ZNF580 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ZNF580
Entrez Gene ID	51157
Full Name	zinc finger protein 580
General protein information	Preferred Names zinc finger protein 580 Names zinc finger protein 580 LDL-induced EC protein
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 19 Map Location: 19q13.42

mRNA and Protein(s)

mRNA	Protein	Name
NM_207115.1	NP_996998.1	zinc finger protein 580
NM_001163423.1	NP_001156895.1	zinc finger protein 580
NM_016202.2	NP_057286.1	zinc finger protein 580
XM_011527022.1	XP_011525324.1	zinc finger protein 580 isoform X1
NM_207115.2	NP_996998.1	zinc finger protein 580
XM_006723236.2	XP_006723299.1	zinc finger protein 580 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Zfp580	XP_218196.3
Pan troglodytes (chimpanzee)	ZNF580	XP_003316741.1
Bos taurus (cattle)	ZNF580	XP_003587386.2
Mus musculus (house mouse)	Zfp580	NP_081176.1
Homo sapiens (human)	ZNF580	NP_057286.1
	LOC702901	XP_002801493.1

Gene Ontology
Bibliography

Related articles in PubMed

ZNF580 mediates eNOS expression and endothelial cell migration/proliferation via the TGF-?1/ALK5/Smad2 pathway.
Luo Y, Zhao Y, Li X, Zhao J, Zhang W
Molecular and cellular biochemistry393(1-2)199-207(2014 Aug)

ROS-induced ZNF580 expression: a key role for H2O2/NF-?B signaling pathway in vascular endothelial inflammation.
DangLi R, HeKong W, JiQin L, MingHua Z, WenCheng Z
Molecular and cellular biochemistry359(1-2)183-91(2012 Jan)

ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-? signal molecule Smad2.
Luo Y, Hu W, Xu R, Hou B, Zhang L, Zhang W
Cell biology international35(11)1153-7(2011 Nov)

Suppression of zinc finger protein 580 by high oxLDL/LDL-ratios is followed by enhanced expression of endothelial IL-8.
Hoffmann CJ, Hohberg M, Chlench S, Maroski J, Drab M, Siegel G, Pries AR, Zakrzewicz A
Atherosclerosis216(1)103-8(2011 May)

Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis.
Sun HY, Wei SP, Xu RC, Xu PX, Zhang WC
Biochemical and biophysical research communications395(3)361-6(2010 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest that ZNF580 mediates eNOS expression and endothelial cell migration/proliferation via the TGF-b1/ALK5/Smad2 pathway, and thus plays a crucial role in vascular endothelial cells.
Title: ZNF580 mediates eNOS expression and endothelial cell migration/proliferation via the TGF-?1/ALK5/Smad2 pathway.

H2O2 upregulates the expression of ZNF580 via the NF-kappaB signaling pathway, and overexpression of ZNF580 plays a critical role in augmenting the release of pro-inflammatory cytokine IL-8.
Title: ROS-induced ZNF580 expression: a key role for H2O2/NF-?B signaling pathway in vascular endothelial inflammation.

ZNF580 is a binding partner of Smad2 and is involved in the signal transduction of the transforming growth factor-beta signalling pathway.
Title: ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-? signal molecule Smad2.

ZNF580 is a novel factor in the lipoprotein-dependent regulation of endothelial IL-8 expression and monocyte arrest.
Title: Suppression of zinc finger protein 580 by high oxLDL/LDL-ratios is followed by enhanced expression of endothelial IL-8.

These results elucidate the important role that ZNF580 plays in the process of migration and proliferation of endothelial cells, which provides a foundation for a novel approach to regulate angiogenesis.
Title: Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis.

The following ZNF580 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ZNF580 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12653	NM_001163423.1 Latest version!	Homo sapiens zinc finger protein 580 (ZNF580), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu12653	NM_207115.2 Latest version!	Homo sapiens zinc finger protein 580 (ZNF580), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu12653	NM_016202.2 Latest version!	Homo sapiens zinc finger protein 580 (ZNF580), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu12653	XM_011527022.1 Latest version!	Homo sapiens zinc finger protein 580 (ZNF580), transcript variant X6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu12653	XM_006723236.2 Latest version!	Homo sapiens zinc finger protein 580 (ZNF580), transcript variant X7, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu12653	NM_207115.1	Homo sapiens zinc finger protein 580 (ZNF580), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ZNF580 ( NM_207115.1 ) cDNA ORF clone, Homo sapiens(Human) -> NP_996998.1 Homo sapiens zinc finger protein 580 (ZNF580), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12653
Clone ID Related Accession (Same CDS sequence)	NM_207115.1 , NM_001163423.1 , NM_016202.2 , XM_011527022.1 , NM_207115.2 , XM_006723236.2
Accession Version	NM_207115.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	zinc finger protein 580
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL359054.1, BU179609.1 and AF184939.1. Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AL359054.1, SRR1163657.525511.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCTGCTGC TGCCGCCGCG GCCACCCCAC CCTCGGTCCT CCTCTCCGGA GGCCATGGAC 
CCACCGCCCC CCAAGGCTCC CCCTTTCCCC AAGGCGGAAG GCCCCTCCTC CACTCCTTCC 
TCGGCGGCGG GGCCCCGACC CCCGCGGCTG GGCCGCCACC TCCTCATCGA CGCCAATGGG 
GTCCCCTACA CATACACGGT GCAGCTGGAG GAGGAGCCCC GGGGCCCGCC CCAGCGCGAG 
GCGCCCCCAG GAGAGCCCGG CCCTCGCAAG GGCTACAGCT GCCCGGAGTG CGCCCGTGTC 
TTTGCCAGCC CTCTGCGGCT GCAGAGCCAC CGCGTGTCGC ACTCGGACCT CAAGCCCTTC 
ACGTGCGGCG CCTGCGGCAA GGCCTTCAAG CGCTCCAGCC ACCTGTCGCG GCATCGCGCC 
ACGCACCGCG CCCGCGCCGG GCCGCCGCAC ACCTGCCCGC TCTGCCCACG CCGCTTCCAG 
GACGCCGCGG AGCTGGCGCA GCACGTGCGC CTCCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996998.1
CDS	171..689
Translation	MLLLPPRPPHPRSSSPEAMDPPPPKAPPFPKAEGPSSTPSSAAGPRPPRLGRHLLIDANGVPYTYTVQLEEEPRGPPQREAPPGEPGPRKGYSCPECARVFASPLRLQSHRVSHSDLKPFTCGACGKAFKRSSHLSRHRATHRARAGPPHTCPLCPRRFQDAAELAQHVRLH

Target ORF information:

RefSeq Version	NM_207115.1
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger protein 580 (ZNF580), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207115.1

ORF Insert Sequence:

ATGCTGCTGC TGCCGCCGCG GCCACCCCAC CCTCGGTCCT CCTCTCCGGA GGCCATGGAC 
CCACCGCCCC CCAAGGCTCC CCCTTTCCCC AAGGCGGAAG GCCCCTCCTC CACTCCTTCC 
TCGGCGGCGG GGCCCCGACC CCCGCGGCTG GGCCGCCACC TCCTCATCGA CGCCAATGGG 
GTCCCCTACA CATACACGGT GCAGCTGGAG GAGGAGCCCC GGGGCCCGCC CCAGCGCGAG 
GCGCCCCCAG GAGAGCCCGG CCCTCGCAAG GGCTACAGCT GCCCGGAGTG CGCCCGTGTC 
TTTGCCAGCC CTCTGCGGCT GCAGAGCCAC CGCGTGTCGC ACTCGGACCT CAAGCCCTTC 
ACGTGCGGCG CCTGCGGCAA GGCCTTCAAG CGCTCCAGCC ACCTGTCGCG GCATCGCGCC 
ACGCACCGCG CCCGCGCCGG GCCGCCGCAC ACCTGCCCGC TCTGCCCACG CCGCTTCCAG 
GACGCCGCGG AGCTGGCGCA GCACGTGCGC CTCCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZNF580 ( NM_001163423.1 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001156895.1 Homo sapiens zinc finger protein 580 (ZNF580), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu12653
Clone ID Related Accession (Same CDS sequence)	NM_207115.1 , NM_001163423.1 , NM_016202.2 , XM_011527022.1 , NM_207115.2 , XM_006723236.2
Accession Version	NM_001163423.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-23
Organism	Homo sapiens(human)
Product	zinc finger protein 580
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM793208.1, AC008735.9 and AF184939.1. Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.264001.1, ERR279842.4955.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END##

