SSB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SSB
Entrez Gene ID	6741
Full Name	Sjogren syndrome antigen B
Synonyms	LARP3,La,La/SSB
General protein information	Preferred Names Sjogren syndrome antigen B Names lupus La protein La ribonucleoprotein domain family, member 3 SS-B SS-B/La protein autoantigen La la autoantigen lupus La antigen sjoegren syndrome type B antigen
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q31.1
Summary	The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014].
Disorder MIM:	109090

mRNA and Protein(s)

mRNA	Protein	Name
NM_001294145.2	NP_001281074.1	lupus La protein
NM_003142.4	NP_003133.1	lupus La protein
NM_001294145.1	NP_001281074.1	lupus La protein
NM_003142.5	NP_003133.1	lupus La protein

Pathways from BioSystems

Homologies

	LOC710344	XP_002808052.1
Canis lupus familiaris (dog)	SSB	XP_535952.2
Drosophila melanogaster (fruit fly)	La	NP_477014.1
Xenopus tropicalis (tropical clawed frog)	ssb	NP_001001455.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008952	XP_319705.4
Homo sapiens (human)	SSB	NP_003133.1
Rattus norvegicus (Norway rat)	Ssb	NP_112381.2
Gallus gallus (chicken)	SSB	NP_001180598.1
Danio rerio (zebrafish)	ssb	NP_955841.1
Mus musculus (house mouse)	Ssb	NP_033304.1
Caenorhabditis elegans (roundworm)	C44E4.4	NP_491411.1
Pan troglodytes (chimpanzee)	SSB	XP_001138273.1
Bos taurus (cattle)	SSB	NP_788838.1

Gene Ontology
Bibliography

Related articles in PubMed

SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability.
Kota V, Sommer G, Hazard ES, Hardiman G, Twiss JL, Heise T
Molecular and cellular biology38(2)(2018 Jan)

Autoantigen La Regulates MicroRNA Processing from Stem-Loop Precursors by Association with DGCR8.
Zheng Q, Yang HJ, Yuan YA
Biochemistry56(46)6098-6110(2017 Nov)

The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives.
Maraia RJ, Mattijssen S, Cruz-Gallardo I, Conte MR
Wiley interdisciplinary reviews. RNA8(6)(2017 Nov)

Distinct Dynamic Modes Enable the Engagement of Dissimilar Ligands in a Promiscuous Atypical RNA Recognition Motif.
Brown KA, Sharifi S, Hussain R, Donaldson L, Bayfield MA, Wilson DJ
Biochemistry55(51)7141-7150(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

La protein is an important microprocessor component regulating miRNA processing efficiency by association with DGCR8 to regulate formation of the DGCR8-Drosha complex for miRNA processing.
Title: Autoantigen La Regulates MicroRNA Processing from Stem-Loop Precursors by Association with DGCR8.

Binding of double-stranded RNA involves less penetration into the RNA recognition motif (RRM2) binding pocket and more engagement with the unstructured C-terminus of the La C-terminal domain (CTD).
Title: Distinct Dynamic Modes Enable the Engagement of Dissimilar Ligands in a Promiscuous Atypical RNA Recognition Motif.

La functions as gatekeeper ensuring correct tRNA maturation and protecting the miRNA pathway from potentially functional tRNA fragments.
Title: The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA Pathway.

our data support a novel model, whereby cancer-associated La protein contributes to cisplatin resistance by stimulating the translation of anti-apoptotic factor Bcl2 in HNSCC cells.
Title: The La protein counteracts cisplatin-induced cell death by stimulating protein synthesis of anti-apoptotic factor Bcl2.

Findings identified two novel SUMO acceptors sites on La and suggest that sumoylation of La alters its RNA-binding activity, which could influence a broad range of RNA processing steps where La's function has been implicated.
Title: SUMO-Modification of the La Protein Facilitates Binding to mRNA In Vitro and in Cells.

