TRPV6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TRPV6
Entrez Gene ID	55503
Full Name	transient receptor potential cation channel subfamily V member 6
Synonyms	ABP/ZF,CAT1,CATL,ECAC2,HSA277909,LP6728,ZFAB
General protein information	Preferred Names transient receptor potential cation channel subfamily V member 6 Names transient receptor potential cation channel subfamily V member 6 Alu-binding protein with zinc finger domain calcium transport protein 1 calcium transporter-like protein epithelial apical membrane calcium transporter/channel CaT1 epithelial calcium channel 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q34
Summary	This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. Translation initiation for this protein occurs at a non-AUG start codon that is decoded as methionine. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds. [provided by RefSeq, Feb 2015].
Disorder MIM:	606680

mRNA and Protein(s)

mRNA	Protein	Name
NM_018646.5	NP_061116.5	transient receptor potential cation channel subfamily V member 6
NM_018646.6	NP_061116.5	transient receptor potential cation channel subfamily V member 6

Pathways from BioSystems

Homologies

Homo sapiens (human)	TRPV6	NP_061116.3
Bos taurus (cattle)	TRPV6	NP_001193118.1
Danio rerio (zebrafish)	trpv6	NP_001001849.1
Xenopus tropicalis (tropical clawed frog)	trpv5	NP_001186854.1
Pan troglodytes (chimpanzee)	TRPV6	XP_001161776.1
	TRPV6	XP_001091685.2
Mus musculus (house mouse)	Trpv6	NP_071858.2
Canis lupus familiaris (dog)	TRPV6	XP_539861.4
Rattus norvegicus (Norway rat)	Trpv6	NP_446138.1
Gallus gallus (chicken)	TRPV6	XP_004938199.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of chondrocyte functions by transient receptor potential cation channel V6 in osteoarthritis.
Song T, Ma J, Guo L, Yang P, Zhou X, Ye T
Journal of cellular physiology232(11)3170-3181(2017 Nov)

1?,25-Dihydroxyvitamin D
Ishizawa M, Akagi D, Yamamoto J, Makishima M
The Journal of steroid biochemistry and molecular biology17255-61(2017 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TRPV6 expression is significantly decreased in chondrocytes from patients with osteoarthritis of the knees. TRPV6 could regulate certain chondrocyte functions, including ECM secretion, cell proliferation, and apoptosis.
Title: Regulation of chondrocyte functions by transient receptor potential cation channel V6 in osteoarthritis.

The findings indicate that p38alpha and GADD45alpha are involved in an enhanced vitamin D signaling on TRPV6 expression.
Title: 1?,25-Dihydroxyvitamin D

TRPV6 down-regulation is associated with decreased Ca(2+) response pattern and reduced NFAT activity.
Title: TRPV6 modulates proliferation of human pancreatic neuroendocrine BON-1 tumour cells.

TRPV6 is down-regulated in esophageal squamous cell carcinoma and plays a role in predicting survival of male and female patients.
Title: TRPV6 plays a new role in predicting survival of patients with esophageal squamous cell carcinoma.

TRPV6 calcium ion channel plays a critical role in flow-induced Ca(2+) influx and microvilli formation.
Title: Fluid shear triggers microvilli formation via mechanosensitive activation of TRPV6.

The following TRPV6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TRPV6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu69418	NM_018646.5 Latest version!	Homo sapiens transient receptor potential cation channel subfamily V member 6 (TRPV6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu107499	NM_018646.6 Latest version!	Homo sapiens transient receptor potential cation channel subfamily V member 6 (TRPV6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TRPV6 ( NM_018646.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_061116.5 Homo sapiens transient receptor potential cation channel subfamily V member 6 (TRPV6), mRNA.

