SOX15 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SOX15
Entrez Gene ID	6665
Full Name	SRY-box 15
Synonyms	SOX20,SOX26,SOX27
General protein information	Preferred Names SRY-box 15 Names protein SOX-15 SRY (sex determining region Y)-box 15 SRY (sex determining region Y)-box 20
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17p13.1
Summary	This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. [provided by RefSeq, Jul 2008].
Disorder MIM:	601297

mRNA and Protein(s)

mRNA	Protein	Name
NM_006942.1	NP_008873.1	protein SOX-15
NM_006942.2	NP_008873.1	protein SOX-15

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SOX15	XP_001171768.1
Homo sapiens (human)	SOX15	NP_008873.1
Canis lupus familiaris (dog)	SOX15	XP_003434661.1
Mus musculus (house mouse)	Sox15	NP_033261.1
Bos taurus (cattle)	SOX15	NP_001179004.1

Gene Ontology
Bibliography

Related articles in PubMed

Rui X, Xu Y, Jiang X, Guo C, Jiang J
Bioscience reports37(5)(2017 Oct)

Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients.
Proestling K, Birner P, Balendran S, Nirtl N, Marton E, Yerlikaya G, Kuessel L, Reischer T, Wenzl R, Streubel B, Husslein H
Reproductive biology and endocrinology : RB&E14(1)81(2016 Nov)

SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/?-catenin signaling.
Thu KL, Radulovich N, Becker-Santos DD, Pikor LA, Pusic A, Lockwood WW, Lam WL, Tsao MS
Oncogene33(3)279-88(2014 Jan)

A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
Yu XQ, Li M, Zhang H, Low HQ, Wei X, Wang JQ, Sun LD, Sim KS, Li Y, Foo JN, Wang W, Li ZJ, Yin XY, Tang XQ, Fan L, Chen J, Li RS, Wan JX, Liu ZS, Lou TQ, Zhu L, Huang XJ, Zhang XJ, Liu ZH, Liu JJ
Nature genetics44(2)178-82(2011 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Increased expression of epithelial OCT4, SOX15 and TWIST1 was detected in endometriotic tissue compared to endometriosis patient endometrium. Epithelial expression of OCT4, SOX15, and TWIST1 was increased in the endometrium of endometriosis patients compared to controls.
Title: Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients.

Results indicate that the expression of SOX15 in pancreatic cancer cell lines with undetectable expression resulted in reduced viability of cancer cells both in vitro and in vivo demonstrating its tumor suppressive capability.
Title: SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/?-catenin signaling.

The gain of function studies indicated that sex-determining region Y (SRY)-box 15 (SOX15) activate NR5A1 gene expression.
Title: Identification of NR5A1 (SF-1/AD4BP) gene expression modulators by large-scale gain and loss of function studies.

We established stable NT2/D1 cell lines overexpressing SOX15 (SOX15-NT2/D1), and a modified 3-(4,5-dime-thylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that the SOX15-NT2/D1 cells exhibited significantly slower growth than controls
Title: Overexpression of SOX15 inhibits proliferation of NT2/D1 cells derived from a testicular embryonal cell carcinoma.

The following SOX15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SOX15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13125	NM_006942.2 Latest version!	Homo sapiens SRY-box transcription factor 15 (SOX15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu13125	NM_006942.1	Homo sapiens SRY-box 15 (SOX15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SOX15 ( NM_006942.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_008873.1 Homo sapiens SRY-box 15 (SOX15), mRNA.

