BTNL2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BTNL2
Entrez Gene ID	56244
Full Name	butyrophilin like 2
Synonyms	BTL-II,BTN7,HSBLMHC1,SS2
General protein information	Preferred Names butyrophilin like 2 Names butyrophilin-like protein 2 butyrophilin-like 2 (MHC class II associated) truncated BTNL2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.32
Summary	This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer. [provided by RefSeq, May 2017].
Disorder MIM:	606000
Disorder Html:	{Sarcoidosis, susceptibility to, 2}, 612387 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017011057.1	XP_016866546.1	butyrophilin-like protein 2 isoform X1
NM_001304561.1	NP_001291490.1	butyrophilin-like protein 2

Pathways from BioSystems

Homologies

Homo sapiens (human)	BTNL2	NP_062548.1
Bos taurus (cattle)	LOC100337245	XP_005223634.1
Mus musculus (house mouse)	Btnl2	NP_524574.1
Bos taurus (cattle)	BTNL2	NP_001095821.1
Canis lupus familiaris (dog)	BTNL2	XP_005627247.1
Rattus norvegicus (Norway rat)	Btnl2	NP_446267.1

Gene Ontology
Bibliography

Related articles in PubMed

Zimmermann A, Knecht H, H?sler R, Zissel G, Gaede KI, Hofmann S, Nebel A, M?ller-Quernheim J, Schreiber S, Fischer A
The European respiratory journal50(6)(2017 Dec)

Correlation analysis of the HLA-DPB1*05:01 and BTNL2 genes within the histocompatibility complex region with a clinical phenotype of psoriasis vulgaris in the Chinese Han population.
Guo H, Huang Y, Wu J, Zheng X, Ye L, Huang H, Wang W, Zhen Q, Wu J, Qian W, Cheng H, Fan X, Zhang X
The journal of gene medicine19(9-10)(2017 Sep)

SNP Variants in Major Histocompatibility Complex Are Associated with Sarcoidosis Susceptibility-A Joint Analysis in Four European Populations.
Wolin A, Lahtela EL, Anttila V, Petrek M, Grunewald J, van Moorsel CHM, Eklund A, Grutters JC, Kolek V, Mrazek F, Kishore A, Padyukov L, Pietinalho A, Ronninger M, Sepp?nen M, Selroos O, Lokki ML
Frontiers in immunology8422(2017)

BTNL2, a butyrophilin/B7-like molecule, is a negative costimulatory molecule modulated in intestinal inflammation.
Arnett HA, Escobar SS, Gonzalez-Suarez E, Budelsky AL, Steffen LA, Boiani N, Zhang M, Siu G, Brewer AW, Viney JL
Journal of immunology (Baltimore, Md. : 1950)178(3)1523-33(2007 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2) which is specific to cases with EGFR mutations. In further sub-analyses by EGFR status, rs9387478 (ROS1/DCBLD1) and rs2179920 (HLA-DPB1) showed stronger estimated associations in EGFR-positive compared to EGFR-negative cases
Title: Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations.

Despite a significant difference in BTNL2 polymorphism between sarcoid patients and controls, there was no such difference between familial and sporadic sarcoidosis cases and no correlation between BTNL2 polymorphism and disease severity or outcome. Thus, BTNL2 difference cannot be considered as a key marker for disease classification or patient management.
Title: Familial vs. sporadic sarcoidosis: BTNL2 polymorphisms, clinical presentations, and outcomes in a French cohort.

Butyrophilin-like 2, expressed at various levels by UM cells and macrophages, might interfere with the immune control of the tumor. Butyrophilin-like 2 variants showed highly variable frequencies among ethnically related cohorts. There was no enrichment of BTNL2 variants in patients with UM compared with control patients.
Title: Analysis of the Expression and Single-Nucleotide Variant Frequencies of the Butyrophilin-like 2 Gene in Patients With Uveal Melanoma.