Price & Availability↑

CloneID	OHu69418
Clone ID Related Accession (Same CDS sequence)	NM_018646.5
Accession Version	NM_018646.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2298bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	transient receptor potential cation channel subfamily V member 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291707.1, AF365927.1 and AW137696.1. This sequence is a reference standard in the RefSeqGene project. On Nov 20, 2014 this sequence version replaced NM_018646.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: KF534785.1, AF365927.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 23612980 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ACGGGACCTC TACAGGGAGA CGGTGGGCCG GCCCTTGGGG GGGCTGATGT GGCCCCAAGG 
CTGAGTCCCG TCAGGGTCTG GCCTCGGCCT CAGGCCCCCA AGGAGCCGGC CCTACACCCC 
ATGGGTTTGT CACTGCCCAA GGAGAAAGGG CTAATTCTCT GCCTATGGAG CAAGTTCTGC 
AGATGGTTCC AGAGACGGGA GTCCTGGGCC CAGAGCCGAG ATGAGCAGAA CCTGCTGCAG 
CAGAAGAGGA TCTGGGAGTC TCCTCTCCTT CTAGCTGCCA AAGATAATGA TGTCCAGGCC 
CTGAACAAGT TGCTCAAGTA TGAGGATTGC AAGGTGCACC AGAGAGGAGC CATGGGGGAA 
ACAGCGCTAC ACATAGCAGC CCTCTATGAC AACCTGGAGG CCGCCATGGT GCTGATGGAG 
GCTGCCCCGG AGCTGGTCTT TGAGCCCATG ACATCTGAGC TCTATGAGGG TCAGACTGCA 
CTGCACATCG CTGTTGTGAA CCAGAACATG AACCTGGTGC GAGCCCTGCT TGCCCGCAGG 
GCCAGTGTCT CTGCCAGAGC CACAGGCACT GCCTTCCGCC GTAGTCCCTG CAACCTCATC 
TACTTTGGGG AGCACCCTTT GTCCTTTGCT GCCTGTGTGA ACAGTGAGGA GATCGTGCGG 
CTGCTCATTG AGCATGGAGC TGACATCCGG GCCCAGGACT CCCTGGGAAA CACAGTGTTA 
CACATCCTCA TCCTCCAGCC CAACAAAACC TTTGCCTGCC AGATGTACAA CCTGTTGCTG 
TCCTACGACA GACATGGGGA CCACCTGCAG CCCCTGGACC TCGTGCCCAA TCACCAGGGT 
CTCACCCCTT TCAAGCTGGC TGGAGTGGAG GGTAACACTG TGATGTTTCA GCACCTGATG 
CAGAAGCGGA AGCACACCCA GTGGACGTAT GGACCACTGA CCTCGACTCT CTATGACCTC 
ACAGAGATCG ACTCCTCAGG GGATGAGCAG TCCCTGCTGG AACTTATCAT CACCACCAAG 