The following SSB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SSB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu28669	NM_003142.5 Latest version!	Homo sapiens small RNA binding exonuclease protection factor La (SSB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu28669	NM_001294145.2 Latest version!	Homo sapiens small RNA binding exonuclease protection factor La (SSB), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu28669	NM_001294145.1	Homo sapiens small RNA binding exonuclease protection factor La (SSB), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu28669	NM_003142.4	Homo sapiens Sjogren syndrome antigen B (SSB), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SSB ( NM_001294145.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001281074.1 Homo sapiens small RNA binding exonuclease protection factor La (SSB), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28669
Clone ID Related Accession (Same CDS sequence)	NM_001294145.2 , NM_003142.4 , NM_001294145.1 , NM_003142.5
Accession Version	NM_001294145.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1227bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-12
Organism	Homo sapiens(human)
Product	lupus La protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X69804.1 and BC001289.1. On May 31, 2019 this sequence version replaced NM_001294145.1. Transcript Variant: This variant (2) has an alternate 5' UTR exon and encodes the same protein, compared to variant 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.141555.1, X69804.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGAAA ATGGTGATAA TGAAAAGATG GCTGCCCTGG AGGCCAAAAT CTGTCATCAA 
ATTGAGTATT ATTTTGGCGA CTTCAATTTG CCACGGGACA AGTTTCTAAA GGAACAGATA 
AAACTGGATG AAGGCTGGGT ACCTTTGGAG ATAATGATAA AATTCAACAG GTTGAACCGT 
CTAACAACAG ACTTTAATGT AATTGTGGAA GCATTGAGCA AATCCAAGGC AGAACTCATG 
GAAATCAGTG AAGATAAAAC TAAAATCAGA AGGTCTCCAA GCAAACCCCT ACCTGAAGTG 
ACTGATGAGT ATAAAAATGA TGTAAAAAAC AGATCTGTTT ATATTAAAGG CTTCCCAACT 
GATGCAACTC TTGATGACAT AAAAGAATGG TTAGAAGATA AAGGTCAAGT ACTAAATATT 
CAGATGAGAA GAACATTGCA TAAAGCATTT AAGGGATCAA TTTTTGTTGT GTTTGATAGC 
ATTGAATCTG CTAAGAAATT TGTAGAGACC CCTGGCCAGA AGTACAAAGA AACAGACCTG 
CTAATACTTT TCAAGGACGA TTACTTTGCC AAAAAAAATG AAGAAAGAAA ACAAAATAAA 
GTGGAAGCTA AATTAAGAGC TAAACAGGAG CAAGAAGCAA AACAAAAGTT AGAAGAAGAT 
GCTGAAATGA AATCTCTAGA AGAAAAGATT GGATGCTTGC TGAAATTTTC GGGTGATTTA 
GATGATCAGA CCTGTAGAGA AGATTTACAC ATACTTTTCT CAAATCATGG TGAAATAAAA 
TGGATAGACT TCGTCAGAGG AGCAAAAGAG GGGATAATTC TATTTAAAGA AAAAGCCAAG 
GAAGCATTGG GTAAAGCCAA AGATGCAAAT AATGGTAACC TACAATTAAG GAACAAAGAA 
GTGACTTGGG AAGTACTAGA AGGAGAGGTG GAAAAAGAAG CACTGAAGAA AATAATAGAA 
GACCAACAAG AATCCCTAAA CAAATGGAAG TCAAAAGGTC GTAGATTTAA AGGAAAAGGA 
AAGGGTAATA AAGCTGCCCA GCCTGGGTCT GGTAAAGGAA AAGTACAGTT TCAGGGCAAG 
AAAACGAAAT TTGCTAGTGA TGATGAACAT GATGAACATG ATGAAAATGG TGCAACTGGA 
CCTGTGAAAA GAGCAAGAGA AGAAACAGAC AAAGAAGAAC CTGCATCCAA ACAACAGAAA 
ACAGAAAATG GTGCTGGAGA CCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001281074.1
CDS	225..1451
Translation	MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ

Target ORF information:

RefSeq Version	NM_001294145.2
Organism	Homo sapiens(human)
Definition	Homo sapiens small RNA binding exonuclease protection factor La (SSB), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001294145.2

ORF Insert Sequence:

