ORM2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ORM2
Entrez Gene ID	5005
Full Name	orosomucoid 2
Synonyms	AGP-B,AGP-B',AGP2
General protein information	Preferred Names orosomucoid 2 Names alpha-1-acid glycoprotein 2 AGP 2 OMD 2 alpha-1-acid glycoprotein, type 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q32
Summary	This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008].
Disorder MIM:	138610

mRNA and Protein(s)

mRNA	Protein	Name
NM_000608.2	NP_000599.1	alpha-1-acid glycoprotein 2 precursor
NM_000608.4	NP_000599.1	alpha-1-acid glycoprotein 2 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	ORM2	NP_000599.1
Pan troglodytes (chimpanzee)	LOC464682	XP_520209.2

Gene Ontology
Bibliography

Related articles in PubMed

Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients.
Jabir RS, Ho GF, Annuar MABA, Stanslas J
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals1-5(2017 Jun)

Glycosylation change of alpha-1-acid glycoprotein as a serum biomarker for hepatocellular carcinoma and cirrhosis.
Zhang D, Huang J, Luo D, Feng X, Liu Y, Liu Y
Biomarkers in medicine11(5)423-430(2017 May)

Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation.
Jo M, Kim JH, Song GJ, Seo M, Hwang EM, Suk K
The Journal of neuroscience : the official journal of the Society for Neuroscience37(11)2878-2894(2017 Mar)

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Barallobre-Barreiro J, Gupta SK, Zoccarato A, Kitazume-Taneike R, Fava M, Yin X, Werner T, Hirt MN, Zampetaki A, Viviano A, Chong M, Bern M, Kourliouros A, Domenech N, Willeit P, Shah AM, Jahangiri M, Schaefer L, Fischer JW, Iozzo RV, Viner R, Thum T, Heineke J, Kichler A, Otsu K, Mayr M
Circulation134(11)817-32(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Neural cell interactions are important for brain physiology and pathology. Particularly, the interaction between non-neuronal cells plays a central role in regulating brain inflammation, which is closely linked to many brain disorders. Here, we newly identified orosomucoid-2 (ORM2) as an endogenous protein that mediates such non-neuronal glial cell interactions
Title: Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation.

Low ORM2 expression is associated with metastasis in hepatocellular carcinoma.
Title: Orosomucoid 2 inhibits tumor metastasis and is upregulated by CCAAT/enhancer binding protein ? in hepatocellular carcinomas.

Data indicate that the band intensity of sialic acid content in alpha-1 Acid glycoprotein (AGP) of alcoholic liver cirrhosis was found to be lower than that in pooled control group.
Title: Structural heterogeneity of glycoform of alpha-1 Acid glycoprotein in alcoholic cirrhosis patients.

Data suggest that human serum albumin (HSA) might serve as a carrier in delivering chitooligomers to target tissues than alpha-1-glycoprotein (AGP) which has pharmacological importance.
Title: Differential interactions and structural stability of chitosan oligomers with human serum albumin and ?-1-glycoprotein.

These findings suggest that the ORM distal promoter region differentially regulates expression of ORM genes at basal level and in acute phase responses.
Title: Distal promoter regions are responsible for differential regulation of human orosomucoid-1 and -2 gene expression and acute phase responses.

The following ORM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ORM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31146	NM_000608.4 Latest version!	Homo sapiens orosomucoid 2 (ORM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
View Old Accession Versions >>
OHu31146	NM_000608.2	Homo sapiens orosomucoid 2 (ORM2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ORM2 ( NM_000608.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000599.1 Homo sapiens orosomucoid 2 (ORM2), mRNA.