AAGCGGGAGG CTCGCCAGAT CCTGGACCAG ACGCCGGTGA AGGAGCTGGT GAGCCTCAAG 
TGGAAGCGGT ACGGGCGGCC GTACTTCTGC ATGCTGGGTG CCATATATCT GCTGTACATC 
ATCTGCTTCA CCATGTGCTG CATCTACCGC CCCCTCAAGC CCAGGACCAA TAACCGCACG 
AGCCCCCGGG ACAACACCCT CTTACAGCAG AAGCTACTTC AGGAAGCCTA CATGACCCCT 
AAGGACGATA TCCGGCTGGT CGGGGAGCTG GTGACTGTCA TTGGGGCTAT CATCATCCTG 
CTGGTAGAGG TTCCAGACAT CTTCAGAATG GGGGTCACTC GCTTCTTTGG ACAGACCATC 
CTTGGGGGCC CATTCCATGT CCTCATCATC ACCTATGCCT TCATGGTGCT GGTGACCATG 
GTGATGCGGC TCATCAGTGC CAGCGGGGAG GTGGTACCCA TGTCCTTTGC ACTCGTGCTG 
GGCTGGTGCA ACGTCATGTA CTTCGCCCGA GGATTCCAGA TGCTAGGCCC CTTCACCATC 
ATGATTCAGA AGATGATTTT TGGCGACCTG ATGCGATTCT GCTGGCTGAT GGCTGTGGTC 
ATCCTGGGCT TTGCTTCAGC CTTCTATATC ATCTTCCAGA CAGAGGACCC CGAGGAGCTA 
GGCCACTTCT ACGACTACCC CATGGCCCTG TTCAGCACCT TCGAGCTGTT CCTTACCATC 
ATCGATGGCC CAGCCAACTA CAACGTGGAC CTGCCCTTCA TGTACAGCAT CACCTATGCT 
GCCTTTGCCA TCATCGCCAC ACTGCTCATG CTCAACCTCC TCATTGCCAT GATGGGCGAC 
ACTCACTGGC GAGTGGCCCA TGAGCGGGAT GAGCTGTGGA GGGCCCAGAT TGTGGCCACC 
ACGGTGATGC TGGAGCGGAA GCTGCCTCGC TGCCTGTGGC CTCGCTCCGG GATCTGCGGA 
CGGGAGTATG GCCTGGGAGA CCGCTGGTTC CTGCGGGTGG AAGACAGGCA AGATCTCAAC 
CGGCAGCGGA TCCAACGCTA CGCACAGGCC TTCCACACCC GGGGCTCTGA GGATTTGGAC 
AAAGACTCAG TGGAAAAACT AGAGCTGGGC TGTCCCTTCA GCCCCCACCT GTCCCTTCCT 
ATGCCCTCAG TGTCTCGAAG TACCTCCCGC AGCAGTGCCA ATTGGGAAAG GCTTCGGCAA 
GGGACCCTGA GGAGAGACCT GCGTGGGATA ATCAACAGGG GTCTGGAGGA CGGGGAGAGC 
TGGGAATATC AGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061116.5
CDS	110..2407
Translation	TGPLQGDGGPALGGADVAPRLSPVRVWPRPQAPKEPALHPMGLSLPKEKGLILCLWSKFCRWFQRRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFHVLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTIIDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLDKDSVEKLELGCPFSPHLSLPMPSVSRSTSRSSANWERLRQGTLRRDLRGIINRGLEDGESWEYQI

