PNN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PNN
Entrez Gene ID	5411
Full Name	pinin, desmosome associated protein
Synonyms	DRS,DRSP,SDK3,memA
General protein information	Preferred Names pinin, desmosome associated protein Names pinin 140 kDa nuclear and cell adhesion-related phosphoprotein SR-like protein desmosome-associated protein domain-rich serine protein melanoma metastasis clone A protein neutrophil protein nuclear protein SDK3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q21.1
Disorder MIM:	603154

mRNA and Protein(s)

mRNA	Protein	Name
NM_002687.3	NP_002678.2	pinin
NM_002687.4	NP_002678.3	pinin

Pathways from BioSystems

Homologies

	LOC700296	XP_002805068.1
Rattus norvegicus (Norway rat)	Pnn	NP_001102493.1
Gallus gallus (chicken)	PNN	XP_421253.1
Bos taurus (cattle)	PNN	NP_001229514.1
Pan troglodytes (chimpanzee)	PNN	XP_001147812.1
Mus musculus (house mouse)	Pnn	NP_032917.2
Homo sapiens (human)	PNN	NP_002678.2

Gene Ontology
Bibliography

Related articles in PubMed

The unique spliceosome signature of human pluripotent stem cells is mediated by SNRPA1, SNRPD1, and PNN.
Kim YD, Lee J, Kim HS, Lee MO, Son MY, Yoo CH, Choi JK, Lee SC, Cho YS
Stem cell research2243-53(2017 Jul)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Pinin associates with prognosis of hepatocellular carcinoma through promoting cell proliferation and suppressing glucose deprivation-induced apoptosis.
Yang X, Sun D, Dong C, Tian Y, Gao Z, Wang L
Oncotarget7(26)39694-39704(2016 Jun)

Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway.
Wei Z, Ma W, Qi X, Zhu X, Wang Y, Xu Z, Luo J, Wang D, Guo W, Li X, Xin S, Yu J, Li G
Oncotarget7(20)29429-39(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pinin contributes to hepatocellular carcinoma progression and resistance to glucose deprivation-induced apoptosis via maintaining ERK1/2 activation
Title: Pinin associates with prognosis of hepatocellular carcinoma through promoting cell proliferation and suppressing glucose deprivation-induced apoptosis.

Our findings suggested that PNN, as a valuable marker of prognosis, has important influence on the progression of colorectal cancer
Title: Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway.

Pinin and CtBP are oncotargets that closely interact with each other to regulate transcription and pre-mRNA alternative splicing and promote cell adhesion and other epithelial characteristics of ovarian cancer cells.
Title: Pinin interacts with C-terminal binding proteins for RNA alternative splicing and epithelial cell identity of human ovarian cancer cells.

These data suggest that lowering of PNN levels in epithelial cells results in dramatic transformation in the number and composition of splicing variants and that PNN plays a crucial role in the selection of which RNA isoforms differentiating cells produce.
Title: RNA-seq analysis of impact of PNN on gene expression and alternative splicing in corneal epithelial cells.

PNN has an important role in alternative splicing of a specific subset of lncRNAs of the corneal epithelium.
Title: Role of Pnn in alternative splicing of a specific subset of lncRNAs of the corneal epithelium.

The following PNN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PNN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu13279	NM_002687.3 Latest version!	Homo sapiens pinin, desmosome associated protein (PNN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
OHu107331	NM_002687.4 Latest version!	Homo sapiens pinin, desmosome associated protein (PNN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PNN ( NM_002687.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002678.2 Homo sapiens pinin, desmosome associated protein (PNN), mRNA.

Price & Availability↑

CloneID	OHu13279
Clone ID Related Accession (Same CDS sequence)	NM_002687.3
Accession Version	NM_002687.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2154bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	pinin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL132639.4, BC062602.1, BQ938918.1 and BG057344.1. On Mar 21, 2007 this sequence version replaced NM_002687.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.224119.1, SRR1660805.135513.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGTCG CCGTGAGAAC TTTGCAGGAA CAGCTGGAAA AGGCCAAAGA GAGTCTTAAG 
AACGTGGATG AGAACATTCG CAAGCTCACC GGGCGGGATC CGAATGACGT GAGGCCCATC 
CAAGCCAGAT TGCTGGCCCT TTCTGGTCCT GGTGGAGGTA GAGGACGTGG TAGTTTATTA 
CTGAGGCGTG GATTCTCAGA TAGTGGAGGA GGACCCCCAG CCAAACAGAG AGACCTTGAA 
GGGGCAGTCA GTAGGCTGGG CGGGGAGCGT CGGACCAGAA GAGAATCACG CCAGGAAAGC 
GACCCGGAGG ATGATGATGT TAAAAAGCCA GCATTGCAGT CTTCAGTTGT AGCTACCTCC 
AAAGAGCGCA CACGTAGAGA CCTTATCCAG GATCAAAATA TGGATGAAAA GGGAAAGCAA 
AGGAACCGGC GAATATTTGG CTTGTTGATG GGTACCCTTC AAAAATTTAA ACAAGAATCC 
ACTGTTGCTA CTGAAAGGCA AAAGCGGCGC CAGGAAATTG AACAAAAACT TGAAGTTCAG 
GCAGAAGAAG AGAGAAAGCA GGTTGAAAAT GAAAGGAGAG AACTGTTTGA AGAGAGGCGT 
GCTAAACAGA CAGAACTGCG GCTTTTGGAA CAGAAAGTTG AGCTTGCGCA GCTGCAAGAA 
GAATGGAATG AACATAATGC CAAAATAATT AAATATATAA GAACTAAGAC AAAGCCCCAT 
TTGTTTTATA TTCCTGGAAG AATGTGTCCA GCTACCCAAA AACTAATAGA AGAGTCACAG 
AGAAAAATGA ACGCTTTATT TGAAGGTAGA CGCATCGAAT TTGCAGAACA AATAAATAAA 
ATGGAGGCTA GGCCTAGAAG ACAATCAATG AAGGAAAAAG AGCATCAGGT GGTGCGTAAT 
GAAGAACAGA AGGCGGAACA AGAAGAGGGT AAGGTGGCTC AGCGAGAGGA AGAGTTGGAG 
GAGACAGGTA ATCAGCACAA TGATGTAGAA ATAGAGGAAG CAGGAGAGGA AGAGGAAAAG 
GAAATAGCGA TTGTTCATAG TGATGCAGAG AAAGAACAGG AGGAGGAAGA ACAAAAACAG 
GAAATGGAGG TTAAGATGGA GGAGGAAACT GAGGTAAGGG AAAGTGAGAA GCAGCAGGAT 
