PTPRCAP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PTPRCAP
Entrez Gene ID	5790
Full Name	protein tyrosine phosphatase, receptor type C associated protein
Synonyms	CD45-AP,LPAP
General protein information	Preferred Names protein tyrosine phosphatase, receptor type C associated protein Names protein tyrosine phosphatase receptor type C-associated protein CD45 associated protein PTPRC-associated protein lymphocyte phosphatase-associated phosphoprotein protein tyrosine phosphatase, receptor type, c polypeptide-associated protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.2
Summary	The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008].
Disorder MIM:	601577

mRNA and Protein(s)

mRNA	Protein	Name
NM_005608.2	NP_005599.1	protein tyrosine phosphatase receptor type C-associated protein precursor
NM_005608.3	NP_005599.1	protein tyrosine phosphatase receptor type C-associated protein precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	PTPRCAP	NP_005599.1
	LOC100424226	XP_002799512.1
Rattus norvegicus (Norway rat)	Ptprcap	NP_001019460.1
Bos taurus (cattle)	PTPRCAP	NP_001040083.1
Pan troglodytes (chimpanzee)	PTPRCAP	XP_508595.3
Mus musculus (house mouse)	Ptprcap	NP_058629.2

Gene Ontology
Bibliography

Related articles in PubMed

Constitutive and activation-dependent phosphorylation of lymphocyte phosphatase-associated phosphoprotein (LPAP).
Kruglova NA, Meshkova TD, Kopylov AT, Mazurov DV, Filatov AV
PloS one12(8)e0182468(2017)

A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression.
Ju H, Lim B, Kim M, Kim YS, Kim WH, Ihm C, Noh SM, Han DS, Yu HJ, Choi BY, Kang C
Neoplasia (New York, N.Y.)11(12)1340-7(2009 Dec)

PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients.
Cocco E, Murru MR, Melis C, Schirru L, Solla E, Lai M, Rolesu M, Marrosu MG
Journal of neurology251(9)1085-8(2004 Sep)

77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link.
Vogel A, Strassburg CP, Manns MP
Genes and immunity4(1)79-81(2003 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results support the model: following phorbol 12-myristate 13-acetate (PMA) or TCR/CD3 activation of T cells, LPAP is rapidly dephosphorylated at Ser-99 and Ser-172 and slowly phosphorylated at Ser-163. Ser-153 exhibited a high basal level of phosphorylation in both resting and activated cells
Title: Constitutive and activation-dependent phosphorylation of lymphocyte phosphatase-associated phosphoprotein (LPAP).

Data show that the minor allele of rs869736 in the PTPRCAP promoter is associated with increased susceptibility to diffuse-type gastric cancer by increasing PTPRCAP expression.
Title: A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression.

We analysed the C77G polymorphism in multiple sclerosis (MS) patients from the genetically homogeneous population of Sardinia. CD45 did not contribute to development of the disease in Sardinian MS.
Title: PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients.

The following PTPRCAP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTPRCAP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00348	NM_005608.3 Latest version!	Homo sapiens protein tyrosine phosphatase receptor type C associated protein (PTPRCAP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu00348	NM_005608.2	Homo sapiens protein tyrosine phosphatase, receptor type C associated protein (PTPRCAP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PTPRCAP ( NM_005608.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005599.1 Homo sapiens protein tyrosine phosphatase, receptor type C associated protein (PTPRCAP), mRNA.