Target ORF information:

RefSeq Version	NM_018646.5
Organism	Homo sapiens(human)
Definition	Homo sapiens transient receptor potential cation channel subfamily V member 6 (TRPV6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018646.5

ORF Insert Sequence:

ACGGGACCTC TACAGGGAGA CGGTGGGCCG GCCCTTGGGG GGGCTGATGT GGCCCCAAGG 
CTGAGTCCCG TCAGGGTCTG GCCTCGGCCT CAGGCCCCCA AGGAGCCGGC CCTACACCCC 
ATGGGTTTGT CACTGCCCAA GGAGAAAGGG CTAATTCTCT GCCTATGGAG CAAGTTCTGC 
AGATGGTTCC AGAGACGGGA GTCCTGGGCC CAGAGCCGAG ATGAGCAGAA CCTGCTGCAG 
CAGAAGAGGA TCTGGGAGTC TCCTCTCCTT CTAGCTGCCA AAGATAATGA TGTCCAGGCC 
CTGAACAAGT TGCTCAAGTA TGAGGATTGC AAGGTGCACC AGAGAGGAGC CATGGGGGAA 
ACAGCGCTAC ACATAGCAGC CCTCTATGAC AACCTGGAGG CCGCCATGGT GCTGATGGAG 
GCTGCCCCGG AGCTGGTCTT TGAGCCCATG ACATCTGAGC TCTATGAGGG TCAGACTGCA 
CTGCACATCG CTGTTGTGAA CCAGAACATG AACCTGGTGC GAGCCCTGCT TGCCCGCAGG 
GCCAGTGTCT CTGCCAGAGC CACAGGCACT GCCTTCCGCC GTAGTCCCTG CAACCTCATC 
TACTTTGGGG AGCACCCTTT GTCCTTTGCT GCCTGTGTGA ACAGTGAGGA GATCGTGCGG 
CTGCTCATTG AGCATGGAGC TGACATCCGG GCCCAGGACT CCCTGGGAAA CACAGTGTTA 
CACATCCTCA TCCTCCAGCC CAACAAAACC TTTGCCTGCC AGATGTACAA CCTGTTGCTG 
TCCTACGACA GACATGGGGA CCACCTGCAG CCCCTGGACC TCGTGCCCAA TCACCAGGGT 
CTCACCCCTT TCAAGCTGGC TGGAGTGGAG GGTAACACTG TGATGTTTCA GCACCTGATG 
CAGAAGCGGA AGCACACCCA GTGGACGTAT GGACCACTGA CCTCGACTCT CTATGACCTC 
ACAGAGATCG ACTCCTCAGG GGATGAGCAG TCCCTGCTGG AACTTATCAT CACCACCAAG 
AAGCGGGAGG CTCGCCAGAT CCTGGACCAG ACGCCGGTGA AGGAGCTGGT GAGCCTCAAG 
TGGAAGCGGT ACGGGCGGCC GTACTTCTGC ATGCTGGGTG CCATATATCT GCTGTACATC 
ATCTGCTTCA CCATGTGCTG CATCTACCGC CCCCTCAAGC CCAGGACCAA TAACCGCACG 
AGCCCCCGGG ACAACACCCT CTTACAGCAG AAGCTACTTC AGGAAGCCTA CATGACCCCT 
AAGGACGATA TCCGGCTGGT CGGGGAGCTG GTGACTGTCA TTGGGGCTAT CATCATCCTG 
CTGGTAGAGG TTCCAGACAT CTTCAGAATG GGGGTCACTC GCTTCTTTGG ACAGACCATC 
CTTGGGGGCC CATTCCATGT CCTCATCATC ACCTATGCCT TCATGGTGCT GGTGACCATG 
GTGATGCGGC TCATCAGTGC CAGCGGGGAG GTGGTACCCA TGTCCTTTGC ACTCGTGCTG 
GGCTGGTGCA ACGTCATGTA CTTCGCCCGA GGATTCCAGA TGCTAGGCCC CTTCACCATC 
ATGATTCAGA AGATGATTTT TGGCGACCTG ATGCGATTCT GCTGGCTGAT GGCTGTGGTC 
ATCCTGGGCT TTGCTTCAGC CTTCTATATC ATCTTCCAGA CAGAGGACCC CGAGGAGCTA 
GGCCACTTCT ACGACTACCC CATGGCCCTG TTCAGCACCT TCGAGCTGTT CCTTACCATC 
ATCGATGGCC CAGCCAACTA CAACGTGGAC CTGCCCTTCA TGTACAGCAT CACCTATGCT 
GCCTTTGCCA TCATCGCCAC ACTGCTCATG CTCAACCTCC TCATTGCCAT GATGGGCGAC 
ACTCACTGGC GAGTGGCCCA TGAGCGGGAT GAGCTGTGGA GGGCCCAGAT TGTGGCCACC 
ACGGTGATGC TGGAGCGGAA GCTGCCTCGC TGCCTGTGGC CTCGCTCCGG GATCTGCGGA 
CGGGAGTATG GCCTGGGAGA CCGCTGGTTC CTGCGGGTGG AAGACAGGCA AGATCTCAAC 
CGGCAGCGGA TCCAACGCTA CGCACAGGCC TTCCACACCC GGGGCTCTGA GGATTTGGAC 
AAAGACTCAG TGGAAAAACT AGAGCTGGGC TGTCCCTTCA GCCCCCACCT GTCCCTTCCT 
ATGCCCTCAG TGTCTCGAAG TACCTCCCGC AGCAGTGCCA ATTGGGAAAG GCTTCGGCAA 
GGGACCCTGA GGAGAGACCT GCGTGGGATA ATCAACAGGG GTCTGGAGGA CGGGGAGAGC 
TGGGAATATC AGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TRPV6 ( NM_018646.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_061116.5 Homo sapiens transient receptor potential cation channel subfamily V member 6 (TRPV6), mRNA.

