RNASE3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RNASE3
Entrez Gene ID	6037
Full Name	ribonuclease A family member 3
Synonyms	ECP,RAF1,RNS3
General protein information	Preferred Names ribonuclease A family member 3 Names eosinophil cationic protein RNase 3 cytotoxic ribonuclease ribonuclease 3 ribonuclease, RNase A family, 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q11.2
Summary	The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014].
Disorder MIM:	131398

mRNA and Protein(s)

mRNA	Protein	Name
NM_002935.2	NP_002926.2	eosinophil cationic protein precursor

Pathways from BioSystems

Homologies

	RNASE3	XP_002805022.1
Homo sapiens (human)	RNASE3	NP_002926.2

Gene Ontology
Bibliography

Related articles in PubMed

Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke.
Sundstr?m J, S?derholm M, Born? Y, Nilsson J, Persson M, ?stling G, Melander O, Orho-Melander M, Engstr?m G
Stroke48(10)2686-2692(2017 Oct)

Eosinophil Cationic Protein in Patients with Differentiated Thyroid Cancer Treated with Radioactive Iodine 131.
Zivancevic-Simonovic S, Mihaljevic O, Kostic I, Ilic N, Mihajlovic D, Vasiljevic D, Mijatovic-Teodorovic L, Miletic-Drakulic S, Colic M
Annals of clinical and laboratory science47(5)541-545(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High circulating levels of eosinophil cationic protein are associated with increased incidence of ischemic stroke.
Title: Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke.

Studies mapped the structural determinants required for the eosinophil cationic protein (ECP)-bacterial lipopolysaccharide (LPS) interaction by nuclear magnetic resonance.
Title: Structural basis for endotoxin neutralization by the eosinophil cationic protein.

our data add new insights into the pathophysiology of AD, suggesting that BDNF which correlates with disease severity and ECP levels contributes to the regulation of inflammation in an eosinophil-, but not Th2-dependent manner.
Title: Childhood atopic dermatitis-Brain-derived neurotrophic factor correlates with serum eosinophil cationic protein and disease severity.

Increased MRP8/14 levels suggest the instability of the atherosclerotic plaque. ECP reflects the severity of coronary arteries stenosis, predicting atherosclerosis burden. They may become the new biomarkers of CAD.
Title: The Correlation of Serum Myeloid-Related Protein-8/14 and Eosinophil Cationic Protein in Patients with Coronary Artery Disease.

Children in the acute-phase group showed higher ECP mRNA expression level than those in the stable-phase and healthy control groups, while the level in the stable-phase was markedly higher than that in the healthy control group.
Title: Eosinophil cationic protein mRNA expression in children with bronchial asthma.

The following RNASE3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RNASE3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu17354	NM_002935.2 Latest version!	Homo sapiens ribonuclease A family member 3 (RNASE3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RNASE3 ( NM_002935.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002926.2 Homo sapiens ribonuclease A family member 3 (RNASE3), mRNA.

Price & Availability↑

CloneID	OHu17354
Clone ID Related Accession (Same CDS sequence)	NM_002935.2
Accession Version	NM_002935.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 483bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	eosinophil cationic protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X15161.1, BX280390.1 and M28128.1. On Mar 8, 2004 this sequence version replaced NM_002935.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X15161.1, BC096061.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 23716047 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTTCCAA AACTGTTCAC TTCCCAAATT TGTCTGCTTC TTCTGTTGGG GCTTATGGGT 
GTGGAGGGCT CACTCCATGC CAGACCCCCA CAGTTTACGA GGGCTCAGTG GTTTGCCATC 
CAGCACATCA GTCTGAACCC CCCTCGATGC ACCATTGCAA TGCGGGCAAT TAACAATTAT 
CGATGGCGTT GCAAAAACCA AAATACTTTT CTTCGTACAA CTTTTGCTAA TGTAGTTAAT 
GTTTGTGGTA ACCAAAGTAT ACGCTGCCCT CATAACAGAA CTCTCAACAA TTGTCATCGG 
AGTAGATTCC GGGTGCCTTT ACTCCACTGT GACCTCATAA ATCCAGGTGC ACAGAATATT 
TCAAACTGCA CGTATGCAGA CAGACCAGGA AGGAGGTTCT ATGTAGTTGC ATGTGACAAC 
AGAGATCCAC GGGATTCTCC ACGGTATCCT GTGGTTCCAG TTCACCTGGA TACCACCATC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002926.2
CDS	55..537
Translation	MVPKLFTSQICLLLLLGLMGVEGSLHARPPQFTRAQWFAIQHISLNPPRCTIAMRAINNYRWRCKNQNTFLRTTFANVVNVCGNQSIRCPHNRTLNNCHRSRFRVPLLHCDLINPGAQNISNCTYADRPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTI

Target ORF information:

RefSeq Version	NM_002935.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ribonuclease A family member 3 (RNASE3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002935.2

ORF Insert Sequence:

ATGGTTCCAA AACTGTTCAC TTCCCAAATT TGTCTGCTTC TTCTGTTGGG GCTTATGGGT 
GTGGAGGGCT CACTCCATGC CAGACCCCCA CAGTTTACGA GGGCTCAGTG GTTTGCCATC 
CAGCACATCA GTCTGAACCC CCCTCGATGC ACCATTGCAA TGCGGGCAAT TAACAATTAT 
CGATGGCGTT GCAAAAACCA AAATACTTTT CTTCGTACAA CTTTTGCTAA TGTAGTTAAT 
GTTTGTGGTA ACCAAAGTAT ACGCTGCCCT CATAACAGAA CTCTCAACAA TTGTCATCGG 
AGTAGATTCC GGGTGCCTTT ACTCCACTGT GACCTCATAA ATCCAGGTGC ACAGAATATT 
TCAAACTGCA CGTATGCAGA CAGACCAGGA AGGAGGTTCT ATGTAGTTGC ATGTGACAAC 
AGAGATCCAC GGGATTCTCC ACGGTATCCT GTGGTTCCAG TTCACCTGGA TACCACCATC 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Eosinophil Cationic Protein, Carotid Plaque, and Incidence of Stroke.
Stroke48(10)2686-2692(2017 Oct)
Sundstr?m J,S?derholm M,Born? Y,Nilsson J,Persson M,?stling G,Melander O,Orho-Melander M,Engstr?m G

Eosinophil Cationic Protein in Patients with Differentiated Thyroid Cancer Treated with Radioactive Iodine 131.
Annals of clinical and laboratory science47(5)541-545(2017 Sep)
Zivancevic-Simonovic S,Mihaljevic O,Kostic I,Ilic N,Mihajlovic D,Vasiljevic D,Mijatovic-Teodorovic L,Miletic-Drakulic S,Colic M

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

RNASE3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報