TRPV5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TRPV5
Entrez Gene ID	56302
Full Name	transient receptor potential cation channel subfamily V member 5
Synonyms	CAT2,ECAC1,OTRPC3
General protein information	Preferred Names transient receptor potential cation channel subfamily V member 5 Names transient receptor potential cation channel subfamily V member 5 calcium transport protein 2 calcium transporter 2 epithelial calcium channel 1 osm-9-like TRP channel 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q34
Summary	This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level. [provided by RefSeq, Jul 2008].
Disorder MIM:	606679

mRNA and Protein(s)

mRNA	Protein	Name
NM_019841.7	NP_062815.3	transient receptor potential cation channel subfamily V member 5
NM_019841.6	NP_062815.3	transient receptor potential cation channel subfamily V member 5

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	TRPV5	XP_003639604.1
Homo sapiens (human)	TRPV5	NP_062815.2
	TRPV5	XP_001089988.2
Bos taurus (cattle)	TRPV5	XP_005205985.1
Rattus norvegicus (Norway rat)	Trpv5	NP_446239.2
Pan troglodytes (chimpanzee)	TRPV5	XP_519444.3
Mus musculus (house mouse)	Trpv5	NP_001007573.1

Gene Ontology
Bibliography

Related articles in PubMed

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.
Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY
Nature structural & molecular biology25(1)53-60(2018 Jan)

The L530R variation associated with recurrent kidney stones impairs the structure and function of TRPV5.
Wang L, Holmes RP, Peng JB
Biochemical and biophysical research communications492(3)362-367(2017 10)

A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.
Velisetty P, Borbiro I, Kasimova MA, Liu L, Badheka D, Carnevale V, Rohacs T
Scientific reports627652(2016 Jun)

Molecular Modeling of the Structural and Dynamical Changes in Calcium Channel TRPV5 Induced by the African-Specific A563T Variation.
Wang L, Holmes RP, Peng JB
Biochemistry55(8)1254-64(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The alterations may lead to misfolding of TRPV5, reduction in translocation of the channel to the plasma membrane and/or impaired Ca(2+) transport function of the channel, and ultimately disrupt TRPV5-mediated Ca(2+) reabsorption.
Title: The L530R variation associated with recurrent kidney stones impairs the structure and function of TRPV5.

These findings indicate that the A563T variation induces structural, dynamical, and electrostatic changes in the TRPV5 pore, providing structural insight into the functional alterations associated with the A563T variation.
Title: Molecular Modeling of the Structural and Dynamical Changes in Calcium Channel TRPV5 Induced by the African-Specific A563T Variation.

Data found that a TRPV5 polymorphism (rs4236480) was observed to be associated with stone multiplicity of calcium nephrolithiasis, as the risk of stone multiplicity was higher in patients with the TT+CT genotype than in patients with the CC genotype
Title: A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients.

Klotho up-regulates TRPV5 from both the inside and outside of cells.
Title: Klotho up-regulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation-dependent mechanisms.

High TRPV5 expression is aassociated with adenoma of parathyroid glands.
Title: First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation.

The following TRPV5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TRPV5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu70044	NM_019841.7 Latest version!	Homo sapiens transient receptor potential cation channel subfamily V member 5 (TRPV5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu70044	NM_019841.6	Homo sapiens transient receptor potential cation channel subfamily V member 5 (TRPV5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TRPV5 ( NM_019841.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_062815.3 Homo sapiens transient receptor potential cation channel subfamily V member 5 (TRPV5), mRNA.