BTNL2 G16071A gene polymorphism may as a likelihood factor contributed to granulomatous disease susceptibility, especially increasing the sarcoidosis susceptibility. In addition, the polymorphism may be greatly associated with likelihood of granulomatous diseases among Caucasians.
Title: The BTNL2 G16071A gene polymorphism increases granulomatous disease susceptibility: A meta-analysis including FPRP test of 8710 participants.

BTNL2 variant is associated with psoriasis.
Title: Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease.

The following BTNL2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BTNL2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu70017	NM_001304561.1 Latest version!	Homo sapiens butyrophilin like 2 (BTNL2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu70017	XM_017011057.1 Latest version!	Homo sapiens butyrophilin like 2 (BTNL2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BTNL2 ( NM_001304561.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291490.1 Homo sapiens butyrophilin like 2 (BTNL2), mRNA.

Price & Availability↑

CloneID	OHu70017
Clone ID Related Accession (Same CDS sequence)	XM_017011057.1 , NM_001304561.1
Accession Version	NM_001304561.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1449bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	butyrophilin-like protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY684332.1, AL662796.6, BC127641.1 and BC119668.1. This sequence is a reference standard in the RefSeqGene project. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The exon combination of this transcript is inferred based on partial and orthologous transcript alignments, RNA-seq data, and data in PMID:17237401. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2152474 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGGTGGATT TTCCAGGCTA CAATCTGTCT GGTGCAGTCG CCTCCTTCCT ATTCATCCTG 
CTGACAATGA AGCAGTCAGA AGACTTTAGA GTCATTGGCC CTGCTCATCC TATCCTGGCC 
GGGGTTGGGG AAGATGCCCT GTTAACCTGC CAGCTACTCC CCAAGAGGAC CACAATGCAC 
