,Kurogi K,Schiefer IT,Liu MY,Sakakibara Y,Suiko M,Liu MC

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SULT1A3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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