Price & Availability↑

CloneID	OHu70044
Clone ID Related Accession (Same CDS sequence)	NM_019841.7 , NM_019841.6
Accession Version	NM_019841.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	transient receptor potential cation channel subfamily V member 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC245427.3, BC034740.1 and AF304464.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_019841.6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF304464.1, AJ487965.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968832, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000265310.6/ ENSP00000265310.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGGGGGTT TTCTACCTAA GGCAGAAGGG CCCGGGAGCC AACTCCAGAA ACTTCTGCCC 
TCCTTTCTGG TCAGAGAACA AGACTGGGAC CAGCACCTGG ACAAGCTTCA TATGCTGCAG 
CAGAAGAGGA TTCTAGAGTC TCCACTGCTT CGAGCATCCA AGGAAAATGA CCTGTCTGTT 
CTTAGGCAAC TTCTACTGGA CTGCACCTGT GACGTTCGAC AAAGAGGAGC CCTGGGGGAG 
ACGGCGCTGC ACATAGCAGC CCTCTATGAC AACTTGGAGG CGGCCTTGGT GCTGATGGAG 
GCTGCCCCAG AGCTGGTCTT TGAGCCCACC ACATGTGAGG CTTTTGCAGG TCAGACTGCA 
CTGCACATCG CTGTTGTGAA CCAGAATGTG AACCTGGTGC GTGCCCTGCT CACCCGCAGG 
GCCAGTGTCT CTGCCAGAGC CACAGGCACT GCCTTCCGCC ATAGTCCCCG CAACCTCATC 
TACTTTGGGG AGCACCCTTT GTCCTTTGCT GCCTGTGTGA ACAGCGAGGA GATCGTGCGG 
CTGCTCATTG AGCATGGAGC TGACATCAGG GCCCAGGACT CCCTGGGAAA CACAGTATTA 
CACATCCTCA TCCTCCAGCC CAACAAAACC TTTGCCTGCC AGATGTACAA CCTGCTGCTG 
TCCTATGATG GACATGGGGA CCACCTGCAG CCCCTGGACC TTGTGCCCAA TCACCAGGGT 
CTCACCCCCT TCAAGCTGGC TGGAGTGGAG GGTAACACTG TGATGTTCCA GCACCTGATG 
CAGAAGCGGA GGCACATCCA GTGGACGTAT GGACCCCTGA CCTCCATTCT CTACGACCTC 
ACGGAGATCG ACTCCTGGGG AGAGGAGCTG TCCTTCCTGG AGCTTGTGGT CTCCTCTGAT 
AAACGAGAGG CTCGCCAAAT TCTGGAACAG ACCCCAGTGA AGGAGCTGGT GAGCTTCAAG 
TGGAACAAGT ATGGCCGGCC GTACTTCTGC ATCCTGGCTG CCTTGTACCT GCTCTACATG 
ATCTGCTTTA CTACGTGCTG CGTCTACCGC CCCCTTAAGT TTCGTGGTGG CAACCGCACT 
CATTCTCGAG ACATCACCAT CCTCCAGCAA AAACTACTAC AGGAGGCCTA TGAGACACGT 
GAAGATATCA TCAGGCTGGT GGGGGAGCTG GTGAGCATCG TTGGGGCTGT GATCATCCTG 
CTCCTAGAGA TTCCAGACAT CTTCAGGGTT GGTGCCTCTC GCTATTTTGG AAAGACGATT 
CTTGGGGGGC CATTCCATGT CATCATCATC ACCTATGCCT CCCTGGTGCT GGTGACCATG 
GTGATGCGGC TCACCAACAC CAATGGGGAG GTGGTGCCCA TGTCCTTTGC CCTGGTGCTG 
GGCTGGTGCA GTGTCATGTA TTTCACTCGA GGATTCCAGA TGCTGGGTCC CTTCACCATC 
ATGATCCAGA AGATGATTTT TGGAGACCTA ATGCGTTTCT GCTGGCTGAT GGCTGTGGTC 
ATCTTGGGAT TTGCCTCCGC GTTCTATATC ATTTTCCAGA CAGAGGACCC AACCAGTCTG 
GGGCAATTCT ATGACTACCC CATGGCACTG TTCACCACCT TTGAGCTTTT TCTCACTGTT 
ATTGATGCAC CTGCCAACTA CGACGTGGAC TTGCCCTTCA TGTTCAGCAT TGTCAACTTC 
GCCTTCACCA TCATTGCCAC ACTGCTCATG CTCAACTTGT TCATCGCCAT GATGGGCGAC 
ACCCACTGGA GGGTGGCCCA GGAGAGGGAT GAGCTCTGGA GGGCCCAGGT CGTGGCCACC 
ACAGTGATGC TGGAGCGGAA GCTGCCTCGC TGCCTGTGGC CTCGCTCCGG GATCTGTGGG 
TGCGAATTCG GGCTGGGGGA CCGCTGGTTC CTGCGGGTTG AGAACCACAA TGATCAGAAT 
CCTCTGCGAG TGCTTCGCTA TGTGGAAGTG TTCAAGAACT CAGACAAGGA GGATGACCAG 
GAGCATCCAT CTGAGAAACA GCCCTCTGGG GCTGAGAGTG GGACTCTAGC CAGAGCCTCT 
TTGGCTCTTC CAACTTCCTC CCTGTCCCGG ACCGCGTCCC AGAGCAGCAG TCACCGAGGC 
TGGGAGATCC TTCGTCAAAA CACCCTGGGG CACTTGAATC TTGGACTGAA CCTTAGTGAG 
GGGGATGGAG AGGAGGTCTA CCATTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062815.3
CDS	288..2477
Translation	MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRHSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTVIDAPANYDVDLPFMFSIVNFAFTIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQEHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSEGDGEEVYHF

Target ORF information:

RefSeq Version	NM_019841.7
Organism	Homo sapiens(human)
Definition	Homo sapiens transient receptor potential cation channel subfamily V member 5 (TRPV5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019841.7

ORF Insert Sequence:

ATGGGGGGTT TTCTACCTAA GGCAGAAGGG CCCGGGAGCC AACTCCAGAA ACTTCTGCCC 
TCCTTTCTGG TCAGAGAACA AGACTGGGAC CAGCACCTGG ACAAGCTTCA TATGCTGCAG 
CAGAAGAGGA TTCTAGAGTC TCCACTGCTT CGAGCATCCA AGGAAAATGA CCTGTCTGTT 
CTTAGGCAAC TTCTACTGGA CTGCACCTGT GACGTTCGAC AAAGAGGAGC CCTGGGGGAG 
ACGGCGCTGC ACATAGCAGC CCTCTATGAC AACTTGGAGG CGGCCTTGGT GCTGATGGAG 
GCTGCCCCAG AGCTGGTCTT TGAGCCCACC ACATGTGAGG CTTTTGCAGG TCAGACTGCA 
CTGCACATCG CTGTTGTGAA CCAGAATGTG AACCTGGTGC GTGCCCTGCT CACCCGCAGG 
GCCAGTGTCT CTGCCAGAGC CACAGGCACT GCCTTCCGCC ATAGTCCCCG CAACCTCATC 
TACTTTGGGG AGCACCCTTT GTCCTTTGCT GCCTGTGTGA ACAGCGAGGA GATCGTGCGG 
CTGCTCATTG AGCATGGAGC TGACATCAGG GCCCAGGACT CCCTGGGAAA CACAGTATTA 
CACATCCTCA TCCTCCAGCC CAACAAAACC TTTGCCTGCC AGATGTACAA CCTGCTGCTG 
TCCTATGATG GACATGGGGA CCACCTGCAG CCCCTGGACC TTGTGCCCAA TCACCAGGGT 
CTCACCCCCT TCAAGCTGGC TGGAGTGGAG GGTAACACTG TGATGTTCCA GCACCTGATG 
CAGAAGCGGA GGCACATCCA GTGGACGTAT GGACCCCTGA CCTCCATTCT CTACGACCTC 
ACGGAGATCG ACTCCTGGGG AGAGGAGCTG TCCTTCCTGG AGCTTGTGGT CTCCTCTGAT 
AAACGAGAGG CTCGCCAAAT TCTGGAACAG ACCCCAGTGA AGGAGCTGGT GAGCTTCAAG 
TGGAACAAGT ATGGCCGGCC GTACTTCTGC ATCCTGGCTG CCTTGTACCT GCTCTACATG 
ATCTGCTTTA CTACGTGCTG CGTCTACCGC CCCCTTAAGT TTCGTGGTGG CAACCGCACT 
CATTCTCGAG ACATCACCAT CCTCCAGCAA AAACTACTAC AGGAGGCCTA TGAGACACGT 
GAAGATATCA TCAGGCTGGT GGGGGAGCTG GTGAGCATCG TTGGGGCTGT GATCATCCTG 
CTCCTAGAGA TTCCAGACAT CTTCAGGGTT GGTGCCTCTC GCTATTTTGG AAAGACGATT 
CTTGGGGGGC CATTCCATGT CATCATCATC ACCTATGCCT CCCTGGTGCT GGTGACCATG 
GTGATGCGGC TCACCAACAC CAATGGGGAG GTGGTGCCCA TGTCCTTTGC CCTGGTGCTG 