Price & Availability↑

CloneID	OHu00348
Clone ID Related Accession (Same CDS sequence)	NM_005608.2 , NM_005608.3
Accession Version	NM_005608.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-15
Organism	Homo sapiens(human)
Product	protein tyrosine phosphatase receptor type C-associated protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X81422.1 and AP003419.3. On May 16, 2005 this sequence version replaced NM_005608.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X81422.1, SRR1163658.394698.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCTCTGC CCTGCACCTT AGGGCTCGGG ATGCTGCTGG CCCTGCCAGG GGCCTTGGGC 
TCGGGTGGCA GCGCGGAGGA CAGCGTGGGC TCCAGCTCTG TCACCGTTGT CCTGCTGCTG 
CTGCTGCTCC TACTGCTGGC CACTGGCCTA GCACTGGCCT GGCGCCGCCT CAGCCGTGAC 
TCAGGGGGCT ACTACCACCC GGCCCGCCTA GGTGCCGCGC TGTGGGGCCG CACGCGGCGC 
CTGCTCTGGG CCAGCCCCCC AGGTCGCTGG CTGCAGGCCC GAGCTGAGCT GGGGTCCACA 
GACAATGACC TTGAGCGACA GGAGGATGAG CAGGACACAG ACTATGACCA CGTCGCGGAT 
GGTGGCCTGC AGGCTGACCC TGGGGAAGGC GAGCAGCAAT GTGGAGAGGC GTCCAGCCCA 
GAGCAGGTCC CCGTGCGGGC TGAGGAAGCC AGAGACAGTG ACACGGAGGG CGACCTGGTC 
CTCGGCTCCC CAGGACCAGC GAGCGCAGGG GGCAGTGCTG AGGCCCTGCT GAGTGACCTG 
CACGCCTTTG CTGGCAGCGC AGCCTGGGAT GACAGCGCCA GGGCAGCTGG GGGCCAGGGC 
CTCCATGTCA CCGCACTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005599.1
CDS	64..684
Translation	MALPCTLGLGMLLALPGALGSGGSAEDSVGSSSVTVVLLLLLLLLLATGLALAWRRLSRDSGGYYHPARLGAALWGRTRRLLWASPPGRWLQARAELGSTDNDLERQEDEQDTDYDHVADGGLQADPGEGEQQCGEASSPEQVPVRAEEARDSDTEGDLVLGSPGPASAGGSAEALLSDLHAFAGSAAWDDSARAAGGQGLHVTAL

Target ORF information:

RefSeq Version	NM_005608.2
Organism	Homo sapiens(human)
Definition	Homo sapiens protein tyrosine phosphatase, receptor type C associated protein (PTPRCAP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005608.2

ORF Insert Sequence:

ATGGCTCTGC CCTGCACCTT AGGGCTCGGG ATGCTGCTGG CCCTGCCAGG GGCCTTGGGC 
TCGGGTGGCA GCGCGGAGGA CAGCGTGGGC TCCAGCTCTG TCACCGTTGT CCTGCTGCTG 
CTGCTGCTCC TACTGCTGGC CACTGGCCTA GCACTGGCCT GGCGCCGCCT CAGCCGTGAC 
TCAGGGGGCT ACTACCACCC GGCCCGCCTA GGTGCCGCGC TGTGGGGCCG CACGCGGCGC 
CTGCTCTGGG CCAGCCCCCC AGGTCGCTGG CTGCAGGCCC GAGCTGAGCT GGGGTCCACA 
GACAATGACC TTGAGCGACA GGAGGATGAG CAGGACACAG ACTATGACCA CGTCGCGGAT 
GGTGGCCTGC AGGCTGACCC TGGGGAAGGC GAGCAGCAAT GTGGAGAGGC GTCCAGCCCA 
GAGCAGGTCC CCGTGCGGGC TGAGGAAGCC AGAGACAGTG ACACGGAGGG CGACCTGGTC 
CTCGGCTCCC CAGGACCAGC GAGCGCAGGG GGCAGTGCTG AGGCCCTGCT GAGTGACCTG 
CACGCCTTTG CTGGCAGCGC AGCCTGGGAT GACAGCGCCA GGGCAGCTGG GGGCCAGGGC 
CTCCATGTCA CCGCACTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTPRCAP ( NM_005608.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005599.1 Homo sapiens protein tyrosine phosphatase receptor type C associated protein (PTPRCAP), mRNA.