ATGGCTGAAA ATGGTGATAA TGAAAAGATG GCTGCCCTGG AGGCCAAAAT CTGTCATCAA 
ATTGAGTATT ATTTTGGCGA CTTCAATTTG CCACGGGACA AGTTTCTAAA GGAACAGATA 
AAACTGGATG AAGGCTGGGT ACCTTTGGAG ATAATGATAA AATTCAACAG GTTGAACCGT 
CTAACAACAG ACTTTAATGT AATTGTGGAA GCATTGAGCA AATCCAAGGC AGAACTCATG 
GAAATCAGTG AAGATAAAAC TAAAATCAGA AGGTCTCCAA GCAAACCCCT ACCTGAAGTG 
ACTGATGAGT ATAAAAATGA TGTAAAAAAC AGATCTGTTT ATATTAAAGG CTTCCCAACT 
GATGCAACTC TTGATGACAT AAAAGAATGG TTAGAAGATA AAGGTCAAGT ACTAAATATT 
CAGATGAGAA GAACATTGCA TAAAGCATTT AAGGGATCAA TTTTTGTTGT GTTTGATAGC 
ATTGAATCTG CTAAGAAATT TGTAGAGACC CCTGGCCAGA AGTACAAAGA AACAGACCTG 
CTAATACTTT TCAAGGACGA TTACTTTGCC AAAAAAAATG AAGAAAGAAA ACAAAATAAA 
GTGGAAGCTA AATTAAGAGC TAAACAGGAG CAAGAAGCAA AACAAAAGTT AGAAGAAGAT 
GCTGAAATGA AATCTCTAGA AGAAAAGATT GGATGCTTGC TGAAATTTTC GGGTGATTTA 
GATGATCAGA CCTGTAGAGA AGATTTACAC ATACTTTTCT CAAATCATGG TGAAATAAAA 
TGGATAGACT TCGTCAGAGG AGCAAAAGAG GGGATAATTC TATTTAAAGA AAAAGCCAAG 
GAAGCATTGG GTAAAGCCAA AGATGCAAAT AATGGTAACC TACAATTAAG GAACAAAGAA 
GTGACTTGGG AAGTACTAGA AGGAGAGGTG GAAAAAGAAG CACTGAAGAA AATAATAGAA 
GACCAACAAG AATCCCTAAA CAAATGGAAG TCAAAAGGTC GTAGATTTAA AGGAAAAGGA 
AAGGGTAATA AAGCTGCCCA GCCTGGGTCT GGTAAAGGAA AAGTACAGTT TCAGGGCAAG 
AAAACGAAAT TTGCTAGTGA TGATGAACAT GATGAACATG ATGAAAATGG TGCAACTGGA 
CCTGTGAAAA GAGCAAGAGA AGAAACAGAC AAAGAAGAAC CTGCATCCAA ACAACAGAAA 
ACAGAAAATG GTGCTGGAGA CCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SSB ( NM_003142.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_003133.1 Homo sapiens Sjogren syndrome antigen B (SSB), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu28669
Clone ID Related Accession (Same CDS sequence)	NM_001294145.2 , NM_003142.4 , NM_001294145.1 , NM_003142.5
Accession Version	NM_003142.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1227bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	lupus La protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD676196.1 and BC001289.1. This sequence is a reference standard in the RefSeqGene project. On Nov 17, 2011 this sequence version replaced NM_003142.3. Transcript Variant: This variant (1) and variant 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001289.1, BC020818.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTGAAA ATGGTGATAA TGAAAAGATG GCTGCCCTGG AGGCCAAAAT CTGTCATCAA 
ATTGAGTATT ATTTTGGCGA CTTCAATTTG CCACGGGACA AGTTTCTAAA GGAACAGATA 
AAACTGGATG AAGGCTGGGT ACCTTTGGAG ATAATGATAA AATTCAACAG GTTGAACCGT 
CTAACAACAG ACTTTAATGT AATTGTGGAA GCATTGAGCA AATCCAAGGC AGAACTCATG 
GAAATCAGTG AAGATAAAAC TAAAATCAGA AGGTCTCCAA GCAAACCCCT ACCTGAAGTG 
ACTGATGAGT ATAAAAATGA TGTAAAAAAC AGATCTGTTT ATATTAAAGG CTTCCCAACT 
GATGCAACTC TTGATGACAT AAAAGAATGG TTAGAAGATA AAGGTCAAGT ACTAAATATT 
CAGATGAGAA GAACATTGCA TAAAGCATTT AAGGGATCAA TTTTTGTTGT GTTTGATAGC 
ATTGAATCTG CTAAGAAATT TGTAGAGACC CCTGGCCAGA AGTACAAAGA AACAGACCTG 
CTAATACTTT TCAAGGACGA TTACTTTGCC AAAAAAAATG AAGAAAGAAA ACAAAATAAA 
GTGGAAGCTA AATTAAGAGC TAAACAGGAG CAAGAAGCAA AACAAAAGTT AGAAGAAGAT 
GCTGAAATGA AATCTCTAGA AGAAAAGATT GGATGCTTGC TGAAATTTTC GGGTGATTTA 
GATGATCAGA CCTGTAGAGA AGATTTACAC ATACTTTTCT CAAATCATGG TGAAATAAAA 
TGGATAGACT TCGTCAGAGG AGCAAAAGAG GGGATAATTC TATTTAAAGA AAAAGCCAAG 
GAAGCATTGG GTAAAGCCAA AGATGCAAAT AATGGTAACC TACAATTAAG GAACAAAGAA 
GTGACTTGGG AAGTACTAGA AGGAGAGGTG GAAAAAGAAG CACTGAAGAA AATAATAGAA 
GACCAACAAG AATCCCTAAA CAAATGGAAG TCAAAAGGTC GTAGATTTAA AGGAAAAGGA 
AAGGGTAATA AAGCTGCCCA GCCTGGGTCT GGTAAAGGAA AAGTACAGTT TCAGGGCAAG 
AAAACGAAAT TTGCTAGTGA TGATGAACAT GATGAACATG ATGAAAATGG TGCAACTGGA 
CCTGTGAAAA GAGCAAGAGA AGAAACAGAC AAAGAAGAAC CTGCATCCAA ACAACAGAAA 
ACAGAAAATG GTGCTGGAGA CCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003133.1
CDS	175..1401
Translation	MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ

Target ORF information:

RefSeq Version	NM_003142.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Sjogren syndrome antigen B (SSB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003142.4

ORF Insert Sequence:

ATGGCTGAAA ATGGTGATAA TGAAAAGATG GCTGCCCTGG AGGCCAAAAT CTGTCATCAA 
ATTGAGTATT ATTTTGGCGA CTTCAATTTG CCACGGGACA AGTTTCTAAA GGAACAGATA 
AAACTGGATG AAGGCTGGGT ACCTTTGGAG ATAATGATAA AATTCAACAG GTTGAACCGT 
CTAACAACAG ACTTTAATGT AATTGTGGAA GCATTGAGCA AATCCAAGGC AGAACTCATG 
GAAATCAGTG AAGATAAAAC TAAAATCAGA AGGTCTCCAA GCAAACCCCT ACCTGAAGTG 
ACTGATGAGT ATAAAAATGA TGTAAAAAAC AGATCTGTTT ATATTAAAGG CTTCCCAACT 
GATGCAACTC TTGATGACAT AAAAGAATGG TTAGAAGATA AAGGTCAAGT ACTAAATATT 
CAGATGAGAA GAACATTGCA TAAAGCATTT AAGGGATCAA TTTTTGTTGT GTTTGATAGC 
ATTGAATCTG CTAAGAAATT TGTAGAGACC CCTGGCCAGA AGTACAAAGA AACAGACCTG 
CTAATACTTT TCAAGGACGA TTACTTTGCC AAAAAAAATG AAGAAAGAAA ACAAAATAAA 
GTGGAAGCTA AATTAAGAGC TAAACAGGAG CAAGAAGCAA AACAAAAGTT AGAAGAAGAT 
GCTGAAATGA AATCTCTAGA AGAAAAGATT GGATGCTTGC TGAAATTTTC GGGTGATTTA 
GATGATCAGA CCTGTAGAGA AGATTTACAC ATACTTTTCT CAAATCATGG TGAAATAAAA 
TGGATAGACT TCGTCAGAGG AGCAAAAGAG GGGATAATTC TATTTAAAGA AAAAGCCAAG 
GAAGCATTGG GTAAAGCCAA AGATGCAAAT AATGGTAACC TACAATTAAG GAACAAAGAA 
GTGACTTGGG AAGTACTAGA AGGAGAGGTG GAAAAAGAAG CACTGAAGAA AATAATAGAA 
GACCAACAAG AATCCCTAAA CAAATGGAAG TCAAAAGGTC GTAGATTTAA AGGAAAAGGA 
AAGGGTAATA AAGCTGCCCA GCCTGGGTCT GGTAAAGGAA AAGTACAGTT TCAGGGCAAG 
AAAACGAAAT TTGCTAGTGA TGATGAACAT GATGAACATG ATGAAAATGG TGCAACTGGA 
CCTGTGAAAA GAGCAAGAGA AGAAACAGAC AAAGAAGAAC CTGCATCCAA ACAACAGAAA 
ACAGAAAATG GTGCTGGAGA CCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SSB ( NM_001294145.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001281074.1 Homo sapiens small RNA binding exonuclease protection factor La (SSB), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu28669
Clone ID Related Accession (Same CDS sequence)	NM_001294145.2 , NM_003142.4 , NM_001294145.1 , NM_003142.5
