ATP5MC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP5MC1
Entrez Gene ID	516
Full Name	ATP synthase membrane subunit c locus 1
Synonyms	ATP5A,ATP5G,ATP5G1
General protein information	Preferred Names ATP synthase membrane subunit c locus 1 Names ATP synthase F(0) complex subunit C1, mitochondrial ATP synthase lipid-binding protein, mitochondrial ATP synthase proteolipid P1 ATP synthase proton-transporting mitochondrial F(0) complex subunit C1 ATP synthase subunit 9 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9) ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9) ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) ATPase protein 9 ATPase subunit 9 ATPase subunit C mitochondrial ATP synthase, subunit 9 mitochondrial ATP synthase, subunit C
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.32
Summary	This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene is one of three genes that encode subunit c of the proton channel. Each of the three genes have distinct mitochondrial import sequences but encode the identical mature protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
Disorder MIM:	603192

mRNA and Protein(s)

mRNA	Protein	Name
NM_005175.2	NP_005166.1	ATP synthase F(0) complex subunit C1, mitochondrial precursor
NM_001002027.1	NP_001002027.1	ATP synthase F(0) complex subunit C1, mitochondrial precursor
NM_005175.3	NP_005166.1	ATP synthase F(0) complex subunit C1, mitochondrial precursor
NM_001002027.2	NP_001002027.1	ATP synthase F(0) complex subunit C1, mitochondrial precursor

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	ATP5G1	XP_001233603.1
Canis lupus familiaris (dog)	ATP5G1	XP_548181.2
Homo sapiens (human)	ATP5G1	NP_001002027.1
Pan troglodytes (chimpanzee)	ATP5G1	XP_001172743.1
Mus musculus (house mouse)	Atp5g1	NP_001154891.1
Bos taurus (cattle)	ATP5G1	NP_788822.1
Rattus norvegicus (Norway rat)	Atp5g1	NP_059007.1

Gene Ontology
Bibliography

Related articles in PubMed

Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase.
He J, Ford HC, Carroll J, Ding S, Fearnley IM, Walker JE
Proceedings of the National Academy of Sciences of the United States of America114(13)3409-3414(2017 Mar)

The Polyadenosine RNA-binding Protein, Zinc Finger Cys3His Protein 14 (ZC3H14), Regulates the Pre-mRNA Processing of a Key ATP Synthase Subunit mRNA.
Wigington CP, Morris KJ, Newman LE, Corbett AH
The Journal of biological chemistry291(43)22442-22459(2016 Oct)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kov?cs IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
Schunkert H, K?nig IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Balmforth AJ, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Boerwinkle E, Braund PS, Brown MJ, Burnett MS, Buysschaert I, , Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, Mokhtari NE, Ellis SG, Elosua R, Engert JC, Epstein SE, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Iribarren C, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Kastelein JJ, Khaw KT, Knowles JW, Kolovou G, Kong A, Laaksonen R, Lambrechts D, Leander K, Lettre G, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Meitinger T, Melander O, Merlini PA, Mooser V, Morgan T, M?hleisen TW, Muhlestein JB, M?nzel T, Musunuru K, Nahrstaedt J, Nelson CP, N?then MM, Olivieri O, Patel RS, Patterson CC, Peters A, Peyvandi F, Qu L, Quyyumi AA, Rader DJ, Rallidis LS, Rice C, Rosendaal FR, Rubin D, Salomaa V, Sampietro ML, Sandhu MS, Schadt E, Sch?fer A, Schillert A, Schreiber S, Schrezenmeir J, Schwartz SM, Siscovick DS, Sivananthan M, Sivapalaratnam S, Smith A, Smith TB, Snoep JD, Soranzo N, Spertus JA, Stark K, Stirrups K, Stoll M, Tang WH, Tennstedt S, Thorgeirsson G, Thorleifsson G, Tomaszewski M, Uitterlinden AG, van Rij AM, Voight BF, Wareham NJ, Wells GA, Wichmann HE, Wild PS, Willenborg C, Witteman JC, Wright BJ, Ye S, Zeller T, Ziegler A, Cambien F, Goodall AH, Cupples LA, Quertermous T, M?rz W, Hengstenberg C, Blankenberg S, Ouwehand WH, Hall AS, Deloukas P, Thompson JR, Stefansson K, Roberts R, Thorsteinsdottir U, O'Donnell CJ, McPherson R, Erdmann J, , Samani NJ
Nature genetics43(4)333-8(2011 Mar)

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ
PloS one5(9)e12862(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ATP5G1 turnover increases upon depletion of ZC3H14, double knockdown of ZC3H14 and the nonsense-mediated decay factor, UPF1, rescues ATP5G1 transcript levels. Furthermore, fractionation reveals an increase in the amount of ATP5G1 pre-mRNA that reaches the cytoplasm when ZC3H14 is depleted and that ZC3H14 binds to ATP5G1 pre-mRNA in the nucleus.
Title: The Polyadenosine RNA-binding Protein, Zinc Finger Cys3His Protein 14 (ZC3H14), Regulates the Pre-mRNA Processing of a Key ATP Synthase Subunit mRNA.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The subunit c isoforms are nonredundant, because they differ functionally by their targeting peptides, which, in addition to mediating mitochondrial protein import, play a yet undiscovered role in respiratory chain maintenance.
Title: Novel role of ATPase subunit C targeting peptides beyond mitochondrial protein import.

The following ATP5MC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP5MC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29370	NM_005175.3 Latest version!	Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu29370	NM_001002027.2 Latest version!	Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29370	NM_005175.2	Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu29370	NM_001002027.1	Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP5MC1 ( NM_005175.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005166.1 Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29370
Clone ID Related Accession (Same CDS sequence)	NM_005175.2 , NM_001002027.1 , NM_005175.3 , NM_001002027.2
Accession Version	NM_005175.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-23
Organism	Homo sapiens(human)
Product	ATP synthase F(0) complex subunit C1, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF129854.1, BU596803.1, BF573360.1 and AL080089.1. On Jul 27, 2004 this sequence version replaced NM_005175.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD239660.1, BF573360.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT 
TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC 
CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT 
GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC 
CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC 
ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005166.1
CDS	135..545
Translation	MQTAGALFISPALIRCCTRGLIRPVSASFLNSPVNSSKQPSYSNFPLQVARREFQTSVVSRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM

Target ORF information:

RefSeq Version	NM_005175.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005175.2

ORF Insert Sequence:

ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT 
TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC 
CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT 
GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC 
CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC 
ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP5MC1 ( NM_001002027.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001002027.1 Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29370
Clone ID Related Accession (Same CDS sequence)	NM_005175.2 , NM_001002027.1 , NM_005175.3 , NM_001002027.2
Accession Version	NM_001002027.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	ATP synthase F(0) complex subunit C1, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF129854.1 and AL080089.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF129854.1, BF568453.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT 
TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC 
CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT 
GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC 
CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC 
ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002027.1
CDS	65..475
Translation	MQTAGALFISPALIRCCTRGLIRPVSASFLNSPVNSSKQPSYSNFPLQVARREFQTSVVSRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM

Target ORF information:

RefSeq Version	NM_001002027.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002027.1

ORF Insert Sequence:

ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT 
TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC 
CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT 
GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC 
CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC 
ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP5MC1 ( NM_005175.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005166.1 Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29370
Clone ID Related Accession (Same CDS sequence)	NM_005175.2 , NM_001002027.1 , NM_005175.3 , NM_001002027.2
Accession Version	NM_005175.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	ATP synthase F(0) complex subunit C1, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091133.11. On Nov 23, 2018 this sequence version replaced NM_005175.2. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279865.441.1, CB111367.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000393366.7/ ENSP00000377033.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT 
TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC 
CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT 
GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC 
CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC 
ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005166.1
CDS	134..544
Translation	MQTAGALFISPALIRCCTRGLIRPVSASFLNSPVNSSKQPSYSNFPLQVARREFQTSVVSRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM

Target ORF information:

RefSeq Version	NM_005175.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005175.3

ORF Insert Sequence:

ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT 
TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC 
CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT 
GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC 
CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC 
ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP5MC1 ( NM_001002027.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001002027.1 Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu29370
Clone ID Related Accession (Same CDS sequence)	NM_005175.2 , NM_001002027.1 , NM_005175.3 , NM_001002027.2
Accession Version	NM_001002027.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-08
Organism	Homo sapiens(human)
Product	ATP synthase F(0) complex subunit C1, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091133.11. On Jun 1, 2019 this sequence version replaced NM_001002027.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB125324.1, BG943476.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT 
TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC 
CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT 
GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC 
CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC 
ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002027.1
CDS	64..474
Translation	MQTAGALFISPALIRCCTRGLIRPVSASFLNSPVNSSKQPSYSNFPLQVARREFQTSVVSRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM

Target ORF information:

RefSeq Version	NM_001002027.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002027.2

ORF Insert Sequence:

ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT 
TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC 
CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT 
GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC 
CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC 
ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase.
Proceedings of the National Academy of Sciences of the United States of America114(13)3409-3414(2017 Mar)
He J,Ford HC,Carroll J,Ding S,Fearnley IM,Walker JE

The Polyadenosine RNA-binding Protein, Zinc Finger Cys3His Protein 14 (ZC3H14), Regulates the Pre-mRNA Processing of a Key ATP Synthase Subunit mRNA.
The Journal of biological chemistry291(43)22442-22459(2016 Oct)
Wigington CP,Morris KJ,Newman LE,Corbett AH

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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
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ATP5MC1 cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

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Target ORF information:

ORF Insert Sequence:

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