ATGCTGCTGC TGCCGCCGCG GCCACCCCAC CCTCGGTCCT CCTCTCCGGA GGCCATGGAC 
CCACCGCCCC CCAAGGCTCC CCCTTTCCCC AAGGCGGAAG GCCCCTCCTC CACTCCTTCC 
TCGGCGGCGG GGCCCCGACC CCCGCGGCTG GGCCGCCACC TCCTCATCGA CGCCAATGGG 
GTCCCCTACA CATACACGGT GCAGCTGGAG GAGGAGCCCC GGGGCCCGCC CCAGCGCGAG 
GCGCCCCCAG GAGAGCCCGG CCCTCGCAAG GGCTACAGCT GCCCGGAGTG CGCCCGTGTC 
TTTGCCAGCC CTCTGCGGCT GCAGAGCCAC CGCGTGTCGC ACTCGGACCT CAAGCCCTTC 
ACGTGCGGCG CCTGCGGCAA GGCCTTCAAG CGCTCCAGCC ACCTGTCGCG GCATCGCGCC 
ACGCACCGCG CCCGCGCCGG GCCGCCGCAC ACCTGCCCGC TCTGCCCACG CCGCTTCCAG 
GACGCCGCGG AGCTGGCGCA GCACGTGCGC CTCCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001156895.1
CDS	65..583
Translation	MLLLPPRPPHPRSSSPEAMDPPPPKAPPFPKAEGPSSTPSSAAGPRPPRLGRHLLIDANGVPYTYTVQLEEEPRGPPQREAPPGEPGPRKGYSCPECARVFASPLRLQSHRVSHSDLKPFTCGACGKAFKRSSHLSRHRATHRARAGPPHTCPLCPRRFQDAAELAQHVRLH

Target ORF information:

RefSeq Version	NM_001163423.1
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger protein 580 (ZNF580), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001163423.1

ORF Insert Sequence:

ATGCTGCTGC TGCCGCCGCG GCCACCCCAC CCTCGGTCCT CCTCTCCGGA GGCCATGGAC 
CCACCGCCCC CCAAGGCTCC CCCTTTCCCC AAGGCGGAAG GCCCCTCCTC CACTCCTTCC 
TCGGCGGCGG GGCCCCGACC CCCGCGGCTG GGCCGCCACC TCCTCATCGA CGCCAATGGG 
GTCCCCTACA CATACACGGT GCAGCTGGAG GAGGAGCCCC GGGGCCCGCC CCAGCGCGAG 
GCGCCCCCAG GAGAGCCCGG CCCTCGCAAG GGCTACAGCT GCCCGGAGTG CGCCCGTGTC 
TTTGCCAGCC CTCTGCGGCT GCAGAGCCAC CGCGTGTCGC ACTCGGACCT CAAGCCCTTC 
ACGTGCGGCG CCTGCGGCAA GGCCTTCAAG CGCTCCAGCC ACCTGTCGCG GCATCGCGCC 
ACGCACCGCG CCCGCGCCGG GCCGCCGCAC ACCTGCCCGC TCTGCCCACG CCGCTTCCAG 
GACGCCGCGG AGCTGGCGCA GCACGTGCGC CTCCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZNF580 ( NM_016202.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_057286.1 Homo sapiens zinc finger protein 580 (ZNF580), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu12653
Clone ID Related Accession (Same CDS sequence)	NM_207115.1 , NM_001163423.1 , NM_016202.2 , XM_011527022.1 , NM_207115.2 , XM_006723236.2
Accession Version	NM_016202.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	zinc finger protein 580
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM700178.1, BM710177.1, AF184939.1 and BQ477323.1. On Apr 13, 2004 this sequence version replaced NM_016202.1. Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 all encode the same protein. COMPLETENESS: complete on the 3' end.

