ATP5MC1 cDNA ORF clone, Homo sapiens(human)

The following ATP5MC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP5MC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu29370 NM_005175.3
Latest version!
Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK
$49.50-$69.30
$99.00
OHu29370 NM_001002027.2
Latest version!
Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK
$49.50-$69.30
$99.00
View Old Accession Versions >>
OHu29370 NM_005175.2 Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK
$49.50-$69.30
$99.00
OHu29370 NM_001002027.1 Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK
$49.50-$69.30
$99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

  • Reference Sequences (Refseq)
    CloneID OHu29370
    Clone ID Related Accession (Same CDS sequence) NM_005175.2 , NM_001002027.1 , NM_005175.3 , NM_001002027.2
    Accession Version NM_005175.2 Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 411bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2017-11-23
    Organism Homo sapiens(human)
    Product ATP synthase F(0) complex subunit C1, mitochondrial precursor
    Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF129854.1, BU596803.1, BF573360.1 and AL080089.1. On Jul 27, 2004 this sequence version replaced NM_005175.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD239660.1, BF573360.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

    1
    61
    121
    181
    241
    301
    361
    ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
    CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT
    TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC
    CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT
    GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC
    CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC
    ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_005166.1
    CDS135..545
    Translation

    Target ORF information:

    RefSeq Version NM_005175.2
    Organism Homo sapiens(human)
    Definition Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 1, mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_005175.2

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
    CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT
    TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC
    CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT
    GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC
    CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC
    ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    CloneID OHu29370
    Clone ID Related Accession (Same CDS sequence) NM_005175.2 , NM_001002027.1 , NM_005175.3 , NM_001002027.2
    Accession Version NM_001002027.1 Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 411bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2019-02-15
    Organism Homo sapiens(human)
    Product ATP synthase F(0) complex subunit C1, mitochondrial precursor
    Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CF129854.1 and AL080089.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CF129854.1, BF568453.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

    1
    61
    121
    181
    241
    301
    361
    ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
    CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT
    TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC
    CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT
    GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC
    CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC
    ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_001002027.1
    CDS65..475
    Translation

    Target ORF information:

    RefSeq Version NM_001002027.1
    Organism Homo sapiens(human)
    Definition Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 2, mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_001002027.1

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
    CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT
    TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC
    CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT
    GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC
    CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC
    ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    CloneID OHu29370
    Clone ID Related Accession (Same CDS sequence) NM_005175.2 , NM_001002027.1 , NM_005175.3 , NM_001002027.2
    Accession Version NM_005175.3 Latest version! Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 411bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2019-08-06
    Organism Homo sapiens(human)
    Product ATP synthase F(0) complex subunit C1, mitochondrial precursor
    Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091133.11. On Nov 23, 2018 this sequence version replaced NM_005175.2. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279865.441.1, CB111367.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000393366.7/ ENSP00000377033.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

    1
    61
    121
    181
    241
    301
    361
    ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
    CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT
    TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC
    CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT
    GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC
    CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC
    ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_005166.1
    CDS134..544
    Translation

    Target ORF information:

    RefSeq Version NM_005175.3
    Organism Homo sapiens(human)
    Definition Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 1, mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_005175.3

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
    CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT
    TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC
    CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT
    GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC
    CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC
    ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    CloneID OHu29370
    Clone ID Related Accession (Same CDS sequence) NM_005175.2 , NM_001002027.1 , NM_005175.3 , NM_001002027.2
    Accession Version NM_001002027.2 Latest version! Documents for ORF clone product in default vector
    Sequence Information ORF Nucleotide Sequence (Length: 411bp)
    Protein sequence
    SNP
    Vector pcDNA3.1-C-(k)DYK or customized vector User Manual
    Clone information Clone Map MSDS
    Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
    ORF Insert Method CloneEZ™ Seamless cloning technology
    Insert Structure linear
    Update Date 2019-08-08
    Organism Homo sapiens(human)
    Product ATP synthase F(0) complex subunit C1, mitochondrial precursor
    Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC091133.11. On Jun 1, 2019 this sequence version replaced NM_001002027.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB125324.1, BG943476.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

    1
    61
    121
    181
    241
    301
    361
    ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
    CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT
    TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC
    CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT
    GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC
    CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC
    ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

    RefSeq NP_001002027.1
    CDS64..474
    Translation

    Target ORF information:

    RefSeq Version NM_001002027.2
    Organism Homo sapiens(human)
    Definition Homo sapiens ATP synthase membrane subunit c locus 1 (ATP5MC1), transcript variant 2, mRNA.