Price & Availability↑

CloneID	OHu107499
Clone ID Related Accession (Same CDS sequence)	NM_018646.6
Accession Version	NM_018646.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2298bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	transient receptor potential cation channel subfamily V member 6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC245427.3. On Nov 23, 2018 this sequence version replaced NM_018646.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: KF534785.1, AF365927.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 23612980 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ACGGGACCTC TACAGGGAGA CGGTGGGCCG GCCCTTGGGG GGGCTGATGT GGCCCCAAGG 
CTGAGTCCCG TCAGGGTCTG GCCTCGGCCT CAGGCCCCCA AGGAGCCGGC CCTACACCCC 
ATGGGTTTGT CACTGCCCAA GGAGAAAGGG CTAATTCTCT GCCTATGGAG CAAGTTCTGC 
AGATGGTTCC AGAGACGGGA GTCCTGGGCC CAGAGCCGAG ATGAGCAGAA CCTGCTGCAG 
CAGAAGAGGA TCTGGGAGTC TCCTCTCCTT CTAGCTGCCA AAGATAATGA TGTCCAGGCC 
CTGAACAAGT TGCTCAAGTA TGAGGATTGC AAGGTGCACC AGAGAGGAGC CATGGGGGAA 
ACAGCGCTAC ACATAGCAGC CCTCTATGAC AACCTGGAGG CCGCCATGGT GCTGATGGAG 
GCTGCCCCGG AGCTGGTCTT TGAGCCCATG ACATCTGAGC TCTATGAGGG TCAGACTGCA 
CTGCACATCG CTGTTGTGAA CCAGAACATG AACCTGGTGC GAGCCCTGCT TGCCCGCAGG 
GCCAGTGTCT CTGCCAGAGC CACAGGCACT GCCTTCCGCC GTAGTCCCTG CAACCTCATC 
TACTTTGGGG AGCACCCTTT GTCCTTTGCT GCCTGTGTGA ACAGTGAGGA GATCGTGCGG 
CTGCTCATTG AGCATGGAGC TGACATCCGG GCCCAGGACT CCCTGGGAAA CACAGTGTTA 
CACATCCTCA TCCTCCAGCC CAACAAAACC TTTGCCTGCC AGATGTACAA CCTGTTGCTG 
TCCTACGACA GACATGGGGA CCACCTGCAG CCCCTGGACC TCGTGCCCAA TCACCAGGGT 
CTCACCCCTT TCAAGCTGGC TGGAGTGGAG GGTAACACTG TGATGTTTCA GCACCTGATG 
CAGAAGCGGA AGCACACCCA GTGGACGTAT GGACCACTGA CCTCGACTCT CTATGACCTC 
ACAGAGATCG ACTCCTCAGG GGATGAGCAG TCCCTGCTGG AACTTATCAT CACCACCAAG 
AAGCGGGAGG CTCGCCAGAT CCTGGACCAG ACGCCGGTGA AGGAGCTGGT GAGCCTCAAG 
TGGAAGCGGT ACGGGCGGCC GTACTTCTGC ATGCTGGGTG CCATATATCT GCTGTACATC 
ATCTGCTTCA CCATGTGCTG CATCTACCGC CCCCTCAAGC CCAGGACCAA TAACCGCACG 
