RABIF cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RABIF
Entrez Gene ID	5877
Full Name	RAB interacting factor
Synonyms	MSS4,RASGFR3,RASGRF3
General protein information	Preferred Names RAB interacting factor Names guanine nucleotide exchange factor MSS4 Ras-specific guanine-releasing factor 3 mammalian suppressor of SEC4 rab-interacting factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q32.1
Summary	This gene encodes a member of the SCE4/YPT1/RAB family of small GTP-binding proteins that are involved in the regulation of intracellular vesicular transport. This protein stimulates GTP-GDP exchange in SEC4, and to a lesser extent in YPT1 and RAB3A, and may play a general role in vesicular transport. [provided by RefSeq, Oct 2011].
Disorder MIM:	603417

mRNA and Protein(s)

mRNA	Protein	Name
NM_002871.5	NP_002862.2	guanine nucleotide exchange factor MSS4
NM_002871.4	NP_002862.2	guanine nucleotide exchange factor MSS4

Pathways from BioSystems

Homologies

Homo sapiens (human)	RABIF	NP_002862.2
Drosophila melanogaster (fruit fly)	CG7787	NP_609209.2
Rattus norvegicus (Norway rat)	RGD1563962	XP_003749349.1
Danio rerio (zebrafish)	rabif	NP_001002511.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP008798	XP_314924.3
Pan troglodytes (chimpanzee)	RABIF	XP_514105.2
Canis lupus familiaris (dog)	RABIF	XP_003639189.1
Mus musculus (house mouse)	Rabif	NP_663485.1
Gallus gallus (chicken)	RABIF	XP_419250.3
	RABIF	XP_001106028.1
Bos taurus (cattle)	RABIF	NP_001035686.1
Rattus norvegicus (Norway rat)	Rabif	NP_001007679.1
Xenopus tropicalis (tropical clawed frog)	rabif	XP_002939675.1

Gene Ontology
Bibliography

Related articles in PubMed

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
Steger M, Diez F, Dhekne HS, Lis P, Nirujogi RS, Karayel O, Tonelli F, Martinez TN, Lorentzen E, Pfeffer SR, Alessi DR, Mann M
eLife6(2017 Nov)

RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis.
Gulbranson DR, Davis EM, Demmitt BA, Ouyang Y, Ye Y, Yu H, Shen J
Proceedings of the National Academy of Sciences of the United States of America114(39)E8224-E8233(2017 Sep)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
Steger M, Tonelli F, Ito G, Davies P, Trost M, Vetter M, Wachter S, Lorentzen E, Duddy G, Wilson S, Baptista MA, Fiske BK, Fell MJ, Morrow JA, Reith AD, Alessi DR, Mann M
eLife5(2016 Jan)

Mss4 protein is a regulator of stress response and apoptosis.
Walter BM, Nordhoff C, Varga G, Goncharenko G, Schneider SW, Ludwig S, Wixler V
Cell death & disease3e297(2012 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The expression levels of cellular Mss4 mRNA and protein are rapidly changed in response to a broad range of extracellular stress stimuli.
Title: Mss4 protein is a regulator of stress response and apoptosis.

Observational study of gene-disease association. (HuGE Navigator)
Title: Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.

MSS4 modulates Rab15 activity in early endocytosis
Title: Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis.

The following RABIF gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RABIF cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu55819	NM_002871.5 Latest version!	Homo sapiens RAB interacting factor (RABIF), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu55819	NM_002871.4	Homo sapiens RAB interacting factor (RABIF), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RABIF ( NM_002871.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002862.2 Homo sapiens RAB interacting factor (RABIF), mRNA.

Price & Availability↑

CloneID	OHu55819
Clone ID Related Accession (Same CDS sequence)	NM_002871.5 , NM_002871.4
Accession Version	NM_002871.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	guanine nucleotide exchange factor MSS4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC098934.3. On May 17, 2019 this sequence version replaced NM_002871.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.41507.1, SRR1803615.120745.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151119, SAMEA2152568 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367262.4/ ENSP00000356231.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAACCAG CGGAGCAGCC GAGCGAGTTA GTGTCAGCCG AGGGCCGAAA CCGGAAGGCG 
GTGCTGTGCC AGCGTTGCGG CTCCCGGGTG CTGCAGCCAG GGACCGCTCT CTTCTCTCGC 
CGACAGCTTT TCCTTCCCTC CATGAGAAAG AAGCCAGCTC TGTCTGACGG CAGCAATCCT 
GACGGCGATC TCCTCCAGGA ACACTGGCTG GTTGAGGACA TGTTCATTTT TGAGAATGTG 
GGCTTCACCA AGGACGTGGG CAACATCAAG TTTCTGGTCT GCGCAGACTG TGAAATTGGA 
CCAATTGGCT GGCATTGCCT AGATGACAAG AACAGTTTCT ATGTGGCCTT GGAACGAGTT 
TCCCATGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002862.2
CDS	52..423
Translation	MEPAEQPSELVSAEGRNRKAVLCQRCGSRVLQPGTALFSRRQLFLPSMRKKPALSDGSNPDGDLLQEHWLVEDMFIFENVGFTKDVGNIKFLVCADCEIGPIGWHCLDDKNSFYVALERVSHE

