PIP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PIP
Entrez Gene ID	5304
Full Name	prolactin induced protein
Synonyms	GCDFP-15,GCDFP15,GPIP4
General protein information	Preferred Names prolactin induced protein Names prolactin-inducible protein SABP gross cystic disease fluid protein 15 secretory actin-binding protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q34
Disorder MIM:	176720

mRNA and Protein(s)

mRNA	Protein	Name
NM_002652.3	NP_002643.1	prolactin-inducible protein precursor
NM_002652.2	NP_002643.1	prolactin-inducible protein precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PIP	XP_851087.1
	PIP	XP_001090222.1
Rattus norvegicus (Norway rat)	Pip	NP_073199.1
Homo sapiens (human)	PIP	NP_002643.1
Pan troglodytes (chimpanzee)	PIP	NP_001009170.1
Mus musculus (house mouse)	Pip	NP_032869.2

Gene Ontology
Bibliography

Related articles in PubMed

GATA-3 is superior to GCDFP-15 and mammaglobin to identify primary and metastatic breast cancer.
Ni YB, Tsang JYS, Shao MM, Chan SK, Cheung SY, Tong J, To KF, Tse GM
Breast cancer research and treatment(2018 Jan)

GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15.
Zhao M, Zhou L, Sun L, Song Y, Guo Y, Zhang X, Zhao F, Wang P, Yue J, Niu D, Li Z, Huang X, Kang Q, Jia L, Lai J, Cao D
Diagnostic pathology12(1)51(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

good coincidence was observed between primary and metastatic tumor GATA3 expression (kappa value = 0.826 >0.75) as compared with the coincidence of GCDFP15 (kappa value =0.492 <0.75) and mammaglobin (kappa value =0.593 <0.75)
Title: GATA3 expression in clinically useful groups of breast carcinoma: a comparison with GCDFP15 and mammaglobin for identifying paired primary and metastatic tumors.

While highly expressed under pathological conditions of the mammary gland, including breast cancers, PIP is expressed in very few other cancers. Although the function of PIP is not well elucidated, numerous studies suggest that its primary role may be related to host defense and immune modulation. Studies in Pip null mice suggest that PIP may play a similar immune-regulatory role in breast cancer. [Review]
Title: Prolactin-Inducible Protein: From Breast Cancer Biomarker to Immune Modulator-Novel Insights from Knockout Mice.

monoclonal antibodies to GATA-3 are very sensitive reagents for the identification of breast CA, surpassing antibodies to GCDFP-15 and mammaglobin A, and offer a significant improvement in identifying TNBCs
Title: Comparative Sensitivities and Specificities of Antibodies to Breast Markers GCDFP-15, Mammaglobin A, and Different Clones of Antibodies to GATA-3: A Study of 338 Tumors Using Whole Sections.

High expression of GCDFP-15 is associated with molecular apocrine breast cancer.
Title: Heat shock protein 27 and gross cystic disease fluid protein 15 play critical roles in molecular apocrine breast cancer.

In summary, this study suggests that PIP expression regulates the process of cell adhesion in breast cancer.
Title: Prolactin-Induced Protein regulates cell adhesion in breast cancer.

The following PIP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PIP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16546	NM_002652.3 Latest version!	Homo sapiens prolactin induced protein (PIP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
View Old Accession Versions >>
OHu16546	NM_002652.2	Homo sapiens prolactin induced protein (PIP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5+	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PIP ( NM_002652.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002643.1 Homo sapiens prolactin induced protein (PIP), mRNA.

Price & Availability↑

CloneID	OHu16546
Clone ID Related Accession (Same CDS sequence)	NM_002652.3 , NM_002652.2
Accession Version	NM_002652.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	prolactin-inducible protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC093659.4 and Y10179.1. On Nov 23, 2018 this sequence version replaced NM_002652.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP334025.1, BP334523.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000291009.4/ ENSP00000291009.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGCTTGC TCCAGCTCCT GTTCAGGGCC AGCCCTGCCA CCCTGCTCCT GGTTCTCTGC 
CTGCAGTTGG GGGCCAACAA AGCTCAGGAC AACACTCGGA AGATCATAAT AAAGAATTTT 
GACATTCCCA AGTCAGTACG TCCAAATGAC GAAGTCACTG CAGTGCTTGC AGTTCAAACA 
GAATTGAAAG AATGCATGGT GGTTAAAACT TACCTCATTA GCAGCATCCC TCTACAAGGT 
GCATTTAACT ATAAGTATAC TGCCTGCCTA TGTGACGACA ATCCAAAAAC CTTCTACTGG 
GACTTTTACA CCAACAGAAC TGTGCAAATT GCAGCCGTCG TTGATGTTAT TCGGGAATTA 
GGCATCTGCC CTGATGATGC TGCTGTAATC CCCATCAAAA ACAACCGGTT TTATACTATT 
GAAATCCTAA AGGTAGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002643.1
CDS	41..481
Translation	MRLLQLLFRASPATLLLVLCLQLGANKAQDNTRKIIIKNFDIPKSVRPNDEVTAVLAVQTELKECMVVKTYLISSIPLQGAFNYKYTACLCDDNPKTFYWDFYTNRTVQIAAVVDVIRELGICPDDAAVIPIKNNRFYTIEILKVE