GGCTGGTGCA GTGTCATGTA TTTCACTCGA GGATTCCAGA TGCTGGGTCC CTTCACCATC 
ATGATCCAGA AGATGATTTT TGGAGACCTA ATGCGTTTCT GCTGGCTGAT GGCTGTGGTC 
ATCTTGGGAT TTGCCTCCGC GTTCTATATC ATTTTCCAGA CAGAGGACCC AACCAGTCTG 
GGGCAATTCT ATGACTACCC CATGGCACTG TTCACCACCT TTGAGCTTTT TCTCACTGTT 
ATTGATGCAC CTGCCAACTA CGACGTGGAC TTGCCCTTCA TGTTCAGCAT TGTCAACTTC 
GCCTTCACCA TCATTGCCAC ACTGCTCATG CTCAACTTGT TCATCGCCAT GATGGGCGAC 
ACCCACTGGA GGGTGGCCCA GGAGAGGGAT GAGCTCTGGA GGGCCCAGGT CGTGGCCACC 
ACAGTGATGC TGGAGCGGAA GCTGCCTCGC TGCCTGTGGC CTCGCTCCGG GATCTGTGGG 
TGCGAATTCG GGCTGGGGGA CCGCTGGTTC CTGCGGGTTG AGAACCACAA TGATCAGAAT 
CCTCTGCGAG TGCTTCGCTA TGTGGAAGTG TTCAAGAACT CAGACAAGGA GGATGACCAG 
GAGCATCCAT CTGAGAAACA GCCCTCTGGG GCTGAGAGTG GGACTCTAGC CAGAGCCTCT 
TTGGCTCTTC CAACTTCCTC CCTGTCCCGG ACCGCGTCCC AGAGCAGCAG TCACCGAGGC 
TGGGAGATCC TTCGTCAAAA CACCCTGGGG CACTTGAATC TTGGACTGAA CCTTAGTGAG 
GGGGATGGAG AGGAGGTCTA CCATTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRPV5 ( NM_019841.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_062815.3 Homo sapiens transient receptor potential cation channel subfamily V member 5 (TRPV5), mRNA.

Price & Availability↑

CloneID	OHu70044
Clone ID Related Accession (Same CDS sequence)	NM_019841.7 , NM_019841.6
Accession Version	NM_019841.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2190bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	transient receptor potential cation channel subfamily V member 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC034740.1, AF304464.1 and AC245427.3. This sequence is a reference standard in the RefSeqGene project. On Dec 9, 2014 this sequence version replaced NM_019841.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF304464.1, AJ487965.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968832, SAMEA1968968 [ECO:0000350] ##Evidence-Data-END##