GTGGAGGTGA GGTGGTACCG CTCAGAGCCC AGCACACCTG TGTTTGTGCA CAGGGATGGA 
GTGGAGGTGA CTGAGATGCA GATGGAGGAG TACAGAGGCT GGGTAGAGTG GATAGAGAAT 
GGCATTGCAA AGGGAAATGT GGCACTGAAG ATACACAACA TCCAGCCCTC CGACAATGGA 
CAATACTGGT GCCATTTCCA GGATGGGAAC TACTGTGGAG AAACAAGCTT GCTGCTCAAA 
GTAGCAGGTC TGGGGTCTGC CCCTAGCATC CACATGGAGG GACCTGGGGA GAGTGGAGTC 
CAGCTTGTGT GCACTGCAAG GGGCTGGTTC CCAGAGCCCC AGGTGTATTG GGAAGACATC 
CGGGGAGAGA AGCTGCTGGC CGTGTCTGAG CATCGCATCC AAGATAAAGA TGGCCTGTTC 
TATGCGGAAG CCACCCTGGT GGTCAGGAAC GCCTCTGCAG AGTCTGTGTC CTGCTTGGTC 
CACAACCCCG TCCTCACTGA GGAGAAGGGG TCGGTCATCA GCCTCCCAGA GAAACTCCAG 
ACTGAGCTGG CTTCTTTAAA AGTGAATGGA CCTTCCCAGC CCATCCTCGT CAGAGTGGGA 
GAAGATATAC AGCTAACCTG TTACCTGTCC CCCAAGGCGA ATGCACAGAG CATGGAGGTG 
AGGTGGGACC GATCCCACCG TTACCCTGCT GTGCATGTGT ATATGGATGG GGACCATGTG 
GCTGGAGAGC AGATGGCAGA GTACAGAGGG AGGACTGTAC TGGTGAGTGA CGCCATTGAC 
GAGGGCAGAC TGACCCTGCA GATACTCAGT GCCAGACCTT CGGACGACGG GCAGTACCGC 
TGCCTTTTTG AAAAAGATGA TGTCTACCAG GAGGCCAGTT TGGATCTGAA GGTGGTAAGT 
CTGGGTTCTT CCCCACTGAT CACTGTGGAG GGGCAAGAAG ATGGAGAAAT GCAGCCGATG 
TGCTCTTCAG ATGGGTGGTT CCCACAGCCC CACGTGCCAT GGAGGGACAT GGAAGGAAAG 
ACGATACCAT CATCTTCCCA GGCCCTGACT CAAGGCAGCC ACGGGCTGTT CCACGTGCAG 
ACATTGCTAA GGGTCACAAA CATCTCCGCT GTGGACGTCA CTTGTTCCAT CAGCATCCCC 
TTTTTGGGCG AGGAGAAAAT CGCAACTTTT TCTCTCTCAG AGTCCAGGAT GACGTTTTTG 
TGGAAAACAC TGCTTGTTTG GGGATTGCTT CTTGCTGTGG CTGTAGGCCT GCCCAGGAAG 
AGGAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291490.1
CDS	8..1456
Translation	MVDFPGYNLSGAVASFLFILLTMKQSEDFRVIGPAHPILAGVGEDALLTCQLLPKRTTMHVEVRWYRSEPSTPVFVHRDGVEVTEMQMEEYRGWVEWIENGIAKGNVALKIHNIQPSDNGQYWCHFQDGNYCGETSLLLKVAGLGSAPSIHMEGPGESGVQLVCTARGWFPEPQVYWEDIRGEKLLAVSEHRIQDKDGLFYAEATLVVRNASAESVSCLVHNPVLTEEKGSVISLPEKLQTELASLKVNGPSQPILVRVGEDIQLTCYLSPKANAQSMEVRWDRSHRYPAVHVYMDGDHVAGEQMAEYRGRTVLVSDAIDEGRLTLQILSARPSDDGQYRCLFEKDDVYQEASLDLKVVSLGSSPLITVEGQEDGEMQPMCSSDGWFPQPHVPWRDMEGKTIPSSSQALTQGSHGLFHVQTLLRVTNISAVDVTCSISIPFLGEEKIATFSLSESRMTFLWKTLLVWGLLLAVAVGLPRKRS