Target ORF information:

RefSeq Version	NM_002652.3
Organism	Homo sapiens(human)
Definition	Homo sapiens prolactin induced protein (PIP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002652.3

ORF Insert Sequence:

ATGCGCTTGC TCCAGCTCCT GTTCAGGGCC AGCCCTGCCA CCCTGCTCCT GGTTCTCTGC 
CTGCAGTTGG GGGCCAACAA AGCTCAGGAC AACACTCGGA AGATCATAAT AAAGAATTTT 
GACATTCCCA AGTCAGTACG TCCAAATGAC GAAGTCACTG CAGTGCTTGC AGTTCAAACA 
GAATTGAAAG AATGCATGGT GGTTAAAACT TACCTCATTA GCAGCATCCC TCTACAAGGT 
GCATTTAACT ATAAGTATAC TGCCTGCCTA TGTGACGACA ATCCAAAAAC CTTCTACTGG 
GACTTTTACA CCAACAGAAC TGTGCAAATT GCAGCCGTCG TTGATGTTAT TCGGGAATTA 
GGCATCTGCC CTGATGATGC TGCTGTAATC CCCATCAAAA ACAACCGGTT TTATACTATT 
GAAATCCTAA AGGTAGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PIP ( NM_002652.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002643.1 Homo sapiens prolactin induced protein (PIP), mRNA.

Price & Availability↑

CloneID	OHu16546
Clone ID Related Accession (Same CDS sequence)	NM_002652.3 , NM_002652.2
Accession Version	NM_002652.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 441bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	prolactin-inducible protein precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from Y10179.1 and CD723133.1. On Apr 9, 2004 this sequence version replaced NM_002652.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y10179.1, BC010950.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END##

ATGCGCTTGC TCCAGCTCCT GTTCAGGGCC AGCCCTGCCA CCCTGCTCCT GGTTCTCTGC 
CTGCAGTTGG GGGCCAACAA AGCTCAGGAC AACACTCGGA AGATCATAAT AAAGAATTTT 
GACATTCCCA AGTCAGTACG TCCAAATGAC GAAGTCACTG CAGTGCTTGC AGTTCAAACA 
GAATTGAAAG AATGCATGGT GGTTAAAACT TACCTCATTA GCAGCATCCC TCTACAAGGT 
GCATTTAACT ATAAGTATAC TGCCTGCCTA TGTGACGACA ATCCAAAAAC CTTCTACTGG 
GACTTTTACA CCAACAGAAC TGTGCAAATT GCAGCCGTCG TTGATGTTAT TCGGGAATTA 
GGCATCTGCC CTGATGATGC TGCTGTAATC CCCATCAAAA ACAACCGGTT TTATACTATT 
GAAATCCTAA AGGTAGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002643.1
CDS	37..477
Translation	MRLLQLLFRASPATLLLVLCLQLGANKAQDNTRKIIIKNFDIPKSVRPNDEVTAVLAVQTELKECMVVKTYLISSIPLQGAFNYKYTACLCDDNPKTFYWDFYTNRTVQIAAVVDVIRELGICPDDAAVIPIKNNRFYTIEILKVE

Target ORF information:

RefSeq Version	NM_002652.2
Organism	Homo sapiens(human)
Definition	Homo sapiens prolactin induced protein (PIP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002652.2

ORF Insert Sequence:

ATGCGCTTGC TCCAGCTCCT GTTCAGGGCC AGCCCTGCCA CCCTGCTCCT GGTTCTCTGC 
CTGCAGTTGG GGGCCAACAA AGCTCAGGAC AACACTCGGA AGATCATAAT AAAGAATTTT 
GACATTCCCA AGTCAGTACG TCCAAATGAC GAAGTCACTG CAGTGCTTGC AGTTCAAACA 
GAATTGAAAG AATGCATGGT GGTTAAAACT TACCTCATTA GCAGCATCCC TCTACAAGGT 
GCATTTAACT ATAAGTATAC TGCCTGCCTA TGTGACGACA ATCCAAAAAC CTTCTACTGG 
GACTTTTACA CCAACAGAAC TGTGCAAATT GCAGCCGTCG TTGATGTTAT TCGGGAATTA 
GGCATCTGCC CTGATGATGC TGCTGTAATC CCCATCAAAA ACAACCGGTT TTATACTATT 
GAAATCCTAA AGGTAGAATA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

GATA-3 is superior to GCDFP-15 and mammaglobin to identify primary and metastatic breast cancer.
Breast cancer research and treatment(2018 Jan)
Ni YB,Tsang JYS,Shao MM,Chan SK,Cheung SY,Tong J,To KF,Tse GM

GATA3 is a sensitive marker for primary genital extramammary paget disease: an immunohistochemical study of 72 cases with comparison to gross cystic disease fluid protein 15.
Diagnostic pathology12(1)51(2017 Jul)
Zhao M,Zhou L,Sun L,Song Y,Guo Y,Zhang X,Zhao F,Wang P,Yue J,Niu D,Li Z,Huang X,Kang Q,Jia L,Lai J,Cao D

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

[email protected]

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

PIP cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム