CDC37L1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CDC37L1
Entrez Gene ID	55664
Full Name	cell division cycle 37 like 1
Synonyms	CDC37B,HARC
General protein information	Preferred Names cell division cycle 37 like 1 Names hsp90 co-chaperone Cdc37-like 1 CDC37 cell division cycle 37 homolog-like 1 Hsp90-associating relative of Cdc37 cell division cycle 37 homolog-like 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p24.1
Summary	CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008].
Disorder MIM:	610346

mRNA and Protein(s)

mRNA	Protein	Name
NM_017913.3	NP_060383.2	hsp90 co-chaperone Cdc37-like 1
NM_017913.4	NP_060383.2	hsp90 co-chaperone Cdc37-like 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Cdc37l1	NP_080226.1
Rattus norvegicus (Norway rat)	Cdc37l1	NP_001011941.1
Gallus gallus (chicken)	CDC37L1	XP_424174.3
	CDC37L1	XP_001085222.1
Xenopus tropicalis (tropical clawed frog)	cdc37l1	NP_001037905.1
Canis lupus familiaris (dog)	CDC37L1	XP_533542.1
Pan troglodytes (chimpanzee)	CDC37L1	XP_528531.2
Bos taurus (cattle)	CDC37L1	NP_001092401.1
Danio rerio (zebrafish)	cdc37l1	NP_001103296.2
Homo sapiens (human)	CDC37L1	NP_060383.2

Gene Ontology
Bibliography

Related articles in PubMed

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Taipale M, Tucker G, Peng J, Krykbaeva I, Lin ZY, Larsen B, Choi H, Berger B, Gingras AC, Lindquist S
Cell158(2)434-448(2014 Jul)

Toward an understanding of the protein interaction network of the human liver.
Wang J, Huo K, Ma L, Tang L, Li D, Huang X, Yuan Y, Li C, Wang W, Guan W, Chen H, Jin C, Wei J, Zhang W, Yang Y, Liu Q, Zhou Y, Zhang C, Wu Z, Xu W, Zhang Y, Liu T, Yu D, Zhang Y, Chen L, Zhu D, Zhong X, Kang L, Gan X, Yu X, Ma Q, Yan J, Zhou L, Liu Z, Zhu Y, Zhou T, He F, Yang X
Molecular systems biology7536(2011 Oct)

Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat shock.
Cartledge K, Elsegood C, Roiniotis J, Hamilton JA, Scholz GM
Biochemistry46(51)15144-52(2007 Dec)

Domain-mediated dimerization of the Hsp90 cochaperones Harc and Cdc37.
Roiniotis J, Masendycz P, Ho S, Scholz GM
Biochemistry44(17)6662-9(2005 May)

Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37.
Scholz GM, Cartledge K, Hall NE
The Journal of biological chemistry276(33)30971-9(2001 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

C-terminal domain of Harc is a key determinant of its cochaperone functions
Title: Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat shock.

Harc forms dimers in vitro. The structural similarities between Harc and Cdc37 suggest that Harc may function to regulate the Hsp90-mediated folding of Cdc37-dependent protein kinases into functional conformations via dimerization with Cdc37.
Title: Domain-mediated dimerization of the Hsp90 cochaperones Harc and Cdc37.

The following CDC37L1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDC37L1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13164	NM_017913.4 Latest version!	Homo sapiens cell division cycle 37 like 1 (CDC37L1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu13164	NM_017913.3	Homo sapiens cell division cycle 37 like 1 (CDC37L1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CDC37L1 ( NM_017913.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060383.2 Homo sapiens cell division cycle 37 like 1 (CDC37L1), mRNA.