Price & Availability↑

CloneID	OHu31146
Clone ID Related Accession (Same CDS sequence)	NM_000608.2 , NM_000608.4
Accession Version	NM_000608.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-20
Organism	Homo sapiens(human)
Product	alpha-1-acid glycoprotein 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AV661485.1 and BC056239.1. On Jan 13, 2004 this sequence version replaced NM_000608.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279873.1371.1, ERR279835.6934.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGCTGT CCTGGGTTCT TACAGTCCTG AGCCTCCTAC CTCTGCTGGA AGCCCAGATC 
CCATTGTGTG CCAACCTAGT ACCGGTGCCC ATCACCAACG CCACCCTGGA CCGGATCACT 
GGCAAGTGGT TTTATATCGC ATCGGCCTTT CGAAACGAGG AGTACAATAA GTCGGTTCAG 
GAGATCCAAG CAACCTTCTT TTACTTTACC CCCAACAAGA CAGAGGACAC GATCTTTCTC 
AGAGAGTACC AGACCCGCCA GAACCAGTGC TTCTATAACT CCAGTTACCT GAATGTCCAG 
CGGGAGAATG GGACCGTCTC CAGATACGAG GGAGGCCGAG AACATGTTGC TCACCTGCTG 
TTCCTTAGGG ACACCAAGAC CTTGATGTTT GGTTCCTACC TGGACGATGA GAAGAACTGG 
GGGCTGTCTT TCTATGCTGA CAAGCCAGAG ACGACCAAGG AGCAACTGGG AGAGTTCTAC 
GAAGCTCTCG ACTGCTTGTG CATTCCCAGG TCAGATGTCA TGTACACCGA CTGGAAAAAG 
GATAAGTGTG AGCCACTGGA GAAGCAGCAC GAGAAGGAGA GGAAACAGGA GGAGGGGGAA 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000599.1
CDS	117..722
Translation	MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQNQCFYNSSYLNVQRENGTVSRYEGGREHVAHLLFLRDTKTLMFGSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLCIPRSDVMYTDWKKDKCEPLEKQHEKERKQEEGES

Target ORF information:

RefSeq Version	NM_000608.2
Organism	Homo sapiens(human)
Definition	Homo sapiens orosomucoid 2 (ORM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000608.2

ORF Insert Sequence:

ATGGCGCTGT CCTGGGTTCT TACAGTCCTG AGCCTCCTAC CTCTGCTGGA AGCCCAGATC 
CCATTGTGTG CCAACCTAGT ACCGGTGCCC ATCACCAACG CCACCCTGGA CCGGATCACT 
GGCAAGTGGT TTTATATCGC ATCGGCCTTT CGAAACGAGG AGTACAATAA GTCGGTTCAG 
GAGATCCAAG CAACCTTCTT TTACTTTACC CCCAACAAGA CAGAGGACAC GATCTTTCTC 
AGAGAGTACC AGACCCGCCA GAACCAGTGC TTCTATAACT CCAGTTACCT GAATGTCCAG 
CGGGAGAATG GGACCGTCTC CAGATACGAG GGAGGCCGAG AACATGTTGC TCACCTGCTG 
TTCCTTAGGG ACACCAAGAC CTTGATGTTT GGTTCCTACC TGGACGATGA GAAGAACTGG 
GGGCTGTCTT TCTATGCTGA CAAGCCAGAG ACGACCAAGG AGCAACTGGG AGAGTTCTAC 
GAAGCTCTCG ACTGCTTGTG CATTCCCAGG TCAGATGTCA TGTACACCGA CTGGAAAAAG 
GATAAGTGTG AGCCACTGGA GAAGCAGCAC GAGAAGGAGA GGAAACAGGA GGAGGGGGAA 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ORM2 ( NM_000608.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000599.1 Homo sapiens orosomucoid 2 (ORM2), mRNA.

