Trpv6 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Trpv6
Entrez Gene ID	64177
Full Name	transient receptor potential cation channel, subfamily V, member 6
Synonyms	CAT,CaT1,Cac,Ecac2,Otrpc3
General protein information	Preferred Names transient receptor potential cation channel, subfamily V, member 6 Names transient receptor potential cation channel subfamily V member 6 calcium transport protein 1 epithelial calcium channel 2 osmosensitive transient receptor potential channel 3
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 6 Map Location: 6\|6 B2.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_022413.4	NP_071858.3	transient receptor potential cation channel subfamily V member 6

Pathways from BioSystems

Homologies

Homo sapiens (human)	TRPV6	NP_061116.3
Bos taurus (cattle)	TRPV6	NP_001193118.1
Danio rerio (zebrafish)	trpv6	NP_001001849.1
Xenopus tropicalis (tropical clawed frog)	trpv5	NP_001186854.1
Pan troglodytes (chimpanzee)	TRPV6	XP_001161776.1
	TRPV6	XP_001091685.2
Mus musculus (house mouse)	Trpv6	NP_071858.2
Canis lupus familiaris (dog)	TRPV6	XP_539861.4
Rattus norvegicus (Norway rat)	Trpv6	NP_446138.1
Gallus gallus (chicken)	TRPV6	XP_004938199.1

Gene Ontology
Bibliography

Related articles in PubMed

Regulation of chondrocyte functions by transient receptor potential cation channel V6 in osteoarthritis.
Song T, Ma J, Guo L, Yang P, Zhou X, Ye T
Journal of cellular physiology232(11)3170-3181(2017 Nov)

NF-?B dependent up-regulation of TRPC6 by A? in BV-2 microglia cells increases COX-2 expression and contributes to hippocampus neuron damage.
Liu N, Zhuang Y, Zhou Z, Zhao J, Chen Q, Zheng J
Neuroscience letters6511-8(2017 Jun)

Transient receptor potential vanilloid 6 (TRPV6) in the mouse brain: Distribution and estrous cycle-related changes in the hypothalamus.
Kumar S, Singh U, Singh O, Goswami C, Singru PS
Neuroscience344204-216(2017 Mar)

Augmented Endothelial-Specific L-Arginine Transport Blunts the Contribution of the Sympathetic Nervous System to Obesity Induced Hypertension in Mice.
Rajapakse NW, Karim F, Evans RG, Kaye DM, Head GA
PloS one10(7)e0131424(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TRPV6-/- mice spontaneously developed osteoarthritis at a younger age and had more severe manifestations of OA than wild-type controls. TRPV6 could regulate certain chondrocyte functions, including ECM secretion, cell proliferation, and apoptosis.
Title: Regulation of chondrocyte functions by transient receptor potential cation channel V6 in osteoarthritis.

Study showed that TRPV6-expressing elements seem to be discretely organized in the brain of mouse. TRPV6-immunoreactive arcuate neurons co-express estrogen receptor alpha and the ion channel protein expression in the mediobasal hypothalamus showed correlation with estrous cycle.
Title: Transient receptor potential vanilloid 6 (TRPV6) in the mouse brain: Distribution and estrous cycle-related changes in the hypothalamus.

CAT1 overexpression prevents obesity-induced hypertension by reducing the influence of the SNS on the maintenance of arterial pressure but not by buffering pressor responses to stress.
Title: Augmented Endothelial-Specific L-Arginine Transport Blunts the Contribution of the Sympathetic Nervous System to Obesity Induced Hypertension in Mice.

focus on TRPV6 gene polymorphisms, the start of TRPV6 translation at a non-AUG codon and the functions of TRPV6 in intestinal Ca(2+) uptake, sperm maturation, and male fertility.
Title: The transient receptor potential cation channel subfamily V member 6 (TRPV6): genetics, biochemical properties, and functions of exceptional calcium channel proteins.

these data indicate that obesity-induced down-regulation of CAT1 expression and subsequent reduced bioavailability of nitric oxide may contribute to the development of obesity-induced hypertension.
Title: Augmented endothelial-specific L-arginine transport prevents obesity-induced hypertension.

The following Trpv6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Trpv6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu69858	NM_022413.4 Latest version!	Mus musculus transient receptor potential cation channel, subfamily V, member 6 (Trpv6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Trpv6 ( NM_022413.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_071858.3 Mus musculus transient receptor potential cation channel, subfamily V, member 6 (Trpv6), mRNA.

Price & Availability↑

CloneID	OMu69858
Clone ID Related Accession (Same CDS sequence)	NM_022413.4
Accession Version	NM_022413.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2304bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-20
Organism	Mus musculus(house mouse)
Product	transient receptor potential cation channel subfamily V member 6
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK168760.1, AK077234.1 and CF583712.1. On Dec 18, 2009 this sequence version replaced NM_022413.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK168760.1, AK077234.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## non-AUG initiation codon :: PMID: 23612980 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ACGGGACCTC TACAGAGAGA GGACAGGCCG GCTCTTGGGG GTGCCAATGT GGCCCCAGGG 
TCGAGCCCAG TTGGGGTCTG GCATCAGCCT CAGCCCCCCA AGGAACCAGC CTTCCACCCC 
ATGGGGTGGT CCCTGCCCAA GGAGAAGGGG TTAATACTCT GCCTATGGAA CAAGTTCTGC 
AGATGGTTCC ACAGACAAGA GTCCTGGGCT CAGAGCCGAG ACGAGCAGAA CCTGCTGCAG 
CAGAAGAGGA TCTGGGAATC ACCTCTTCTT CTAGCTGCCA AAGAAAACGA TGTCCAGGCT 
CTGAGCAAGC TGCTCAAGTT TGAAGGATGT GAGGTGCACC AGAGAGGAGC CATGGGGGAA 
ACTGCACTTC ACATAGCAGC CCTCTATGAT AACCTGGAGG CTGCAATGGT GCTAATGGAG 
GCTGCCCCAG AACTAGTCTT TGAGCCCATG ACTTCGGAGC TATATGAAGG TCAGACTGCA 
CTACACATTG CAGTAATAAA CCAGAATGTA AACTTGGTCC GTGCTCTGCT TGCCCGAGGG 
GCCAGTGTCT CTGCCAGAGC TACAGGCTCT GTCTTCCACT ACAGGCCTCA CAACCTCATT 
TACTATGGAG AGCACCCTTT GTCCTTTGCT GCCTGTGTGG GTAGTGAGGA GATTGTTAGA 
CTGCTCATTG AGCATGGAGC TGACATCCGT GCCCAGGACT CTCTGGGAAA TACAGTACTA 
CACATACTCA TCCTGCAGCC CAACAAAACC TTTGCCTGCC AGATGTACAA CTTGCTACTG 
TCCTATGATG GGGGAGACCA CCTGAAGTCC CTGGAACTTG TGCCAAATAA CCAGGGACTC 
ACCCCCTTCA AGTTGGCTGG GGTGGAAGGC AACATTGTGA TGTTCCAACA CCTGATGCAG 
AAGCGGAAAC ACATCCAGTG GACATATGGG CCATTGACCT CCACACTGTA TGACCTCACT 
GAGATTGACT CCTCAGGAGA TGATCAATCC CTACTGGAAC TTATTGTTAC TACCAAGAAA 
CGGGAGGCTC GCCAGATCCT GGACCAGACA CCTGTAAAGG AACTGGTGAG CCTCAAGTGG 
AAGAGGTATG GGCGGCCCTA CTTCTGCGTG CTGGGTGCCA TCTATGTGCT GTACATCATC 
TGCTTTACCA TGTGCTGTGT CTACCGCCCG CTCAAGCCCA GGATCACTAA CCGCACCAAC 