Price & Availability↑

CloneID	OHu13125
Clone ID Related Accession (Same CDS sequence)	NM_006942.1 , NM_006942.2
Accession Version	NM_006942.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	protein SOX-15
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB006867.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB006867.1, BC000985.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCTAC CAGGCTCCTC ACAGGACCAG GCCTGGAGCC TGGAGCCTCC GGCTGCCACG 
GCTGCTGCCT CCTCATCTTC GGGACCCCAG GAGCGGGAGG GCGCTGGGAG CCCCGCGGCC 
CCCGGGACGC TGCCCCTGGA GAAGGTGAAG CGGCCGATGA ACGCGTTCAT GGTGTGGAGC 
TCCGCTCAGC GCCGCCAGAT GGCGCAGCAG AACCCCAAGA TGCACAACTC CGAGATCTCC 
AAGCGCCTGG GCGCGCAGTG GAAGCTGCTG GACGAGGACG AGAAGCGGCC CTTCGTGGAG 
GAGGCCAAGC GGCTCCGCGC CCGACACCTG CGCGACTACC CCGACTACAA GTACCGGCCT 
CGGCGCAAGG CCAAGAGCTC GGGCGCCGGA CCTTCCCGCT GCGGACAGGG AAGAGGCAAC 
CTGGCCAGCG GCGGCCCGCT CTGGGGGCCG GGGTACGCGA CCACCCAACC GAGCAGAGGC 
TTTGGGTACA GACCCCCCAG CTACTCGACA GCCTACCTGC CTGGCAGCTA TGGCTCTTCC 
CACTGCAAAC TGGAAGCCCC CTCACCGTGC TCCCTCCCTC AGAGTGACCC TAGGCTCCAG 
GGGGAACTGC TGCCCACCTA TACCCACTAC CTGCCCCCTG GCTCTCCCAC TCCATACAAC 
CCTCCCCTTG CTGGTGCCCC CATGCCCCTA ACCCACCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008873.1
CDS	495..1196
Translation	MALPGSSQDQAWSLEPPAATAAASSSSGPQEREGAGSPAAPGTLPLEKVKRPMNAFMVWSSAQRRQMAQQNPKMHNSEISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKYRPRRKAKSSGAGPSRCGQGRGNLASGGPLWGPGYATTQPSRGFGYRPPSYSTAYLPGSYGSSHCKLEAPSPCSLPQSDPRLQGELLPTYTHYLPPGSPTPYNPPLAGAPMPLTHL

Target ORF information:

RefSeq Version	NM_006942.1
Organism	Homo sapiens(human)
Definition	Homo sapiens SRY-box 15 (SOX15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006942.1

ORF Insert Sequence:

ATGGCGCTAC CAGGCTCCTC ACAGGACCAG GCCTGGAGCC TGGAGCCTCC GGCTGCCACG 
GCTGCTGCCT CCTCATCTTC GGGACCCCAG GAGCGGGAGG GCGCTGGGAG CCCCGCGGCC 
CCCGGGACGC TGCCCCTGGA GAAGGTGAAG CGGCCGATGA ACGCGTTCAT GGTGTGGAGC 
TCCGCTCAGC GCCGCCAGAT GGCGCAGCAG AACCCCAAGA TGCACAACTC CGAGATCTCC 
AAGCGCCTGG GCGCGCAGTG GAAGCTGCTG GACGAGGACG AGAAGCGGCC CTTCGTGGAG 
GAGGCCAAGC GGCTCCGCGC CCGACACCTG CGCGACTACC CCGACTACAA GTACCGGCCT 
CGGCGCAAGG CCAAGAGCTC GGGCGCCGGA CCTTCCCGCT GCGGACAGGG AAGAGGCAAC 
CTGGCCAGCG GCGGCCCGCT CTGGGGGCCG GGGTACGCGA CCACCCAACC GAGCAGAGGC 
TTTGGGTACA GACCCCCCAG CTACTCGACA GCCTACCTGC CTGGCAGCTA TGGCTCTTCC 
CACTGCAAAC TGGAAGCCCC CTCACCGTGC TCCCTCCCTC AGAGTGACCC TAGGCTCCAG 
GGGGAACTGC TGCCCACCTA TACCCACTAC CTGCCCCCTG GCTCTCCCAC TCCATACAAC 
CCTCCCCTTG CTGGTGCCCC CATGCCCCTA ACCCACCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SOX15 ( NM_006942.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_008873.1 Homo sapiens SRY-box transcription factor 15 (SOX15), mRNA.

