LMOD3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LMOD3
Entrez Gene ID	56203
Full Name	leiomodin 3
Synonyms	NEM10
General protein information	Preferred Names leiomodin 3 Names leiomodin-3 leiomodin 3 (fetal) leiomodin, fetal form
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p14.1
Summary	The protein encoded by this gene is a member of the leiomodin family of proteins. This protein contains three actin-binding domains, a tropomyosin domain, a leucine-rich repeat domain, and a Wiskott-Aldrich syndrome protein homology 2 domain (WH2). Localization of this protein to the pointed ends of thin filaments has been observed, and there is evidence that this protein acts as a catalyst of actin nucleation, and is important to the organization of sarcomeric thin filaments in skeletal muscles. Mutations in this gene have been associated as one cause of Nemaline myopathy, as other genes have also been linked to this disorder. Nemaline myopathy is a disorder characterized by nonprogressive generalized muscle weakness and protein inclusions (nemaline bodies) in skeletal myofibers. Patients with mutations in this gene often present with a severe congenital form of the disorder. [provided by RefSeq, Jan 2015].
Disorder MIM:	616112
Disorder Html:	Nemaline myopathy 10, 616165 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001304418.3	NP_001291347.1	leiomodin-3
NM_198271.5	NP_938012.2	leiomodin-3
NM_001304418.1	NP_001291347.1	leiomodin-3
NM_198271.4	NP_938012.2	leiomodin-3
NM_001304418.2	NP_001291347.1	leiomodin-3

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Lmod3	XP_006237035.1
	LMOD3	XP_001087095.1
Gallus gallus (chicken)	LOC426075	XP_004944738.1
Xenopus tropicalis (tropical clawed frog)	lmod3	NP_001072680.1
Homo sapiens (human)	LMOD3	NP_938012.2
Canis lupus familiaris (dog)	LMOD3	XP_549501.3
Pan troglodytes (chimpanzee)	LMOD3	XP_001137511.1
Mus musculus (house mouse)	Lmod3	NP_001074626.1
Bos taurus (cattle)	LMOD3	NP_001093802.1
Danio rerio (zebrafish)	si:dkey-90a13.7	XP_003201226.1

Gene Ontology
Bibliography

Related articles in PubMed

LMOD3-Associated Nemaline Myopathy: Prenatal Ultrasonographic, Pathologic, and Molecular Findings.
Berkenstadt M, Pode-Shakked B, Barel O, Barash H, Achiron R, Gilboa Y, Kidron D, Raas-Rothschild A
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine(2018 Jan)

Neonatal fractures as a presenting feature of LMOD3-associated congenital myopathy.
Abbott M, Jain M, Pferdehirt R, Chen Y, Tran A, Duz MB, Seven M, Gibbs RA, Muzny D, Lee B, Marom R, Burrage LC
American journal of medical genetics. Part A173(10)2789-2794(2017 Oct)

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.
Yuen M, Sandaradura SA, Dowling JJ, Kostyukova AS, Moroz N, Quinlan KG, Lehtokari VL, Ravenscroft G, Todd EJ, Ceyhan-Birsoy O, Gokhin DS, Maluenda J, Lek M, Nolent F, Pappas CT, Novak SM, D'Amico A, Malfatti E, Thomas BP, Gabriel SB, Gupta N, Daly MJ, Ilkovski B, Houweling PJ, Davidson AE, Swanson LC, Brownstein CA, Gupta VA, Medne L, Shannon P, Martin N, Bick DP, Flisberg A, Holmberg E, Van den Bergh P, Lapunzina P, Waddell LB, Sloboda DD, Bertini E, Chitayat D, Telfer WR, Laquerri?re A, Gregorio CC, Ottenheijm CA, B?nnemann CG, Pelin K, Beggs AH, Hayashi YK, Romero NB, Laing NG, Nishino I, Wallgren-Pettersson C, Melki J, Fowler VM, MacArthur DG, North KN, Clarke NF
The Journal of clinical investigation124(11)4693-708(2014 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LMOD3 is essential for the organization of sarcomeric thin filaments in skeletal muscle.
Title: Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Risperidone-related weight gain: genetic and nongenetic predictors.

The following LMOD3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LMOD3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30563	NM_001304418.3 Latest version!	Homo sapiens leiomodin 3 (LMOD3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu30563	NM_198271.5 Latest version!	Homo sapiens leiomodin 3 (LMOD3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu30563	NM_001304418.1	Homo sapiens leiomodin 3 (LMOD3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu30563	NM_198271.4	Homo sapiens leiomodin 3 (LMOD3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu30563	NM_001304418.2	Homo sapiens leiomodin 3 (LMOD3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LMOD3 ( NM_001304418.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291347.1 Homo sapiens leiomodin 3 (LMOD3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu30563
Clone ID Related Accession (Same CDS sequence)	NM_001304418.3 , NM_198271.5 , NM_001304418.1 , NM_198271.4 , NM_001304418.2
Accession Version	NM_001304418.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1683bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-29
Organism	Homo sapiens(human)
Product	leiomodin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA563370.1, AL832033.1, BC121019.2, AI014510.1, AK300096.1 and AC092060.2. On Nov 30, 2019 this sequence version replaced NM_001304418.2. Transcript Variant: This variant (2) contains an alternate splice structure in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AK300096.1, DRR138527.20681.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAGAGC ACAGCAGAAA TTCAGATCAA GAAGAACTTC TCGATGAGGA GATTAATGAA 
GATGAAATCT TGGCCAACTT GTCTGCTGAA GAACTGAAAG AACTGCAGTC GGAAATGGAA 
GTCATGGCCC CTGACCCCAG CCTTCCCGTG GGAATGATTC AGAAAGATCA AACTGACAAG 
CCACCGACAG GAAACTTCAA TCATAAATCT CTTGTTGATT ATATGTATTG GGAAAAGGCA 
TCCAGGCGCA TGCTGGAAGA GGAACGAGTT CCTGTCACCT TTGTGAAATC CGAGGAAAAG 
ACTCAAGAAG AGCATGAAGA AATAGAAAAA CGTAATAAAA ATATGGCCCA GTATTTAAAA 
GAAAAGCTCA ATAATGAAAT AGTTGCAAAT AAAAGAGAAT CAAAGGGCAG CAGCAATATC 
CAAGAAACAG ATGAAGAAGA TGAAGAAGAA GAAGATGATG ATGATGACGA CGAAGGAGAA 
GATGATGGTG AAGAGAGTGA AGAAACGAAC AGAGAAGAGG AAGGCAAAGC AAAGGAACAA 
ATTAGAAATT GTGAGAACAA CTGCCAGCAG GTAACTGACA AAGCATTCAA AGAACAGAGA 
GACAGACCAG AGGCCCAAGA ACAAAGTGAG AAAAAAATAT CGAAATTAGA TCCTAAGAAG 
TTAGCTCTAG ACACCAGCTT TTTGAAGGTA AGTACAAGGC CTTCAGGAAA CCAGACAGAC 
CTGGATGGGA GCTTGAGGAG AGTTAGGAAA AATGATCCTG ACATGAAGGA ACTCAACCTG 
AACAACATTG AAAACATCCC CAAAGAAATG TTACTGGACT TTGTCAATGC AATGAAGAAA 
AACAAGCACA TCAAAACATT CAGTTTAGCC AATGTGGGTG CAGATGAGAA TGTAGCATTT 
GCCTTGGCTA ACATGTTGCG TGAAAATAGA AGCATCACCA CTCTCAACAT CGAGTCCAAT 
TTCATCACAG GTAAAGGGAT TGTGGCCATC ATGAGGTGTC TCCAGTTTAA TGAGACGCTA 
ACTGAGCTTC GGTTTCACAA TCAGAGGCAC ATGTTGGGTC ACCATGCTGA AATGGAAATA 
GCCAGGCTTT TGAAGGCAAA CAACACTCTC CTGAAGATGG GCTACCATTT TGAGCTTCCG 
GGTCCCAGAA TGGTGGTCAC TAATCTGCTC ACCAGGAATC AGGATAAACA AAGGCAGAAA 
CGACAGGAAG AGCAAAAACA GCAGCAACTC AAGGAACAGA AGAAGCTGAT AGCCATGTTA 
GAGAATGGGT TGGGGCTGCC CCCTGGGATG TGGGAGCTGT TGGGAGGACC CAAGCCAGAT 
TCCAGAATGC AGGAATTCTT CCAGCCACCG CCACCTCGGC CTCCCAACCC CCAAAATGTC 
CCCTTTAGTC AACGCAGTGA AATGATGAAA AAGCCATCGC AGGCCCCGAA GTACAGGACA 
GACCCTGACT CCTTCCGGGT GGTGAAGCTG AAGAGAATCC AGCGCAAATC TCGGATGCCG 
GAAGCCAGAG AACCACCCGA GAAAACCAAC CTCAAAGATG TCATCAAAAC GCTCAAGCCA 
GTGCCGAGAA ACAGGCCACC CCCATTGGTG GAAATCACTC CCAGAGATCA GCTGCTAAAC 
GACATTCGTC ACAGCAGTGT CGCCTATCTT AAACCTGTGC AACTGCCAAA AGAACTGGCG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291347.1
CDS	116..1798
Translation	MSEHSRNSDQEELLDEEINEDEILANLSAEELKELQSEMEVMAPDPSLPVGMIQKDQTDKPPTGNFNHKSLVDYMYWEKASRRMLEEERVPVTFVKSEEKTQEEHEEIEKRNKNMAQYLKEKLNNEIVANKRESKGSSNIQETDEEDEEEEDDDDDDEGEDDGEESEETNREEEGKAKEQIRNCENNCQQVTDKAFKEQRDRPEAQEQSEKKISKLDPKKLALDTSFLKVSTRPSGNQTDLDGSLRRVRKNDPDMKELNLNNIENIPKEMLLDFVNAMKKNKHIKTFSLANVGADENVAFALANMLRENRSITTLNIESNFITGKGIVAIMRCLQFNETLTELRFHNQRHMLGHHAEMEIARLLKANNTLLKMGYHFELPGPRMVVTNLLTRNQDKQRQKRQEEQKQQQLKEQKKLIAMLENGLGLPPGMWELLGGPKPDSRMQEFFQPPPPRPPNPQNVPFSQRSEMMKKPSQAPKYRTDPDSFRVVKLKRIQRKSRMPEAREPPEKTNLKDVIKTLKPVPRNRPPPLVEITPRDQLLNDIRHSSVAYLKPVQLPKELA

Target ORF information:

RefSeq Version	NM_001304418.3
Organism	Homo sapiens(human)
Definition	Homo sapiens leiomodin 3 (LMOD3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304418.3

ORF Insert Sequence:

ATGTCAGAGC ACAGCAGAAA TTCAGATCAA GAAGAACTTC TCGATGAGGA GATTAATGAA 
GATGAAATCT TGGCCAACTT GTCTGCTGAA GAACTGAAAG AACTGCAGTC GGAAATGGAA 
GTCATGGCCC CTGACCCCAG CCTTCCCGTG GGAATGATTC AGAAAGATCA AACTGACAAG 
CCACCGACAG GAAACTTCAA TCATAAATCT CTTGTTGATT ATATGTATTG GGAAAAGGCA 
TCCAGGCGCA TGCTGGAAGA GGAACGAGTT CCTGTCACCT TTGTGAAATC CGAGGAAAAG 
ACTCAAGAAG AGCATGAAGA AATAGAAAAA CGTAATAAAA ATATGGCCCA GTATTTAAAA 
GAAAAGCTCA ATAATGAAAT AGTTGCAAAT AAAAGAGAAT CAAAGGGCAG CAGCAATATC 
CAAGAAACAG ATGAAGAAGA TGAAGAAGAA GAAGATGATG ATGATGACGA CGAAGGAGAA 
GATGATGGTG AAGAGAGTGA AGAAACGAAC AGAGAAGAGG AAGGCAAAGC AAAGGAACAA 
ATTAGAAATT GTGAGAACAA CTGCCAGCAG GTAACTGACA AAGCATTCAA AGAACAGAGA 
GACAGACCAG AGGCCCAAGA ACAAAGTGAG AAAAAAATAT CGAAATTAGA TCCTAAGAAG 
TTAGCTCTAG ACACCAGCTT TTTGAAGGTA AGTACAAGGC CTTCAGGAAA CCAGACAGAC 
CTGGATGGGA GCTTGAGGAG AGTTAGGAAA AATGATCCTG ACATGAAGGA ACTCAACCTG 
AACAACATTG AAAACATCCC CAAAGAAATG TTACTGGACT TTGTCAATGC AATGAAGAAA 
AACAAGCACA TCAAAACATT CAGTTTAGCC AATGTGGGTG CAGATGAGAA TGTAGCATTT 
GCCTTGGCTA ACATGTTGCG TGAAAATAGA AGCATCACCA CTCTCAACAT CGAGTCCAAT 
TTCATCACAG GTAAAGGGAT TGTGGCCATC ATGAGGTGTC TCCAGTTTAA TGAGACGCTA 
ACTGAGCTTC GGTTTCACAA TCAGAGGCAC ATGTTGGGTC ACCATGCTGA AATGGAAATA 
GCCAGGCTTT TGAAGGCAAA CAACACTCTC CTGAAGATGG GCTACCATTT TGAGCTTCCG 
GGTCCCAGAA TGGTGGTCAC TAATCTGCTC ACCAGGAATC AGGATAAACA AAGGCAGAAA 
CGACAGGAAG AGCAAAAACA GCAGCAACTC AAGGAACAGA AGAAGCTGAT AGCCATGTTA 
GAGAATGGGT TGGGGCTGCC CCCTGGGATG TGGGAGCTGT TGGGAGGACC CAAGCCAGAT 
TCCAGAATGC AGGAATTCTT CCAGCCACCG CCACCTCGGC CTCCCAACCC CCAAAATGTC 
CCCTTTAGTC AACGCAGTGA AATGATGAAA AAGCCATCGC AGGCCCCGAA GTACAGGACA 
GACCCTGACT CCTTCCGGGT GGTGAAGCTG AAGAGAATCC AGCGCAAATC TCGGATGCCG 
GAAGCCAGAG AACCACCCGA GAAAACCAAC CTCAAAGATG TCATCAAAAC GCTCAAGCCA 
GTGCCGAGAA ACAGGCCACC CCCATTGGTG GAAATCACTC CCAGAGATCA GCTGCTAAAC 
GACATTCGTC ACAGCAGTGT CGCCTATCTT AAACCTGTGC AACTGCCAAA AGAACTGGCG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LMOD3 ( NM_198271.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_938012.2 Homo sapiens leiomodin 3 (LMOD3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu30563
Clone ID Related Accession (Same CDS sequence)	NM_001304418.3 , NM_198271.5 , NM_001304418.1 , NM_198271.4 , NM_001304418.2
Accession Version	NM_198271.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1683bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	leiomodin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL832709.1, AL832033.1, BC121019.2, AI014510.1, AK300096.1 and AC092060.2. On Nov 30, 2019 this sequence version replaced NM_198271.4. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AL832033.1, AL832709.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCAGAGC ACAGCAGAAA TTCAGATCAA GAAGAACTTC TCGATGAGGA GATTAATGAA 
GATGAAATCT TGGCCAACTT GTCTGCTGAA GAACTGAAAG AACTGCAGTC GGAAATGGAA 
GTCATGGCCC CTGACCCCAG CCTTCCCGTG GGAATGATTC AGAAAGATCA AACTGACAAG 
CCACCGACAG GAAACTTCAA TCATAAATCT CTTGTTGATT ATATGTATTG GGAAAAGGCA 
TCCAGGCGCA TGCTGGAAGA GGAACGAGTT CCTGTCACCT TTGTGAAATC CGAGGAAAAG 
ACTCAAGAAG AGCATGAAGA AATAGAAAAA CGTAATAAAA ATATGGCCCA GTATTTAAAA 
GAAAAGCTCA ATAATGAAAT AGTTGCAAAT AAAAGAGAAT CAAAGGGCAG CAGCAATATC 
CAAGAAACAG ATGAAGAAGA TGAAGAAGAA GAAGATGATG ATGATGACGA CGAAGGAGAA 
GATGATGGTG AAGAGAGTGA AGAAACGAAC AGAGAAGAGG AAGGCAAAGC AAAGGAACAA 
ATTAGAAATT GTGAGAACAA CTGCCAGCAG GTAACTGACA AAGCATTCAA AGAACAGAGA 
GACAGACCAG AGGCCCAAGA ACAAAGTGAG AAAAAAATAT CGAAATTAGA TCCTAAGAAG 
TTAGCTCTAG ACACCAGCTT TTTGAAGGTA AGTACAAGGC CTTCAGGAAA CCAGACAGAC 
CTGGATGGGA GCTTGAGGAG AGTTAGGAAA AATGATCCTG ACATGAAGGA ACTCAACCTG 
AACAACATTG AAAACATCCC CAAAGAAATG TTACTGGACT TTGTCAATGC AATGAAGAAA 
AACAAGCACA TCAAAACATT CAGTTTAGCC AATGTGGGTG CAGATGAGAA TGTAGCATTT 
GCCTTGGCTA ACATGTTGCG TGAAAATAGA AGCATCACCA CTCTCAACAT CGAGTCCAAT 
TTCATCACAG GTAAAGGGAT TGTGGCCATC ATGAGGTGTC TCCAGTTTAA TGAGACGCTA 
ACTGAGCTTC GGTTTCACAA TCAGAGGCAC ATGTTGGGTC ACCATGCTGA AATGGAAATA 
GCCAGGCTTT TGAAGGCAAA CAACACTCTC CTGAAGATGG GCTACCATTT TGAGCTTCCG 
GGTCCCAGAA TGGTGGTCAC TAATCTGCTC ACCAGGAATC AGGATAAACA AAGGCAGAAA 
CGACAGGAAG AGCAAAAACA GCAGCAACTC AAGGAACAGA AGAAGCTGAT AGCCATGTTA 
GAGAATGGGT TGGGGCTGCC CCCTGGGATG TGGGAGCTGT TGGGAGGACC CAAGCCAGAT 
TCCAGAATGC AGGAATTCTT CCAGCCACCG CCACCTCGGC CTCCCAACCC CCAAAATGTC 
CCCTTTAGTC AACGCAGTGA AATGATGAAA AAGCCATCGC AGGCCCCGAA GTACAGGACA 
GACCCTGACT CCTTCCGGGT GGTGAAGCTG AAGAGAATCC AGCGCAAATC TCGGATGCCG 
GAAGCCAGAG AACCACCCGA GAAAACCAAC CTCAAAGATG TCATCAAAAC GCTCAAGCCA 
GTGCCGAGAA ACAGGCCACC CCCATTGGTG GAAATCACTC CCAGAGATCA GCTGCTAAAC 
GACATTCGTC ACAGCAGTGT CGCCTATCTT AAACCTGTGC AACTGCCAAA AGAACTGGCG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_938012.2
CDS	210..1892
Translation	MSEHSRNSDQEELLDEEINEDEILANLSAEELKELQSEMEVMAPDPSLPVGMIQKDQTDKPPTGNFNHKSLVDYMYWEKASRRMLEEERVPVTFVKSEEKTQEEHEEIEKRNKNMAQYLKEKLNNEIVANKRESKGSSNIQETDEEDEEEEDDDDDDEGEDDGEESEETNREEEGKAKEQIRNCENNCQQVTDKAFKEQRDRPEAQEQSEKKISKLDPKKLALDTSFLKVSTRPSGNQTDLDGSLRRVRKNDPDMKELNLNNIENIPKEMLLDFVNAMKKNKHIKTFSLANVGADENVAFALANMLRENRSITTLNIESNFITGKGIVAIMRCLQFNETLTELRFHNQRHMLGHHAEMEIARLLKANNTLLKMGYHFELPGPRMVVTNLLTRNQDKQRQKRQEEQKQQQLKEQKKLIAMLENGLGLPPGMWELLGGPKPDSRMQEFFQPPPPRPPNPQNVPFSQRSEMMKKPSQAPKYRTDPDSFRVVKLKRIQRKSRMPEAREPPEKTNLKDVIKTLKPVPRNRPPPLVEITPRDQLLNDIRHSSVAYLKPVQLPKELA

Target ORF information:

RefSeq Version	NM_198271.5
Organism	Homo sapiens(human)
Definition	Homo sapiens leiomodin 3 (LMOD3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198271.5

ORF Insert Sequence:

ATGTCAGAGC ACAGCAGAAA TTCAGATCAA GAAGAACTTC TCGATGAGGA GATTAATGAA 
GATGAAATCT TGGCCAACTT GTCTGCTGAA GAACTGAAAG AACTGCAGTC GGAAATGGAA 
GTCATGGCCC CTGACCCCAG CCTTCCCGTG GGAATGATTC AGAAAGATCA AACTGACAAG 
CCACCGACAG GAAACTTCAA TCATAAATCT CTTGTTGATT ATATGTATTG GGAAAAGGCA 
TCCAGGCGCA TGCTGGAAGA GGAACGAGTT CCTGTCACCT TTGTGAAATC CGAGGAAAAG 
ACTCAAGAAG AGCATGAAGA AATAGAAAAA CGTAATAAAA ATATGGCCCA GTATTTAAAA 
GAAAAGCTCA ATAATGAAAT AGTTGCAAAT AAAAGAGAAT CAAAGGGCAG CAGCAATATC 
CAAGAAACAG ATGAAGAAGA TGAAGAAGAA GAAGATGATG ATGATGACGA CGAAGGAGAA 
GATGATGGTG AAGAGAGTGA AGAAACGAAC AGAGAAGAGG AAGGCAAAGC AAAGGAACAA 
ATTAGAAATT GTGAGAACAA CTGCCAGCAG GTAACTGACA AAGCATTCAA AGAACAGAGA 
GACAGACCAG AGGCCCAAGA ACAAAGTGAG AAAAAAATAT CGAAATTAGA TCCTAAGAAG 
TTAGCTCTAG ACACCAGCTT TTTGAAGGTA AGTACAAGGC CTTCAGGAAA CCAGACAGAC 
CTGGATGGGA GCTTGAGGAG AGTTAGGAAA AATGATCCTG ACATGAAGGA ACTCAACCTG 
AACAACATTG AAAACATCCC CAAAGAAATG TTACTGGACT TTGTCAATGC AATGAAGAAA 
AACAAGCACA TCAAAACATT CAGTTTAGCC AATGTGGGTG CAGATGAGAA TGTAGCATTT 
GCCTTGGCTA ACATGTTGCG TGAAAATAGA AGCATCACCA CTCTCAACAT CGAGTCCAAT 
TTCATCACAG GTAAAGGGAT TGTGGCCATC ATGAGGTGTC TCCAGTTTAA TGAGACGCTA 
ACTGAGCTTC GGTTTCACAA TCAGAGGCAC ATGTTGGGTC ACCATGCTGA AATGGAAATA 
GCCAGGCTTT TGAAGGCAAA CAACACTCTC CTGAAGATGG GCTACCATTT TGAGCTTCCG 
GGTCCCAGAA TGGTGGTCAC TAATCTGCTC ACCAGGAATC AGGATAAACA AAGGCAGAAA 
CGACAGGAAG AGCAAAAACA GCAGCAACTC AAGGAACAGA AGAAGCTGAT AGCCATGTTA 
GAGAATGGGT TGGGGCTGCC CCCTGGGATG TGGGAGCTGT TGGGAGGACC CAAGCCAGAT 
TCCAGAATGC AGGAATTCTT CCAGCCACCG CCACCTCGGC CTCCCAACCC CCAAAATGTC 
CCCTTTAGTC AACGCAGTGA AATGATGAAA AAGCCATCGC AGGCCCCGAA GTACAGGACA 
GACCCTGACT CCTTCCGGGT GGTGAAGCTG AAGAGAATCC AGCGCAAATC TCGGATGCCG 
GAAGCCAGAG AACCACCCGA GAAAACCAAC CTCAAAGATG TCATCAAAAC GCTCAAGCCA 
GTGCCGAGAA ACAGGCCACC CCCATTGGTG GAAATCACTC CCAGAGATCA GCTGCTAAAC 
GACATTCGTC ACAGCAGTGT CGCCTATCTT AAACCTGTGC AACTGCCAAA AGAACTGGCG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LMOD3 ( NM_001304418.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291347.1 Homo sapiens leiomodin 3 (LMOD3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu30563
Clone ID Related Accession (Same CDS sequence)	NM_001304418.3 , NM_198271.5 , NM_001304418.1 , NM_198271.4 , NM_001304418.2
Accession Version	NM_001304418.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1683bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	leiomodin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA563370.1, AL832033.1, BC121019.2, AI014510.1 and AK300096.1. On Jan 23, 2015 this sequence version replaced XM_005264767.1. Transcript Variant: This variant (2) contains an alternate splice structure in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AK300096.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267760 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAGAGC ACAGCAGAAA TTCAGATCAA GAAGAACTTC TCGATGAGGA GATTAATGAA 
GATGAAATCT TGGCCAACTT GTCTGCTGAA GAACTGAAAG AACTGCAGTC GGAAATGGAA 
GTCATGGCCC CTGACCCCAG CCTTCCCGTG GGAATGATTC AGAAAGATCA AACTGACAAG 
CCACCGACAG GAAACTTCAA TCATAAATCT CTTGTTGATT ATATGTATTG GGAAAAGGCA 
TCCAGGCGCA TGCTGGAAGA GGAACGAGTT CCTGTCACCT TTGTGAAATC CGAGGAAAAG 
ACTCAAGAAG AGCATGAAGA AATAGAAAAA CGTAATAAAA ATATGGCCCA GTATTTAAAA 
GAAAAGCTCA ATAATGAAAT AGTTGCAAAT AAAAGAGAAT CAAAGGGCAG CAGCAATATC 
CAAGAAACAG ATGAAGAAGA TGAAGAAGAA GAAGATGATG ATGATGACGA CGAAGGAGAA 
GATGATGGTG AAGAGAGTGA AGAAACGAAC AGAGAAGAGG AAGGCAAAGC AAAGGAACAA 
ATTAGAAATT GTGAGAACAA CTGCCAGCAG GTAACTGACA AAGCATTCAA AGAACAGAGA 
GACAGACCAG AGGCCCAAGA ACAAAGTGAG AAAAAAATAT CGAAATTAGA TCCTAAGAAG 
TTAGCTCTAG ACACCAGCTT TTTGAAGGTA AGTACAAGGC CTTCAGGAAA CCAGACAGAC 
CTGGATGGGA GCTTGAGGAG AGTTAGGAAA AATGATCCTG ACATGAAGGA ACTCAACCTG 
AACAACATTG AAAACATCCC CAAAGAAATG TTACTGGACT TTGTCAATGC AATGAAGAAA 
AACAAGCACA TCAAAACATT CAGTTTAGCC AATGTGGGTG CAGATGAGAA TGTAGCATTT 
GCCTTGGCTA ACATGTTGCG TGAAAATAGA AGCATCACCA CTCTCAACAT CGAGTCCAAT 
TTCATCACAG GTAAAGGGAT TGTGGCCATC ATGAGGTGTC TCCAGTTTAA TGAGACGCTA 
ACTGAGCTTC GGTTTCACAA TCAGAGGCAC ATGTTGGGTC ACCATGCTGA AATGGAAATA 
GCCAGGCTTT TGAAGGCAAA CAACACTCTC CTGAAGATGG GCTACCATTT TGAGCTTCCG 
GGTCCCAGAA TGGTGGTCAC TAATCTGCTC ACCAGGAATC AGGATAAACA AAGGCAGAAA 
CGACAGGAAG AGCAAAAACA GCAGCAACTC AAGGAACAGA AGAAGCTGAT AGCCATGTTA 
GAGAATGGGT TGGGGCTGCC CCCTGGGATG TGGGAGCTGT TGGGAGGACC CAAGCCAGAT 
TCCAGAATGC AGGAATTCTT CCAGCCACCG CCACCTCGGC CTCCCAACCC CCAAAATGTC 
CCCTTTAGTC AACGCAGTGA AATGATGAAA AAGCCATCGC AGGCCCCGAA GTACAGGACA 
GACCCTGACT CCTTCCGGGT GGTGAAGCTG AAGAGAATCC AGCGCAAATC TCGGATGCCG 
GAAGCCAGAG AACCACCCGA GAAAACCAAC CTCAAAGATG TCATCAAAAC GCTCAAGCCA 
GTGCCGAGAA ACAGGCCACC CCCATTGGTG GAAATCACTC CCAGAGATCA GCTGCTAAAC 
GACATTCGTC ACAGCAGTGT CGCCTATCTT AAACCTGTGC AACTGCCAAA AGAACTGGCG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291347.1
CDS	116..1798
Translation	MSEHSRNSDQEELLDEEINEDEILANLSAEELKELQSEMEVMAPDPSLPVGMIQKDQTDKPPTGNFNHKSLVDYMYWEKASRRMLEEERVPVTFVKSEEKTQEEHEEIEKRNKNMAQYLKEKLNNEIVANKRESKGSSNIQETDEEDEEEEDDDDDDEGEDDGEESEETNREEEGKAKEQIRNCENNCQQVTDKAFKEQRDRPEAQEQSEKKISKLDPKKLALDTSFLKVSTRPSGNQTDLDGSLRRVRKNDPDMKELNLNNIENIPKEMLLDFVNAMKKNKHIKTFSLANVGADENVAFALANMLRENRSITTLNIESNFITGKGIVAIMRCLQFNETLTELRFHNQRHMLGHHAEMEIARLLKANNTLLKMGYHFELPGPRMVVTNLLTRNQDKQRQKRQEEQKQQQLKEQKKLIAMLENGLGLPPGMWELLGGPKPDSRMQEFFQPPPPRPPNPQNVPFSQRSEMMKKPSQAPKYRTDPDSFRVVKLKRIQRKSRMPEAREPPEKTNLKDVIKTLKPVPRNRPPPLVEITPRDQLLNDIRHSSVAYLKPVQLPKELA

Target ORF information:

RefSeq Version	NM_001304418.1
Organism	Homo sapiens(human)
Definition	Homo sapiens leiomodin 3 (LMOD3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304418.1

ORF Insert Sequence:

ATGTCAGAGC ACAGCAGAAA TTCAGATCAA GAAGAACTTC TCGATGAGGA GATTAATGAA 
GATGAAATCT TGGCCAACTT GTCTGCTGAA GAACTGAAAG AACTGCAGTC GGAAATGGAA 
GTCATGGCCC CTGACCCCAG CCTTCCCGTG GGAATGATTC AGAAAGATCA AACTGACAAG 
CCACCGACAG GAAACTTCAA TCATAAATCT CTTGTTGATT ATATGTATTG GGAAAAGGCA 
TCCAGGCGCA TGCTGGAAGA GGAACGAGTT CCTGTCACCT TTGTGAAATC CGAGGAAAAG 
ACTCAAGAAG AGCATGAAGA AATAGAAAAA CGTAATAAAA ATATGGCCCA GTATTTAAAA 
GAAAAGCTCA ATAATGAAAT AGTTGCAAAT AAAAGAGAAT CAAAGGGCAG CAGCAATATC 
CAAGAAACAG ATGAAGAAGA TGAAGAAGAA GAAGATGATG ATGATGACGA CGAAGGAGAA 
GATGATGGTG AAGAGAGTGA AGAAACGAAC AGAGAAGAGG AAGGCAAAGC AAAGGAACAA 
ATTAGAAATT GTGAGAACAA CTGCCAGCAG GTAACTGACA AAGCATTCAA AGAACAGAGA 
GACAGACCAG AGGCCCAAGA ACAAAGTGAG AAAAAAATAT CGAAATTAGA TCCTAAGAAG 
TTAGCTCTAG ACACCAGCTT TTTGAAGGTA AGTACAAGGC CTTCAGGAAA CCAGACAGAC 
CTGGATGGGA GCTTGAGGAG AGTTAGGAAA AATGATCCTG ACATGAAGGA ACTCAACCTG 
AACAACATTG AAAACATCCC CAAAGAAATG TTACTGGACT TTGTCAATGC AATGAAGAAA 
AACAAGCACA TCAAAACATT CAGTTTAGCC AATGTGGGTG CAGATGAGAA TGTAGCATTT 
GCCTTGGCTA ACATGTTGCG TGAAAATAGA AGCATCACCA CTCTCAACAT CGAGTCCAAT 
TTCATCACAG GTAAAGGGAT TGTGGCCATC ATGAGGTGTC TCCAGTTTAA TGAGACGCTA 
ACTGAGCTTC GGTTTCACAA TCAGAGGCAC ATGTTGGGTC ACCATGCTGA AATGGAAATA 
GCCAGGCTTT TGAAGGCAAA CAACACTCTC CTGAAGATGG GCTACCATTT TGAGCTTCCG 
GGTCCCAGAA TGGTGGTCAC TAATCTGCTC ACCAGGAATC AGGATAAACA AAGGCAGAAA 
CGACAGGAAG AGCAAAAACA GCAGCAACTC AAGGAACAGA AGAAGCTGAT AGCCATGTTA 
GAGAATGGGT TGGGGCTGCC CCCTGGGATG TGGGAGCTGT TGGGAGGACC CAAGCCAGAT 
TCCAGAATGC AGGAATTCTT CCAGCCACCG CCACCTCGGC CTCCCAACCC CCAAAATGTC 
CCCTTTAGTC AACGCAGTGA AATGATGAAA AAGCCATCGC AGGCCCCGAA GTACAGGACA 
GACCCTGACT CCTTCCGGGT GGTGAAGCTG AAGAGAATCC AGCGCAAATC TCGGATGCCG 
GAAGCCAGAG AACCACCCGA GAAAACCAAC CTCAAAGATG TCATCAAAAC GCTCAAGCCA 
GTGCCGAGAA ACAGGCCACC CCCATTGGTG GAAATCACTC CCAGAGATCA GCTGCTAAAC 
GACATTCGTC ACAGCAGTGT CGCCTATCTT AAACCTGTGC AACTGCCAAA AGAACTGGCG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LMOD3 ( NM_198271.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_938012.2 Homo sapiens leiomodin 3 (LMOD3), transcript variant 1, mRNA.

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CloneID	OHu30563
Clone ID Related Accession (Same CDS sequence)	NM_001304418.3 , NM_198271.5 , NM_001304418.1 , NM_198271.4 , NM_001304418.2
Accession Version	NM_198271.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1683bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	leiomodin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL832709.1, AL832033.1, BC121019.2, AI014510.1 and AK300096.1. This sequence is a reference standard in the RefSeqGene project. On Jan 23, 2015 this sequence version replaced NM_198271.3. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AL832033.1, AL832709.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2147975 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCAGAGC ACAGCAGAAA TTCAGATCAA GAAGAACTTC TCGATGAGGA GATTAATGAA 
GATGAAATCT TGGCCAACTT GTCTGCTGAA GAACTGAAAG AACTGCAGTC GGAAATGGAA 
GTCATGGCCC CTGACCCCAG CCTTCCCGTG GGAATGATTC AGAAAGATCA AACTGACAAG 
CCACCGACAG GAAACTTCAA TCATAAATCT CTTGTTGATT ATATGTATTG GGAAAAGGCA 
TCCAGGCGCA TGCTGGAAGA GGAACGAGTT CCTGTCACCT TTGTGAAATC CGAGGAAAAG 
ACTCAAGAAG AGCATGAAGA AATAGAAAAA CGTAATAAAA ATATGGCCCA GTATTTAAAA 
GAAAAGCTCA ATAATGAAAT AGTTGCAAAT AAAAGAGAAT CAAAGGGCAG CAGCAATATC 
CAAGAAACAG ATGAAGAAGA TGAAGAAGAA GAAGATGATG ATGATGACGA CGAAGGAGAA 
GATGATGGTG AAGAGAGTGA AGAAACGAAC AGAGAAGAGG AAGGCAAAGC AAAGGAACAA 
ATTAGAAATT GTGAGAACAA CTGCCAGCAG GTAACTGACA AAGCATTCAA AGAACAGAGA 
GACAGACCAG AGGCCCAAGA ACAAAGTGAG AAAAAAATAT CGAAATTAGA TCCTAAGAAG 
TTAGCTCTAG ACACCAGCTT TTTGAAGGTA AGTACAAGGC CTTCAGGAAA CCAGACAGAC 
CTGGATGGGA GCTTGAGGAG AGTTAGGAAA AATGATCCTG ACATGAAGGA ACTCAACCTG 
AACAACATTG AAAACATCCC CAAAGAAATG TTACTGGACT TTGTCAATGC AATGAAGAAA 
AACAAGCACA TCAAAACATT CAGTTTAGCC AATGTGGGTG CAGATGAGAA TGTAGCATTT 
GCCTTGGCTA ACATGTTGCG TGAAAATAGA AGCATCACCA CTCTCAACAT CGAGTCCAAT 
TTCATCACAG GTAAAGGGAT TGTGGCCATC ATGAGGTGTC TCCAGTTTAA TGAGACGCTA 
ACTGAGCTTC GGTTTCACAA TCAGAGGCAC ATGTTGGGTC ACCATGCTGA AATGGAAATA 
GCCAGGCTTT TGAAGGCAAA CAACACTCTC CTGAAGATGG GCTACCATTT TGAGCTTCCG 
GGTCCCAGAA TGGTGGTCAC TAATCTGCTC ACCAGGAATC AGGATAAACA AAGGCAGAAA 
CGACAGGAAG AGCAAAAACA GCAGCAACTC AAGGAACAGA AGAAGCTGAT AGCCATGTTA 
GAGAATGGGT TGGGGCTGCC CCCTGGGATG TGGGAGCTGT TGGGAGGACC CAAGCCAGAT 
TCCAGAATGC AGGAATTCTT CCAGCCACCG CCACCTCGGC CTCCCAACCC CCAAAATGTC 
CCCTTTAGTC AACGCAGTGA AATGATGAAA AAGCCATCGC AGGCCCCGAA GTACAGGACA 
GACCCTGACT CCTTCCGGGT GGTGAAGCTG AAGAGAATCC AGCGCAAATC TCGGATGCCG 
GAAGCCAGAG AACCACCCGA GAAAACCAAC CTCAAAGATG TCATCAAAAC GCTCAAGCCA 
GTGCCGAGAA ACAGGCCACC CCCATTGGTG GAAATCACTC CCAGAGATCA GCTGCTAAAC 
GACATTCGTC ACAGCAGTGT CGCCTATCTT AAACCTGTGC AACTGCCAAA AGAACTGGCG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_938012.2
CDS	210..1892
Translation	MSEHSRNSDQEELLDEEINEDEILANLSAEELKELQSEMEVMAPDPSLPVGMIQKDQTDKPPTGNFNHKSLVDYMYWEKASRRMLEEERVPVTFVKSEEKTQEEHEEIEKRNKNMAQYLKEKLNNEIVANKRESKGSSNIQETDEEDEEEEDDDDDDEGEDDGEESEETNREEEGKAKEQIRNCENNCQQVTDKAFKEQRDRPEAQEQSEKKISKLDPKKLALDTSFLKVSTRPSGNQTDLDGSLRRVRKNDPDMKELNLNNIENIPKEMLLDFVNAMKKNKHIKTFSLANVGADENVAFALANMLRENRSITTLNIESNFITGKGIVAIMRCLQFNETLTELRFHNQRHMLGHHAEMEIARLLKANNTLLKMGYHFELPGPRMVVTNLLTRNQDKQRQKRQEEQKQQQLKEQKKLIAMLENGLGLPPGMWELLGGPKPDSRMQEFFQPPPPRPPNPQNVPFSQRSEMMKKPSQAPKYRTDPDSFRVVKLKRIQRKSRMPEAREPPEKTNLKDVIKTLKPVPRNRPPPLVEITPRDQLLNDIRHSSVAYLKPVQLPKELA

Target ORF information:

RefSeq Version	NM_198271.4
Organism	Homo sapiens(human)
Definition	Homo sapiens leiomodin 3 (LMOD3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_198271.4

ORF Insert Sequence:

ATGTCAGAGC ACAGCAGAAA TTCAGATCAA GAAGAACTTC TCGATGAGGA GATTAATGAA 
GATGAAATCT TGGCCAACTT GTCTGCTGAA GAACTGAAAG AACTGCAGTC GGAAATGGAA 
GTCATGGCCC CTGACCCCAG CCTTCCCGTG GGAATGATTC AGAAAGATCA AACTGACAAG 
CCACCGACAG GAAACTTCAA TCATAAATCT CTTGTTGATT ATATGTATTG GGAAAAGGCA 
TCCAGGCGCA TGCTGGAAGA GGAACGAGTT CCTGTCACCT TTGTGAAATC CGAGGAAAAG 
ACTCAAGAAG AGCATGAAGA AATAGAAAAA CGTAATAAAA ATATGGCCCA GTATTTAAAA 
GAAAAGCTCA ATAATGAAAT AGTTGCAAAT AAAAGAGAAT CAAAGGGCAG CAGCAATATC 
CAAGAAACAG ATGAAGAAGA TGAAGAAGAA GAAGATGATG ATGATGACGA CGAAGGAGAA 
GATGATGGTG AAGAGAGTGA AGAAACGAAC AGAGAAGAGG AAGGCAAAGC AAAGGAACAA 
ATTAGAAATT GTGAGAACAA CTGCCAGCAG GTAACTGACA AAGCATTCAA AGAACAGAGA 
GACAGACCAG AGGCCCAAGA ACAAAGTGAG AAAAAAATAT CGAAATTAGA TCCTAAGAAG 
TTAGCTCTAG ACACCAGCTT TTTGAAGGTA AGTACAAGGC CTTCAGGAAA CCAGACAGAC 
CTGGATGGGA GCTTGAGGAG AGTTAGGAAA AATGATCCTG ACATGAAGGA ACTCAACCTG 
AACAACATTG AAAACATCCC CAAAGAAATG TTACTGGACT TTGTCAATGC AATGAAGAAA 
AACAAGCACA TCAAAACATT CAGTTTAGCC AATGTGGGTG CAGATGAGAA TGTAGCATTT 
GCCTTGGCTA ACATGTTGCG TGAAAATAGA AGCATCACCA CTCTCAACAT CGAGTCCAAT 
TTCATCACAG GTAAAGGGAT TGTGGCCATC ATGAGGTGTC TCCAGTTTAA TGAGACGCTA 
ACTGAGCTTC GGTTTCACAA TCAGAGGCAC ATGTTGGGTC ACCATGCTGA AATGGAAATA 
GCCAGGCTTT TGAAGGCAAA CAACACTCTC CTGAAGATGG GCTACCATTT TGAGCTTCCG 
GGTCCCAGAA TGGTGGTCAC TAATCTGCTC ACCAGGAATC AGGATAAACA AAGGCAGAAA 
CGACAGGAAG AGCAAAAACA GCAGCAACTC AAGGAACAGA AGAAGCTGAT AGCCATGTTA 
GAGAATGGGT TGGGGCTGCC CCCTGGGATG TGGGAGCTGT TGGGAGGACC CAAGCCAGAT 
TCCAGAATGC AGGAATTCTT CCAGCCACCG CCACCTCGGC CTCCCAACCC CCAAAATGTC 
CCCTTTAGTC AACGCAGTGA AATGATGAAA AAGCCATCGC AGGCCCCGAA GTACAGGACA 
GACCCTGACT CCTTCCGGGT GGTGAAGCTG AAGAGAATCC AGCGCAAATC TCGGATGCCG 
GAAGCCAGAG AACCACCCGA GAAAACCAAC CTCAAAGATG TCATCAAAAC GCTCAAGCCA 
GTGCCGAGAA ACAGGCCACC CCCATTGGTG GAAATCACTC CCAGAGATCA GCTGCTAAAC 
GACATTCGTC ACAGCAGTGT CGCCTATCTT AAACCTGTGC AACTGCCAAA AGAACTGGCG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LMOD3 ( NM_001304418.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291347.1 Homo sapiens leiomodin 3 (LMOD3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu30563
Clone ID Related Accession (Same CDS sequence)	NM_001304418.3 , NM_198271.5 , NM_001304418.1 , NM_198271.4 , NM_001304418.2
Accession Version	NM_001304418.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1683bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	leiomodin-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA563370.1, AL832033.1, BC121019.2, AI014510.1, AK300096.1 and AC092060.2. On Jun 2, 2019 this sequence version replaced NM_001304418.1. Transcript Variant: This variant (2) contains an alternate splice structure in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AK300096.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267760 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAGAGC ACAGCAGAAA TTCAGATCAA GAAGAACTTC TCGATGAGGA GATTAATGAA 
GATGAAATCT TGGCCAACTT GTCTGCTGAA GAACTGAAAG AACTGCAGTC GGAAATGGAA 
GTCATGGCCC CTGACCCCAG CCTTCCCGTG GGAATGATTC AGAAAGATCA AACTGACAAG 
CCACCGACAG GAAACTTCAA TCATAAATCT CTTGTTGATT ATATGTATTG GGAAAAGGCA 
TCCAGGCGCA TGCTGGAAGA GGAACGAGTT CCTGTCACCT TTGTGAAATC CGAGGAAAAG 
ACTCAAGAAG AGCATGAAGA AATAGAAAAA CGTAATAAAA ATATGGCCCA GTATTTAAAA 
GAAAAGCTCA ATAATGAAAT AGTTGCAAAT AAAAGAGAAT CAAAGGGCAG CAGCAATATC 
CAAGAAACAG ATGAAGAAGA TGAAGAAGAA GAAGATGATG ATGATGACGA CGAAGGAGAA 
GATGATGGTG AAGAGAGTGA AGAAACGAAC AGAGAAGAGG AAGGCAAAGC AAAGGAACAA 
ATTAGAAATT GTGAGAACAA CTGCCAGCAG GTAACTGACA AAGCATTCAA AGAACAGAGA 
GACAGACCAG AGGCCCAAGA ACAAAGTGAG AAAAAAATAT CGAAATTAGA TCCTAAGAAG 
TTAGCTCTAG ACACCAGCTT TTTGAAGGTA AGTACAAGGC CTTCAGGAAA CCAGACAGAC 
CTGGATGGGA GCTTGAGGAG AGTTAGGAAA AATGATCCTG ACATGAAGGA ACTCAACCTG 
AACAACATTG AAAACATCCC CAAAGAAATG TTACTGGACT TTGTCAATGC AATGAAGAAA 
AACAAGCACA TCAAAACATT CAGTTTAGCC AATGTGGGTG CAGATGAGAA TGTAGCATTT 
GCCTTGGCTA ACATGTTGCG TGAAAATAGA AGCATCACCA CTCTCAACAT CGAGTCCAAT 
TTCATCACAG GTAAAGGGAT TGTGGCCATC ATGAGGTGTC TCCAGTTTAA TGAGACGCTA 
ACTGAGCTTC GGTTTCACAA TCAGAGGCAC ATGTTGGGTC ACCATGCTGA AATGGAAATA 
GCCAGGCTTT TGAAGGCAAA CAACACTCTC CTGAAGATGG GCTACCATTT TGAGCTTCCG 
GGTCCCAGAA TGGTGGTCAC TAATCTGCTC ACCAGGAATC AGGATAAACA AAGGCAGAAA 
CGACAGGAAG AGCAAAAACA GCAGCAACTC AAGGAACAGA AGAAGCTGAT AGCCATGTTA 
GAGAATGGGT TGGGGCTGCC CCCTGGGATG TGGGAGCTGT TGGGAGGACC CAAGCCAGAT 
TCCAGAATGC AGGAATTCTT CCAGCCACCG CCACCTCGGC CTCCCAACCC CCAAAATGTC 
CCCTTTAGTC AACGCAGTGA AATGATGAAA AAGCCATCGC AGGCCCCGAA GTACAGGACA 
GACCCTGACT CCTTCCGGGT GGTGAAGCTG AAGAGAATCC AGCGCAAATC TCGGATGCCG 
GAAGCCAGAG AACCACCCGA GAAAACCAAC CTCAAAGATG TCATCAAAAC GCTCAAGCCA 
GTGCCGAGAA ACAGGCCACC CCCATTGGTG GAAATCACTC CCAGAGATCA GCTGCTAAAC 
GACATTCGTC ACAGCAGTGT CGCCTATCTT AAACCTGTGC AACTGCCAAA AGAACTGGCG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291347.1
CDS	116..1798
Translation	MSEHSRNSDQEELLDEEINEDEILANLSAEELKELQSEMEVMAPDPSLPVGMIQKDQTDKPPTGNFNHKSLVDYMYWEKASRRMLEEERVPVTFVKSEEKTQEEHEEIEKRNKNMAQYLKEKLNNEIVANKRESKGSSNIQETDEEDEEEEDDDDDDEGEDDGEESEETNREEEGKAKEQIRNCENNCQQVTDKAFKEQRDRPEAQEQSEKKISKLDPKKLALDTSFLKVSTRPSGNQTDLDGSLRRVRKNDPDMKELNLNNIENIPKEMLLDFVNAMKKNKHIKTFSLANVGADENVAFALANMLRENRSITTLNIESNFITGKGIVAIMRCLQFNETLTELRFHNQRHMLGHHAEMEIARLLKANNTLLKMGYHFELPGPRMVVTNLLTRNQDKQRQKRQEEQKQQQLKEQKKLIAMLENGLGLPPGMWELLGGPKPDSRMQEFFQPPPPRPPNPQNVPFSQRSEMMKKPSQAPKYRTDPDSFRVVKLKRIQRKSRMPEAREPPEKTNLKDVIKTLKPVPRNRPPPLVEITPRDQLLNDIRHSSVAYLKPVQLPKELA

Target ORF information:

RefSeq Version	NM_001304418.2
Organism	Homo sapiens(human)
Definition	Homo sapiens leiomodin 3 (LMOD3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304418.2

ORF Insert Sequence:

ATGTCAGAGC ACAGCAGAAA TTCAGATCAA GAAGAACTTC TCGATGAGGA GATTAATGAA 
GATGAAATCT TGGCCAACTT GTCTGCTGAA GAACTGAAAG AACTGCAGTC GGAAATGGAA 
GTCATGGCCC CTGACCCCAG CCTTCCCGTG GGAATGATTC AGAAAGATCA AACTGACAAG 
CCACCGACAG GAAACTTCAA TCATAAATCT CTTGTTGATT ATATGTATTG GGAAAAGGCA 
TCCAGGCGCA TGCTGGAAGA GGAACGAGTT CCTGTCACCT TTGTGAAATC CGAGGAAAAG 
ACTCAAGAAG AGCATGAAGA AATAGAAAAA CGTAATAAAA ATATGGCCCA GTATTTAAAA 
GAAAAGCTCA ATAATGAAAT AGTTGCAAAT AAAAGAGAAT CAAAGGGCAG CAGCAATATC 
CAAGAAACAG ATGAAGAAGA TGAAGAAGAA GAAGATGATG ATGATGACGA CGAAGGAGAA 
GATGATGGTG AAGAGAGTGA AGAAACGAAC AGAGAAGAGG AAGGCAAAGC AAAGGAACAA 
ATTAGAAATT GTGAGAACAA CTGCCAGCAG GTAACTGACA AAGCATTCAA AGAACAGAGA 
GACAGACCAG AGGCCCAAGA ACAAAGTGAG AAAAAAATAT CGAAATTAGA TCCTAAGAAG 
TTAGCTCTAG ACACCAGCTT TTTGAAGGTA AGTACAAGGC CTTCAGGAAA CCAGACAGAC 
CTGGATGGGA GCTTGAGGAG AGTTAGGAAA AATGATCCTG ACATGAAGGA ACTCAACCTG 
AACAACATTG AAAACATCCC CAAAGAAATG TTACTGGACT TTGTCAATGC AATGAAGAAA 
AACAAGCACA TCAAAACATT CAGTTTAGCC AATGTGGGTG CAGATGAGAA TGTAGCATTT 
GCCTTGGCTA ACATGTTGCG TGAAAATAGA AGCATCACCA CTCTCAACAT CGAGTCCAAT 
TTCATCACAG GTAAAGGGAT TGTGGCCATC ATGAGGTGTC TCCAGTTTAA TGAGACGCTA 
ACTGAGCTTC GGTTTCACAA TCAGAGGCAC ATGTTGGGTC ACCATGCTGA AATGGAAATA 
GCCAGGCTTT TGAAGGCAAA CAACACTCTC CTGAAGATGG GCTACCATTT TGAGCTTCCG 
GGTCCCAGAA TGGTGGTCAC TAATCTGCTC ACCAGGAATC AGGATAAACA AAGGCAGAAA 
CGACAGGAAG AGCAAAAACA GCAGCAACTC AAGGAACAGA AGAAGCTGAT AGCCATGTTA 
GAGAATGGGT TGGGGCTGCC CCCTGGGATG TGGGAGCTGT TGGGAGGACC CAAGCCAGAT 
TCCAGAATGC AGGAATTCTT CCAGCCACCG CCACCTCGGC CTCCCAACCC CCAAAATGTC 
CCCTTTAGTC AACGCAGTGA AATGATGAAA AAGCCATCGC AGGCCCCGAA GTACAGGACA 
GACCCTGACT CCTTCCGGGT GGTGAAGCTG AAGAGAATCC AGCGCAAATC TCGGATGCCG 
GAAGCCAGAG AACCACCCGA GAAAACCAAC CTCAAAGATG TCATCAAAAC GCTCAAGCCA 
GTGCCGAGAA ACAGGCCACC CCCATTGGTG GAAATCACTC CCAGAGATCA GCTGCTAAAC 
GACATTCGTC ACAGCAGTGT CGCCTATCTT AAACCTGTGC AACTGCCAAA AGAACTGGCG 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LMOD3-Associated Nemaline Myopathy: Prenatal Ultrasonographic, Pathologic, and Molecular Findings.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine(2018 Jan)
Berkenstadt M,Pode-Shakked B,Barel O,Barash H,Achiron R,Gilboa Y,Kidron D,Raas-Rothschild A

Neonatal fractures as a presenting feature of LMOD3-associated congenital myopathy.
American journal of medical genetics. Part A173(10)2789-2794(2017 Oct)
Abbott M,Jain M,Pferdehirt R,Chen Y,Tran A,Duz MB,Seven M,Gibbs RA,Muzny D,Lee B,Marom R,Burrage LC

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy.
The Journal of clinical investigation124(11)4693-708(2014 Nov)
Yuen M,Sandaradura SA,Dowling JJ,Kostyukova AS,Moroz N,Quinlan KG,Lehtokari VL,Ravenscroft G,Todd EJ,Ceyhan-Birsoy O,Gokhin DS,Maluenda J,Lek M,Nolent F,Pappas CT,Novak SM,D'Amico A,Malfatti E,Thomas BP,Gabriel SB,Gupta N,Daly MJ,Ilkovski B,Houweling PJ,Davidson AE,Swanson LC,Brownstein CA,Gupta VA,Medne L,Shannon P,Martin N,Bick DP,Flisberg A,Holmberg E,Van den Bergh P,Lapunzina P,Waddell LB,Sloboda DD,Bertini E,Chitayat D,Telfer WR,Laquerri?re A,Gregorio CC,Ottenheijm CA,B?nnemann CG,Pelin K,Beggs AH,Hayashi YK,Romero NB,Laing NG,Nishino I,Wallgren-Pettersson C,Melki J,Fowler VM,MacArthur DG,North KN,Clarke NF

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LMOD3 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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