REG1B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	REG1B
Entrez Gene ID	5968
Full Name	regenerating family member 1 beta
Synonyms	PSPS2,REGH,REGI-BETA,REGL
General protein information	Preferred Names regenerating family member 1 beta Names lithostathine-1-beta PSP-2 REG-1-beta pancreatic stone protein 2 regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein) regenerating islet-derived protein 1-beta regenerating protein I beta secretory pancreatic stone protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p12
Summary	This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV based on the primary structures of the encoded proteins. This gene encodes a protein secreted by the exocrine pancreas that is highly similar to the REG1A protein. The related REG1A protein is associated with islet cell regeneration and diabetogenesis, and may be involved in pancreatic lithogenesis. Reg family members REG1A, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008].
Disorder MIM:	167771

mRNA and Protein(s)

mRNA	Protein	Name
NM_006507.3	NP_006498.1	lithostathine-1-beta precursor
NM_006507.4	NP_006498.1	lithostathine-1-beta precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	REG1B	XP_001163951.2
Mus musculus (house mouse)	Reg2	NP_033069.1
Homo sapiens (human)	REG1B	NP_006498.1
	REG1B	XP_001112647.1

Gene Ontology
Bibliography

Related articles in PubMed

Prognostic role of regenerating gene-I in patients with stage-IV head and neck squamous cell carcinoma.
Aboshanif M, Kawasaki Y, Omori Y, Suzuki S, Honda K, Motoyama S, Ishikawa K
Diagnostic pathology11(1)79(2016 Aug)

Synergistic activations of REG I ? and REG I ? promoters by IL-6 and Glucocorticoids through JAK/STAT pathway in human pancreatic ? cells.
Yamauchi A, Itaya-Hironaka A, Sakuramoto-Tsuchida S, Takeda M, Yoshimoto K, Miyaoka T, Fujimura T, Tsujinaka H, Tsuchida C, Ota H, Takasawa S
Journal of diabetes research2015173058(2015)

Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
Goodbourn PT, Bosten JM, Bargary G, Hogg RE, Lawrance-Owen AJ, Mollon JD
Genes, brain, and behavior13(2)144-51(2014 Feb)

Validation of four candidate pancreatic cancer serological biomarkers that improve the performance of CA19.9.
Makawita S, Dimitromanolakis A, Soosaipillai A, Soleas I, Chan A, Gallinger S, Haun RS, Blasutig IM, Diamandis EP
BMC cancer13404(2013 Sep)

REG1B as a predictor of childhood stunting in Bangladesh and Peru.
Peterson KM, Buss J, Easley R, Yang Z, Korpe PS, Niu F, Ma JZ, Olortegui MP, Haque R, Kosek MN, Petri WA Jr
The American journal of clinical nutrition97(5)1129-33(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

REG-I is expressed in head and neck squamous cell carcinoma and is associated with a longer survival status.
Title: Prognostic role of regenerating gene-I in patients with stage-IV head and neck squamous cell carcinoma.

the expression of REG Ialpha and REG Ibeta may be upregulated in human beta cells under inflammatory conditions through the JAK/STAT pathway
Title: Synergistic activations of REG I ? and REG I ? promoters by IL-6 and Glucocorticoids through JAK/STAT pathway in human pancreatic ? cells.

Additional serum biomarkers, particularly SYCN and REG1B, when combined with CA19.9, show promise as improved diagnostic indicators of pancreatic cancer, which therefore warrants further validation.
Title: Validation of four candidate pancreatic cancer serological biomarkers that improve the performance of CA19.9.

Immunohistochemistry against known cell-type markers on serial sections has localised the expression of REGs to metaplastic Paneth cells (REG1A, REG1B and REG3A) and enteroendocrine cells (REG4), with a marked expansion of expression during inflammation.
Title: REG gene expression in inflamed and healthy colon mucosa explored by in situ hybridisation.

Higher REG1B stool concentrations at month 3 were significantly and independently associated with a growth shortfall in Bangladeshi and Peruvian children.
Title: REG1B as a predictor of childhood stunting in Bangladesh and Peru.

The following REG1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the REG1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16392	NM_006507.4 Latest version!	Homo sapiens regenerating family member 1 beta (REG1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu16392	NM_006507.3	Homo sapiens regenerating family member 1 beta (REG1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

REG1B ( NM_006507.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_006498.1 Homo sapiens regenerating family member 1 beta (REG1B), mRNA.