Accession Version	NM_001294145.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1227bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	lupus La protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009967.8, X69804.1 and BC001289.1. On Jun 26, 2014 this sequence version replaced XM_005246811.1. Transcript Variant: This variant (2) has an alternate 5' UTR exon and encodes the same protein, compared to variant 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X69804.1, SRR1803613.125469.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGAAA ATGGTGATAA TGAAAAGATG GCTGCCCTGG AGGCCAAAAT CTGTCATCAA 
ATTGAGTATT ATTTTGGCGA CTTCAATTTG CCACGGGACA AGTTTCTAAA GGAACAGATA 
AAACTGGATG AAGGCTGGGT ACCTTTGGAG ATAATGATAA AATTCAACAG GTTGAACCGT 
CTAACAACAG ACTTTAATGT AATTGTGGAA GCATTGAGCA AATCCAAGGC AGAACTCATG 
GAAATCAGTG AAGATAAAAC TAAAATCAGA AGGTCTCCAA GCAAACCCCT ACCTGAAGTG 
ACTGATGAGT ATAAAAATGA TGTAAAAAAC AGATCTGTTT ATATTAAAGG CTTCCCAACT 
GATGCAACTC TTGATGACAT AAAAGAATGG TTAGAAGATA AAGGTCAAGT ACTAAATATT 
CAGATGAGAA GAACATTGCA TAAAGCATTT AAGGGATCAA TTTTTGTTGT GTTTGATAGC 
ATTGAATCTG CTAAGAAATT TGTAGAGACC CCTGGCCAGA AGTACAAAGA AACAGACCTG 
CTAATACTTT TCAAGGACGA TTACTTTGCC AAAAAAAATG AAGAAAGAAA ACAAAATAAA 
GTGGAAGCTA AATTAAGAGC TAAACAGGAG CAAGAAGCAA AACAAAAGTT AGAAGAAGAT 
GCTGAAATGA AATCTCTAGA AGAAAAGATT GGATGCTTGC TGAAATTTTC GGGTGATTTA 
GATGATCAGA CCTGTAGAGA AGATTTACAC ATACTTTTCT CAAATCATGG TGAAATAAAA 
TGGATAGACT TCGTCAGAGG AGCAAAAGAG GGGATAATTC TATTTAAAGA AAAAGCCAAG 
GAAGCATTGG GTAAAGCCAA AGATGCAAAT AATGGTAACC TACAATTAAG GAACAAAGAA 
GTGACTTGGG AAGTACTAGA AGGAGAGGTG GAAAAAGAAG CACTGAAGAA AATAATAGAA 
GACCAACAAG AATCCCTAAA CAAATGGAAG TCAAAAGGTC GTAGATTTAA AGGAAAAGGA 
AAGGGTAATA AAGCTGCCCA GCCTGGGTCT GGTAAAGGAA AAGTACAGTT TCAGGGCAAG 
AAAACGAAAT TTGCTAGTGA TGATGAACAT GATGAACATG ATGAAAATGG TGCAACTGGA 
CCTGTGAAAA GAGCAAGAGA AGAAACAGAC AAAGAAGAAC CTGCATCCAA ACAACAGAAA 
ACAGAAAATG GTGCTGGAGA CCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001281074.1
CDS	499..1725
Translation	MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ

Target ORF information:

RefSeq Version	NM_001294145.1
Organism	Homo sapiens(human)
Definition	Homo sapiens small RNA binding exonuclease protection factor La (SSB), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001294145.1

ORF Insert Sequence:

ATGGCTGAAA ATGGTGATAA TGAAAAGATG GCTGCCCTGG AGGCCAAAAT CTGTCATCAA 
ATTGAGTATT ATTTTGGCGA CTTCAATTTG CCACGGGACA AGTTTCTAAA GGAACAGATA 
AAACTGGATG AAGGCTGGGT ACCTTTGGAG ATAATGATAA AATTCAACAG GTTGAACCGT 
CTAACAACAG ACTTTAATGT AATTGTGGAA GCATTGAGCA AATCCAAGGC AGAACTCATG 
GAAATCAGTG AAGATAAAAC TAAAATCAGA AGGTCTCCAA GCAAACCCCT ACCTGAAGTG 
ACTGATGAGT ATAAAAATGA TGTAAAAAAC AGATCTGTTT ATATTAAAGG CTTCCCAACT 
GATGCAACTC TTGATGACAT AAAAGAATGG TTAGAAGATA AAGGTCAAGT ACTAAATATT 
CAGATGAGAA GAACATTGCA TAAAGCATTT AAGGGATCAA TTTTTGTTGT GTTTGATAGC 
ATTGAATCTG CTAAGAAATT TGTAGAGACC CCTGGCCAGA AGTACAAAGA AACAGACCTG 
CTAATACTTT TCAAGGACGA TTACTTTGCC AAAAAAAATG AAGAAAGAAA ACAAAATAAA 
GTGGAAGCTA AATTAAGAGC TAAACAGGAG CAAGAAGCAA AACAAAAGTT AGAAGAAGAT 
GCTGAAATGA AATCTCTAGA AGAAAAGATT GGATGCTTGC TGAAATTTTC GGGTGATTTA 
GATGATCAGA CCTGTAGAGA AGATTTACAC ATACTTTTCT CAAATCATGG TGAAATAAAA 
TGGATAGACT TCGTCAGAGG AGCAAAAGAG GGGATAATTC TATTTAAAGA AAAAGCCAAG 
GAAGCATTGG GTAAAGCCAA AGATGCAAAT AATGGTAACC TACAATTAAG GAACAAAGAA 
GTGACTTGGG AAGTACTAGA AGGAGAGGTG GAAAAAGAAG CACTGAAGAA AATAATAGAA 
GACCAACAAG AATCCCTAAA CAAATGGAAG TCAAAAGGTC GTAGATTTAA AGGAAAAGGA 
AAGGGTAATA AAGCTGCCCA GCCTGGGTCT GGTAAAGGAA AAGTACAGTT TCAGGGCAAG 
AAAACGAAAT TTGCTAGTGA TGATGAACAT GATGAACATG ATGAAAATGG TGCAACTGGA 
CCTGTGAAAA GAGCAAGAGA AGAAACAGAC AAAGAAGAAC CTGCATCCAA ACAACAGAAA 
ACAGAAAATG GTGCTGGAGA CCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SSB ( NM_003142.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_003133.1 Homo sapiens small RNA binding exonuclease protection factor La (SSB), transcript variant 1, mRNA.