ATGGGGGGTT TTCTACCTAA GGCAGAAGGG CCCGGGAGCC AACTCCAGAA ACTTCTGCCC 
TCCTTTCTGG TCAGAGAACA AGACTGGGAC CAGCACCTGG ACAAGCTTCA TATGCTGCAG 
CAGAAGAGGA TTCTAGAGTC TCCACTGCTT CGAGCATCCA AGGAAAATGA CCTGTCTGTT 
CTTAGGCAAC TTCTACTGGA CTGCACCTGT GACGTTCGAC AAAGAGGAGC CCTGGGGGAG 
ACGGCGCTGC ACATAGCAGC CCTCTATGAC AACTTGGAGG CGGCCTTGGT GCTGATGGAG 
GCTGCCCCAG AGCTGGTCTT TGAGCCCACC ACATGTGAGG CTTTTGCAGG TCAGACTGCA 
CTGCACATCG CTGTTGTGAA CCAGAATGTG AACCTGGTGC GTGCCCTGCT CACCCGCAGG 
GCCAGTGTCT CTGCCAGAGC CACAGGCACT GCCTTCCGCC ATAGTCCCCG CAACCTCATC 
TACTTTGGGG AGCACCCTTT GTCCTTTGCT GCCTGTGTGA ACAGCGAGGA GATCGTGCGG 
CTGCTCATTG AGCATGGAGC TGACATCAGG GCCCAGGACT CCCTGGGAAA CACAGTATTA 
CACATCCTCA TCCTCCAGCC CAACAAAACC TTTGCCTGCC AGATGTACAA CCTGCTGCTG 
TCCTATGATG GACATGGGGA CCACCTGCAG CCCCTGGACC TTGTGCCCAA TCACCAGGGT 
CTCACCCCCT TCAAGCTGGC TGGAGTGGAG GGTAACACTG TGATGTTCCA GCACCTGATG 
CAGAAGCGGA GGCACATCCA GTGGACGTAT GGACCCCTGA CCTCCATTCT CTACGACCTC 
ACGGAGATCG ACTCCTGGGG AGAGGAGCTG TCCTTCCTGG AGCTTGTGGT CTCCTCTGAT 
AAACGAGAGG CTCGCCAAAT TCTGGAACAG ACCCCAGTGA AGGAGCTGGT GAGCTTCAAG 
TGGAACAAGT ATGGCCGGCC GTACTTCTGC ATCCTGGCTG CCTTGTACCT GCTCTACATG 
ATCTGCTTTA CTACGTGCTG CGTCTACCGC CCCCTTAAGT TTCGTGGTGG CAACCGCACT 
CATTCTCGAG ACATCACCAT CCTCCAGCAA AAACTACTAC AGGAGGCCTA TGAGACACGT 
GAAGATATCA TCAGGCTGGT GGGGGAGCTG GTGAGCATCG TTGGGGCTGT GATCATCCTG 
CTCCTAGAGA TTCCAGACAT CTTCAGGGTT GGTGCCTCTC GCTATTTTGG AAAGACGATT 
CTTGGGGGGC CATTCCATGT CATCATCATC ACCTATGCCT CCCTGGTGCT GGTGACCATG 
GTGATGCGGC TCACCAACAC CAATGGGGAG GTGGTGCCCA TGTCCTTTGC CCTGGTGCTG 
GGCTGGTGCA GTGTCATGTA TTTCACTCGA GGATTCCAGA TGCTGGGTCC CTTCACCATC 
ATGATCCAGA AGATGATTTT TGGAGACCTA ATGCGTTTCT GCTGGCTGAT GGCTGTGGTC 
ATCTTGGGAT TTGCCTCCGC GTTCTATATC ATTTTCCAGA CAGAGGACCC AACCAGTCTG 
GGGCAATTCT ATGACTACCC CATGGCACTG TTCACCACCT TTGAGCTTTT TCTCACTGTT 
ATTGATGCAC CTGCCAACTA CGACGTGGAC TTGCCCTTCA TGTTCAGCAT TGTCAACTTC 
GCCTTCACCA TCATTGCCAC ACTGCTCATG CTCAACTTGT TCATCGCCAT GATGGGCGAC 
ACCCACTGGA GGGTGGCCCA GGAGAGGGAT GAGCTCTGGA GGGCCCAGGT CGTGGCCACC 
ACAGTGATGC TGGAGCGGAA GCTGCCTCGC TGCCTGTGGC CTCGCTCCGG GATCTGTGGG 
TGCGAATTCG GGCTGGGGGA CCGCTGGTTC CTGCGGGTTG AGAACCACAA TGATCAGAAT 
CCTCTGCGAG TGCTTCGCTA TGTGGAAGTG TTCAAGAACT CAGACAAGGA GGATGACCAG 
GAGCATCCAT CTGAGAAACA GCCCTCTGGG GCTGAGAGTG GGACTCTAGC CAGAGCCTCT 
TTGGCTCTTC CAACTTCCTC CCTGTCCCGG ACCGCGTCCC AGAGCAGCAG TCACCGAGGC 
TGGGAGATCC TTCGTCAAAA CACCCTGGGG CACTTGAATC TTGGACTGAA CCTTAGTGAG 
GGGGATGGAG AGGAGGTCTA CCATTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_062815.3
CDS	265..2454
Translation	MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRHSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTVIDAPANYDVDLPFMFSIVNFAFTIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQEHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSEGDGEEVYHF

Target ORF information:

RefSeq Version	NM_019841.6
Organism	Homo sapiens(human)
Definition	Homo sapiens transient receptor potential cation channel subfamily V member 5 (TRPV5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019841.6

ORF Insert Sequence:

ATGGGGGGTT TTCTACCTAA GGCAGAAGGG CCCGGGAGCC AACTCCAGAA ACTTCTGCCC 
TCCTTTCTGG TCAGAGAACA AGACTGGGAC CAGCACCTGG ACAAGCTTCA TATGCTGCAG 
CAGAAGAGGA TTCTAGAGTC TCCACTGCTT CGAGCATCCA AGGAAAATGA CCTGTCTGTT 
CTTAGGCAAC TTCTACTGGA CTGCACCTGT GACGTTCGAC AAAGAGGAGC CCTGGGGGAG 
ACGGCGCTGC ACATAGCAGC CCTCTATGAC AACTTGGAGG CGGCCTTGGT GCTGATGGAG 
GCTGCCCCAG AGCTGGTCTT TGAGCCCACC ACATGTGAGG CTTTTGCAGG TCAGACTGCA 
CTGCACATCG CTGTTGTGAA CCAGAATGTG AACCTGGTGC GTGCCCTGCT CACCCGCAGG 
GCCAGTGTCT CTGCCAGAGC CACAGGCACT GCCTTCCGCC ATAGTCCCCG CAACCTCATC 
TACTTTGGGG AGCACCCTTT GTCCTTTGCT GCCTGTGTGA ACAGCGAGGA GATCGTGCGG 
CTGCTCATTG AGCATGGAGC TGACATCAGG GCCCAGGACT CCCTGGGAAA CACAGTATTA 
CACATCCTCA TCCTCCAGCC CAACAAAACC TTTGCCTGCC AGATGTACAA CCTGCTGCTG 
TCCTATGATG GACATGGGGA CCACCTGCAG CCCCTGGACC TTGTGCCCAA TCACCAGGGT 
CTCACCCCCT TCAAGCTGGC TGGAGTGGAG GGTAACACTG TGATGTTCCA GCACCTGATG 
CAGAAGCGGA GGCACATCCA GTGGACGTAT GGACCCCTGA CCTCCATTCT CTACGACCTC 
ACGGAGATCG ACTCCTGGGG AGAGGAGCTG TCCTTCCTGG AGCTTGTGGT CTCCTCTGAT 
AAACGAGAGG CTCGCCAAAT TCTGGAACAG ACCCCAGTGA AGGAGCTGGT GAGCTTCAAG 
TGGAACAAGT ATGGCCGGCC GTACTTCTGC ATCCTGGCTG CCTTGTACCT GCTCTACATG 
ATCTGCTTTA CTACGTGCTG CGTCTACCGC CCCCTTAAGT TTCGTGGTGG CAACCGCACT 
CATTCTCGAG ACATCACCAT CCTCCAGCAA AAACTACTAC AGGAGGCCTA TGAGACACGT 
GAAGATATCA TCAGGCTGGT GGGGGAGCTG GTGAGCATCG TTGGGGCTGT GATCATCCTG 
CTCCTAGAGA TTCCAGACAT CTTCAGGGTT GGTGCCTCTC GCTATTTTGG AAAGACGATT 
CTTGGGGGGC CATTCCATGT CATCATCATC ACCTATGCCT CCCTGGTGCT GGTGACCATG 
GTGATGCGGC TCACCAACAC CAATGGGGAG GTGGTGCCCA TGTCCTTTGC CCTGGTGCTG 
GGCTGGTGCA GTGTCATGTA TTTCACTCGA GGATTCCAGA TGCTGGGTCC CTTCACCATC 