Price & Availability↑

CloneID	OHu16392
Clone ID Related Accession (Same CDS sequence)	NM_006507.3 , NM_006507.4
Accession Version	NM_006507.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-17
Organism	Homo sapiens(human)
Product	lithostathine-1-beta precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP321590.1, D16816.1 and CA867116.1. On Jun 8, 2008 this sequence version replaced NM_006507.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP325486.1, D16816.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153733, SAMEA2153932 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTCAGA CCAACTCGTT CTTCATGCTG ATCTCCTCCC TGATGTTCCT GTCTCTGAGC 
CAAGGCCAGG AGTCCCAGAC AGAGCTGCCT AATCCCCGAA TCAGCTGCCC AGAAGGCACC 
AATGCCTATC GCTCCTACTG CTACTACTTT AATGAAGACC CTGAGACCTG GGTTGATGCA 
GATCTCTATT GCCAGAACAT GAATTCAGGC AACCTGGTGT CTGTGCTCAC CCAGGCGGAG 
GGTGCCTTCG TGGCCTCACT GATTAAGGAG AGTAGCACTG ATGACAGCAA TGTCTGGATT 
GGCCTCCATG ACCCAAAAAA GAACCGCCGC TGGCACTGGA GTAGTGGGTC CCTGGTCTCC 
TACAAGTCCT GGGACACTGG ATCCCCGAGC AGTGCTAATG CTGGCTACTG TGCAAGCCTG 
ACTTCATGCT CAGGATTCAA GAAATGGAAG GATGAATCTT GTGAGAAGAA GTTCTCCTTT 
GTTTGCAAGT TCAAAAACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006498.1
CDS	113..613
Translation	MAQTNSFFMLISSLMFLSLSQGQESQTELPNPRISCPEGTNAYRSYCYYFNEDPETWVDADLYCQNMNSGNLVSVLTQAEGAFVASLIKESSTDDSNVWIGLHDPKKNRRWHWSSGSLVSYKSWDTGSPSSANAGYCASLTSCSGFKKWKDESCEKKFSFVCKFKN

Target ORF information:

RefSeq Version	NM_006507.3
Organism	Homo sapiens(human)
Definition	Homo sapiens regenerating family member 1 beta (REG1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006507.3

ORF Insert Sequence:

ATGGCTCAGA CCAACTCGTT CTTCATGCTG ATCTCCTCCC TGATGTTCCT GTCTCTGAGC 
CAAGGCCAGG AGTCCCAGAC AGAGCTGCCT AATCCCCGAA TCAGCTGCCC AGAAGGCACC 
AATGCCTATC GCTCCTACTG CTACTACTTT AATGAAGACC CTGAGACCTG GGTTGATGCA 
GATCTCTATT GCCAGAACAT GAATTCAGGC AACCTGGTGT CTGTGCTCAC CCAGGCGGAG 
GGTGCCTTCG TGGCCTCACT GATTAAGGAG AGTAGCACTG ATGACAGCAA TGTCTGGATT 
GGCCTCCATG ACCCAAAAAA GAACCGCCGC TGGCACTGGA GTAGTGGGTC CCTGGTCTCC 
TACAAGTCCT GGGACACTGG ATCCCCGAGC AGTGCTAATG CTGGCTACTG TGCAAGCCTG 
ACTTCATGCT CAGGATTCAA GAAATGGAAG GATGAATCTT GTGAGAAGAA GTTCTCCTTT 
GTTTGCAAGT TCAAAAACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

REG1B ( NM_006507.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_006498.1 Homo sapiens regenerating family member 1 beta (REG1B), mRNA.