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CloneID	OHu28669
Clone ID Related Accession (Same CDS sequence)	NM_001294145.2 , NM_003142.4 , NM_001294145.1 , NM_003142.5
Accession Version	NM_003142.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1227bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	lupus La protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CD676196.1 and BC001289.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_003142.4. Transcript Variant: This variant (1) and variant 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.797275.1, SRR3476690.825370.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000260956.9/ ENSP00000260956.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGAAA ATGGTGATAA TGAAAAGATG GCTGCCCTGG AGGCCAAAAT CTGTCATCAA 
ATTGAGTATT ATTTTGGCGA CTTCAATTTG CCACGGGACA AGTTTCTAAA GGAACAGATA 
AAACTGGATG AAGGCTGGGT ACCTTTGGAG ATAATGATAA AATTCAACAG GTTGAACCGT 
CTAACAACAG ACTTTAATGT AATTGTGGAA GCATTGAGCA AATCCAAGGC AGAACTCATG 
GAAATCAGTG AAGATAAAAC TAAAATCAGA AGGTCTCCAA GCAAACCCCT ACCTGAAGTG 
ACTGATGAGT ATAAAAATGA TGTAAAAAAC AGATCTGTTT ATATTAAAGG CTTCCCAACT 
GATGCAACTC TTGATGACAT AAAAGAATGG TTAGAAGATA AAGGTCAAGT ACTAAATATT 
CAGATGAGAA GAACATTGCA TAAAGCATTT AAGGGATCAA TTTTTGTTGT GTTTGATAGC 
ATTGAATCTG CTAAGAAATT TGTAGAGACC CCTGGCCAGA AGTACAAAGA AACAGACCTG 
CTAATACTTT TCAAGGACGA TTACTTTGCC AAAAAAAATG AAGAAAGAAA ACAAAATAAA 
GTGGAAGCTA AATTAAGAGC TAAACAGGAG CAAGAAGCAA AACAAAAGTT AGAAGAAGAT 
GCTGAAATGA AATCTCTAGA AGAAAAGATT GGATGCTTGC TGAAATTTTC GGGTGATTTA 
GATGATCAGA CCTGTAGAGA AGATTTACAC ATACTTTTCT CAAATCATGG TGAAATAAAA 
TGGATAGACT TCGTCAGAGG AGCAAAAGAG GGGATAATTC TATTTAAAGA AAAAGCCAAG 
GAAGCATTGG GTAAAGCCAA AGATGCAAAT AATGGTAACC TACAATTAAG GAACAAAGAA 
GTGACTTGGG AAGTACTAGA AGGAGAGGTG GAAAAAGAAG CACTGAAGAA AATAATAGAA 
GACCAACAAG AATCCCTAAA CAAATGGAAG TCAAAAGGTC GTAGATTTAA AGGAAAAGGA 
AAGGGTAATA AAGCTGCCCA GCCTGGGTCT GGTAAAGGAA AAGTACAGTT TCAGGGCAAG 
AAAACGAAAT TTGCTAGTGA TGATGAACAT GATGAACATG ATGAAAATGG TGCAACTGGA 
CCTGTGAAAA GAGCAAGAGA AGAAACAGAC AAAGAAGAAC CTGCATCCAA ACAACAGAAA 
ACAGAAAATG GTGCTGGAGA CCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_003133.1
CDS	116..1342
Translation	MAENGDNEKMAALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLEIMIKFNRLNRLTTDFNVIVEALSKSKAELMEISEDKTKIRRSPSKPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLEDKGQVLNIQMRRTLHKAFKGSIFVVFDSIESAKKFVETPGQKYKETDLLILFKDDYFAKKNEERKQNKVEAKLRAKQEQEAKQKLEEDAEMKSLEEKIGCLLKFSGDLDDQTCREDLHILFSNHGEIKWIDFVRGAKEGIILFKEKAKEALGKAKDANNGNLQLRNKEVTWEVLEGEVEKEALKKIIEDQQESLNKWKSKGRRFKGKGKGNKAAQPGSGKGKVQFQGKKTKFASDDEHDEHDENGATGPVKRAREETDKEEPASKQQKTENGAGDQ