AGTCAGCCTG AAGAAGTTAT GGATGTGCTA GAGATGGTTG AGAATGTCAA ACATGTAATT 
GCTGACCAGG AGGTAATGGA AACTAATCGA GTTGAAAGTG TAGAACCTTC AGAAAATGAA 
GCTAGCAAAG AATTGGAACC AGAAATGGAA TTTGAAATTG AGCCAGATAA AGAATGTAAA 
TCCCTTTCTC CTGGGAAAGA GAATGTCAGT GCTTTAGACA TGGAAAAGGA GTCTGAGGAA 
AAAGAAGAAA AAGAATCTGA GCCCCAACCT GAGCCTGTGG CTCAACCTCA GCCTCAGTCT 
CAGCCCCAGC TTCAGCTTCA ATCCCAGTCC CAACCAGTAC TCCAGTCCCA GCCTCCCTCT 
CAGCCTGAGG ATTTGTCATT AGCTGTTTTA CAGCCAACAC CCCAAGTTAC TCAGGAGCAA 
GGGCATTTAC TACCTGAGAG GAAGGATTTT CCTGTAGAGT CTGTAAAACT CACTGAGGTA 
CCAGTAGAGC CAGTCTTGAC AGTACATCCA GAGAGCAAGA GCAAAACCAA AACTAGGAGC 
AGAAGTAGAG GTCGAGCTAG AAATAAAACA AGCAAGAGTA GAAGTCGAAG CAGTAGCAGT 
AGCAGTTCTA GTAGCAGTTC AACCAGTAGC AGCAGTGGAA GTAGTTCCAG CAGTGGAAGT 
AGTAGCAGTC GCAGTAGTTC CAGTAGCAGC TCCAGTACAA GTGGCAGCAG CAGCAGAGAT 
AGTAGCAGTA GCACTAGTAG TAGTAGTGAG AGTAGAAGTC GGAGTAGGGG CCGGGGACAT 
AATAGAGATA GAAAGCACAG AAGGAGCGTG GATCGGAAGA GAAGGGATAC TTCAGGACTA 
GAAAGAAGTC ACAAATCTTC AAAAGGTGGT AGTAGTAGAG ATACAAAAGG ATCAAAGGAT 
AAGAATTCCC GGTCCGACAG AAAGAGGTCT ATATCAGAGA GTAGTCGATC AGGCAAAAGA 
TCTTCAAGAA GTGAAAGAGA CCGAAAATCA GACAGGAAAG ACAAAAGGCG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002678.2
CDS	98..2251
Translation	MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRRGFSDSGGGPPAKQRDLEGAVSRLGGERRTRRESRQESDPEDDDVKKPALQSSVVATSKERTRRDLIQDQNMDEKGKQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRRIEFAEQINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQREEELEETGNQHNDVEIEEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDSQPEEVMDVLEMVENVKHVIADQEVMETNRVESVEPSENEASKELEPEMEFEIEPDKECKSLSPGKENVSALDMEKESEEKEEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLAVLQPTPQVTQEQGHLLPERKDFPVESVKLTEVPVEPVLTVHPESKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGSKDKNSRSDRKRSISESSRSGKRSSRSERDRKSDRKDKRR