AGCCCCCGGG ACAACACCCT CTTACAGCAG AAGCTACTTC AGGAAGCCTA CATGACCCCT 
AAGGACGATA TCCGGCTGGT CGGGGAGCTG GTGACTGTCA TTGGGGCTAT CATCATCCTG 
CTGGTAGAGG TTCCAGACAT CTTCAGAATG GGGGTCACTC GCTTCTTTGG ACAGACCATC 
CTTGGGGGCC CATTCCATGT CCTCATCATC ACCTATGCCT TCATGGTGCT GGTGACCATG 
GTGATGCGGC TCATCAGTGC CAGCGGGGAG GTGGTACCCA TGTCCTTTGC ACTCGTGCTG 
GGCTGGTGCA ACGTCATGTA CTTCGCCCGA GGATTCCAGA TGCTAGGCCC CTTCACCATC 
ATGATTCAGA AGATGATTTT TGGCGACCTG ATGCGATTCT GCTGGCTGAT GGCTGTGGTC 
ATCCTGGGCT TTGCTTCAGC CTTCTATATC ATCTTCCAGA CAGAGGACCC CGAGGAGCTA 
GGCCACTTCT ACGACTACCC CATGGCCCTG TTCAGCACCT TCGAGCTGTT CCTTACCATC 
ATCGATGGCC CAGCCAACTA CAACGTGGAC CTGCCCTTCA TGTACAGCAT CACCTATGCT 
GCCTTTGCCA TCATCGCCAC ACTGCTCATG CTCAACCTCC TCATTGCCAT GATGGGCGAC 
ACTCACTGGC GAGTGGCCCA TGAGCGGGAT GAGCTGTGGA GGGCCCAGAT TGTGGCCACC 
ACAGTGATGC TGGAGCGGAA GCTGCCTCGC TGCCTGTGGC CTCGCTCCGG GATCTGCGGA 
CGGGAGTATG GCCTGGGAGA CCGCTGGTTC CTGCGGGTGG AAGACAGGCA AGATCTCAAC 
CGGCAGCGGA TCCAACGCTA CGCACAGGCC TTCCACACCC GGGGCTCTGA GGATTTGGAC 
AAAGACTCAG TGGAAAAACT AGAGCTGGGC TGTCCCTTCA GCCCCCACCT GTCCCTTCCT 
ATGCCCTCAG TGTCTCGAAG TACCTCCCGC AGCAGTGCCA ATTGGGAAAG GCTTCGGCAA 
GGGACCCTGA GGAGAGACCT GCGTGGGATA ATCAACAGGG GTCTGGAGGA CGGGGAGAGC 
TGGGAATATC AGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_061116.5
CDS	110..2407
Translation	TGPLQGDGGPALGGADVAPRLSPVRVWPRPQAPKEPALHPMGLSLPKEKGLILCLWSKFCRWFQRRESWAQSRDEQNLLQQKRIWESPLLLAAKDNDVQALNKLLKYEDCKVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDRHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRKHTQWTYGPLTSTLYDLTEIDSSGDEQSLLELIITTKKREARQILDQTPVKELVSLKWKRYGRPYFCMLGAIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTVIGAIIILLVEVPDIFRMGVTRFFGQTILGGPFHVLIITYAFMVLVTMVMRLISASGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPEELGHFYDYPMALFSTFELFLTIIDGPANYNVDLPFMYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIQRYAQAFHTRGSEDLDKDSVEKLELGCPFSPHLSLPMPSVSRSTSRSSANWERLRQGTLRRDLRGIINRGLEDGESWEYQI

