KIR2DL5A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KIR2DL5A
Entrez Gene ID	57292
Full Name	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A
Synonyms	CD158F,KIR2DL5,KIR2DL5.1,KIR2DL5.3
General protein information	Preferred Names killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A Names killer cell immunoglobulin-like receptor 2DL5A killer cell immunoglobulin-like receptor KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008].
Disorder MIM:	605305

mRNA and Protein(s)

mRNA	Protein	Name
NM_020535.3	NP_065396.1	killer cell immunoglobulin-like receptor 2DL5A precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

The effect of killer cell immunoglobulin-like receptor genotype on outcome of hematopoietic stem cell transplantation from matched sibling.
Elfishawi SM, Mossallam GI, El-Fattah RA, El-Haddad A, Kamel AM
Human immunology78(11-12)684-691(2017 Nov)

KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth.
Anastasaki C, Dahiya S, Gutmann DH
Oncotarget8(29)47574-47585(2017 Jul)

Association of the genetic diversity of killer cell immunoglobulin-like receptor genes and HLA-C ligand in Saudi women with breast cancer.
Alomar SY, Alkhuriji A, Trayhyrn P, Alhetheel A, Al-Jurayyan A, Mansour L
Immunogenetics69(2)69-76(2017 Feb)

Killer-cell immunoglobulin-like receptors and cytomegalovirus reactivation during late pregnancy.
Alvarado-Hern?ndez DL, Ben?tez-S?nchez A, Rodr?guez-Cuevas JS, Rosales-Saavedra T, Guerra-Palomares SE, Comas-Garc?a A, Noyola DE, Garc?a-Sep?lveda CA
International journal of immunogenetics43(4)189-99(2016 Aug)

The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to HIV-1 infection in the Polish population.
Zwoli?ska K, B?achowicz O, Tomczyk T, Knysz B, G?siorowski J, Zalewska M, Orzechowska BU, Sochocka M, Piasecki E
Immunogenetics68(5)327-37(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Loss of KIR2DL5A gene is associated with breast cancer.
Title: Association of the genetic diversity of killer cell immunoglobulin-like receptor genes and HLA-C ligand in Saudi women with breast cancer.

We observed statistically lower carrier frequencies of cB03|tA01 gene-content haplotype, of cB03 haplotype motif, of the KIR2DL5 + 2DS3/2DS5 gene pair and of KIR2DL5 amongst CMV-positive pregnant women in comparison with those CMV negative
Title: Killer-cell immunoglobulin-like receptors and cytomegalovirus reactivation during late pregnancy.

KIR2DL5 gene polymorphism is associated with HIV-1 infection.
Title: The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to HIV-1 infection in the Polish population.

Data show that KIR2DL5 receptor, KIR2DS1 protein, KIR2DS5 protein and KIR3DS1 receptors were all significantly associated with high viral load.
Title: Killer immunoglobulin-like receptor gene repertoire influences viral load of primary human cytomegalovirus infection in renal transplant patients.

The genes KIR2DL5, KIR2DS3 and KIR2DS5 were present in a significantly higher proportion of individuals in the asymptomatic control group than in the malaria cases.
Title: Killer-cell immunoglobulin-like receptors and falciparum malaria in southwest Nigeria.

The following KIR2DL5A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KIR2DL5A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu25683	NM_020535.3 Latest version!	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A (KIR2DL5A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KIR2DL5A ( NM_020535.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065396.1 Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A (KIR2DL5A), mRNA.

Price & Availability↑

CloneID	OHu25683
Clone ID Related Accession (Same CDS sequence)	NM_020535.3
Accession Version	NM_020535.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1128bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-23
Organism	Homo sapiens(human)
Product	killer cell immunoglobulin-like receptor 2DL5A precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF204903.1. On or before Mar 4, 2006 this sequence version replaced XM_936740.1, NM_020535.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF204903.1, AF271607.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTCGCTCA TGGTCATCAG CATGGCGTGT GTTGGGTTCT TCTTGCTGCA GGGGGCCTGG 
ACACATGAGG GTGGTCAGGA CAAGCCCTTG CTGTCTGCCT GGCCCAGCGC TGTGGTGCCT 
CGAGGAGGAC ATGTGACTCT TCTGTGTCGC TCTCGTCTTG GGTTTACCAT CTTCAGTCTG 
TACAAAGAAG ATGGGGTGCC TGTCCCTGAG CTCTACAACA AAATATTCTG GAAGAGCATC 
CTCATGGGCC CTGTGACCCC TGCACACGCA GGGACCTACA GATGTCGGGG TTCACACCCA 
CGCTCCCCCA TTGAGTGGTC AGCACCCAGC AACCCCCTGG TGATCGTGGT CACAGGTCTA 
TTTGGGAAAC CTTCACTCTC AGCCCAGCCG GGCCCCACGG TTCGCACAGG AGAGAACGTG 
ACCTTGTCCT GCAGCTCCAG GAGCTCATTT GACATGTACC ATCTATCCAG GGAGGGGAGG 
GCCCATGAAC CTAGGCTCCC TGCAGTGCCC AGCGTCAATG GAACATTCCA GGCTGACTTT 
CCTCTGGGCC CTGCCACCCA CGGAGGGACC TACACATGCT TCGGCTCTCT CCATGACTCA 
CCCTATGAGT GGTCAGACCC GAGTGACCCA CTGCTTGTTT CTGTCACAGG AAACTCTTCA 
AGTAGTTCAT CTTCACCCAC TGAACCAAGC TCCAAAACTG GTATCCGCAG ACACCTGCAC 
ATTCTGATTG GGACCTCAGT GGCTATCATC CTCTTCATCA TCCTCTTCTT CTTTCTCCTT 
CATTGCTGCT GCTCCAACAA AAAGAATGCT GCTGTAATGG ACCAAGAGCC TGCCGGGGAC 
AGAACAGTGA ACAGGGAGGA CTCTGATGAT CAAGACCCTC AGGAGGTGAC ATATGCACAG 
TTGGATCACT GCGTTTTCAC ACAGACAAAA ATCACTTCCC CTTCTCAGAG GCCCAAGACA 
CCTCCAACAG ATACCACCAT GTACATGGAA CTTCCAAATG CTAAGCCAAG ATCATTGTCT 
CCTGCCCATA AGCACCACAG TCAGGCCTTG AGGGGATCTT CTAGGGAGAC AACAGCCCTG 
TCTCAAAACC GGGTTGCTAG CTCCCATGTA CCAGCAGCTG GAATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065396.1
CDS	56..1183
Translation	MSLMVISMACVGFFLLQGAWTHEGGQDKPLLSAWPSAVVPRGGHVTLLCRSRLGFTIFSLYKEDGVPVPELYNKIFWKSILMGPVTPAHAGTYRCRGSHPRSPIEWSAPSNPLVIVVTGLFGKPSLSAQPGPTVRTGENVTLSCSSRSSFDMYHLSREGRAHEPRLPAVPSVNGTFQADFPLGPATHGGTYTCFGSLHDSPYEWSDPSDPLLVSVTGNSSSSSSSPTEPSSKTGIRRHLHILIGTSVAIILFIILFFFLLHCCCSNKKNAAVMDQEPAGDRTVNREDSDDQDPQEVTYAQLDHCVFTQTKITSPSQRPKTPPTDTTMYMELPNAKPRSLSPAHKHHSQALRGSSRETTALSQNRVASSHVPAAGI

Target ORF information:

RefSeq Version	NM_020535.3
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A (KIR2DL5A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020535.3

ORF Insert Sequence:

ATGTCGCTCA TGGTCATCAG CATGGCGTGT GTTGGGTTCT TCTTGCTGCA GGGGGCCTGG 
ACACATGAGG GTGGTCAGGA CAAGCCCTTG CTGTCTGCCT GGCCCAGCGC TGTGGTGCCT 
CGAGGAGGAC ATGTGACTCT TCTGTGTCGC TCTCGTCTTG GGTTTACCAT CTTCAGTCTG 
TACAAAGAAG ATGGGGTGCC TGTCCCTGAG CTCTACAACA AAATATTCTG GAAGAGCATC 
CTCATGGGCC CTGTGACCCC TGCACACGCA GGGACCTACA GATGTCGGGG TTCACACCCA 
CGCTCCCCCA TTGAGTGGTC AGCACCCAGC AACCCCCTGG TGATCGTGGT CACAGGTCTA 
TTTGGGAAAC CTTCACTCTC AGCCCAGCCG GGCCCCACGG TTCGCACAGG AGAGAACGTG 
ACCTTGTCCT GCAGCTCCAG GAGCTCATTT GACATGTACC ATCTATCCAG GGAGGGGAGG 
GCCCATGAAC CTAGGCTCCC TGCAGTGCCC AGCGTCAATG GAACATTCCA GGCTGACTTT 
CCTCTGGGCC CTGCCACCCA CGGAGGGACC TACACATGCT TCGGCTCTCT CCATGACTCA 
CCCTATGAGT GGTCAGACCC GAGTGACCCA CTGCTTGTTT CTGTCACAGG AAACTCTTCA 
AGTAGTTCAT CTTCACCCAC TGAACCAAGC TCCAAAACTG GTATCCGCAG ACACCTGCAC 
ATTCTGATTG GGACCTCAGT GGCTATCATC CTCTTCATCA TCCTCTTCTT CTTTCTCCTT 
CATTGCTGCT GCTCCAACAA AAAGAATGCT GCTGTAATGG ACCAAGAGCC TGCCGGGGAC 
AGAACAGTGA ACAGGGAGGA CTCTGATGAT CAAGACCCTC AGGAGGTGAC ATATGCACAG 
TTGGATCACT GCGTTTTCAC ACAGACAAAA ATCACTTCCC CTTCTCAGAG GCCCAAGACA 
CCTCCAACAG ATACCACCAT GTACATGGAA CTTCCAAATG CTAAGCCAAG ATCATTGTCT 
CCTGCCCATA AGCACCACAG TCAGGCCTTG AGGGGATCTT CTAGGGAGAC AACAGCCCTG 
TCTCAAAACC GGGTTGCTAG CTCCCATGTA CCAGCAGCTG GAATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The effect of killer cell immunoglobulin-like receptor genotype on outcome of hematopoietic stem cell transplantation from matched sibling.
Human immunology78(11-12)684-691(2017 Nov)
Elfishawi SM,Mossallam GI,El-Fattah RA,El-Haddad A,Kamel AM

KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth.
Oncotarget8(29)47574-47585(2017 Jul)
Anastasaki C,Dahiya S,Gutmann DH

Association of the genetic diversity of killer cell immunoglobulin-like receptor genes and HLA-C ligand in Saudi women with breast cancer.
Immunogenetics69(2)69-76(2017 Feb)
Alomar SY,Alkhuriji A,Trayhyrn P,Alhetheel A,Al-Jurayyan A,Mansour L

Killer-cell immunoglobulin-like receptors and cytomegalovirus reactivation during late pregnancy.
International journal of immunogenetics43(4)189-99(2016 Aug)
Alvarado-Hern?ndez DL,Ben?tez-S?nchez A,Rodr?guez-Cuevas JS,Rosales-Saavedra T,Guerra-Palomares SE,Comas-Garc?a A,Noyola DE,Garc?a-Sep?lveda CA

The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to HIV-1 infection in the Polish population.
Immunogenetics68(5)327-37(2016 May)
Zwoli?ska K,B?achowicz O,Tomczyk T,Knysz B,G?siorowski J,Zalewska M,Orzechowska BU,Sochocka M,Piasecki E

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KIR2DL5A cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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