Target ORF information:

RefSeq Version	NM_001304561.1
Organism	Homo sapiens(human)
Definition	Homo sapiens butyrophilin like 2 (BTNL2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304561.1

ORF Insert Sequence:

ATGGTGGATT TTCCAGGCTA CAATCTGTCT GGTGCAGTCG CCTCCTTCCT ATTCATCCTG 
CTGACAATGA AGCAGTCAGA AGACTTTAGA GTCATTGGCC CTGCTCATCC TATCCTGGCC 
GGGGTTGGGG AAGATGCCCT GTTAACCTGC CAGCTACTCC CCAAGAGGAC CACAATGCAC 
GTGGAGGTGA GGTGGTACCG CTCAGAGCCC AGCACACCTG TGTTTGTGCA CAGGGATGGA 
GTGGAGGTGA CTGAGATGCA GATGGAGGAG TACAGAGGCT GGGTAGAGTG GATAGAGAAT 
GGCATTGCAA AGGGAAATGT GGCACTGAAG ATACACAACA TCCAGCCCTC CGACAATGGA 
CAATACTGGT GCCATTTCCA GGATGGGAAC TACTGTGGAG AAACAAGCTT GCTGCTCAAA 
GTAGCAGGTC TGGGGTCTGC CCCTAGCATC CACATGGAGG GACCTGGGGA GAGTGGAGTC 
CAGCTTGTGT GCACTGCAAG GGGCTGGTTC CCAGAGCCCC AGGTGTATTG GGAAGACATC 
CGGGGAGAGA AGCTGCTGGC CGTGTCTGAG CATCGCATCC AAGATAAAGA TGGCCTGTTC 
TATGCGGAAG CCACCCTGGT GGTCAGGAAC GCCTCTGCAG AGTCTGTGTC CTGCTTGGTC 
CACAACCCCG TCCTCACTGA GGAGAAGGGG TCGGTCATCA GCCTCCCAGA GAAACTCCAG 
ACTGAGCTGG CTTCTTTAAA AGTGAATGGA CCTTCCCAGC CCATCCTCGT CAGAGTGGGA 
GAAGATATAC AGCTAACCTG TTACCTGTCC CCCAAGGCGA ATGCACAGAG CATGGAGGTG 
AGGTGGGACC GATCCCACCG TTACCCTGCT GTGCATGTGT ATATGGATGG GGACCATGTG 
GCTGGAGAGC AGATGGCAGA GTACAGAGGG AGGACTGTAC TGGTGAGTGA CGCCATTGAC 
GAGGGCAGAC TGACCCTGCA GATACTCAGT GCCAGACCTT CGGACGACGG GCAGTACCGC 
TGCCTTTTTG AAAAAGATGA TGTCTACCAG GAGGCCAGTT TGGATCTGAA GGTGGTAAGT 
CTGGGTTCTT CCCCACTGAT CACTGTGGAG GGGCAAGAAG ATGGAGAAAT GCAGCCGATG 
TGCTCTTCAG ATGGGTGGTT CCCACAGCCC CACGTGCCAT GGAGGGACAT GGAAGGAAAG 
ACGATACCAT CATCTTCCCA GGCCCTGACT CAAGGCAGCC ACGGGCTGTT CCACGTGCAG 
ACATTGCTAA GGGTCACAAA CATCTCCGCT GTGGACGTCA CTTGTTCCAT CAGCATCCCC 
TTTTTGGGCG AGGAGAAAAT CGCAACTTTT TCTCTCTCAG AGTCCAGGAT GACGTTTTTG 
TGGAAAACAC TGCTTGTTTG GGGATTGCTT CTTGCTGTGG CTGTAGGCCT GCCCAGGAAG 
AGGAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