Price & Availability↑

CloneID	OHu00348
Clone ID Related Accession (Same CDS sequence)	NM_005608.2 , NM_005608.3
Accession Version	NM_005608.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	protein tyrosine phosphatase receptor type C-associated protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X81422.1 and AP003419.3. On Nov 23, 2018 this sequence version replaced NM_005608.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X81422.1, SRR1163657.120619.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000326294.4/ ENSP00000325589.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTCTGC CCTGCACCTT AGGGCTCGGG ATGCTGCTGG CCCTGCCAGG GGCCTTGGGC 
TCGGGTGGCA GCGCGGAGGA CAGCGTGGGC TCCAGCTCTG TCACCGTTGT CCTGCTGCTG 
CTGCTGCTCC TACTGCTGGC CACTGGCCTA GCACTGGCCT GGCGCCGCCT CAGCCGTGAC 
TCAGGGGGCT ACTACCACCC GGCCCGCCTA GGTGCCGCGC TGTGGGGCCG CACGCGGCGC 
CTGCTCTGGG CCAGCCCCCC AGGTCGCTGG CTGCAGGCCC GAGCTGAGCT GGGGTCCACA 
GACAATGACC TTGAGCGACA GGAGGATGAG CAGGACACAG ACTATGACCA CGTCGCGGAT 
GGTGGCCTGC AGGCTGACCC TGGGGAAGGC GAGCAGCAAT GTGGAGAGGC GTCCAGCCCA 
GAGCAGGTCC CCGTGCGGGC TGAGGAAGCC AGAGACAGTG ACACGGAGGG CGACCTGGTC 
CTCGGCTCCC CAGGACCAGC GAGCGCAGGG GGCAGTGCTG AGGCCCTGCT GAGTGACCTG 
CACGCCTTTG CTGGCAGCGC AGCCTGGGAT GACAGCGCCA GGGCAGCTGG GGGCCAGGGC 
CTCCATGTCA CCGCACTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005599.1
CDS	64..684
Translation	MALPCTLGLGMLLALPGALGSGGSAEDSVGSSSVTVVLLLLLLLLLATGLALAWRRLSRDSGGYYHPARLGAALWGRTRRLLWASPPGRWLQARAELGSTDNDLERQEDEQDTDYDHVADGGLQADPGEGEQQCGEASSPEQVPVRAEEARDSDTEGDLVLGSPGPASAGGSAEALLSDLHAFAGSAAWDDSARAAGGQGLHVTAL

Target ORF information:

RefSeq Version	NM_005608.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protein tyrosine phosphatase receptor type C associated protein (PTPRCAP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005608.3

ORF Insert Sequence:

ATGGCTCTGC CCTGCACCTT AGGGCTCGGG ATGCTGCTGG CCCTGCCAGG GGCCTTGGGC 
TCGGGTGGCA GCGCGGAGGA CAGCGTGGGC TCCAGCTCTG TCACCGTTGT CCTGCTGCTG 
CTGCTGCTCC TACTGCTGGC CACTGGCCTA GCACTGGCCT GGCGCCGCCT CAGCCGTGAC 
TCAGGGGGCT ACTACCACCC GGCCCGCCTA GGTGCCGCGC TGTGGGGCCG CACGCGGCGC 
CTGCTCTGGG CCAGCCCCCC AGGTCGCTGG CTGCAGGCCC GAGCTGAGCT GGGGTCCACA 
GACAATGACC TTGAGCGACA GGAGGATGAG CAGGACACAG ACTATGACCA CGTCGCGGAT 
GGTGGCCTGC AGGCTGACCC TGGGGAAGGC GAGCAGCAAT GTGGAGAGGC GTCCAGCCCA 
GAGCAGGTCC CCGTGCGGGC TGAGGAAGCC AGAGACAGTG ACACGGAGGG CGACCTGGTC 
CTCGGCTCCC CAGGACCAGC GAGCGCAGGG GGCAGTGCTG AGGCCCTGCT GAGTGACCTG 
CACGCCTTTG CTGGCAGCGC AGCCTGGGAT GACAGCGCCA GGGCAGCTGG GGGCCAGGGC 
CTCCATGTCA CCGCACTGTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Constitutive and activation-dependent phosphorylation of lymphocyte phosphatase-associated phosphoprotein (LPAP).
PloS one12(8)e0182468(2017)
Kruglova NA,Meshkova TD,Kopylov AT,Mazurov DV,Filatov AV

A regulatory polymorphism at position -309 in PTPRCAP is associated with susceptibility to diffuse-type gastric cancer and gene expression.
Neoplasia (New York, N.Y.)11(12)1340-7(2009 Dec)
Ju H,Lim B,Kim M,Kim YS,Kim WH,Ihm C,Noh SM,Han DS,Yu HJ,Choi BY,Kang C

PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients.
Journal of neurology251(9)1085-8(2004 Sep)
Cocco E,Murru MR,Melis C,Schirru L,Solla E,Lai M,Rolesu M,Marrosu MG

77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link.
Genes and immunity4(1)79-81(2003 Jan)
Vogel A,Strassburg CP,Manns MP

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PTPRCAP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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