Price & Availability↑

CloneID	OHu13125
Clone ID Related Accession (Same CDS sequence)	NM_006942.1 , NM_006942.2
Accession Version	NM_006942.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 702bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	protein SOX-15
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB006867.1 and AC016876.10. On May 17, 2019 this sequence version replaced NM_006942.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC000985.2, AB006867.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000250055.3/ ENSP00000355354.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCTAC CAGGCTCCTC ACAGGACCAG GCCTGGAGCC TGGAGCCTCC GGCTGCCACG 
GCTGCTGCCT CCTCATCTTC GGGACCCCAG GAGCGGGAGG GCGCTGGGAG CCCCGCGGCC 
CCCGGGACGC TGCCCCTGGA GAAGGTGAAG CGGCCGATGA ACGCGTTCAT GGTGTGGAGC 
TCCGCTCAGC GCCGCCAGAT GGCGCAGCAG AACCCCAAGA TGCACAACTC CGAGATCTCC 
AAGCGCCTGG GCGCGCAGTG GAAGCTGCTG GACGAGGACG AGAAGCGGCC CTTCGTGGAG 
GAGGCCAAGC GGCTCCGCGC CCGACACCTG CGCGACTACC CCGACTACAA GTACCGGCCT 
CGGCGCAAGG CCAAGAGCTC GGGCGCCGGA CCTTCCCGCT GCGGACAGGG AAGAGGCAAC 
CTGGCCAGCG GCGGCCCGCT CTGGGGGCCG GGGTACGCGA CCACCCAACC GAGCAGAGGC 
TTTGGGTACA GACCCCCCAG CTACTCGACA GCCTACCTGC CTGGCAGCTA TGGCTCTTCC 
CACTGCAAAC TGGAAGCCCC CTCACCGTGC TCCCTCCCTC AGAGTGACCC TAGGCTCCAG 
GGGGAACTGC TGCCCACCTA TACCCACTAC CTGCCCCCTG GCTCTCCCAC TCCATACAAC 
CCTCCCCTTG CTGGTGCCCC CATGCCCCTA ACCCACCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_008873.1
CDS	419..1120
Translation	MALPGSSQDQAWSLEPPAATAAASSSSGPQEREGAGSPAAPGTLPLEKVKRPMNAFMVWSSAQRRQMAQQNPKMHNSEISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKYRPRRKAKSSGAGPSRCGQGRGNLASGGPLWGPGYATTQPSRGFGYRPPSYSTAYLPGSYGSSHCKLEAPSPCSLPQSDPRLQGELLPTYTHYLPPGSPTPYNPPLAGAPMPLTHL

Target ORF information:

RefSeq Version	NM_006942.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SRY-box transcription factor 15 (SOX15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006942.2

ORF Insert Sequence:

ATGGCGCTAC CAGGCTCCTC ACAGGACCAG GCCTGGAGCC TGGAGCCTCC GGCTGCCACG 
GCTGCTGCCT CCTCATCTTC GGGACCCCAG GAGCGGGAGG GCGCTGGGAG CCCCGCGGCC 
CCCGGGACGC TGCCCCTGGA GAAGGTGAAG CGGCCGATGA ACGCGTTCAT GGTGTGGAGC 
TCCGCTCAGC GCCGCCAGAT GGCGCAGCAG AACCCCAAGA TGCACAACTC CGAGATCTCC 
AAGCGCCTGG GCGCGCAGTG GAAGCTGCTG GACGAGGACG AGAAGCGGCC CTTCGTGGAG 
GAGGCCAAGC GGCTCCGCGC CCGACACCTG CGCGACTACC CCGACTACAA GTACCGGCCT 
CGGCGCAAGG CCAAGAGCTC GGGCGCCGGA CCTTCCCGCT GCGGACAGGG AAGAGGCAAC 
CTGGCCAGCG GCGGCCCGCT CTGGGGGCCG GGGTACGCGA CCACCCAACC GAGCAGAGGC 
TTTGGGTACA GACCCCCCAG CTACTCGACA GCCTACCTGC CTGGCAGCTA TGGCTCTTCC 
CACTGCAAAC TGGAAGCCCC CTCACCGTGC TCCCTCCCTC AGAGTGACCC TAGGCTCCAG 
GGGGAACTGC TGCCCACCTA TACCCACTAC CTGCCCCCTG GCTCTCCCAC TCCATACAAC 
CCTCCCCTTG CTGGTGCCCC CATGCCCCTA ACCCACCTCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Bioscience reports37(5)(2017 Oct)
Rui X,Xu Y,Jiang X,Guo C,Jiang J

Enhanced expression of the stemness-related factors OCT4, SOX15 and TWIST1 in ectopic endometrium of endometriosis patients.
Reproductive biology and endocrinology : RB&E14(1)81(2016 Nov)
Proestling K,Birner P,Balendran S,Nirtl N,Marton E,Yerlikaya G,Kuessel L,Reischer T,Wenzl R,Streubel B,Husslein H

SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/?-catenin signaling.
Oncogene33(3)279-88(2014 Jan)
Thu KL,Radulovich N,Becker-Santos DD,Pikor LA,Pusic A,Lockwood WW,Lam WL,Tsao MS

A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
Nature genetics44(2)178-82(2011 Dec)
Yu XQ,Li M,Zhang H,Low HQ,Wei X,Wang JQ,Sun LD,Sim KS,Li Y,Foo JN,Wang W,Li ZJ,Yin XY,Tang XQ,Fan L,Chen J,Li RS,Wan JX,Liu ZS,Lou TQ,Zhu L,Huang XJ,Zhang XJ,Liu ZH,Liu JJ

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SOX15 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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