CCCCGGGACA ACACTCTGAT GCAACAGAAG CTCCTTCAGG AGGCCTATGT GACCCCTAAG 
GATGACCTCC GGTTGGTGGG GGAACTCGTG AGCATCGTTG GGGCTGTGAT CATCCTGCTG 
GTGGAGATTC CAGACATCTT CAGGTTGGGG GTCACTCGAT TCTTTGGACA GACCATTCTC 
GGGGGGCCAT TCCATGTCAT CATTATCACT TATGCCTTCA TGGTGCTGGT GACCATGGTG 
ATGCGACTCA CCAATGTAGA TGGAGAAGTG GTGCCCATGT CCTTTGCTCT GGTGTTGGGC 
TGGTGCAATG TCATGTACTT TGCCAGAGGA TTCCAGATGC TGGGTCCCTT CACCATCATG 
ATTCAGAAGA TGATTTTTGG TGACTTGATG CGATTCTGCT GGCTGATGGC TGTGGTAATT 
CTGGGATTTG CTTCAGCCTT CTATATCATT TTCCAGACAG AGGATCCCGA TGAGCTGGGT 
CATTTCTATG ACTACCCCAT GGCACTGTTC AGCACCTTTG AACTCTTCCT CACCATCATC 
GATGGCCCTG CCAACTATGA CGTGGATCTG CCCTTCATGT ACAGCGTTAC CTACGCTGCC 
TTTGCCATCA TCGCCACACT GCTCATGCTT AACCTCCTCA TTGCCATGAT GGGTGACACT 
CACTGGAGAG TTGCCCATGA GCGAGATGAG CTCTGGAGAG CACAGGTTGT GGCCACCACT 
GTGATGTTAG AGCGGAAGCT ACCTCGTTGC CTGTGGCCTC GCTCTGGGAT ATGTGGGCGA 
GAGTATGGTC TTGGCGACCG CTGGTTCTTG AGGGTGGAAG ACAGGCAAGA TCTCAACAGA 
CAACGCATCC GCCGCTATGC ACAGGCCTTC CAGCAACAAG ATGGCCTCTA CTCTGAGGAC 
TTGGAAAAAG ATTCAGGAGA AAAACTGGAG ACAGCACGTC CCTTTGGTGC CTATCTGTCC 
TTTCCTACAC CCTCAGTATC TCGAAGTACC TCCCGAAGCA GCACCAATTG GGAAAGGCTT 
CGACAAGGGG CCCTGAGGAA GGACCTGCGG GGGATAATCA ACCGGGGCCT AGAAGATGGG 
GAGGGCTGGG AGTACCAGAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071858.3
CDS	176..2479
Translation	TGPLQREDRPALGGANVAPGSSPVGVWHQPQPPKEPAFHPMGWSLPKEKGLILCLWNKFCRWFHRQESWAQSRDEQNLLQQKRIWESPLLLAAKENDVQALSKLLKFEGCEVHQRGAMGETALHIAALYDNLEAAMVLMEAAPELVFEPMTSELYEGQTALHIAVINQNVNLVRALLARGASVSARATGSVFHYRPHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGGDHLKSLELVPNNQGLTPFKLAGVEGNIVMFQHLMQKRKHIQWTYGPLTSTLYDLTEIDSSGDDQSLLELIVTTKKREARQILDQTPVKELVSLKWKRYGRPYFCVLGAIYVLYIICFTMCCVYRPLKPRITNRTNPRDNTLMQQKLLQEAYVTPKDDLRLVGELVSIVGAVIILLVEIPDIFRLGVTRFFGQTILGGPFHVIIITYAFMVLVTMVMRLTNVDGEVVPMSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPDELGHFYDYPMALFSTFELFLTIIDGPANYDVDLPFMYSVTYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQVVATTVMLERKLPRCLWPRSGICGREYGLGDRWFLRVEDRQDLNRQRIRRYAQAFQQQDGLYSEDLEKDSGEKLETARPFGAYLSFPTPSVSRSTSRSSTNWERLRQGALRKDLRGIINRGLEDGEGWEYQI