ATGATCCAGA AGATGATTTT TGGAGACCTA ATGCGTTTCT GCTGGCTGAT GGCTGTGGTC 
ATCTTGGGAT TTGCCTCCGC GTTCTATATC ATTTTCCAGA CAGAGGACCC AACCAGTCTG 
GGGCAATTCT ATGACTACCC CATGGCACTG TTCACCACCT TTGAGCTTTT TCTCACTGTT 
ATTGATGCAC CTGCCAACTA CGACGTGGAC TTGCCCTTCA TGTTCAGCAT TGTCAACTTC 
GCCTTCACCA TCATTGCCAC ACTGCTCATG CTCAACTTGT TCATCGCCAT GATGGGCGAC 
ACCCACTGGA GGGTGGCCCA GGAGAGGGAT GAGCTCTGGA GGGCCCAGGT CGTGGCCACC 
ACAGTGATGC TGGAGCGGAA GCTGCCTCGC TGCCTGTGGC CTCGCTCCGG GATCTGTGGG 
TGCGAATTCG GGCTGGGGGA CCGCTGGTTC CTGCGGGTTG AGAACCACAA TGATCAGAAT 
CCTCTGCGAG TGCTTCGCTA TGTGGAAGTG TTCAAGAACT CAGACAAGGA GGATGACCAG 
GAGCATCCAT CTGAGAAACA GCCCTCTGGG GCTGAGAGTG GGACTCTAGC CAGAGCCTCT 
TTGGCTCTTC CAACTTCCTC CCTGTCCCGG ACCGCGTCCC AGAGCAGCAG TCACCGAGGC 
TGGGAGATCC TTCGTCAAAA CACCCTGGGG CACTTGAATC TTGGACTGAA CCTTAGTGAG 
GGGGATGGAG AGGAGGTCTA CCATTTTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.
Nature structural & molecular biology25(1)53-60(2018 Jan)
Hughes TET,Lodowski DT,Huynh KW,Yazici A,Del Rosario J,Kapoor A,Basak S,Samanta A,Han X,Chakrapani S,Zhou ZH,Filizola M,Rohacs T,Han S,Moiseenkova-Bell VY

The L530R variation associated with recurrent kidney stones impairs the structure and function of TRPV5.
Biochemical and biophysical research communications492(3)362-367(2017 10)
Wang L,Holmes RP,Peng JB

A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.
Scientific reports627652(2016 Jun)
Velisetty P,Borbiro I,Kasimova MA,Liu L,Badheka D,Carnevale V,Rohacs T

Molecular Modeling of the Structural and Dynamical Changes in Calcium Channel TRPV5 Induced by the African-Specific A563T Variation.
Biochemistry55(8)1254-64(2016 Mar)
Wang L,Holmes RP,Peng JB

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TRPV5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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