RAP2C cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAP2C
Entrez Gene ID	57826
Full Name	RAP2C, member of RAS oncogene family
General protein information	Preferred Names RAP2C, member of RAS oncogene family Names ras-related protein Rap-2c small GTPase RAP2C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq26.2
Summary	The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily. Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation, differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of the serum response element. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001271187.1	NP_001258116.1	ras-related protein Rap-2c isoform 2
NM_001271186.1	NP_001258115.1	ras-related protein Rap-2c isoform 1 precursor
XM_011531376.1	XP_011529678.1	ras-related protein Rap-2c isoform X1
XM_006724775.2	XP_006724838.1	ras-related protein Rap-2c isoform X2
NM_001271186.2	NP_001258115.1	ras-related protein Rap-2c isoform 1 precursor
NM_021183.4	NP_067006.3	ras-related protein Rap-2c isoform 1 precursor
NM_021183.5	NP_067006.3	ras-related protein Rap-2c isoform 1 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RAP2C	XP_538176.3
Bos taurus (cattle)	RAP2C	NP_001069168.1
Rattus norvegicus (Norway rat)	Rap2c	NP_001100420.1
Danio rerio (zebrafish)	rap2c	NP_001007056.1
Xenopus tropicalis (tropical clawed frog)	rap2c	NP_001016898.1
Mus musculus (house mouse)	Rap2c	NP_766001.1
Homo sapiens (human)	RAP2C	NP_001258115.1
	RAP2C	XP_001096020.1

Gene Ontology
Bibliography

Related articles in PubMed

Spinal cord ischemia-reperfusion causes damage of neurocyte by inhibiting RAP2C.
Qiao Y, Peng C, Li J, Wu D, Wang X
Neurological research39(10)877-884(2017 Oct)

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
Molecular biology of the cell24(18)2849-60(2013 Sep)

Rap2A links intestinal cell polarity to brush border formation.
Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ, Clevers H, Bos JL
Nature cell biology14(8)793-801(2012 Aug)

A computational approach to candidate gene prioritization for X-linked mental retardation using annotation-based binary filtering and motif-based linear discriminatory analysis.
Lombard Z, Park C, Makova KD, Ramsay M
Biology direct630(2011 Jun)

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W
Immunology and cell biology88(8)851-6(2010 Nov-Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton.
Title: JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.

RAP2C is a novel member of the Ras family, belonging to the Rap branch of small GTPase proteins and may be involved in SRE-mediated gene transcription.
Title: Cloning and characterization of the human gene RAP2C, a novel member of Ras family, which activates transcriptional activities of SRE.

This work demonstrates that Rap2C is a new member of the Rap2 subfamily of proteins, able to bind guanine nucleotides with peculiar properties, and differently expressed by various hematopoietic subsets
Title: Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins.

The following RAP2C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAP2C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09964	NM_001271186.2 Latest version!	Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu09751	NM_001271187.1 Latest version!	Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu09751	XM_006724775.2 Latest version!	Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu09964	NM_021183.5 Latest version!	Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu09964	XM_011531376.1 Latest version!	Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu09964	NM_001271186.1	Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu09964	NM_021183.4	Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAP2C ( NM_001271186.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258115.1 Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09964
Clone ID Related Accession (Same CDS sequence)	NM_001271186.1 , XM_011531376.1 , NM_001271186.2 , NM_021183.4 , NM_021183.5
Accession Version	NM_001271186.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	ras-related protein Rap-2c isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX399437.2, DB252216.1, BC035382.1 and AY298955.1. On Nov 23, 2018 this sequence version replaced NM_001271186.1. Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035382.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2153980 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370874.2/ ENSP00000359911.1 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGGGAAT ACAAGGTAGT GGTGTTAGGG AGTGGAGGGG TTGGCAAATC TGCCCTTACT 
GTGCAGTTTG TCACTGGGAC TTTCATTGAG AAATATGACC CCACCATTGA AGATTTCTAC 
CGCAAAGAGA TCGAAGTGGA CTCTTCCCCC TCCGTGCTGG AAATTCTGGA CACCGCAGGA 
ACTGAGCAGT TTGCCTCCAT GAGAGATCTC TACATCAAAA ACGGCCAAGG TTTCATCCTG 
GTTTATAGCC TGGTTAATCA ACAGTCTTTT CAGGATATCA AGCCAATGAG AGATCAAATT 
GTCAGAGTGA AGAGATATGA AAAAGTCCCA CTAATCCTAG TAGGAAATAA AGTGGATCTG 
GAACCAGAAA GAGAGGTTAT GTCTTCAGAA GGCAGAGCTC TGGCTCAAGA ATGGGGCTGT 
CCTTTCATGG AGACATCGGC AAAAAGTAAA TCAATGGTGG ATGAACTTTT TGCTGAGATC 
GTCAGGCAAA TGAACTATTC ATCCCTGCCG GAGAAGCAAG ATCAGTGTTG TACAACTTGT 
GTCGTCCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258115.1
CDS	824..1375
Translation	MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ

Target ORF information:

RefSeq Version	NM_001271186.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271186.2

ORF Insert Sequence:

ATGAGGGAAT ACAAGGTAGT GGTGTTAGGG AGTGGAGGGG TTGGCAAATC TGCCCTTACT 
GTGCAGTTTG TCACTGGGAC TTTCATTGAG AAATATGACC CCACCATTGA AGATTTCTAC 
CGCAAAGAGA TCGAAGTGGA CTCTTCCCCC TCCGTGCTGG AAATTCTGGA CACCGCAGGA 
ACTGAGCAGT TTGCCTCCAT GAGAGATCTC TACATCAAAA ACGGCCAAGG TTTCATCCTG 
GTTTATAGCC TGGTTAATCA ACAGTCTTTT CAGGATATCA AGCCAATGAG AGATCAAATT 
GTCAGAGTGA AGAGATATGA AAAAGTCCCA CTAATCCTAG TAGGAAATAA AGTGGATCTG 
GAACCAGAAA GAGAGGTTAT GTCTTCAGAA GGCAGAGCTC TGGCTCAAGA ATGGGGCTGT 
CCTTTCATGG AGACATCGGC AAAAAGTAAA TCAATGGTGG ATGAACTTTT TGCTGAGATC 
GTCAGGCAAA TGAACTATTC ATCCCTGCCG GAGAAGCAAG ATCAGTGTTG TACAACTTGT 
GTCGTCCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAP2C ( NM_001271187.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258116.1 Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu09751
Clone ID Related Accession (Same CDS sequence)	NM_001271187.1 , XM_006724775.2
Accession Version	NM_001271187.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-09-11
Organism	Homo sapiens(human)
Product	ras-related protein Rap-2c isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX399437.2, AK310997.1, BI767215.1, CN308919.1, AY298955.1 and DB535605.1. Transcript Variant: This variant (3) uses an alternate 5' structure, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BX647223.1, SRR1163657.364823.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGAGATC TCTACATCAA AAACGGCCAA GGTTTCATCC TGGTTTATAG CCTGGTTAAT 
CAACAGTCTT TTCAGGATAT CAAGCCAATG AGAGATCAAA TTGTCAGAGT GAAGAGATAT 
GAAAAAGTCC CACTAATCCT AGTAGGAAAT AAAGTGGATC TGGAACCAGA AAGAGAGGTT 
ATGTCTTCAG AAGGCAGAGC TCTGGCTCAA GAATGGGGCT GTCCTTTCAT GGAGACATCG 
GCAAAAAGTA AATCAATGGT GGATGAACTT TTTGCTGAGA TCGTCAGGCA AATGAACTAT 
TCATCCCTGC CGGAGAAGCA AGATCAGTGT TGTACAACTT GTGTCGTCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258116.1
CDS	390..743
Translation	MRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ

Target ORF information:

RefSeq Version	NM_001271187.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271187.1

ORF Insert Sequence:

ATGAGAGATC TCTACATCAA AAACGGCCAA GGTTTCATCC TGGTTTATAG CCTGGTTAAT 
CAACAGTCTT TTCAGGATAT CAAGCCAATG AGAGATCAAA TTGTCAGAGT GAAGAGATAT 
GAAAAAGTCC CACTAATCCT AGTAGGAAAT AAAGTGGATC TGGAACCAGA AAGAGAGGTT 
ATGTCTTCAG AAGGCAGAGC TCTGGCTCAA GAATGGGGCT GTCCTTTCAT GGAGACATCG 
GCAAAAAGTA AATCAATGGT GGATGAACTT TTTGCTGAGA TCGTCAGGCA AATGAACTAT 
TCATCCCTGC CGGAGAAGCA AGATCAGTGT TGTACAACTT GTGTCGTCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAP2C ( XM_006724775.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_006724838.1 Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu09751
Clone ID Related Accession (Same CDS sequence)	NM_001271187.1 , XM_006724775.2
Accession Version	XM_006724775.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ras-related protein Rap-2c isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_006724775.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGAGATC TCTACATCAA AAACGGCCAA GGTTTCATCC TGGTTTATAG CCTGGTTAAT 
CAACAGTCTT TTCAGGATAT CAAGCCAATG AGAGATCAAA TTGTCAGAGT GAAGAGATAT 
GAAAAAGTCC CACTAATCCT AGTAGGAAAT AAAGTGGATC TGGAACCAGA AAGAGAGGTT 
ATGTCTTCAG AAGGCAGAGC TCTGGCTCAA GAATGGGGCT GTCCTTTCAT GGAGACATCG 
GCAAAAAGTA AATCAATGGT GGATGAACTT TTTGCTGAGA TCGTCAGGCA AATGAACTAT 
TCATCCCTGC CGGAGAAGCA AGATCAGTGT TGTACAACTT GTGTCGTCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006724838.1
CDS	713..1066
Translation	MRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ

Target ORF information:

RefSeq Version	XM_006724775.2
Organism	Homo sapiens(human)
Definition	Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006724775.2

ORF Insert Sequence:

ATGAGAGATC TCTACATCAA AAACGGCCAA GGTTTCATCC TGGTTTATAG CCTGGTTAAT 
CAACAGTCTT TTCAGGATAT CAAGCCAATG AGAGATCAAA TTGTCAGAGT GAAGAGATAT 
GAAAAAGTCC CACTAATCCT AGTAGGAAAT AAAGTGGATC TGGAACCAGA AAGAGAGGTT 
ATGTCTTCAG AAGGCAGAGC TCTGGCTCAA GAATGGGGCT GTCCTTTCAT GGAGACATCG 
GCAAAAAGTA AATCAATGGT GGATGAACTT TTTGCTGAGA TCGTCAGGCA AATGAACTAT 
TCATCCCTGC CGGAGAAGCA AGATCAGTGT TGTACAACTT GTGTCGTCCA GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAP2C ( NM_001271186.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001258115.1 Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09964
Clone ID Related Accession (Same CDS sequence)	NM_001271186.1 , XM_011531376.1 , NM_001271186.2 , NM_021183.4 , NM_021183.5
Accession Version	NM_001271186.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	ras-related protein Rap-2c isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX399437.2, DB252216.1, BC035382.1, AY298955.1 and DB535605.1. Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC035382.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2153980 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGGAAT ACAAGGTAGT GGTGTTAGGG AGTGGAGGGG TTGGCAAATC TGCCCTTACT 
GTGCAGTTTG TCACTGGGAC TTTCATTGAG AAATATGACC CCACCATTGA AGATTTCTAC 
CGCAAAGAGA TCGAAGTGGA CTCTTCCCCC TCCGTGCTGG AAATTCTGGA CACCGCAGGA 
ACTGAGCAGT TTGCCTCCAT GAGAGATCTC TACATCAAAA ACGGCCAAGG TTTCATCCTG 
GTTTATAGCC TGGTTAATCA ACAGTCTTTT CAGGATATCA AGCCAATGAG AGATCAAATT 
GTCAGAGTGA AGAGATATGA AAAAGTCCCA CTAATCCTAG TAGGAAATAA AGTGGATCTG 
GAACCAGAAA GAGAGGTTAT GTCTTCAGAA GGCAGAGCTC TGGCTCAAGA ATGGGGCTGT 
CCTTTCATGG AGACATCGGC AAAAAGTAAA TCAATGGTGG ATGAACTTTT TGCTGAGATC 
GTCAGGCAAA TGAACTATTC ATCCCTGCCG GAGAAGCAAG ATCAGTGTTG TACAACTTGT 
GTCGTCCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001258115.1
CDS	857..1408
Translation	MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ

Target ORF information:

RefSeq Version	NM_001271186.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001271186.1

ORF Insert Sequence:

ATGAGGGAAT ACAAGGTAGT GGTGTTAGGG AGTGGAGGGG TTGGCAAATC TGCCCTTACT 
GTGCAGTTTG TCACTGGGAC TTTCATTGAG AAATATGACC CCACCATTGA AGATTTCTAC 
CGCAAAGAGA TCGAAGTGGA CTCTTCCCCC TCCGTGCTGG AAATTCTGGA CACCGCAGGA 
ACTGAGCAGT TTGCCTCCAT GAGAGATCTC TACATCAAAA ACGGCCAAGG TTTCATCCTG 
GTTTATAGCC TGGTTAATCA ACAGTCTTTT CAGGATATCA AGCCAATGAG AGATCAAATT 
GTCAGAGTGA AGAGATATGA AAAAGTCCCA CTAATCCTAG TAGGAAATAA AGTGGATCTG 
GAACCAGAAA GAGAGGTTAT GTCTTCAGAA GGCAGAGCTC TGGCTCAAGA ATGGGGCTGT 
CCTTTCATGG AGACATCGGC AAAAAGTAAA TCAATGGTGG ATGAACTTTT TGCTGAGATC 
GTCAGGCAAA TGAACTATTC ATCCCTGCCG GAGAAGCAAG ATCAGTGTTG TACAACTTGT 
GTCGTCCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAP2C ( NM_021183.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_067006.3 Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu09964
Clone ID Related Accession (Same CDS sequence)	NM_001271186.1 , XM_011531376.1 , NM_001271186.2 , NM_021183.4 , NM_021183.5
Accession Version	NM_021183.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	ras-related protein Rap-2c isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY298955.1 and DB535605.1. On or before Aug 31, 2013 this sequence version replaced XM_005262451.1, NM_021183.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY298955.1, BC051467.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2153980 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGGAAT ACAAGGTAGT GGTGTTAGGG AGTGGAGGGG TTGGCAAATC TGCCCTTACT 
GTGCAGTTTG TCACTGGGAC TTTCATTGAG AAATATGACC CCACCATTGA AGATTTCTAC 
CGCAAAGAGA TCGAAGTGGA CTCTTCCCCC TCCGTGCTGG AAATTCTGGA CACCGCAGGA 
ACTGAGCAGT TTGCCTCCAT GAGAGATCTC TACATCAAAA ACGGCCAAGG TTTCATCCTG 
GTTTATAGCC TGGTTAATCA ACAGTCTTTT CAGGATATCA AGCCAATGAG AGATCAAATT 
GTCAGAGTGA AGAGATATGA AAAAGTCCCA CTAATCCTAG TAGGAAATAA AGTGGATCTG 
GAACCAGAAA GAGAGGTTAT GTCTTCAGAA GGCAGAGCTC TGGCTCAAGA ATGGGGCTGT 
CCTTTCATGG AGACATCGGC AAAAAGTAAA TCAATGGTGG ATGAACTTTT TGCTGAGATC 
GTCAGGCAAA TGAACTATTC ATCCCTGCCG GAGAAGCAAG ATCAGTGTTG TACAACTTGT 
GTCGTCCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067006.3
CDS	785..1336
Translation	MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ

Target ORF information:

RefSeq Version	NM_021183.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021183.4

ORF Insert Sequence:

ATGAGGGAAT ACAAGGTAGT GGTGTTAGGG AGTGGAGGGG TTGGCAAATC TGCCCTTACT 
GTGCAGTTTG TCACTGGGAC TTTCATTGAG AAATATGACC CCACCATTGA AGATTTCTAC 
CGCAAAGAGA TCGAAGTGGA CTCTTCCCCC TCCGTGCTGG AAATTCTGGA CACCGCAGGA 
ACTGAGCAGT TTGCCTCCAT GAGAGATCTC TACATCAAAA ACGGCCAAGG TTTCATCCTG 
GTTTATAGCC TGGTTAATCA ACAGTCTTTT CAGGATATCA AGCCAATGAG AGATCAAATT 
GTCAGAGTGA AGAGATATGA AAAAGTCCCA CTAATCCTAG TAGGAAATAA AGTGGATCTG 
GAACCAGAAA GAGAGGTTAT GTCTTCAGAA GGCAGAGCTC TGGCTCAAGA ATGGGGCTGT 
CCTTTCATGG AGACATCGGC AAAAAGTAAA TCAATGGTGG ATGAACTTTT TGCTGAGATC 
GTCAGGCAAA TGAACTATTC ATCCCTGCCG GAGAAGCAAG ATCAGTGTTG TACAACTTGT 
GTCGTCCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAP2C ( NM_021183.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_067006.3 Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 2, mRNA.