Target ORF information:

RefSeq Version	NM_018646.6
Organism	Homo sapiens(human)
Definition	Homo sapiens transient receptor potential cation channel subfamily V member 6 (TRPV6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018646.6

ORF Insert Sequence:

ACGGGACCTC TACAGGGAGA CGGTGGGCCG GCCCTTGGGG GGGCTGATGT GGCCCCAAGG 
CTGAGTCCCG TCAGGGTCTG GCCTCGGCCT CAGGCCCCCA AGGAGCCGGC CCTACACCCC 
ATGGGTTTGT CACTGCCCAA GGAGAAAGGG CTAATTCTCT GCCTATGGAG CAAGTTCTGC 
AGATGGTTCC AGAGACGGGA GTCCTGGGCC CAGAGCCGAG ATGAGCAGAA CCTGCTGCAG 
CAGAAGAGGA TCTGGGAGTC TCCTCTCCTT CTAGCTGCCA AAGATAATGA TGTCCAGGCC 
CTGAACAAGT TGCTCAAGTA TGAGGATTGC AAGGTGCACC AGAGAGGAGC CATGGGGGAA 
ACAGCGCTAC ACATAGCAGC CCTCTATGAC AACCTGGAGG CCGCCATGGT GCTGATGGAG 
GCTGCCCCGG AGCTGGTCTT TGAGCCCATG ACATCTGAGC TCTATGAGGG TCAGACTGCA 
CTGCACATCG CTGTTGTGAA CCAGAACATG AACCTGGTGC GAGCCCTGCT TGCCCGCAGG 
GCCAGTGTCT CTGCCAGAGC CACAGGCACT GCCTTCCGCC GTAGTCCCTG CAACCTCATC 
TACTTTGGGG AGCACCCTTT GTCCTTTGCT GCCTGTGTGA ACAGTGAGGA GATCGTGCGG 
CTGCTCATTG AGCATGGAGC TGACATCCGG GCCCAGGACT CCCTGGGAAA CACAGTGTTA 
CACATCCTCA TCCTCCAGCC CAACAAAACC TTTGCCTGCC AGATGTACAA CCTGTTGCTG 
TCCTACGACA GACATGGGGA CCACCTGCAG CCCCTGGACC TCGTGCCCAA TCACCAGGGT 
CTCACCCCTT TCAAGCTGGC TGGAGTGGAG GGTAACACTG TGATGTTTCA GCACCTGATG 
CAGAAGCGGA AGCACACCCA GTGGACGTAT GGACCACTGA CCTCGACTCT CTATGACCTC 
ACAGAGATCG ACTCCTCAGG GGATGAGCAG TCCCTGCTGG AACTTATCAT CACCACCAAG 
AAGCGGGAGG CTCGCCAGAT CCTGGACCAG ACGCCGGTGA AGGAGCTGGT GAGCCTCAAG 
TGGAAGCGGT ACGGGCGGCC GTACTTCTGC ATGCTGGGTG CCATATATCT GCTGTACATC 
ATCTGCTTCA CCATGTGCTG CATCTACCGC CCCCTCAAGC CCAGGACCAA TAACCGCACG 
AGCCCCCGGG ACAACACCCT CTTACAGCAG AAGCTACTTC AGGAAGCCTA CATGACCCCT 
AAGGACGATA TCCGGCTGGT CGGGGAGCTG GTGACTGTCA TTGGGGCTAT CATCATCCTG 
CTGGTAGAGG TTCCAGACAT CTTCAGAATG GGGGTCACTC GCTTCTTTGG ACAGACCATC 
CTTGGGGGCC CATTCCATGT CCTCATCATC ACCTATGCCT TCATGGTGCT GGTGACCATG 
GTGATGCGGC TCATCAGTGC CAGCGGGGAG GTGGTACCCA TGTCCTTTGC ACTCGTGCTG 
GGCTGGTGCA ACGTCATGTA CTTCGCCCGA GGATTCCAGA TGCTAGGCCC CTTCACCATC 
ATGATTCAGA AGATGATTTT TGGCGACCTG ATGCGATTCT GCTGGCTGAT GGCTGTGGTC 
ATCCTGGGCT TTGCTTCAGC CTTCTATATC ATCTTCCAGA CAGAGGACCC CGAGGAGCTA 
GGCCACTTCT ACGACTACCC CATGGCCCTG TTCAGCACCT TCGAGCTGTT CCTTACCATC 
ATCGATGGCC CAGCCAACTA CAACGTGGAC CTGCCCTTCA TGTACAGCAT CACCTATGCT 
GCCTTTGCCA TCATCGCCAC ACTGCTCATG CTCAACCTCC TCATTGCCAT GATGGGCGAC 
ACTCACTGGC GAGTGGCCCA TGAGCGGGAT GAGCTGTGGA GGGCCCAGAT TGTGGCCACC 
ACAGTGATGC TGGAGCGGAA GCTGCCTCGC TGCCTGTGGC CTCGCTCCGG GATCTGCGGA 
CGGGAGTATG GCCTGGGAGA CCGCTGGTTC CTGCGGGTGG AAGACAGGCA AGATCTCAAC 
CGGCAGCGGA TCCAACGCTA CGCACAGGCC TTCCACACCC GGGGCTCTGA GGATTTGGAC 
AAAGACTCAG TGGAAAAACT AGAGCTGGGC TGTCCCTTCA GCCCCCACCT GTCCCTTCCT 
ATGCCCTCAG TGTCTCGAAG TACCTCCCGC AGCAGTGCCA ATTGGGAAAG GCTTCGGCAA 
GGGACCCTGA GGAGAGACCT GCGTGGGATA ATCAACAGGG GTCTGGAGGA CGGGGAGAGC 
TGGGAATATC AGATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of chondrocyte functions by transient receptor potential cation channel V6 in osteoarthritis.
Journal of cellular physiology232(11)3170-3181(2017 Nov)
Song T,Ma J,Guo L,Yang P,Zhou X,Ye T

1?,25-Dihydroxyvitamin D
The Journal of steroid biochemistry and molecular biology17255-61(2017 09)
Ishizawa M,Akagi D,Yamamoto J,Makishima M

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TRPV6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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