BTNL2 ( XM_017011057.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016866546.1 Homo sapiens butyrophilin like 2 (BTNL2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu70017
Clone ID Related Accession (Same CDS sequence)	XM_017011057.1 , NM_001304561.1
Accession Version	XM_017011057.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1449bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	butyrophilin-like protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000006.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGGATT TTCCAGGCTA CAATCTGTCT GGTGCAGTCG CCTCCTTCCT ATTCATCCTG 
CTGACAATGA AGCAGTCAGA AGACTTTAGA GTCATTGGCC CTGCTCATCC TATCCTGGCC 
GGGGTTGGGG AAGATGCCCT GTTAACCTGC CAGCTACTCC CCAAGAGGAC CACAATGCAC 
GTGGAGGTGA GGTGGTACCG CTCAGAGCCC AGCACACCTG TGTTTGTGCA CAGGGATGGA 
GTGGAGGTGA CTGAGATGCA GATGGAGGAG TACAGAGGCT GGGTAGAGTG GATAGAGAAT 
GGCATTGCAA AGGGAAATGT GGCACTGAAG ATACACAACA TCCAGCCCTC CGACAATGGA 
CAATACTGGT GCCATTTCCA GGATGGGAAC TACTGTGGAG AAACAAGCTT GCTGCTCAAA 
GTAGCAGGTC TGGGGTCTGC CCCTAGCATC CACATGGAGG GACCTGGGGA GAGTGGAGTC 
CAGCTTGTGT GCACTGCAAG GGGCTGGTTC CCAGAGCCCC AGGTGTATTG GGAAGACATC 
CGGGGAGAGA AGCTGCTGGC CGTGTCTGAG CATCGCATCC AAGATAAAGA TGGCCTGTTC 
TATGCGGAAG CCACCCTGGT GGTCAGGAAC GCCTCTGCAG AGTCTGTGTC CTGCTTGGTC 
CACAACCCCG TCCTCACTGA GGAGAAGGGG TCGGTCATCA GCCTCCCAGA GAAACTCCAG 
ACTGAGCTGG CTTCTTTAAA AGTGAATGGA CCTTCCCAGC CCATCCTCGT CAGAGTGGGA 
GAAGATATAC AGCTAACCTG TTACCTGTCC CCCAAGGCGA ATGCACAGAG CATGGAGGTG 
AGGTGGGACC GATCCCACCG TTACCCTGCT GTGCATGTGT ATATGGATGG GGACCATGTG 
GCTGGAGAGC AGATGGCAGA GTACAGAGGG AGGACTGTAC TGGTGAGTGA CGCCATTGAC 
GAGGGCAGAC TGACCCTGCA GATACTCAGT GCCAGACCTT CGGACGACGG GCAGTACCGC 
TGCCTTTTTG AAAAAGATGA TGTCTACCAG GAGGCCAGTT TGGATCTGAA GGTGGTAAGT 
CTGGGTTCTT CCCCACTGAT CACTGTGGAG GGGCAAGAAG ATGGAGAAAT GCAGCCGATG 
TGCTCTTCAG ATGGGTGGTT CCCACAGCCC CACGTGCCAT GGAGGGACAT GGAAGGAAAG 
ACGATACCAT CATCTTCCCA GGCCCTGACT CAAGGCAGCC ACGGGCTGTT CCACGTGCAG 
ACATTGCTAA GGGTCACAAA CATCTCCGCT GTGGACGTCA CTTGTTCCAT CAGCATCCCC 
TTTTTGGGCG AGGAGAAAAT CGCAACTTTT TCTCTCTCAG AGTCCAGGAT GACGTTTTTG 
TGGAAAACAC TGCTTGTTTG GGGATTGCTT CTTGCTGTGG CTGTAGGCCT GCCCAGGAAG 
AGGAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016866546.1
CDS	1757..3205
Translation	MVDFPGYNLSGAVASFLFILLTMKQSEDFRVIGPAHPILAGVGEDALLTCQLLPKRTTMHVEVRWYRSEPSTPVFVHRDGVEVTEMQMEEYRGWVEWIENGIAKGNVALKIHNIQPSDNGQYWCHFQDGNYCGETSLLLKVAGLGSAPSIHMEGPGESGVQLVCTARGWFPEPQVYWEDIRGEKLLAVSEHRIQDKDGLFYAEATLVVRNASAESVSCLVHNPVLTEEKGSVISLPEKLQTELASLKVNGPSQPILVRVGEDIQLTCYLSPKANAQSMEVRWDRSHRYPAVHVYMDGDHVAGEQMAEYRGRTVLVSDAIDEGRLTLQILSARPSDDGQYRCLFEKDDVYQEASLDLKVVSLGSSPLITVEGQEDGEMQPMCSSDGWFPQPHVPWRDMEGKTIPSSSQALTQGSHGLFHVQTLLRVTNISAVDVTCSISIPFLGEEKIATFSLSESRMTFLWKTLLVWGLLLAVAVGLPRKRS