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CloneID	OHu09964
Clone ID Related Accession (Same CDS sequence)	NM_001271186.1 , XM_011531376.1 , NM_001271186.2 , NM_021183.4 , NM_021183.5
Accession Version	NM_021183.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	ras-related protein Rap-2c isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY298955.1. On May 31, 2019 this sequence version replaced NM_021183.4. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY298955.1, BC051467.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2153980 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGGGAAT ACAAGGTAGT GGTGTTAGGG AGTGGAGGGG TTGGCAAATC TGCCCTTACT 
GTGCAGTTTG TCACTGGGAC TTTCATTGAG AAATATGACC CCACCATTGA AGATTTCTAC 
CGCAAAGAGA TCGAAGTGGA CTCTTCCCCC TCCGTGCTGG AAATTCTGGA CACCGCAGGA 
ACTGAGCAGT TTGCCTCCAT GAGAGATCTC TACATCAAAA ACGGCCAAGG TTTCATCCTG 
GTTTATAGCC TGGTTAATCA ACAGTCTTTT CAGGATATCA AGCCAATGAG AGATCAAATT 
GTCAGAGTGA AGAGATATGA AAAAGTCCCA CTAATCCTAG TAGGAAATAA AGTGGATCTG 
GAACCAGAAA GAGAGGTTAT GTCTTCAGAA GGCAGAGCTC TGGCTCAAGA ATGGGGCTGT 
CCTTTCATGG AGACATCGGC AAAAAGTAAA TCAATGGTGG ATGAACTTTT TGCTGAGATC 
GTCAGGCAAA TGAACTATTC ATCCCTGCCG GAGAAGCAAG ATCAGTGTTG TACAACTTGT 
GTCGTCCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067006.3
CDS	657..1208
Translation	MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ

Target ORF information:

RefSeq Version	NM_021183.5
Organism	Homo sapiens(human)
Definition	Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021183.5

ORF Insert Sequence:

ATGAGGGAAT ACAAGGTAGT GGTGTTAGGG AGTGGAGGGG TTGGCAAATC TGCCCTTACT 
GTGCAGTTTG TCACTGGGAC TTTCATTGAG AAATATGACC CCACCATTGA AGATTTCTAC 
CGCAAAGAGA TCGAAGTGGA CTCTTCCCCC TCCGTGCTGG AAATTCTGGA CACCGCAGGA 
ACTGAGCAGT TTGCCTCCAT GAGAGATCTC TACATCAAAA ACGGCCAAGG TTTCATCCTG 
GTTTATAGCC TGGTTAATCA ACAGTCTTTT CAGGATATCA AGCCAATGAG AGATCAAATT 
GTCAGAGTGA AGAGATATGA AAAAGTCCCA CTAATCCTAG TAGGAAATAA AGTGGATCTG 
GAACCAGAAA GAGAGGTTAT GTCTTCAGAA GGCAGAGCTC TGGCTCAAGA ATGGGGCTGT 
CCTTTCATGG AGACATCGGC AAAAAGTAAA TCAATGGTGG ATGAACTTTT TGCTGAGATC 
GTCAGGCAAA TGAACTATTC ATCCCTGCCG GAGAAGCAAG ATCAGTGTTG TACAACTTGT 
GTCGTCCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAP2C ( XM_011531376.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011529678.1 Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant X1, mRNA.