Target ORF information:

RefSeq Version	NM_003142.5
Organism	Homo sapiens(human)
Definition	Homo sapiens small RNA binding exonuclease protection factor La (SSB), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_003142.5

ORF Insert Sequence:

ATGGCTGAAA ATGGTGATAA TGAAAAGATG GCTGCCCTGG AGGCCAAAAT CTGTCATCAA 
ATTGAGTATT ATTTTGGCGA CTTCAATTTG CCACGGGACA AGTTTCTAAA GGAACAGATA 
AAACTGGATG AAGGCTGGGT ACCTTTGGAG ATAATGATAA AATTCAACAG GTTGAACCGT 
CTAACAACAG ACTTTAATGT AATTGTGGAA GCATTGAGCA AATCCAAGGC AGAACTCATG 
GAAATCAGTG AAGATAAAAC TAAAATCAGA AGGTCTCCAA GCAAACCCCT ACCTGAAGTG 
ACTGATGAGT ATAAAAATGA TGTAAAAAAC AGATCTGTTT ATATTAAAGG CTTCCCAACT 
GATGCAACTC TTGATGACAT AAAAGAATGG TTAGAAGATA AAGGTCAAGT ACTAAATATT 
CAGATGAGAA GAACATTGCA TAAAGCATTT AAGGGATCAA TTTTTGTTGT GTTTGATAGC 
ATTGAATCTG CTAAGAAATT TGTAGAGACC CCTGGCCAGA AGTACAAAGA AACAGACCTG 
CTAATACTTT TCAAGGACGA TTACTTTGCC AAAAAAAATG AAGAAAGAAA ACAAAATAAA 
GTGGAAGCTA AATTAAGAGC TAAACAGGAG CAAGAAGCAA AACAAAAGTT AGAAGAAGAT 
GCTGAAATGA AATCTCTAGA AGAAAAGATT GGATGCTTGC TGAAATTTTC GGGTGATTTA 
GATGATCAGA CCTGTAGAGA AGATTTACAC ATACTTTTCT CAAATCATGG TGAAATAAAA 
TGGATAGACT TCGTCAGAGG AGCAAAAGAG GGGATAATTC TATTTAAAGA AAAAGCCAAG 
GAAGCATTGG GTAAAGCCAA AGATGCAAAT AATGGTAACC TACAATTAAG GAACAAAGAA 
GTGACTTGGG AAGTACTAGA AGGAGAGGTG GAAAAAGAAG CACTGAAGAA AATAATAGAA 
GACCAACAAG AATCCCTAAA CAAATGGAAG TCAAAAGGTC GTAGATTTAA AGGAAAAGGA 
AAGGGTAATA AAGCTGCCCA GCCTGGGTCT GGTAAAGGAA AAGTACAGTT TCAGGGCAAG 
AAAACGAAAT TTGCTAGTGA TGATGAACAT GATGAACATG ATGAAAATGG TGCAACTGGA 
CCTGTGAAAA GAGCAAGAGA AGAAACAGAC AAAGAAGAAC CTGCATCCAA ACAACAGAAA 
ACAGAAAATG GTGCTGGAGA CCAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability.
Molecular and cellular biology38(2)(2018 Jan)
Kota V,Sommer G,Hazard ES,Hardiman G,Twiss JL,Heise T

Autoantigen La Regulates MicroRNA Processing from Stem-Loop Precursors by Association with DGCR8.
Biochemistry56(46)6098-6110(2017 Nov)
Zheng Q,Yang HJ,Yuan YA

The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives.
Wiley interdisciplinary reviews. RNA8(6)(2017 Nov)
Maraia RJ,Mattijssen S,Cruz-Gallardo I,Conte MR

Distinct Dynamic Modes Enable the Engagement of Dissimilar Ligands in a Promiscuous Atypical RNA Recognition Motif.
Biochemistry55(51)7141-7150(2016 Dec)
Brown KA,Sharifi S,Hussain R,Donaldson L,Bayfield MA,Wilson DJ

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SSB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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