Target ORF information:

RefSeq Version	NM_002871.5
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB interacting factor (RABIF), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002871.5

ORF Insert Sequence:

ATGGAACCAG CGGAGCAGCC GAGCGAGTTA GTGTCAGCCG AGGGCCGAAA CCGGAAGGCG 
GTGCTGTGCC AGCGTTGCGG CTCCCGGGTG CTGCAGCCAG GGACCGCTCT CTTCTCTCGC 
CGACAGCTTT TCCTTCCCTC CATGAGAAAG AAGCCAGCTC TGTCTGACGG CAGCAATCCT 
GACGGCGATC TCCTCCAGGA ACACTGGCTG GTTGAGGACA TGTTCATTTT TGAGAATGTG 
GGCTTCACCA AGGACGTGGG CAACATCAAG TTTCTGGTCT GCGCAGACTG TGAAATTGGA 
CCAATTGGCT GGCATTGCCT AGATGACAAG AACAGTTTCT ATGTGGCCTT GGAACGAGTT 
TCCCATGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RABIF ( NM_002871.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002862.2 Homo sapiens RAB interacting factor (RABIF), mRNA.

Price & Availability↑

CloneID	OHu55819
Clone ID Related Accession (Same CDS sequence)	NM_002871.5 , NM_002871.4
Accession Version	NM_002871.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 372bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	guanine nucleotide exchange factor MSS4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK223538.1, BC037392.1, U74324.1, DA674111.1 and BQ898100.1. On Oct 20, 2011 this sequence version replaced NM_002871.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223538.1, SRR1803615.184073.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151119, SAMEA2152568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAACCAG CGGAGCAGCC GAGCGAGTTA GTGTCAGCCG AGGGCCGAAA CCGGAAGGCG 
GTGCTGTGCC AGCGTTGCGG CTCCCGGGTG CTGCAGCCAG GGACCGCTCT CTTCTCTCGC 
CGACAGCTTT TCCTTCCCTC CATGAGAAAG AAGCCAGCTC TGTCTGACGG CAGCAATCCT 
GACGGCGATC TCCTCCAGGA ACACTGGCTG GTTGAGGACA TGTTCATTTT TGAGAATGTG 
GGCTTCACCA AGGACGTGGG CAACATCAAG TTTCTGGTCT GCGCAGACTG TGAAATTGGA 
CCAATTGGCT GGCATTGCCT AGATGACAAG AACAGTTTCT ATGTGGCCTT GGAACGAGTT 
TCCCATGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002862.2
CDS	160..531
Translation	MEPAEQPSELVSAEGRNRKAVLCQRCGSRVLQPGTALFSRRQLFLPSMRKKPALSDGSNPDGDLLQEHWLVEDMFIFENVGFTKDVGNIKFLVCADCEIGPIGWHCLDDKNSFYVALERVSHE

Target ORF information:

RefSeq Version	NM_002871.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RAB interacting factor (RABIF), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002871.4

ORF Insert Sequence:

ATGGAACCAG CGGAGCAGCC GAGCGAGTTA GTGTCAGCCG AGGGCCGAAA CCGGAAGGCG 
GTGCTGTGCC AGCGTTGCGG CTCCCGGGTG CTGCAGCCAG GGACCGCTCT CTTCTCTCGC 
CGACAGCTTT TCCTTCCCTC CATGAGAAAG AAGCCAGCTC TGTCTGACGG CAGCAATCCT 
GACGGCGATC TCCTCCAGGA ACACTGGCTG GTTGAGGACA TGTTCATTTT TGAGAATGTG 
GGCTTCACCA AGGACGTGGG CAACATCAAG TTTCTGGTCT GCGCAGACTG TGAAATTGGA 
CCAATTGGCT GGCATTGCCT AGATGACAAG AACAGTTTCT ATGTGGCCTT GGAACGAGTT 
TCCCATGAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.
eLife6(2017 Nov)
Steger M,Diez F,Dhekne HS,Lis P,Nirujogi RS,Karayel O,Tonelli F,Martinez TN,Lorentzen E,Pfeffer SR,Alessi DR,Mann M

RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis.
Proceedings of the National Academy of Sciences of the United States of America114(39)E8224-E8233(2017 Sep)
Gulbranson DR,Davis EM,Demmitt BA,Ouyang Y,Ye Y,Yu H,Shen J

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.
eLife5(2016 Jan)
Steger M,Tonelli F,Ito G,Davies P,Trost M,Vetter M,Wachter S,Lorentzen E,Duddy G,Wilson S,Baptista MA,Fiske BK,Fell MJ,Morrow JA,Reith AD,Alessi DR,Mann M

Mss4 protein is a regulator of stress response and apoptosis.
Cell death & disease3e297(2012 Apr)
Walter BM,Nordhoff C,Varga G,Goncharenko G,Schneider SW,Ludwig S,Wixler V

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RABIF cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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