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CloneID	OHu09964
Clone ID Related Accession (Same CDS sequence)	NM_001271186.1 , XM_011531376.1 , NM_001271186.2 , NM_021183.4 , NM_021183.5
Accession Version	XM_011531376.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ras-related protein Rap-2c isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGGGAAT ACAAGGTAGT GGTGTTAGGG AGTGGAGGGG TTGGCAAATC TGCCCTTACT 
GTGCAGTTTG TCACTGGGAC TTTCATTGAG AAATATGACC CCACCATTGA AGATTTCTAC 
CGCAAAGAGA TCGAAGTGGA CTCTTCCCCC TCCGTGCTGG AAATTCTGGA CACCGCAGGA 
ACTGAGCAGT TTGCCTCCAT GAGAGATCTC TACATCAAAA ACGGCCAAGG TTTCATCCTG 
GTTTATAGCC TGGTTAATCA ACAGTCTTTT CAGGATATCA AGCCAATGAG AGATCAAATT 
GTCAGAGTGA AGAGATATGA AAAAGTCCCA CTAATCCTAG TAGGAAATAA AGTGGATCTG 
GAACCAGAAA GAGAGGTTAT GTCTTCAGAA GGCAGAGCTC TGGCTCAAGA ATGGGGCTGT 
CCTTTCATGG AGACATCGGC AAAAAGTAAA TCAATGGTGG ATGAACTTTT TGCTGAGATC 
GTCAGGCAAA TGAACTATTC ATCCCTGCCG GAGAAGCAAG ATCAGTGTTG TACAACTTGT 
GTCGTCCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011529678.1
CDS	925..1476
Translation	MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDLEPEREVMSSEGRALAQEWGCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTTCVVQ

Target ORF information:

RefSeq Version	XM_011531376.1
Organism	Homo sapiens(human)
Definition	Homo sapiens RAP2C, member of RAS oncogene family (RAP2C), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011531376.1

ORF Insert Sequence:

ATGAGGGAAT ACAAGGTAGT GGTGTTAGGG AGTGGAGGGG TTGGCAAATC TGCCCTTACT 
GTGCAGTTTG TCACTGGGAC TTTCATTGAG AAATATGACC CCACCATTGA AGATTTCTAC 
CGCAAAGAGA TCGAAGTGGA CTCTTCCCCC TCCGTGCTGG AAATTCTGGA CACCGCAGGA 
ACTGAGCAGT TTGCCTCCAT GAGAGATCTC TACATCAAAA ACGGCCAAGG TTTCATCCTG 
GTTTATAGCC TGGTTAATCA ACAGTCTTTT CAGGATATCA AGCCAATGAG AGATCAAATT 
GTCAGAGTGA AGAGATATGA AAAAGTCCCA CTAATCCTAG TAGGAAATAA AGTGGATCTG 
GAACCAGAAA GAGAGGTTAT GTCTTCAGAA GGCAGAGCTC TGGCTCAAGA ATGGGGCTGT 
CCTTTCATGG AGACATCGGC AAAAAGTAAA TCAATGGTGG ATGAACTTTT TGCTGAGATC 
GTCAGGCAAA TGAACTATTC ATCCCTGCCG GAGAAGCAAG ATCAGTGTTG TACAACTTGT 
GTCGTCCAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Spinal cord ischemia-reperfusion causes damage of neurocyte by inhibiting RAP2C.
Neurological research39(10)877-884(2017 Oct)
Qiao Y,Peng C,Li J,Wu D,Wang X

JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
Molecular biology of the cell24(18)2849-60(2013 Sep)
Monteiro AC,Sumagin R,Rankin CR,Leoni G,Mina MJ,Reiter DM,Stehle T,Dermody TS,Schaefer SA,Hall RA,Nusrat A,Parkos CA

Rap2A links intestinal cell polarity to brush border formation.
Nature cell biology14(8)793-801(2012 Aug)
Gloerich M,ten Klooster JP,Vliem MJ,Koorman T,Zwartkruis FJ,Clevers H,Bos JL

A computational approach to candidate gene prioritization for X-linked mental retardation using annotation-based binary filtering and motif-based linear discriminatory analysis.
Biology direct630(2011 Jun)
Lombard Z,Park C,Makova KD,Ramsay M

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Immunology and cell biology88(8)851-6(2010 Nov-Dec)
Buschow SI,van Balkom BW,Aalberts M,Heck AJ,Wauben M,Stoorvogel W

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RAP2C cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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