ATGCTGCTGC TGCCGCCGCG GCCACCCCAC CCTCGGTCCT CCTCTCCGGA GGCCATGGAC 
CCACCGCCCC CCAAGGCTCC CCCTTTCCCC AAGGCGGAAG GCCCCTCCTC CACTCCTTCC 
TCGGCGGCGG GGCCCCGACC CCCGCGGCTG GGCCGCCACC TCCTCATCGA CGCCAATGGG 
GTCCCCTACA CATACACGGT GCAGCTGGAG GAGGAGCCCC GGGGCCCGCC CCAGCGCGAG 
GCGCCCCCAG GAGAGCCCGG CCCTCGCAAG GGCTACAGCT GCCCGGAGTG CGCCCGTGTC 
TTTGCCAGCC CTCTGCGGCT GCAGAGCCAC CGCGTGTCGC ACTCGGACCT CAAGCCCTTC 
ACGTGCGGCG CCTGCGGCAA GGCCTTCAAG CGCTCCAGCC ACCTGTCGCG GCATCGCGCC 
ACGCACCGCG CCCGCGCCGG GCCGCCGCAC ACCTGCCCGC TCTGCCCACG CCGCTTCCAG 
GACGCCGCGG AGCTGGCGCA GCACGTGCGC CTCCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057286.1
CDS	458..976
Translation	MLLLPPRPPHPRSSSPEAMDPPPPKAPPFPKAEGPSSTPSSAAGPRPPRLGRHLLIDANGVPYTYTVQLEEEPRGPPQREAPPGEPGPRKGYSCPECARVFASPLRLQSHRVSHSDLKPFTCGACGKAFKRSSHLSRHRATHRARAGPPHTCPLCPRRFQDAAELAQHVRLH

Target ORF information:

RefSeq Version	NM_016202.2
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger protein 580 (ZNF580), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016202.2

ORF Insert Sequence:

ATGCTGCTGC TGCCGCCGCG GCCACCCCAC CCTCGGTCCT CCTCTCCGGA GGCCATGGAC 
CCACCGCCCC CCAAGGCTCC CCCTTTCCCC AAGGCGGAAG GCCCCTCCTC CACTCCTTCC 
TCGGCGGCGG GGCCCCGACC CCCGCGGCTG GGCCGCCACC TCCTCATCGA CGCCAATGGG 
GTCCCCTACA CATACACGGT GCAGCTGGAG GAGGAGCCCC GGGGCCCGCC CCAGCGCGAG 
GCGCCCCCAG GAGAGCCCGG CCCTCGCAAG GGCTACAGCT GCCCGGAGTG CGCCCGTGTC 
TTTGCCAGCC CTCTGCGGCT GCAGAGCCAC CGCGTGTCGC ACTCGGACCT CAAGCCCTTC 
ACGTGCGGCG CCTGCGGCAA GGCCTTCAAG CGCTCCAGCC ACCTGTCGCG GCATCGCGCC 
ACGCACCGCG CCCGCGCCGG GCCGCCGCAC ACCTGCCCGC TCTGCCCACG CCGCTTCCAG 
GACGCCGCGG AGCTGGCGCA GCACGTGCGC CTCCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZNF580 ( NM_207115.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_996998.1 Homo sapiens zinc finger protein 580 (ZNF580), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu12653
Clone ID Related Accession (Same CDS sequence)	NM_207115.1 , NM_001163423.1 , NM_016202.2 , XM_011527022.1 , NM_207115.2 , XM_006723236.2
Accession Version	NM_207115.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	zinc finger protein 580
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC008735.9, AL359054.1, BU179609.1 and AF184939.1. On Nov 23, 2018 this sequence version replaced NM_207115.1. Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AL359054.1, SRR1163655.278522.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000325333.10/ ENSP00000320050.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGCTGC TGCCGCCGCG GCCACCCCAC CCTCGGTCCT CCTCTCCGGA GGCCATGGAC 
CCACCGCCCC CCAAGGCTCC CCCTTTCCCC AAGGCGGAAG GCCCCTCCTC CACTCCTTCC 
TCGGCGGCGG GGCCCCGACC CCCGCGGCTG GGCCGCCACC TCCTCATCGA CGCCAATGGG 
GTCCCCTACA CATACACGGT GCAGCTGGAG GAGGAGCCCC GGGGCCCGCC CCAGCGCGAG 
GCGCCCCCAG GAGAGCCCGG CCCTCGCAAG GGCTACAGCT GCCCGGAGTG CGCCCGTGTC 
TTTGCCAGCC CTCTGCGGCT GCAGAGCCAC CGCGTGTCGC ACTCGGACCT CAAGCCCTTC 
ACGTGCGGCG CCTGCGGCAA GGCCTTCAAG CGCTCCAGCC ACCTGTCGCG GCATCGCGCC 
ACGCACCGCG CCCGCGCCGG GCCGCCGCAC ACCTGCCCGC TCTGCCCACG CCGCTTCCAG 
GACGCCGCGG AGCTGGCGCA GCACGTGCGC CTCCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996998.1
CDS	195..713
Translation	MLLLPPRPPHPRSSSPEAMDPPPPKAPPFPKAEGPSSTPSSAAGPRPPRLGRHLLIDANGVPYTYTVQLEEEPRGPPQREAPPGEPGPRKGYSCPECARVFASPLRLQSHRVSHSDLKPFTCGACGKAFKRSSHLSRHRATHRARAGPPHTCPLCPRRFQDAAELAQHVRLH

Target ORF information:

RefSeq Version	NM_207115.2
Organism	Homo sapiens(human)
Definition	Homo sapiens zinc finger protein 580 (ZNF580), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207115.2

ORF Insert Sequence:

ATGCTGCTGC TGCCGCCGCG GCCACCCCAC CCTCGGTCCT CCTCTCCGGA GGCCATGGAC 
CCACCGCCCC CCAAGGCTCC CCCTTTCCCC AAGGCGGAAG GCCCCTCCTC CACTCCTTCC 
TCGGCGGCGG GGCCCCGACC CCCGCGGCTG GGCCGCCACC TCCTCATCGA CGCCAATGGG 
GTCCCCTACA CATACACGGT GCAGCTGGAG GAGGAGCCCC GGGGCCCGCC CCAGCGCGAG 
GCGCCCCCAG GAGAGCCCGG CCCTCGCAAG GGCTACAGCT GCCCGGAGTG CGCCCGTGTC 
TTTGCCAGCC CTCTGCGGCT GCAGAGCCAC CGCGTGTCGC ACTCGGACCT CAAGCCCTTC 
ACGTGCGGCG CCTGCGGCAA GGCCTTCAAG CGCTCCAGCC ACCTGTCGCG GCATCGCGCC 
ACGCACCGCG CCCGCGCCGG GCCGCCGCAC ACCTGCCCGC TCTGCCCACG CCGCTTCCAG 
GACGCCGCGG AGCTGGCGCA GCACGTGCGC CTCCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZNF580 ( XM_011527022.1 ) cDNA ORF clone, Homo sapiens(Human) -> XP_011525324.1 Homo sapiens zinc finger protein 580 (ZNF580), transcript variant X6, mRNA.

