Gene Symbol | OLR1 |
Entrez Gene ID | 4973 |
Full Name | oxidized low density lipoprotein receptor 1 |
Synonyms | CLEC8A,LOX1,LOXIN,SCARE1,SLOX1 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]. |
Disorder MIM: | |
Disorder Html: | {Myocardial infarction, susceptibility to}, 608446 (3) |