Target ORF information:

RefSeq Version	NM_022413.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus transient receptor potential cation channel, subfamily V, member 6 (Trpv6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022413.4

ORF Insert Sequence:

ACGGGACCTC TACAGAGAGA GGACAGGCCG GCTCTTGGGG GTGCCAATGT GGCCCCAGGG 
TCGAGCCCAG TTGGGGTCTG GCATCAGCCT CAGCCCCCCA AGGAACCAGC CTTCCACCCC 
ATGGGGTGGT CCCTGCCCAA GGAGAAGGGG TTAATACTCT GCCTATGGAA CAAGTTCTGC 
AGATGGTTCC ACAGACAAGA GTCCTGGGCT CAGAGCCGAG ACGAGCAGAA CCTGCTGCAG 
CAGAAGAGGA TCTGGGAATC ACCTCTTCTT CTAGCTGCCA AAGAAAACGA TGTCCAGGCT 
CTGAGCAAGC TGCTCAAGTT TGAAGGATGT GAGGTGCACC AGAGAGGAGC CATGGGGGAA 
ACTGCACTTC ACATAGCAGC CCTCTATGAT AACCTGGAGG CTGCAATGGT GCTAATGGAG 
GCTGCCCCAG AACTAGTCTT TGAGCCCATG ACTTCGGAGC TATATGAAGG TCAGACTGCA 
CTACACATTG CAGTAATAAA CCAGAATGTA AACTTGGTCC GTGCTCTGCT TGCCCGAGGG 
GCCAGTGTCT CTGCCAGAGC TACAGGCTCT GTCTTCCACT ACAGGCCTCA CAACCTCATT 
TACTATGGAG AGCACCCTTT GTCCTTTGCT GCCTGTGTGG GTAGTGAGGA GATTGTTAGA 
CTGCTCATTG AGCATGGAGC TGACATCCGT GCCCAGGACT CTCTGGGAAA TACAGTACTA 
CACATACTCA TCCTGCAGCC CAACAAAACC TTTGCCTGCC AGATGTACAA CTTGCTACTG 
TCCTATGATG GGGGAGACCA CCTGAAGTCC CTGGAACTTG TGCCAAATAA CCAGGGACTC 
ACCCCCTTCA AGTTGGCTGG GGTGGAAGGC AACATTGTGA TGTTCCAACA CCTGATGCAG 
AAGCGGAAAC ACATCCAGTG GACATATGGG CCATTGACCT CCACACTGTA TGACCTCACT 
GAGATTGACT CCTCAGGAGA TGATCAATCC CTACTGGAAC TTATTGTTAC TACCAAGAAA 
CGGGAGGCTC GCCAGATCCT GGACCAGACA CCTGTAAAGG AACTGGTGAG CCTCAAGTGG 
AAGAGGTATG GGCGGCCCTA CTTCTGCGTG CTGGGTGCCA TCTATGTGCT GTACATCATC 
TGCTTTACCA TGTGCTGTGT CTACCGCCCG CTCAAGCCCA GGATCACTAA CCGCACCAAC 
CCCCGGGACA ACACTCTGAT GCAACAGAAG CTCCTTCAGG AGGCCTATGT GACCCCTAAG 
GATGACCTCC GGTTGGTGGG GGAACTCGTG AGCATCGTTG GGGCTGTGAT CATCCTGCTG 
GTGGAGATTC CAGACATCTT CAGGTTGGGG GTCACTCGAT TCTTTGGACA GACCATTCTC 
GGGGGGCCAT TCCATGTCAT CATTATCACT TATGCCTTCA TGGTGCTGGT GACCATGGTG 
ATGCGACTCA CCAATGTAGA TGGAGAAGTG GTGCCCATGT CCTTTGCTCT GGTGTTGGGC 
TGGTGCAATG TCATGTACTT TGCCAGAGGA TTCCAGATGC TGGGTCCCTT CACCATCATG 
ATTCAGAAGA TGATTTTTGG TGACTTGATG CGATTCTGCT GGCTGATGGC TGTGGTAATT 
CTGGGATTTG CTTCAGCCTT CTATATCATT TTCCAGACAG AGGATCCCGA TGAGCTGGGT 
CATTTCTATG ACTACCCCAT GGCACTGTTC AGCACCTTTG AACTCTTCCT CACCATCATC 
GATGGCCCTG CCAACTATGA CGTGGATCTG CCCTTCATGT ACAGCGTTAC CTACGCTGCC 
TTTGCCATCA TCGCCACACT GCTCATGCTT AACCTCCTCA TTGCCATGAT GGGTGACACT 
CACTGGAGAG TTGCCCATGA GCGAGATGAG CTCTGGAGAG CACAGGTTGT GGCCACCACT 
GTGATGTTAG AGCGGAAGCT ACCTCGTTGC CTGTGGCCTC GCTCTGGGAT ATGTGGGCGA 
GAGTATGGTC TTGGCGACCG CTGGTTCTTG AGGGTGGAAG ACAGGCAAGA TCTCAACAGA 
CAACGCATCC GCCGCTATGC ACAGGCCTTC CAGCAACAAG ATGGCCTCTA CTCTGAGGAC 
TTGGAAAAAG ATTCAGGAGA AAAACTGGAG ACAGCACGTC CCTTTGGTGC CTATCTGTCC 
TTTCCTACAC CCTCAGTATC TCGAAGTACC TCCCGAAGCA GCACCAATTG GGAAAGGCTT 
CGACAAGGGG CCCTGAGGAA GGACCTGCGG GGGATAATCA ACCGGGGCCT AGAAGATGGG 
GAGGGCTGGG AGTACCAGAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Regulation of chondrocyte functions by transient receptor potential cation channel V6 in osteoarthritis.
Journal of cellular physiology232(11)3170-3181(2017 Nov)
Song T,Ma J,Guo L,Yang P,Zhou X,Ye T

NF-?B dependent up-regulation of TRPC6 by A? in BV-2 microglia cells increases COX-2 expression and contributes to hippocampus neuron damage.
Neuroscience letters6511-8(2017 Jun)
Liu N,Zhuang Y,Zhou Z,Zhao J,Chen Q,Zheng J

Transient receptor potential vanilloid 6 (TRPV6) in the mouse brain: Distribution and estrous cycle-related changes in the hypothalamus.
Neuroscience344204-216(2017 Mar)
Kumar S,Singh U,Singh O,Goswami C,Singru PS

Augmented Endothelial-Specific L-Arginine Transport Blunts the Contribution of the Sympathetic Nervous System to Obesity Induced Hypertension in Mice.
PloS one10(7)e0131424(2015)
Rajapakse NW,Karim F,Evans RG,Kaye DM,Head GA

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Trpv6 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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