Price & Availability↑

CloneID	OHu12653
Clone ID Related Accession (Same CDS sequence)	NM_207115.1 , NM_001163423.1 , NM_016202.2 , XM_011527022.1 , NM_207115.2 , XM_006723236.2
Accession Version	XM_011527022.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	zinc finger protein 580 isoform X1
Comment

ATGCTGCTGC TGCCGCCGCG GCCACCCCAC CCTCGGTCCT CCTCTCCGGA GGCCATGGAC 
CCACCGCCCC CCAAGGCTCC CCCTTTCCCC AAGGCGGAAG GCCCCTCCTC CACTCCTTCC 
TCGGCGGCGG GGCCCCGACC CCCGCGGCTG GGCCGCCACC TCCTCATCGA CGCCAATGGG 
GTCCCCTACA CATACACGGT GCAGCTGGAG GAGGAGCCCC GGGGCCCGCC CCAGCGCGAG 
GCGCCCCCAG GAGAGCCCGG CCCTCGCAAG GGCTACAGCT GCCCGGAGTG CGCCCGTGTC 
TTTGCCAGCC CTCTGCGGCT GCAGAGCCAC CGCGTGTCGC ACTCGGACCT CAAGCCCTTC 
ACGTGCGGCG CCTGCGGCAA GGCCTTCAAG CGCTCCAGCC ACCTGTCGCG GCATCGCGCC 
ACGCACCGCG CCCGCGCCGG GCCGCCGCAC ACCTGCCCGC TCTGCCCACG CCGCTTCCAG 
GACGCCGCGG AGCTGGCGCA GCACGTGCGC CTCCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011525324.1
Translation	MLLLPPRPPHPRSSSPEAMDPPPPKAPPFPKAEGPSSTPSSAAGPRPPRLGRHLLIDANGVPYTYTVQLEEEPRGPPQREAPPGEPGPRKGYSCPECARVFASPLRLQSHRVSHSDLKPFTCGACGKAFKRSSHLSRHRATHRARAGPPHTCPLCPRRFQDAAELAQHVRLH

Target ORF information:

RefSeq Version	XM_011527022.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens zinc finger protein 580 (ZNF580), transcript variant X6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011527022.1

ORF Insert Sequence:

ATGCTGCTGC TGCCGCCGCG GCCACCCCAC CCTCGGTCCT CCTCTCCGGA GGCCATGGAC 
CCACCGCCCC CCAAGGCTCC CCCTTTCCCC AAGGCGGAAG GCCCCTCCTC CACTCCTTCC 
TCGGCGGCGG GGCCCCGACC CCCGCGGCTG GGCCGCCACC TCCTCATCGA CGCCAATGGG 
GTCCCCTACA CATACACGGT GCAGCTGGAG GAGGAGCCCC GGGGCCCGCC CCAGCGCGAG 
GCGCCCCCAG GAGAGCCCGG CCCTCGCAAG GGCTACAGCT GCCCGGAGTG CGCCCGTGTC 
TTTGCCAGCC CTCTGCGGCT GCAGAGCCAC CGCGTGTCGC ACTCGGACCT CAAGCCCTTC 
ACGTGCGGCG CCTGCGGCAA GGCCTTCAAG CGCTCCAGCC ACCTGTCGCG GCATCGCGCC 
ACGCACCGCG CCCGCGCCGG GCCGCCGCAC ACCTGCCCGC TCTGCCCACG CCGCTTCCAG 
GACGCCGCGG AGCTGGCGCA GCACGTGCGC CTCCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ZNF580 ( XM_006723236.2 ) cDNA ORF clone, Homo sapiens(Human) -> XP_006723299.1 Homo sapiens zinc finger protein 580 (ZNF580), transcript variant X7, mRNA.

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CloneID	OHu12653
Clone ID Related Accession (Same CDS sequence)	NM_207115.1 , NM_001163423.1 , NM_016202.2 , XM_011527022.1 , NM_207115.2 , XM_006723236.2
Accession Version	XM_006723236.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 519bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	zinc finger protein 580 isoform X1
Comment

ATGCTGCTGC TGCCGCCGCG GCCACCCCAC CCTCGGTCCT CCTCTCCGGA GGCCATGGAC 
CCACCGCCCC CCAAGGCTCC CCCTTTCCCC AAGGCGGAAG GCCCCTCCTC CACTCCTTCC 
TCGGCGGCGG GGCCCCGACC CCCGCGGCTG GGCCGCCACC TCCTCATCGA CGCCAATGGG 
GTCCCCTACA CATACACGGT GCAGCTGGAG GAGGAGCCCC GGGGCCCGCC CCAGCGCGAG 
GCGCCCCCAG GAGAGCCCGG CCCTCGCAAG GGCTACAGCT GCCCGGAGTG CGCCCGTGTC 
TTTGCCAGCC CTCTGCGGCT GCAGAGCCAC CGCGTGTCGC ACTCGGACCT CAAGCCCTTC 
ACGTGCGGCG CCTGCGGCAA GGCCTTCAAG CGCTCCAGCC ACCTGTCGCG GCATCGCGCC 
ACGCACCGCG CCCGCGCCGG GCCGCCGCAC ACCTGCCCGC TCTGCCCACG CCGCTTCCAG 
GACGCCGCGG AGCTGGCGCA GCACGTGCGC CTCCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006723299.1
Translation	MLLLPPRPPHPRSSSPEAMDPPPPKAPPFPKAEGPSSTPSSAAGPRPPRLGRHLLIDANGVPYTYTVQLEEEPRGPPQREAPPGEPGPRKGYSCPECARVFASPLRLQSHRVSHSDLKPFTCGACGKAFKRSSHLSRHRATHRARAGPPHTCPLCPRRFQDAAELAQHVRLH

Target ORF information:

RefSeq Version	XM_006723236.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens zinc finger protein 580 (ZNF580), transcript variant X7, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006723236.2

ORF Insert Sequence:

ATGCTGCTGC TGCCGCCGCG GCCACCCCAC CCTCGGTCCT CCTCTCCGGA GGCCATGGAC 
CCACCGCCCC CCAAGGCTCC CCCTTTCCCC AAGGCGGAAG GCCCCTCCTC CACTCCTTCC 
TCGGCGGCGG GGCCCCGACC CCCGCGGCTG GGCCGCCACC TCCTCATCGA CGCCAATGGG 
GTCCCCTACA CATACACGGT GCAGCTGGAG GAGGAGCCCC GGGGCCCGCC CCAGCGCGAG 
GCGCCCCCAG GAGAGCCCGG CCCTCGCAAG GGCTACAGCT GCCCGGAGTG CGCCCGTGTC 
TTTGCCAGCC CTCTGCGGCT GCAGAGCCAC CGCGTGTCGC ACTCGGACCT CAAGCCCTTC 
ACGTGCGGCG CCTGCGGCAA GGCCTTCAAG CGCTCCAGCC ACCTGTCGCG GCATCGCGCC 
ACGCACCGCG CCCGCGCCGG GCCGCCGCAC ACCTGCCCGC TCTGCCCACG CCGCTTCCAG 
GACGCCGCGG AGCTGGCGCA GCACGTGCGC CTCCACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ZNF580 mediates eNOS expression and endothelial cell migration/proliferation via the TGF-?1/ALK5/Smad2 pathway.
Molecular and cellular biochemistry393(1-2)199-207(2014 Aug)
Luo Y,Zhao Y,Li X,Zhao J,Zhang W

ROS-induced ZNF580 expression: a key role for H2O2/NF-?B signaling pathway in vascular endothelial inflammation.
Molecular and cellular biochemistry359(1-2)183-91(2012 Jan)
DangLi R,HeKong W,JiQin L,MingHua Z,WenCheng Z

ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-? signal molecule Smad2.
Cell biology international35(11)1153-7(2011 Nov)
Luo Y,Hu W,Xu R,Hou B,Zhang L,Zhang W

Suppression of zinc finger protein 580 by high oxLDL/LDL-ratios is followed by enhanced expression of endothelial IL-8.
Atherosclerosis216(1)103-8(2011 May)
Hoffmann CJ,Hohberg M,Chlench S,Maroski J,Drab M,Siegel G,Pries AR,Zakrzewicz A

Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis.
Biochemical and biophysical research communications395(3)361-6(2010 May)
Sun HY,Wei SP,Xu RC,Xu PX,Zhang WC

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ZNF580 cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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