NEUROD6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NEUROD6
Entrez Gene ID	63974
Full Name	neuronal differentiation 6
Synonyms	Atoh2,MATH2,Math-2,NEX1M,Nex1,bHLHa2
General protein information	Preferred Names neuronal differentiation 6 Names neurogenic differentiation factor 6 brain my051 protein class A basic helix-loop-helix protein 2 protein atonal homolog 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p14.3
Summary	This gene is a member of the NEUROD family of basic helix-loop-helix transcription factors. The encoded protein may be involved in the development and differentiation of the nervous system. [provided by RefSeq, Nov 2012].
Disorder MIM:	611513

mRNA and Protein(s)

mRNA	Protein	Name
NM_022728.4	NP_073565.2	neurogenic differentiation factor 6
NM_022728.3	NP_073565.2	neurogenic differentiation factor 6

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	NEUROD6	XP_539504.1
Xenopus tropicalis (tropical clawed frog)	neurod6	NP_001072273.1
Homo sapiens (human)	NEUROD6	NP_073565.2
Pan troglodytes (chimpanzee)	NEUROD6	XP_001166748.1
Danio rerio (zebrafish)	neurod6a	NP_571891.1
Rattus norvegicus (Norway rat)	Neurod6	NP_001102707.1
Gallus gallus (chicken)	NEUROD6	XP_418852.1
Caenorhabditis elegans (roundworm)	cnd-1	NP_498115.1
	NEUROD6	XP_001084292.1
Bos taurus (cattle)	NEUROD6	NP_001069689.1
Mus musculus (house mouse)	Neurod6	NP_033847.1

Gene Ontology
Bibliography

Related articles in PubMed

Leveraging existing data sets to generate new insights into Alzheimer's disease biology in specific patient subsets.
Fowler KD, Funt JM, Artyomov MN, Zeskind B, Kolitz SE, Towfic F
Scientific reports514324(2015 Sep)

Genetic loci associated with circulating levels of very long-chain saturated fatty acids.
Lemaitre RN, King IB, Kabagambe EK, Wu JH, McKnight B, Manichaikul A, Guan W, Sun Q, Chasman DI, Foy M, Wang L, Zhu J, Siscovick DS, Tsai MY, Arnett DK, Psaty BM, Djousse L, Chen YD, Tang W, Weng LC, Wu H, Jensen MK, Chu AY, Jacobs DR Jr, Rich SS, Mozaffarian D, Steffen L, Rimm EB, Hu FB, Ridker PM, Fornage M, Friedlander Y
Journal of lipid research56(1)176-84(2015 Jan)

RNA-Seq data mining: downregulation of NeuroD6 serves as a possible biomarker for alzheimer's disease brains.
Satoh J, Yamamoto Y, Asahina N, Kitano S, Kino Y
Disease markers2014123165(2014)

Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder.
Ribas?s M, Bosch R, Herv?s A, Ramos-Quiroga JA, S?nchez-Mora C, Bielsa A, Gastaminza X, Guijarro-Domingo S, Nogueira M, G?mez-Barros N, Kreiker S, Gross-Lesch S, Jacob CP, Lesch KP, Reif A, Johansson S, Plessen KJ, Knappskog PM, Haavik J, Estivill X, Casas M, Bay?s M, Cormand B
Biological psychiatry66(10)926-34(2009 Nov)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

single nucleotide polymorphisms in either the region of NEUROD6 or SNAP25 were significantly associated with Alzheimer's Disease, in APOE4+ females and APOE4+ males, respectively.
Title: Leveraging existing data sets to generate new insights into Alzheimer's disease biology in specific patient subsets.

NeuroD6 serves as a possible biomarker for Alzheimer disease brains.
Title: RNA-Seq data mining: downregulation of NeuroD6 serves as a possible biomarker for alzheimer's disease brains.

Observational study of gene-disease association. (HuGE Navigator)
Title: Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder.

cloning and some features of a novel human gene, MATH2, which encodes a protein of 337 amino acid residues with a basic helix loop helix domain and exhibits 98% similarity to mouse Math2
Title: Cloning, chromosome localization and features of a novel human gene, MATH2.

The following NEUROD6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NEUROD6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00460	NM_022728.4 Latest version!	Homo sapiens neuronal differentiation 6 (NEUROD6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu00460	NM_022728.3	Homo sapiens neuronal differentiation 6 (NEUROD6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NEUROD6 ( NM_022728.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_073565.2 Homo sapiens neuronal differentiation 6 (NEUROD6), mRNA.