Price & Availability↑

CloneID	OHu13164
Clone ID Related Accession (Same CDS sequence)	NM_017913.3 , NM_017913.4
Accession Version	NM_017913.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	hsp90 co-chaperone Cdc37-like 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA180237.1, BC014133.2 and AL136231.12. On Jan 7, 2015 this sequence version replaced NM_017913.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.3552.1, SRR1660807.125889.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAACAAC CGTGGCCGCC TCCGGGACCC TGGAGCCTCC CTCGGGCCGA GGGTGAGGCT 
GAGGAAGAGA GTGACTTCGA CGTGTTCCCC AGTTCTCCCC GCTGCCCGCA GCTGCCAGGC 
GGCGGCGCCC AGATGTATAG CCATGGAATT GAATTGGCTT GCCAAAAGCA GAAAGAGTTT 
GTGAAGAGCT CTGTGGCGTG CAAATGGAAT CTTGCTGAAG CTCAACAGAA ACTTGGTAGC 
TTAGCACTGC ATAATTCTGA GTCCTTGGAT CAGGAGCATG CCAAAGCACA AACAGCAGTA 
TCAGAACTGA GGCAACGGGA AGAAGAGTGG CGACAGAAAG AAGAAGCTCT AGTACAAAGA 
GAGAAGATGT GTCTGTGGAG CACGGATGCC ATTAGCAAGG ATGTTTTTAA TAAGAGTTTT 
ATTAATCAAG ATAAAAGAAA AGACACAGAA GATGAAGATA AATCAGAATC ATTTATGCAA 
AAATATGAGC AAAAAATCAG ACATTTTGGT ATGTTGAGTC GATGGGATGA TAGCCAGAGA 
TTTTTGTCTG ACCATCCATA CCTTGTATGT GAAGAAACTG CTAAATATCT TATTTTATGG 
TGTTTTCACC TGGAAGCTGA GAAGAAAGGG GCTTTAATGG AACAAATAGC ACATCAAGCT 
GTTGTAATGC AGTTTATTAT GGAAATGGCC AAAAACTGTA ATGTGGATCC AAGAGGGTGT 
TTTCGTTTAT TTTTCCAGAA AGCCAAAGCA GAGGAAGAAG GTTATTTTGA AGCATTCAAA 
AATGAACTTG AAGCTTTCAA GTCAAGAGTA AGACTTTATT CTCAATCACA AAGTTTTCAA 
CCTATGACAG TTCAGAATCA TGTTCCCCAT TCTGGTGTTG GATCTATAGG TTTATTAGAA 
TCCTTACCAC AGAATCCAGA TTATCTTCAG TATTCTATCA GTACAGCTCT CTGCAGCTTA 
AACTCGGTGG TACATAAAGA AGATGATGAA CCCAAAATGA TGGACACTGT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060383.2
CDS	216..1229
Translation	MEQPWPPPGPWSLPRAEGEAEEESDFDVFPSSPRCPQLPGGGAQMYSHGIELACQKQKEFVKSSVACKWNLAEAQQKLGSLALHNSESLDQEHAKAQTAVSELRQREEEWRQKEEALVQREKMCLWSTDAISKDVFNKSFINQDKRKDTEDEDKSESFMQKYEQKIRHFGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPHSGVGSIGLLESLPQNPDYLQYSISTALCSLNSVVHKEDDEPKMMDTV

Target ORF information:

RefSeq Version	NM_017913.3
Organism	Homo sapiens(human)
Definition	Homo sapiens cell division cycle 37 like 1 (CDC37L1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017913.3

ORF Insert Sequence:

ATGGAACAAC CGTGGCCGCC TCCGGGACCC TGGAGCCTCC CTCGGGCCGA GGGTGAGGCT 
GAGGAAGAGA GTGACTTCGA CGTGTTCCCC AGTTCTCCCC GCTGCCCGCA GCTGCCAGGC 
GGCGGCGCCC AGATGTATAG CCATGGAATT GAATTGGCTT GCCAAAAGCA GAAAGAGTTT 
GTGAAGAGCT CTGTGGCGTG CAAATGGAAT CTTGCTGAAG CTCAACAGAA ACTTGGTAGC 
TTAGCACTGC ATAATTCTGA GTCCTTGGAT CAGGAGCATG CCAAAGCACA AACAGCAGTA 
TCAGAACTGA GGCAACGGGA AGAAGAGTGG CGACAGAAAG AAGAAGCTCT AGTACAAAGA 
GAGAAGATGT GTCTGTGGAG CACGGATGCC ATTAGCAAGG ATGTTTTTAA TAAGAGTTTT 
ATTAATCAAG ATAAAAGAAA AGACACAGAA GATGAAGATA AATCAGAATC ATTTATGCAA 
AAATATGAGC AAAAAATCAG ACATTTTGGT ATGTTGAGTC GATGGGATGA TAGCCAGAGA 
TTTTTGTCTG ACCATCCATA CCTTGTATGT GAAGAAACTG CTAAATATCT TATTTTATGG 
TGTTTTCACC TGGAAGCTGA GAAGAAAGGG GCTTTAATGG AACAAATAGC ACATCAAGCT 
GTTGTAATGC AGTTTATTAT GGAAATGGCC AAAAACTGTA ATGTGGATCC AAGAGGGTGT 
TTTCGTTTAT TTTTCCAGAA AGCCAAAGCA GAGGAAGAAG GTTATTTTGA AGCATTCAAA 
AATGAACTTG AAGCTTTCAA GTCAAGAGTA AGACTTTATT CTCAATCACA AAGTTTTCAA 
CCTATGACAG TTCAGAATCA TGTTCCCCAT TCTGGTGTTG GATCTATAGG TTTATTAGAA 
TCCTTACCAC AGAATCCAGA TTATCTTCAG TATTCTATCA GTACAGCTCT CTGCAGCTTA 
AACTCGGTGG TACATAAAGA AGATGATGAA CCCAAAATGA TGGACACTGT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CDC37L1 ( NM_017913.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060383.2 Homo sapiens cell division cycle 37 like 1 (CDC37L1), mRNA.

Price & Availability↑

CloneID	OHu13164
Clone ID Related Accession (Same CDS sequence)	NM_017913.3 , NM_017913.4
Accession Version	NM_017913.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1014bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	hsp90 co-chaperone Cdc37-like 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA180237.1, BC014133.2 and AL136231.12. On Nov 23, 2018 this sequence version replaced NM_017913.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.420111.1, SRR1660803.3552.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000381854.4/ ENSP00000371278.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAACAAC CGTGGCCGCC TCCGGGACCC TGGAGCCTCC CTCGGGCCGA GGGTGAGGCT 
GAGGAAGAGA GTGACTTCGA CGTGTTCCCC AGTTCTCCCC GCTGCCCGCA GCTGCCAGGC 
GGCGGCGCCC AGATGTATAG CCATGGAATT GAATTGGCTT GCCAAAAGCA GAAAGAGTTT 
GTGAAGAGCT CTGTGGCGTG CAAATGGAAT CTTGCTGAAG CTCAACAGAA ACTTGGTAGC 
TTAGCACTGC ATAATTCTGA GTCCTTGGAT CAGGAGCATG CCAAAGCACA AACAGCAGTA 
TCAGAACTGA GGCAACGGGA AGAAGAGTGG CGACAGAAAG AAGAAGCTCT AGTACAAAGA 
GAGAAGATGT GTCTGTGGAG CACGGATGCC ATTAGCAAGG ATGTTTTTAA TAAGAGTTTT 
ATTAATCAAG ATAAAAGAAA AGACACAGAA GATGAAGATA AATCAGAATC ATTTATGCAA 
AAATATGAGC AAAAAATCAG ACATTTTGGT ATGTTGAGTC GATGGGATGA TAGCCAGAGA 
TTTTTGTCTG ACCATCCATA CCTTGTATGT GAAGAAACTG CTAAATATCT TATTTTATGG 
TGTTTTCACC TGGAAGCTGA GAAGAAAGGG GCTTTAATGG AACAAATAGC ACATCAAGCT 
GTTGTAATGC AGTTTATTAT GGAAATGGCC AAAAACTGTA ATGTGGATCC AAGAGGGTGT 
TTTCGTTTAT TTTTCCAGAA AGCCAAAGCA GAGGAAGAAG GTTATTTTGA AGCATTCAAA 
AATGAACTTG AAGCTTTCAA GTCAAGAGTA AGACTTTATT CTCAATCACA AAGTTTTCAA 
CCTATGACAG TTCAGAATCA TGTTCCCCAT TCTGGTGTTG GATCTATAGG TTTATTAGAA 
TCCTTACCAC AGAATCCAGA TTATCTTCAG TATTCTATCA GTACAGCTCT CTGCAGCTTA 
AACTCGGTGG TACATAAAGA AGATGATGAA CCCAAAATGA TGGACACTGT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060383.2
CDS	200..1213
Translation	MEQPWPPPGPWSLPRAEGEAEEESDFDVFPSSPRCPQLPGGGAQMYSHGIELACQKQKEFVKSSVACKWNLAEAQQKLGSLALHNSESLDQEHAKAQTAVSELRQREEEWRQKEEALVQREKMCLWSTDAISKDVFNKSFINQDKRKDTEDEDKSESFMQKYEQKIRHFGMLSRWDDSQRFLSDHPYLVCEETAKYLILWCFHLEAEKKGALMEQIAHQAVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYSQSQSFQPMTVQNHVPHSGVGSIGLLESLPQNPDYLQYSISTALCSLNSVVHKEDDEPKMMDTV