Target ORF information:

RefSeq Version	NM_002687.3
Organism	Homo sapiens(human)
Definition	Homo sapiens pinin, desmosome associated protein (PNN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002687.3

ORF Insert Sequence:

ATGGCGGTCG CCGTGAGAAC TTTGCAGGAA CAGCTGGAAA AGGCCAAAGA GAGTCTTAAG 
AACGTGGATG AGAACATTCG CAAGCTCACC GGGCGGGATC CGAATGACGT GAGGCCCATC 
CAAGCCAGAT TGCTGGCCCT TTCTGGTCCT GGTGGAGGTA GAGGACGTGG TAGTTTATTA 
CTGAGGCGTG GATTCTCAGA TAGTGGAGGA GGACCCCCAG CCAAACAGAG AGACCTTGAA 
GGGGCAGTCA GTAGGCTGGG CGGGGAGCGT CGGACCAGAA GAGAATCACG CCAGGAAAGC 
GACCCGGAGG ATGATGATGT TAAAAAGCCA GCATTGCAGT CTTCAGTTGT AGCTACCTCC 
AAAGAGCGCA CACGTAGAGA CCTTATCCAG GATCAAAATA TGGATGAAAA GGGAAAGCAA 
AGGAACCGGC GAATATTTGG CTTGTTGATG GGTACCCTTC AAAAATTTAA ACAAGAATCC 
ACTGTTGCTA CTGAAAGGCA AAAGCGGCGC CAGGAAATTG AACAAAAACT TGAAGTTCAG 
GCAGAAGAAG AGAGAAAGCA GGTTGAAAAT GAAAGGAGAG AACTGTTTGA AGAGAGGCGT 
GCTAAACAGA CAGAACTGCG GCTTTTGGAA CAGAAAGTTG AGCTTGCGCA GCTGCAAGAA 
GAATGGAATG AACATAATGC CAAAATAATT AAATATATAA GAACTAAGAC AAAGCCCCAT 
TTGTTTTATA TTCCTGGAAG AATGTGTCCA GCTACCCAAA AACTAATAGA AGAGTCACAG 
AGAAAAATGA ACGCTTTATT TGAAGGTAGA CGCATCGAAT TTGCAGAACA AATAAATAAA 
ATGGAGGCTA GGCCTAGAAG ACAATCAATG AAGGAAAAAG AGCATCAGGT GGTGCGTAAT 
GAAGAACAGA AGGCGGAACA AGAAGAGGGT AAGGTGGCTC AGCGAGAGGA AGAGTTGGAG 
GAGACAGGTA ATCAGCACAA TGATGTAGAA ATAGAGGAAG CAGGAGAGGA AGAGGAAAAG 
GAAATAGCGA TTGTTCATAG TGATGCAGAG AAAGAACAGG AGGAGGAAGA ACAAAAACAG 
GAAATGGAGG TTAAGATGGA GGAGGAAACT GAGGTAAGGG AAAGTGAGAA GCAGCAGGAT 
AGTCAGCCTG AAGAAGTTAT GGATGTGCTA GAGATGGTTG AGAATGTCAA ACATGTAATT 
GCTGACCAGG AGGTAATGGA AACTAATCGA GTTGAAAGTG TAGAACCTTC AGAAAATGAA 
GCTAGCAAAG AATTGGAACC AGAAATGGAA TTTGAAATTG AGCCAGATAA AGAATGTAAA 
TCCCTTTCTC CTGGGAAAGA GAATGTCAGT GCTTTAGACA TGGAAAAGGA GTCTGAGGAA 
AAAGAAGAAA AAGAATCTGA GCCCCAACCT GAGCCTGTGG CTCAACCTCA GCCTCAGTCT 
CAGCCCCAGC TTCAGCTTCA ATCCCAGTCC CAACCAGTAC TCCAGTCCCA GCCTCCCTCT 
CAGCCTGAGG ATTTGTCATT AGCTGTTTTA CAGCCAACAC CCCAAGTTAC TCAGGAGCAA 
GGGCATTTAC TACCTGAGAG GAAGGATTTT CCTGTAGAGT CTGTAAAACT CACTGAGGTA 
CCAGTAGAGC CAGTCTTGAC AGTACATCCA GAGAGCAAGA GCAAAACCAA AACTAGGAGC 
AGAAGTAGAG GTCGAGCTAG AAATAAAACA AGCAAGAGTA GAAGTCGAAG CAGTAGCAGT 
AGCAGTTCTA GTAGCAGTTC AACCAGTAGC AGCAGTGGAA GTAGTTCCAG CAGTGGAAGT 
AGTAGCAGTC GCAGTAGTTC CAGTAGCAGC TCCAGTACAA GTGGCAGCAG CAGCAGAGAT 
AGTAGCAGTA GCACTAGTAG TAGTAGTGAG AGTAGAAGTC GGAGTAGGGG CCGGGGACAT 
AATAGAGATA GAAAGCACAG AAGGAGCGTG GATCGGAAGA GAAGGGATAC TTCAGGACTA 
GAAAGAAGTC ACAAATCTTC AAAAGGTGGT AGTAGTAGAG ATACAAAAGG ATCAAAGGAT 
AAGAATTCCC GGTCCGACAG AAAGAGGTCT ATATCAGAGA GTAGTCGATC AGGCAAAAGA 
TCTTCAAGAA GTGAAAGAGA CCGAAAATCA GACAGGAAAG ACAAAAGGCG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PNN ( NM_002687.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002678.3 Homo sapiens pinin, desmosome associated protein (PNN), mRNA.

Price & Availability↑

CloneID	OHu107331
Clone ID Related Accession (Same CDS sequence)	NM_002687.4
Accession Version	NM_002687.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2154bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	pinin
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL132639.4. On Nov 23, 2018 this sequence version replaced NM_002687.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.112731.1, SRR1660803.118083.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000216832.9/ ENSP00000216832.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGTCG CCGTGAGAAC TTTGCAGGAA CAGCTGGAAA AGGCCAAAGA GAGTCTTAAG 
AACGTGGATG AGAACATTCG CAAGCTCACC GGGCGGGATC CGAATGACGT GAGGCCCATC 
CAAGCCAGAT TGCTGGCCCT TTCTGGTCCT GGTGGAGGTA GAGGACGTGG TAGTTTATTA 
CTGAGGCGTG GATTCTCAGA TAGTGGAGGA GGACCCCCAG CCAAACAGAG AGACCTTGAA 
GGGGCAGTCA GTAGGCTGGG CGGGGAGCGT CGGACCAGAA GAGAATCACG CCAGGAAAGC 
GACCCGGAGG ATGATGATGT TAAAAAGCCA GCATTGCAGT CTTCAGTTGT AGCTACCTCC 
AAAGAGCGCA CACGTAGAGA CCTTATCCAG GATCAAAATA TGGATGAAAA GGGAAAGCAA 
AGGAACCGGC GAATATTTGG CTTGTTGATG GGTACCCTTC AAAAATTTAA ACAAGAATCC 
ACTGTTGCTA CTGAAAGGCA AAAGCGGCGC CAGGAAATTG AACAAAAACT TGAAGTTCAG 
GCAGAAGAAG AGAGAAAGCA GGTTGAAAAT GAAAGGAGAG AACTGTTTGA AGAGAGGCGT 
GCTAAACAGA CAGAACTGCG GCTTTTGGAA CAGAAAGTTG AGCTTGCGCA GCTGCAAGAA 
GAATGGAATG AACATAATGC CAAAATAATT AAATATATAA GAACTAAGAC AAAGCCCCAT 
TTGTTTTATA TTCCTGGAAG AATGTGTCCA GCTACCCAAA AACTAATAGA AGAGTCACAG 
AGAAAAATGA ACGCTTTATT TGAAGGTAGA CGCATCGAAT TTGCAGAACA AATAAATAAA 
ATGGAGGCTA GGCCTAGAAG ACAATCAATG AAGGAAAAAG AGCATCAGGT GGTGCGTAAT 
GAAGAACAGA AGGCGGAACA AGAAGAGGGT AAGGTGGCTC AGCGAGAGGA AGAGTTGGAG 
GAGACAGGTA ATCAGCACAA TGATGTAGAA ATAGAGGAAG CAGGAGAGGA AGAGGAAAAG 
GAAATAGCGA TTGTTCATAG TGATGCAGAG AAAGAACAGG AGGAGGAAGA ACAAAAACAG 
GAAATGGAGG TTAAGATGGA GGAGGAAACT GAGGTAAGGG AAAGTGAGAA GCAGCAGGAT 
AGTCAGCCTG AAGAAGTTAT GGATGTGCTA GAGATGGTTG AGAATGTCAA ACATGTAATT 
GCTGACCAGG AGGTAATGGA AACTAATCGA GTTGAAAGTG TAGAACCTTC AGAAAATGAA 
GCTAGCAAAG AATTGGAACC AGAAATGGAA TTTGAAATTG AGCCAGATAA AGAATGTAAA 
ACCCTTTCTC CTGGGAAAGA GAATGTCAGT GCTTTAGACA TGGAAAAGGA GTCTGAGGAA 
AAAGAAGAAA AAGAATCTGA GCCCCAACCT GAGCCTGTGG CTCAACCTCA GCCTCAGTCT 
CAGCCCCAGC TTCAGCTTCA ATCCCAGTCC CAACCAGTAC TCCAGTCCCA GCCTCCCTCT 
CAGCCTGAGG ATTTGTCATT AGCTGTTTTA CAGCCAACAC CCCAAGTTAC TCAGGAGCAA 
GGGCATTTAC TACCTGAGAG GAAGGATTTT CCTGTAGAGT CTGTAAAACT CACTGAGGTA 
CCAGTAGAGC CAGTCTTGAC AGTACATCCA GAGAGCAAGA GCAAAACCAA AACTAGGAGC 
AGAAGTAGAG GTCGAGCTAG AAATAAAACA AGCAAGAGTA GAAGTCGAAG CAGTAGCAGT 
AGCAGTTCTA GTAGCAGTTC AACCAGTAGC AGCAGTGGAA GTAGTTCCAG CAGTGGAAGT 
AGTAGCAGTC GCAGTAGTTC CAGTAGCAGC TCCAGTACAA GTGGCAGCAG CAGCAGAGAT 
AGTAGCAGTA GCACTAGTAG TAGTAGTGAG AGTAGAAGTC GGAGTAGGGG CCGGGGACAT 
AATAGAGATA GAAAGCACAG AAGGAGCGTG GATCGGAAGA GAAGGGATAC TTCAGGACTA 
GAAAGAAGTC ACAAATCTTC AAAAGGTGGT AGTAGTAGAG ATACAAAAGG ATCAAAGGAT 
AAGAATTCCC GGTCCGACAG AAAGAGGTCT ATATCAGAGA GTAGTCGATC AGGCAAAAGA 
TCTTCAAGAA GTGAAAGAGA CCGAAAATCA GACAGGAAAG ACAAAAGGCG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002678.3
CDS	27..2180
Translation	MAVAVRTLQEQLEKAKESLKNVDENIRKLTGRDPNDVRPIQARLLALSGPGGGRGRGSLLLRRGFSDSGGGPPAKQRDLEGAVSRLGGERRTRRESRQESDPEDDDVKKPALQSSVVATSKERTRRDLIQDQNMDEKGKQRNRRIFGLLMGTLQKFKQESTVATERQKRRQEIEQKLEVQAEEERKQVENERRELFEERRAKQTELRLLEQKVELAQLQEEWNEHNAKIIKYIRTKTKPHLFYIPGRMCPATQKLIEESQRKMNALFEGRRIEFAEQINKMEARPRRQSMKEKEHQVVRNEEQKAEQEEGKVAQREEELEETGNQHNDVEIEEAGEEEEKEIAIVHSDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDSQPEEVMDVLEMVENVKHVIADQEVMETNRVESVEPSENEASKELEPEMEFEIEPDKECKTLSPGKENVSALDMEKESEEKEEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLAVLQPTPQVTQEQGHLLPERKDFPVESVKLTEVPVEPVLTVHPESKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGSKDKNSRSDRKRSISESSRSGKRSSRSERDRKSDRKDKRR