    Target ORF information:

    Epitope DYKDDDDK
    Bacterial selection AMPR
    Mammalian selection NeoR
    Vector pcDNA3.1+/C-(K)DYK
    NM_001002027.2

    ORF Insert Sequence:

    1
    61
    121
    181
    241
    301
    361
    ATGCAGACCG CCGGGGCATT ATTCATTTCT CCAGCTCTGA TCCGCTGTTG TACCAGGGGT 
    CTAATCAGGC CTGTGTCTGC CTCCTTCTTG AATAGCCCAG TGAATTCATC TAAACAGCCT
    TCCTACAGCA ACTTCCCACT CCAGGTGGCC AGACGGGAGT TCCAGACCAG TGTTGTCTCC
    CGGGACATTG ACACAGCAGC CAAGTTTATT GGTGCTGGGG CAGCCACAGT TGGTGTGGCT
    GGTTCAGGGG CTGGCATTGG AACCGTGTTT GGCAGCTTGA TCATTGGCTA TGCCAGGAAC
    CCGTCTCTCA AGCAGCAGCT CTTCTCCTAT GCCATTCTTG GCTTTGCCCT GTCTGAGGCC
    ATGGGGCTTT TCTGTTTGAT GGTCGCCTTC CTCATCCTCT TCGCCATGTG A

    The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

  • PubMed

    Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase.
    Proceedings of the National Academy of Sciences of the United States of America114(13)3409-3414(2017 Mar)
    He J,Ford HC,Carroll J,Ding S,Fearnley IM,Walker JE


    The Polyadenosine RNA-binding Protein, Zinc Finger Cys3His Protein 14 (ZC3H14), Regulates the Pre-mRNA Processing of a Key ATP Synthase Subunit mRNA.
    The Journal of biological chemistry291(43)22442-22459(2016 Oct)
    Wigington CP,Morris KJ,Newman LE,Corbett AH


    Widespread macromolecular interaction perturbations in human genetic disorders.
    Cell161(3)647-660(2015 Apr)
    Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kov?cs IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barab?si AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M


    Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
    Nature genetics43(4)333-8(2011 Mar)
    Schunkert H,K?nig IR,Kathiresan S,Reilly MP,Assimes TL,Holm H,Preuss M,Stewart AF,Barbalic M,Gieger C,Absher D,Aherrahrou Z,Allayee H,Altshuler D,Anand SS,Andersen K,Anderson JL,Ardissino D,Ball SG,Balmforth AJ,Barnes TA,Becker DM,Becker LC,Berger K,Bis JC,Boekholdt SM,Boerwinkle E,Braund PS,Brown MJ,Burnett MS,Buysschaert I,,Carlquist JF,Chen L,Cichon S,Codd V,Davies RW,Dedoussis G,Dehghan A,Demissie S,Devaney JM,Diemert P,Do R,Doering A,Eifert S,Mokhtari NE,Ellis SG,Elosua R,Engert JC,Epstein SE,de Faire U,Fischer M,Folsom AR,Freyer J,Gigante B,Girelli D,Gretarsdottir S,Gudnason V,Gulcher JR,Halperin E,Hammond N,Hazen SL,Hofman A,Horne BD,Illig T,Iribarren C,Jones GT,Jukema JW,Kaiser MA,Kaplan LM,Kastelein JJ,Khaw KT,Knowles JW,Kolovou G,Kong A,Laaksonen R,Lambrechts D,Leander K,Lettre G,Li M,Lieb W,Loley C,Lotery AJ,Mannucci PM,Maouche S,Martinelli N,McKeown PP,Meisinger C,Meitinger T,Melander O,Merlini PA,Mooser V,Morgan T,M?hleisen TW,Muhlestein JB,M?nzel T,Musunuru K,Nahrstaedt J,Nelson CP,N?then MM,Olivieri O,Patel RS,Patterson CC,Peters A,Peyvandi F,Qu L,Quyyumi AA,Rader DJ,Rallidis LS,Rice C,Rosendaal FR,Rubin D,Salomaa V,Sampietro ML,Sandhu MS,Schadt E,Sch?fer A,Schillert A,Schreiber S,Schrezenmeir J,Schwartz SM,Siscovick DS,Sivananthan M,Sivapalaratnam S,Smith A,Smith TB,Snoep JD,Soranzo N,Spertus JA,Stark K,Stirrups K,Stoll M,Tang WH,Tennstedt S,Thorgeirsson G,Thorleifsson G,Tomaszewski M,Uitterlinden AG,van Rij AM,Voight BF,Wareham NJ,Wells GA,Wichmann HE,Wild PS,Willenborg C,Witteman JC,Wright BJ,Ye S,Zeller T,Ziegler A,Cambien F,Goodall AH,Cupples LA,Quertermous T,M?rz W,Hengstenberg C,Blankenberg S,Ouwehand WH,Hall AS,Deloukas P,Thompson JR,Stefansson K,Roberts R,Thorsteinsdottir U,O'Donnell CJ,McPherson R,Erdmann J,,Samani NJ


    Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    PloS one5(9)e12862(2010 Sep)
    Hendrickson SL,Lautenberger JA,Chinn LW,Malasky M,Sezgin E,Kingsley LA,Goedert JJ,Kirk GD,Gomperts ED,Buchbinder SP,Troyer JL,O'Brien SJ