Target ORF information:

RefSeq Version	NM_017913.4
Organism	Homo sapiens(human)
Definition	Homo sapiens cell division cycle 37 like 1 (CDC37L1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_017913.4

ORF Insert Sequence:

ATGGAACAAC CGTGGCCGCC TCCGGGACCC TGGAGCCTCC CTCGGGCCGA GGGTGAGGCT 
GAGGAAGAGA GTGACTTCGA CGTGTTCCCC AGTTCTCCCC GCTGCCCGCA GCTGCCAGGC 
GGCGGCGCCC AGATGTATAG CCATGGAATT GAATTGGCTT GCCAAAAGCA GAAAGAGTTT 
GTGAAGAGCT CTGTGGCGTG CAAATGGAAT CTTGCTGAAG CTCAACAGAA ACTTGGTAGC 
TTAGCACTGC ATAATTCTGA GTCCTTGGAT CAGGAGCATG CCAAAGCACA AACAGCAGTA 
TCAGAACTGA GGCAACGGGA AGAAGAGTGG CGACAGAAAG AAGAAGCTCT AGTACAAAGA 
GAGAAGATGT GTCTGTGGAG CACGGATGCC ATTAGCAAGG ATGTTTTTAA TAAGAGTTTT 
ATTAATCAAG ATAAAAGAAA AGACACAGAA GATGAAGATA AATCAGAATC ATTTATGCAA 
AAATATGAGC AAAAAATCAG ACATTTTGGT ATGTTGAGTC GATGGGATGA TAGCCAGAGA 
TTTTTGTCTG ACCATCCATA CCTTGTATGT GAAGAAACTG CTAAATATCT TATTTTATGG 
TGTTTTCACC TGGAAGCTGA GAAGAAAGGG GCTTTAATGG AACAAATAGC ACATCAAGCT 
GTTGTAATGC AGTTTATTAT GGAAATGGCC AAAAACTGTA ATGTGGATCC AAGAGGGTGT 
TTTCGTTTAT TTTTCCAGAA AGCCAAAGCA GAGGAAGAAG GTTATTTTGA AGCATTCAAA 
AATGAACTTG AAGCTTTCAA GTCAAGAGTA AGACTTTATT CTCAATCACA AAGTTTTCAA 
CCTATGACAG TTCAGAATCA TGTTCCCCAT TCTGGTGTTG GATCTATAGG TTTATTAGAA 
TCCTTACCAC AGAATCCAGA TTATCTTCAG TATTCTATCA GTACAGCTCT CTGCAGCTTA 
AACTCGGTGG TACATAAAGA AGATGATGAA CCCAAAATGA TGGACACTGT ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Cell158(2)434-448(2014 Jul)
Taipale M,Tucker G,Peng J,Krykbaeva I,Lin ZY,Larsen B,Choi H,Berger B,Gingras AC,Lindquist S

Toward an understanding of the protein interaction network of the human liver.
Molecular systems biology7536(2011 Oct)
Wang J,Huo K,Ma L,Tang L,Li D,Huang X,Yuan Y,Li C,Wang W,Guan W,Chen H,Jin C,Wei J,Zhang W,Yang Y,Liu Q,Zhou Y,Zhang C,Wu Z,Xu W,Zhang Y,Liu T,Yu D,Zhang Y,Chen L,Zhu D,Zhong X,Kang L,Gan X,Yu X,Ma Q,Yan J,Zhou L,Liu Z,Zhu Y,Zhou T,He F,Yang X

Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat shock.
Biochemistry46(51)15144-52(2007 Dec)
Cartledge K,Elsegood C,Roiniotis J,Hamilton JA,Scholz GM

Domain-mediated dimerization of the Hsp90 cochaperones Harc and Cdc37.
Biochemistry44(17)6662-9(2005 May)
Roiniotis J,Masendycz P,Ho S,Scholz GM

Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37.
The Journal of biological chemistry276(33)30971-9(2001 Aug)
Scholz GM,Cartledge K,Hall NE

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CDC37L1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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