Target ORF information:

RefSeq Version	XM_017011057.1
Organism	Homo sapiens(human)
Definition	Homo sapiens butyrophilin like 2 (BTNL2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011057.1

ORF Insert Sequence:

ATGGTGGATT TTCCAGGCTA CAATCTGTCT GGTGCAGTCG CCTCCTTCCT ATTCATCCTG 
CTGACAATGA AGCAGTCAGA AGACTTTAGA GTCATTGGCC CTGCTCATCC TATCCTGGCC 
GGGGTTGGGG AAGATGCCCT GTTAACCTGC CAGCTACTCC CCAAGAGGAC CACAATGCAC 
GTGGAGGTGA GGTGGTACCG CTCAGAGCCC AGCACACCTG TGTTTGTGCA CAGGGATGGA 
GTGGAGGTGA CTGAGATGCA GATGGAGGAG TACAGAGGCT GGGTAGAGTG GATAGAGAAT 
GGCATTGCAA AGGGAAATGT GGCACTGAAG ATACACAACA TCCAGCCCTC CGACAATGGA 
CAATACTGGT GCCATTTCCA GGATGGGAAC TACTGTGGAG AAACAAGCTT GCTGCTCAAA 
GTAGCAGGTC TGGGGTCTGC CCCTAGCATC CACATGGAGG GACCTGGGGA GAGTGGAGTC 
CAGCTTGTGT GCACTGCAAG GGGCTGGTTC CCAGAGCCCC AGGTGTATTG GGAAGACATC 
CGGGGAGAGA AGCTGCTGGC CGTGTCTGAG CATCGCATCC AAGATAAAGA TGGCCTGTTC 
TATGCGGAAG CCACCCTGGT GGTCAGGAAC GCCTCTGCAG AGTCTGTGTC CTGCTTGGTC 
CACAACCCCG TCCTCACTGA GGAGAAGGGG TCGGTCATCA GCCTCCCAGA GAAACTCCAG 
ACTGAGCTGG CTTCTTTAAA AGTGAATGGA CCTTCCCAGC CCATCCTCGT CAGAGTGGGA 
GAAGATATAC AGCTAACCTG TTACCTGTCC CCCAAGGCGA ATGCACAGAG CATGGAGGTG 
AGGTGGGACC GATCCCACCG TTACCCTGCT GTGCATGTGT ATATGGATGG GGACCATGTG 
GCTGGAGAGC AGATGGCAGA GTACAGAGGG AGGACTGTAC TGGTGAGTGA CGCCATTGAC 
GAGGGCAGAC TGACCCTGCA GATACTCAGT GCCAGACCTT CGGACGACGG GCAGTACCGC 
TGCCTTTTTG AAAAAGATGA TGTCTACCAG GAGGCCAGTT TGGATCTGAA GGTGGTAAGT 
CTGGGTTCTT CCCCACTGAT CACTGTGGAG GGGCAAGAAG ATGGAGAAAT GCAGCCGATG 
TGCTCTTCAG ATGGGTGGTT CCCACAGCCC CACGTGCCAT GGAGGGACAT GGAAGGAAAG 
ACGATACCAT CATCTTCCCA GGCCCTGACT CAAGGCAGCC ACGGGCTGTT CCACGTGCAG 
ACATTGCTAA GGGTCACAAA CATCTCCGCT GTGGACGTCA CTTGTTCCAT CAGCATCCCC 
TTTTTGGGCG AGGAGAAAAT CGCAACTTTT TCTCTCTCAG AGTCCAGGAT GACGTTTTTG 
TGGAAAACAC TGCTTGTTTG GGGATTGCTT CTTGCTGTGG CTGTAGGCCT GCCCAGGAAG 
AGGAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The European respiratory journal50(6)(2017 Dec)
Zimmermann A,Knecht H,H?sler R,Zissel G,Gaede KI,Hofmann S,Nebel A,M?ller-Quernheim J,Schreiber S,Fischer A

Correlation analysis of the HLA-DPB1*05:01 and BTNL2 genes within the histocompatibility complex region with a clinical phenotype of psoriasis vulgaris in the Chinese Han population.
The journal of gene medicine19(9-10)(2017 Sep)
Guo H,Huang Y,Wu J,Zheng X,Ye L,Huang H,Wang W,Zhen Q,Wu J,Qian W,Cheng H,Fan X,Zhang X

SNP Variants in Major Histocompatibility Complex Are Associated with Sarcoidosis Susceptibility-A Joint Analysis in Four European Populations.
Frontiers in immunology8422(2017)
Wolin A,Lahtela EL,Anttila V,Petrek M,Grunewald J,van Moorsel CHM,Eklund A,Grutters JC,Kolek V,Mrazek F,Kishore A,Padyukov L,Pietinalho A,Ronninger M,Sepp?nen M,Selroos O,Lokki ML

BTNL2, a butyrophilin/B7-like molecule, is a negative costimulatory molecule modulated in intestinal inflammation.
Journal of immunology (Baltimore, Md. : 1950)178(3)1523-33(2007 Feb)
Arnett HA,Escobar SS,Gonzalez-Suarez E,Budelsky AL,Steffen LA,Boiani N,Zhang M,Siu G,Brewer AW,Viney JL

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BTNL2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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