Price & Availability↑

CloneID	OHu00460
Clone ID Related Accession (Same CDS sequence)	NM_022728.4 , NM_022728.3
Accession Version	NM_022728.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	neurogenic differentiation factor 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF248954.1. On Nov 23, 2018 this sequence version replaced NM_022728.3. ##Evidence-Data-START## Transcript exon combination :: BC035048.2, AF248954.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000297142.4/ ENSP00000297142.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTAACAC TACCGTTTGA TGAGTCTGTT GTAATGCCAG AATCCCAGAT GTGCAGAAAG 
TTTTCTAGAG AATGCGAGGA CCAGAAGCAA ATTAAGAAGC CAGAAAGCTT TTCCAAACAG 
ATTGTCCTTC GAGGAAAGAG CATCAAAAGG GCCCCTGGAG AAGAAACCGA GAAAGAAGAA 
GAGGAGGAAG ACAGGGAAGA GGAAGATGAA AATGGGTTGC CTAGAAGGAG GGGTCTTAGG 
AAAAAAAAGA CAACAAAGCT GCGATTGGAA AGGGTCAAGT TCAGGAGACA GGAAGCGAAC 
GCGCGCGAGA GGAACAGGAT GCACGGCCTC AACGACGCTC TGGACAACTT AAGAAAAGTG 
GTCCCCTGTT ATTCTAAAAC CCAGAAACTG TCCAAAATAG AGACTTTACG ACTGGCCAAA 
AACTACATCT GGGCACTTTC TGAAATTCTG AGAATCGGCA AGAGACCAGA TCTGCTCACA 
TTCGTCCAAA ACTTATGCAA AGGTCTTTCC CAGCCAACTA CAAACTTGGT GGCAGGCTGC 
TTGCAGCTCA ACGCCAGGAG TTTCCTGATG GGTCAGGGTG GGGAGGCTGC ACACCACACA 
AGGTCACCCT ACTCTACCTT CTACCCACCC TACCACAGCC CTGAGCTCAC CACTCCCCCA 
GGGCATGGGA CTCTTGATAA TTCCAAGTCC ATGAAACCCT ACAATTATTG CAGTGCGTAT 
GAATCCTTCT ATGAAAGTAC TTCCCCTGAG TGTGCCAGCC CTCAGTTTGA AGGTCCCTTA 
AGTCCTCCCC CAATTAACTA TAATGGGATA TTTTCCCTGA AGCAAGAAGA AACCTTGGAC 
TATGGTAAAA ATTACAATTA CGGCATGCAT TACTGTGCAG TGCCACCCAG GGGTCCCCTT 
GGGCAGGGTG CCATGTTCAG GTTGCCCACC GACAGCCACT TCCCTTACGA CTTACATCTG 
CGCAGCCAAT CTCTCACAAT GCAAGATGAA TTAAATGCAG TTTTTCATAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073565.2
CDS	156..1169
Translation	MLTLPFDESVVMPESQMCRKFSRECEDQKQIKKPESFSKQIVLRGKSIKRAPGEETEKEEEEEDREEEDENGLPRRRGLRKKKTTKLRLERVKFRRQEANARERNRMHGLNDALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRIGKRPDLLTFVQNLCKGLSQPTTNLVAGCLQLNARSFLMGQGGEAAHHTRSPYSTFYPPYHSPELTTPPGHGTLDNSKSMKPYNYCSAYESFYESTSPECASPQFEGPLSPPPINYNGIFSLKQEETLDYGKNYNYGMHYCAVPPRGPLGQGAMFRLPTDSHFPYDLHLRSQSLTMQDELNAVFHN

Target ORF information:

RefSeq Version	NM_022728.4
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronal differentiation 6 (NEUROD6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022728.4

ORF Insert Sequence:

ATGTTAACAC TACCGTTTGA TGAGTCTGTT GTAATGCCAG AATCCCAGAT GTGCAGAAAG 
TTTTCTAGAG AATGCGAGGA CCAGAAGCAA ATTAAGAAGC CAGAAAGCTT TTCCAAACAG 
ATTGTCCTTC GAGGAAAGAG CATCAAAAGG GCCCCTGGAG AAGAAACCGA GAAAGAAGAA 
GAGGAGGAAG ACAGGGAAGA GGAAGATGAA AATGGGTTGC CTAGAAGGAG GGGTCTTAGG 
AAAAAAAAGA CAACAAAGCT GCGATTGGAA AGGGTCAAGT TCAGGAGACA GGAAGCGAAC 
GCGCGCGAGA GGAACAGGAT GCACGGCCTC AACGACGCTC TGGACAACTT AAGAAAAGTG 
GTCCCCTGTT ATTCTAAAAC CCAGAAACTG TCCAAAATAG AGACTTTACG ACTGGCCAAA 
AACTACATCT GGGCACTTTC TGAAATTCTG AGAATCGGCA AGAGACCAGA TCTGCTCACA 
TTCGTCCAAA ACTTATGCAA AGGTCTTTCC CAGCCAACTA CAAACTTGGT GGCAGGCTGC 
TTGCAGCTCA ACGCCAGGAG TTTCCTGATG GGTCAGGGTG GGGAGGCTGC ACACCACACA 
AGGTCACCCT ACTCTACCTT CTACCCACCC TACCACAGCC CTGAGCTCAC CACTCCCCCA 
GGGCATGGGA CTCTTGATAA TTCCAAGTCC ATGAAACCCT ACAATTATTG CAGTGCGTAT 
GAATCCTTCT ATGAAAGTAC TTCCCCTGAG TGTGCCAGCC CTCAGTTTGA AGGTCCCTTA 
AGTCCTCCCC CAATTAACTA TAATGGGATA TTTTCCCTGA AGCAAGAAGA AACCTTGGAC 
TATGGTAAAA ATTACAATTA CGGCATGCAT TACTGTGCAG TGCCACCCAG GGGTCCCCTT 
GGGCAGGGTG CCATGTTCAG GTTGCCCACC GACAGCCACT TCCCTTACGA CTTACATCTG 
CGCAGCCAAT CTCTCACAAT GCAAGATGAA TTAAATGCAG TTTTTCATAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NEUROD6 ( NM_022728.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_073565.2 Homo sapiens neuronal differentiation 6 (NEUROD6), mRNA.

Price & Availability↑

CloneID	OHu00460
Clone ID Related Accession (Same CDS sequence)	NM_022728.4 , NM_022728.3
Accession Version	NM_022728.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	neurogenic differentiation factor 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF248954.1 and AK055238.1. On Nov 22, 2012 this sequence version replaced NM_022728.2. ##Evidence-Data-START## Transcript exon combination :: AF248954.1, SRR1660805.170007.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTAACAC TACCGTTTGA TGAGTCTGTT GTAATGCCAG AATCCCAGAT GTGCAGAAAG 
TTTTCTAGAG AATGCGAGGA CCAGAAGCAA ATTAAGAAGC CAGAAAGCTT TTCCAAACAG 
ATTGTCCTTC GAGGAAAGAG CATCAAAAGG GCCCCTGGAG AAGAAACCGA GAAAGAAGAA 
GAGGAGGAAG ACAGGGAAGA GGAAGATGAA AATGGGTTGC CTAGAAGGAG GGGTCTTAGG 
AAAAAAAAGA CAACAAAGCT GCGATTGGAA AGGGTCAAGT TCAGGAGACA GGAAGCGAAC 
GCGCGCGAGA GGAACAGGAT GCACGGCCTC AACGACGCTC TGGACAACTT AAGAAAAGTG 
GTCCCCTGTT ATTCTAAAAC CCAGAAACTG TCCAAAATAG AGACTTTACG ACTGGCCAAA 
AACTACATCT GGGCACTTTC TGAAATTCTG AGAATCGGCA AGAGACCAGA TCTGCTCACA 
TTCGTCCAAA ACTTATGCAA AGGTCTTTCC CAGCCAACTA CAAACTTGGT GGCAGGCTGC 
TTGCAGCTCA ACGCCAGGAG TTTCCTGATG GGTCAGGGTG GGGAGGCTGC ACACCACACA 
AGGTCACCCT ACTCTACCTT CTACCCACCC TACCACAGCC CTGAGCTCAC CACTCCCCCA 
GGGCATGGGA CTCTTGATAA TTCCAAGTCC ATGAAACCCT ACAATTATTG CAGTGCGTAT 
GAATCCTTCT ATGAAAGTAC TTCCCCTGAG TGTGCCAGCC CTCAGTTTGA AGGTCCCTTA 
AGTCCTCCCC CAATTAACTA TAATGGGATA TTTTCCCTGA AGCAAGAAGA AACCTTGGAC 
TATGGTAAAA ATTACAATTA CGGCATGCAT TACTGTGCAG TGCCACCCAG GGGTCCCCTT 
GGGCAGGGTG CCATGTTCAG GTTGCCCACC GACAGCCACT TCCCTTACGA CTTACATCTG 
CGCAGCCAAT CTCTCACAAT GCAAGATGAA TTAAATGCAG TTTTTCATAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_073565.2
CDS	354..1367
Translation	MLTLPFDESVVMPESQMCRKFSRECEDQKQIKKPESFSKQIVLRGKSIKRAPGEETEKEEEEEDREEEDENGLPRRRGLRKKKTTKLRLERVKFRRQEANARERNRMHGLNDALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRIGKRPDLLTFVQNLCKGLSQPTTNLVAGCLQLNARSFLMGQGGEAAHHTRSPYSTFYPPYHSPELTTPPGHGTLDNSKSMKPYNYCSAYESFYESTSPECASPQFEGPLSPPPINYNGIFSLKQEETLDYGKNYNYGMHYCAVPPRGPLGQGAMFRLPTDSHFPYDLHLRSQSLTMQDELNAVFHN

Target ORF information:

RefSeq Version	NM_022728.3
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronal differentiation 6 (NEUROD6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022728.3

ORF Insert Sequence:

ATGTTAACAC TACCGTTTGA TGAGTCTGTT GTAATGCCAG AATCCCAGAT GTGCAGAAAG 
TTTTCTAGAG AATGCGAGGA CCAGAAGCAA ATTAAGAAGC CAGAAAGCTT TTCCAAACAG 
ATTGTCCTTC GAGGAAAGAG CATCAAAAGG GCCCCTGGAG AAGAAACCGA GAAAGAAGAA 
GAGGAGGAAG ACAGGGAAGA GGAAGATGAA AATGGGTTGC CTAGAAGGAG GGGTCTTAGG 
AAAAAAAAGA CAACAAAGCT GCGATTGGAA AGGGTCAAGT TCAGGAGACA GGAAGCGAAC 
GCGCGCGAGA GGAACAGGAT GCACGGCCTC AACGACGCTC TGGACAACTT AAGAAAAGTG 
GTCCCCTGTT ATTCTAAAAC CCAGAAACTG TCCAAAATAG AGACTTTACG ACTGGCCAAA 
AACTACATCT GGGCACTTTC TGAAATTCTG AGAATCGGCA AGAGACCAGA TCTGCTCACA 
TTCGTCCAAA ACTTATGCAA AGGTCTTTCC CAGCCAACTA CAAACTTGGT GGCAGGCTGC 
TTGCAGCTCA ACGCCAGGAG TTTCCTGATG GGTCAGGGTG GGGAGGCTGC ACACCACACA 
AGGTCACCCT ACTCTACCTT CTACCCACCC TACCACAGCC CTGAGCTCAC CACTCCCCCA 
GGGCATGGGA CTCTTGATAA TTCCAAGTCC ATGAAACCCT ACAATTATTG CAGTGCGTAT 
GAATCCTTCT ATGAAAGTAC TTCCCCTGAG TGTGCCAGCC CTCAGTTTGA AGGTCCCTTA 
AGTCCTCCCC CAATTAACTA TAATGGGATA TTTTCCCTGA AGCAAGAAGA AACCTTGGAC 
TATGGTAAAA ATTACAATTA CGGCATGCAT TACTGTGCAG TGCCACCCAG GGGTCCCCTT 
GGGCAGGGTG CCATGTTCAG GTTGCCCACC GACAGCCACT TCCCTTACGA CTTACATCTG 
CGCAGCCAAT CTCTCACAAT GCAAGATGAA TTAAATGCAG TTTTTCATAA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Leveraging existing data sets to generate new insights into Alzheimer's disease biology in specific patient subsets.
Scientific reports514324(2015 Sep)
Fowler KD,Funt JM,Artyomov MN,Zeskind B,Kolitz SE,Towfic F

Genetic loci associated with circulating levels of very long-chain saturated fatty acids.
Journal of lipid research56(1)176-84(2015 Jan)
Lemaitre RN,King IB,Kabagambe EK,Wu JH,McKnight B,Manichaikul A,Guan W,Sun Q,Chasman DI,Foy M,Wang L,Zhu J,Siscovick DS,Tsai MY,Arnett DK,Psaty BM,Djousse L,Chen YD,Tang W,Weng LC,Wu H,Jensen MK,Chu AY,Jacobs DR Jr,Rich SS,Mozaffarian D,Steffen L,Rimm EB,Hu FB,Ridker PM,Fornage M,Friedlander Y

RNA-Seq data mining: downregulation of NeuroD6 serves as a possible biomarker for alzheimer's disease brains.
Disease markers2014123165(2014)
Satoh J,Yamamoto Y,Asahina N,Kitano S,Kino Y

Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder.
Biological psychiatry66(10)926-34(2009 Nov)
Ribas?s M,Bosch R,Herv?s A,Ramos-Quiroga JA,S?nchez-Mora C,Bielsa A,Gastaminza X,Guijarro-Domingo S,Nogueira M,G?mez-Barros N,Kreiker S,Gross-Lesch S,Jacob CP,Lesch KP,Reif A,Johansson S,Plessen KJ,Knappskog PM,Haavik J,Estivill X,Casas M,Bay?s M,Cormand B

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

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NEUROD6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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