Target ORF information:

RefSeq Version	NM_002687.4
Organism	Homo sapiens(human)
Definition	Homo sapiens pinin, desmosome associated protein (PNN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002687.4

ORF Insert Sequence:

ATGGCGGTCG CCGTGAGAAC TTTGCAGGAA CAGCTGGAAA AGGCCAAAGA GAGTCTTAAG 
AACGTGGATG AGAACATTCG CAAGCTCACC GGGCGGGATC CGAATGACGT GAGGCCCATC 
CAAGCCAGAT TGCTGGCCCT TTCTGGTCCT GGTGGAGGTA GAGGACGTGG TAGTTTATTA 
CTGAGGCGTG GATTCTCAGA TAGTGGAGGA GGACCCCCAG CCAAACAGAG AGACCTTGAA 
GGGGCAGTCA GTAGGCTGGG CGGGGAGCGT CGGACCAGAA GAGAATCACG CCAGGAAAGC 
GACCCGGAGG ATGATGATGT TAAAAAGCCA GCATTGCAGT CTTCAGTTGT AGCTACCTCC 
AAAGAGCGCA CACGTAGAGA CCTTATCCAG GATCAAAATA TGGATGAAAA GGGAAAGCAA 
AGGAACCGGC GAATATTTGG CTTGTTGATG GGTACCCTTC AAAAATTTAA ACAAGAATCC 
ACTGTTGCTA CTGAAAGGCA AAAGCGGCGC CAGGAAATTG AACAAAAACT TGAAGTTCAG 
GCAGAAGAAG AGAGAAAGCA GGTTGAAAAT GAAAGGAGAG AACTGTTTGA AGAGAGGCGT 
GCTAAACAGA CAGAACTGCG GCTTTTGGAA CAGAAAGTTG AGCTTGCGCA GCTGCAAGAA 
GAATGGAATG AACATAATGC CAAAATAATT AAATATATAA GAACTAAGAC AAAGCCCCAT 
TTGTTTTATA TTCCTGGAAG AATGTGTCCA GCTACCCAAA AACTAATAGA AGAGTCACAG 
AGAAAAATGA ACGCTTTATT TGAAGGTAGA CGCATCGAAT TTGCAGAACA AATAAATAAA 
ATGGAGGCTA GGCCTAGAAG ACAATCAATG AAGGAAAAAG AGCATCAGGT GGTGCGTAAT 
GAAGAACAGA AGGCGGAACA AGAAGAGGGT AAGGTGGCTC AGCGAGAGGA AGAGTTGGAG 
GAGACAGGTA ATCAGCACAA TGATGTAGAA ATAGAGGAAG CAGGAGAGGA AGAGGAAAAG 
GAAATAGCGA TTGTTCATAG TGATGCAGAG AAAGAACAGG AGGAGGAAGA ACAAAAACAG 
GAAATGGAGG TTAAGATGGA GGAGGAAACT GAGGTAAGGG AAAGTGAGAA GCAGCAGGAT 
AGTCAGCCTG AAGAAGTTAT GGATGTGCTA GAGATGGTTG AGAATGTCAA ACATGTAATT 
GCTGACCAGG AGGTAATGGA AACTAATCGA GTTGAAAGTG TAGAACCTTC AGAAAATGAA 
GCTAGCAAAG AATTGGAACC AGAAATGGAA TTTGAAATTG AGCCAGATAA AGAATGTAAA 
ACCCTTTCTC CTGGGAAAGA GAATGTCAGT GCTTTAGACA TGGAAAAGGA GTCTGAGGAA 
AAAGAAGAAA AAGAATCTGA GCCCCAACCT GAGCCTGTGG CTCAACCTCA GCCTCAGTCT 
CAGCCCCAGC TTCAGCTTCA ATCCCAGTCC CAACCAGTAC TCCAGTCCCA GCCTCCCTCT 
CAGCCTGAGG ATTTGTCATT AGCTGTTTTA CAGCCAACAC CCCAAGTTAC TCAGGAGCAA 
GGGCATTTAC TACCTGAGAG GAAGGATTTT CCTGTAGAGT CTGTAAAACT CACTGAGGTA 
CCAGTAGAGC CAGTCTTGAC AGTACATCCA GAGAGCAAGA GCAAAACCAA AACTAGGAGC 
AGAAGTAGAG GTCGAGCTAG AAATAAAACA AGCAAGAGTA GAAGTCGAAG CAGTAGCAGT 
AGCAGTTCTA GTAGCAGTTC AACCAGTAGC AGCAGTGGAA GTAGTTCCAG CAGTGGAAGT 
AGTAGCAGTC GCAGTAGTTC CAGTAGCAGC TCCAGTACAA GTGGCAGCAG CAGCAGAGAT 
AGTAGCAGTA GCACTAGTAG TAGTAGTGAG AGTAGAAGTC GGAGTAGGGG CCGGGGACAT 
AATAGAGATA GAAAGCACAG AAGGAGCGTG GATCGGAAGA GAAGGGATAC TTCAGGACTA 
GAAAGAAGTC ACAAATCTTC AAAAGGTGGT AGTAGTAGAG ATACAAAAGG ATCAAAGGAT 
AAGAATTCCC GGTCCGACAG AAAGAGGTCT ATATCAGAGA GTAGTCGATC AGGCAAAAGA 
TCTTCAAGAA GTGAAAGAGA CCGAAAATCA GACAGGAAAG ACAAAAGGCG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The unique spliceosome signature of human pluripotent stem cells is mediated by SNRPA1, SNRPD1, and PNN.
Stem cell research2243-53(2017 Jul)
Kim YD,Lee J,Kim HS,Lee MO,Son MY,Yoo CH,Choi JK,Lee SC,Cho YS

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Pinin associates with prognosis of hepatocellular carcinoma through promoting cell proliferation and suppressing glucose deprivation-induced apoptosis.
Oncotarget7(26)39694-39704(2016 Jun)
Yang X,Sun D,Dong C,Tian Y,Gao Z,Wang L

Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway.
Oncotarget7(20)29429-39(2016 May)
Wei Z,Ma W,Qi X,Zhu X,Wang Y,Xu Z,Luo J,Wang D,Guo W,Li X,Xin S,Yu J,Li G