Price & Availability↑

CloneID	OHu16392
Clone ID Related Accession (Same CDS sequence)	NM_006507.3 , NM_006507.4
Accession Version	NM_006507.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	lithostathine-1-beta precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D16816.1 and CA867116.1. On May 17, 2019 this sequence version replaced NM_006507.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D16816.1, BM769964.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153733, SAMEA2153932 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000305089.8/ ENSP00000303206.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCAGA CCAACTCGTT CTTCATGCTG ATCTCCTCCC TGATGTTCCT GTCTCTGAGC 
CAAGGCCAGG AGTCCCAGAC AGAGCTGCCT AATCCCCGAA TCAGCTGCCC AGAAGGCACC 
AATGCCTATC GCTCCTACTG CTACTACTTT AATGAAGACC CTGAGACCTG GGTTGATGCA 
GATCTCTATT GCCAGAACAT GAATTCAGGC AACCTGGTGT CTGTGCTCAC CCAGGCGGAG 
GGTGCCTTCG TGGCCTCACT GATTAAGGAG AGTAGCACTG ATGACAGCAA TGTCTGGATT 
GGCCTCCATG ACCCAAAAAA GAACCGCCGC TGGCACTGGA GTAGTGGGTC CCTGGTCTCC 
TACAAGTCCT GGGACACTGG ATCCCCGAGC AGTGCTAATG CTGGCTACTG TGCAAGCCTG 
ACTTCATGCT CAGGATTCAA GAAATGGAAG GATGAATCTT GTGAGAAGAA GTTCTCCTTT 
GTTTGCAAGT TCAAAAACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006498.1
CDS	82..582
Translation	MAQTNSFFMLISSLMFLSLSQGQESQTELPNPRISCPEGTNAYRSYCYYFNEDPETWVDADLYCQNMNSGNLVSVLTQAEGAFVASLIKESSTDDSNVWIGLHDPKKNRRWHWSSGSLVSYKSWDTGSPSSANAGYCASLTSCSGFKKWKDESCEKKFSFVCKFKN

Target ORF information:

RefSeq Version	NM_006507.4
Organism	Homo sapiens(human)
Definition	Homo sapiens regenerating family member 1 beta (REG1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006507.4

ORF Insert Sequence:

ATGGCTCAGA CCAACTCGTT CTTCATGCTG ATCTCCTCCC TGATGTTCCT GTCTCTGAGC 
CAAGGCCAGG AGTCCCAGAC AGAGCTGCCT AATCCCCGAA TCAGCTGCCC AGAAGGCACC 
AATGCCTATC GCTCCTACTG CTACTACTTT AATGAAGACC CTGAGACCTG GGTTGATGCA 
GATCTCTATT GCCAGAACAT GAATTCAGGC AACCTGGTGT CTGTGCTCAC CCAGGCGGAG 
GGTGCCTTCG TGGCCTCACT GATTAAGGAG AGTAGCACTG ATGACAGCAA TGTCTGGATT 
GGCCTCCATG ACCCAAAAAA GAACCGCCGC TGGCACTGGA GTAGTGGGTC CCTGGTCTCC 
TACAAGTCCT GGGACACTGG ATCCCCGAGC AGTGCTAATG CTGGCTACTG TGCAAGCCTG 
ACTTCATGCT CAGGATTCAA GAAATGGAAG GATGAATCTT GTGAGAAGAA GTTCTCCTTT 
GTTTGCAAGT TCAAAAACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prognostic role of regenerating gene-I in patients with stage-IV head and neck squamous cell carcinoma.
Diagnostic pathology11(1)79(2016 Aug)
Aboshanif M,Kawasaki Y,Omori Y,Suzuki S,Honda K,Motoyama S,Ishikawa K

Synergistic activations of REG I ? and REG I ? promoters by IL-6 and Glucocorticoids through JAK/STAT pathway in human pancreatic ? cells.
Journal of diabetes research2015173058(2015)
Yamauchi A,Itaya-Hironaka A,Sakuramoto-Tsuchida S,Takeda M,Yoshimoto K,Miyaoka T,Fujimura T,Tsujinaka H,Tsuchida C,Ota H,Takasawa S

Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
Genes, brain, and behavior13(2)144-51(2014 Feb)
Goodbourn PT,Bosten JM,Bargary G,Hogg RE,Lawrance-Owen AJ,Mollon JD

Validation of four candidate pancreatic cancer serological biomarkers that improve the performance of CA19.9.
BMC cancer13404(2013 Sep)
Makawita S,Dimitromanolakis A,Soosaipillai A,Soleas I,Chan A,Gallinger S,Haun RS,Blasutig IM,Diamandis EP

REG1B as a predictor of childhood stunting in Bangladesh and Peru.
The American journal of clinical nutrition97(5)1129-33(2013 May)
Peterson KM,Buss J,Easley R,Yang Z,Korpe PS,Niu F,Ma JZ,Olortegui MP,Haque R,Kosek MN,Petri WA Jr

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REG1B cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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