Price & Availability↑

CloneID	OHu31146
Clone ID Related Accession (Same CDS sequence)	NM_000608.2 , NM_000608.4
Accession Version	NM_000608.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-10
Organism	Homo sapiens(human)
Product	alpha-1-acid glycoprotein 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL356796.16. On Dec 11, 2019 this sequence version replaced NM_000608.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG618005.1, BC056239.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCTGT CCTGGGTTCT TACAGTCCTG AGCCTCCTAC CTCTGCTGGA AGCCCAGATC 
CCATTGTGTG CCAACCTAGT ACCGGTGCCC ATCACCAACG CCACCCTGGA CCGGATCACT 
GGCAAGTGGT TTTATATCGC ATCGGCCTTT CGAAACGAGG AGTACAATAA GTCGGTTCAG 
GAGATCCAAG CAACCTTCTT TTACTTTACC CCCAACAAGA CAGAGGACAC GATCTTTCTC 
AGAGAGTACC AGACCCGCCA GAACCAGTGC TTCTATAACT CCAGTTACCT GAATGTCCAG 
CGGGAGAATG GGACCGTCTC CAGATACGAG GGAGGCCGAG AACATGTTGC TCACCTGCTG 
TTCCTTAGGG ACACCAAGAC CTTGATGTTT GGTTCCTACC TGGACGATGA GAAGAACTGG 
GGGCTGTCTT TCTATGCTGA CAAGCCAGAG ACGACCAAGG AGCAACTGGG AGAGTTCTAC 
GAAGCTCTCG ACTGCTTGTG CATTCCCAGG TCAGATGTCA TGTACACCGA CTGGAAAAAG 
GATAAGTGTG AGCCACTGGA GAAGCAGCAC GAGAAGGAGA GGAAACAGGA GGAGGGGGAA 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000599.1
CDS	37..642
Translation	MALSWVLTVLSLLPLLEAQIPLCANLVPVPITNATLDRITGKWFYIASAFRNEEYNKSVQEIQATFFYFTPNKTEDTIFLREYQTRQNQCFYNSSYLNVQRENGTVSRYEGGREHVAHLLFLRDTKTLMFGSYLDDEKNWGLSFYADKPETTKEQLGEFYEALDCLCIPRSDVMYTDWKKDKCEPLEKQHEKERKQEEGES

Target ORF information:

RefSeq Version	NM_000608.4
Organism	Homo sapiens(human)
Definition	Homo sapiens orosomucoid 2 (ORM2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000608.4

ORF Insert Sequence:

ATGGCGCTGT CCTGGGTTCT TACAGTCCTG AGCCTCCTAC CTCTGCTGGA AGCCCAGATC 
CCATTGTGTG CCAACCTAGT ACCGGTGCCC ATCACCAACG CCACCCTGGA CCGGATCACT 
GGCAAGTGGT TTTATATCGC ATCGGCCTTT CGAAACGAGG AGTACAATAA GTCGGTTCAG 
GAGATCCAAG CAACCTTCTT TTACTTTACC CCCAACAAGA CAGAGGACAC GATCTTTCTC 
AGAGAGTACC AGACCCGCCA GAACCAGTGC TTCTATAACT CCAGTTACCT GAATGTCCAG 
CGGGAGAATG GGACCGTCTC CAGATACGAG GGAGGCCGAG AACATGTTGC TCACCTGCTG 
TTCCTTAGGG ACACCAAGAC CTTGATGTTT GGTTCCTACC TGGACGATGA GAAGAACTGG 
GGGCTGTCTT TCTATGCTGA CAAGCCAGAG ACGACCAAGG AGCAACTGGG AGAGTTCTAC 
GAAGCTCTCG ACTGCTTGTG CATTCCCAGG TCAGATGTCA TGTACACCGA CTGGAAAAAG 
GATAAGTGTG AGCCACTGGA GAAGCAGCAC GAGAAGGAGA GGAAACAGGA GGAGGGGGAA 
TCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals1-5(2017 Jun)
Jabir RS,Ho GF,Annuar MABA,Stanslas J

Glycosylation change of alpha-1-acid glycoprotein as a serum biomarker for hepatocellular carcinoma and cirrhosis.
Biomarkers in medicine11(5)423-430(2017 May)
Zhang D,Huang J,Luo D,Feng X,Liu Y,Liu Y

Astrocytic Orosomucoid-2 Modulates Microglial Activation and Neuroinflammation.
The Journal of neuroscience : the official journal of the Society for Neuroscience37(11)2878-2894(2017 Mar)
Jo M,Kim JH,Song GJ,Seo M,Hwang EM,Suk K

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation.
Circulation134(11)817-32(2016 Sep)
Barallobre-Barreiro J,Gupta SK,Zoccarato A,Kitazume-Taneike R,Fava M,Yin X,Werner T,Hirt MN,Zampetaki A,Viviano A,Chong M,Bern M,Kourliouros A,Domenech N,Willeit P,Shah AM,Jahangiri M,Schaefer L,Fischer JW,Iozzo RV,Viner R,Thum T,Heineke J,Kichler A,Otsu K,Mayr M

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ORM2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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