Gene Symbol | ATR |
Entrez Gene ID | 545 |
Full Name | ATR serine/threonine kinase |
Synonyms | FCTCS,FRP1,MEC1,SCKL,SCKL1 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]. |
Disorder MIM: | |
Disorder Html: | Seckel syndrome 1, 210600 (3); ?Cutaneous telangiectasia and cancer syndrome, familial, 614564 (3) |