OLR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OLR1
Entrez Gene ID	4973
Full Name	oxidized low density lipoprotein receptor 1
Synonyms	CLEC8A,LOX1,LOXIN,SCARE1,SLOX1
General protein information	Preferred Names oxidized low density lipoprotein receptor 1 Names oxidized low-density lipoprotein receptor 1 C-type lectin domain family 8 member A hLOX-1 lectin-type oxidized LDL receptor 1 ox LDL receptor 1 oxidized low density lipoprotein (lectin-like) receptor 1 oxidized low-density lipoprotein receptor 1, soluble form scavenger receptor class E, member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.2
Summary	This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010].
Disorder MIM:	602601
Disorder Html:	{Myocardial infarction, susceptibility to}, 608446 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002543.3	NP_002534.1	oxidized low-density lipoprotein receptor 1 isoform 1
NM_001172632.1	NP_001166103.1	oxidized low-density lipoprotein receptor 1 isoform 2
XM_011520682.1	XP_011518984.1	oxidized low-density lipoprotein receptor 1 isoform X1
NM_002543.4	NP_002534.1	oxidized low-density lipoprotein receptor 1 isoform 1
NM_001172633.1	NP_001166104.1	oxidized low-density lipoprotein receptor 1 isoform 3

Pathways from BioSystems

Homologies

Bos taurus (cattle)	OLR1	NP_776557.1
Mus musculus (house mouse)	Olr1	NP_619589.2
Rattus norvegicus (Norway rat)	Olr1	NP_579840.2
Pan troglodytes (chimpanzee)	OLR1	XP_001145768.1
Homo sapiens (human)	OLR1	NP_002534.1
	OLR1	XP_001115025.1
Canis lupus familiaris (dog)	OLR1	XP_543821.3

Gene Ontology
Bibliography

Related articles in PubMed

Scavenger Receptor LOX1 Genotype Predicts Coronary Artery Disease in Patients With Familial Hypercholesterolemia.
Paquette M, Dufour R, Baass A
The Canadian journal of cardiology33(10)1312-1318(2017 Oct)

LOX-1: A potential target for therapy in atherosclerosis; an in vitro study.
Arjuman A, Chandra NC
The international journal of biochemistry & cell biology91(Pt A)65-80(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

High OLR1 expression is associated with breast cancer.
Title: Up-regulation of OLR1 expression by TBC1D3 through activation of TNF?/NF-?B pathway promotes the migration of human breast cancer cells.

Multiple classical molecular dynamics simulations have been applied to the human LOX-1 receptor to clarify the role of the Trp150Ala mutation in the loss of binding activity. Results indicate that the substitution of this crucial residue, located at the dimer interface, markedly disrupts the wild-type receptor dynamics
Title: Multiple molecular dynamics simulations of human LOX-1 and Trp150Ala mutant reveal the structural determinants causing the full deactivation of the receptor.

Carrying the C allele of the rs11053646 variant of the OLR1 gene was associated with an increased risk of CAD in heterozygous adult patients with FH, and this risk could be even greater in smokers as well as in younger patients.
Title: Scavenger Receptor LOX1 Genotype Predicts Coronary Artery Disease in Patients With Familial Hypercholesterolemia.

LOX-1 signalling and the crucial role of cytokines
Title: LOX-1: A potential target for therapy in atherosclerosis; an in vitro study.

Berberine could prevent the oxLDL and TNFalpha - induced LOX1 expression and oxidative stress, key events that lead to NOX, MAPK/Erk1/2 and NF-kappaB activation linked to endothelial dysfunction.
Title: Novel role of the nutraceutical bioactive compound berberine in lectin-like OxLDL receptor 1-mediated endothelial dysfunction in comparison to lovastatin.

The following OLR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OLR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12373	NM_001172633.1 Latest version!	Homo sapiens oxidized low density lipoprotein receptor 1 (OLR1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu21845	NM_002543.4 Latest version!	Homo sapiens oxidized low density lipoprotein receptor 1 (OLR1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu21845	XM_011520682.1 Latest version!	Homo sapiens oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu12227	NM_001172632.1 Latest version!	Homo sapiens oxidized low density lipoprotein receptor 1 (OLR1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu21845	NM_002543.3	Homo sapiens oxidized low density lipoprotein receptor 1 (OLR1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OLR1 ( NM_001172633.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001166104.1 Homo sapiens oxidized low density lipoprotein receptor 1 (OLR1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu12373
Clone ID Related Accession (Same CDS sequence)	NM_001172633.1
Accession Version	NM_001172633.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	oxidized low-density lipoprotein receptor 1 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP219342.1, AL551100.3, AC024224.33, AK295409.1 and CA309323.1. Transcript Variant: This variant (3) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.21080.1, SRR1803612.12575.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTTTG ATGACCTAAA GATCCAGACT GTGAAGGACC AGCCTGATGA GAAGTCAAAT 
GGAAAAAAAG CTAAAGGTCT TCAGTTTCTT TACTCTCCAT GGTGGTGCCT GGCTGCTGCG 
ACTCTAGGGG TCCTTTGCCT GGGATTAGTA GTGACCATTA TGGTGCTGGG CATGCAATTA 
TCCCAGGTGT CTGACCTCCT AACACAAGAG CAAGCAAACC TAACTCACCA GAAAAAGAAA 
CTGGAGGGAC AGATCTCAGC CCGGCAACAA GCAGAAGAAG CTTCACAGGA GTCAGAAAAC 
GAACTCAAGG AAATGATAGA AACCCTTGCT CGGAAGCTGA ATGAGAAATC CAAAGAGCAA 
ATGGAACTTC ACCACCAGAA TCTGAATCTC CAAGAAACAC TGAAGAGAGT AGCAAATTGT 
TCAGCTCCTT GTCCGCAAGA CTGGATCTGG CATGGAGAAA ACTGTTACCT ATTTTCCTCG 
GGCTCATTTA ACTGGGAAAA GAGCCAAGAG AAGTGCTTGT CTTTGGATGC CAAGTTGCTG 
AAAATTAATA GCACAGCTGA TCTGATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166104.1
CDS	115..684
Translation	MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLI

Target ORF information:

RefSeq Version	NM_001172633.1
Organism	Homo sapiens(human)
Definition	Homo sapiens oxidized low density lipoprotein receptor 1 (OLR1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172633.1

ORF Insert Sequence:

ATGACTTTTG ATGACCTAAA GATCCAGACT GTGAAGGACC AGCCTGATGA GAAGTCAAAT 
GGAAAAAAAG CTAAAGGTCT TCAGTTTCTT TACTCTCCAT GGTGGTGCCT GGCTGCTGCG 
ACTCTAGGGG TCCTTTGCCT GGGATTAGTA GTGACCATTA TGGTGCTGGG CATGCAATTA 
TCCCAGGTGT CTGACCTCCT AACACAAGAG CAAGCAAACC TAACTCACCA GAAAAAGAAA 
CTGGAGGGAC AGATCTCAGC CCGGCAACAA GCAGAAGAAG CTTCACAGGA GTCAGAAAAC 
GAACTCAAGG AAATGATAGA AACCCTTGCT CGGAAGCTGA ATGAGAAATC CAAAGAGCAA 
ATGGAACTTC ACCACCAGAA TCTGAATCTC CAAGAAACAC TGAAGAGAGT AGCAAATTGT 
TCAGCTCCTT GTCCGCAAGA CTGGATCTGG CATGGAGAAA ACTGTTACCT ATTTTCCTCG 
GGCTCATTTA ACTGGGAAAA GAGCCAAGAG AAGTGCTTGT CTTTGGATGC CAAGTTGCTG 
AAAATTAATA GCACAGCTGA TCTGATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OLR1 ( NM_002543.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002534.1 Homo sapiens oxidized low density lipoprotein receptor 1 (OLR1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21845
Clone ID Related Accession (Same CDS sequence)	NM_002543.3 , XM_011520682.1 , NM_002543.4
Accession Version	NM_002543.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Homo sapiens(human)
Product	oxidized low-density lipoprotein receptor 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP219342.1, AB010710.1, AC024224.33 and CA309323.1. This sequence is a reference standard in the RefSeqGene project. On Dec 14, 2006 this sequence version replaced NM_002543.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC022295.1, AB010710.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTTTG ATGACCTAAA GATCCAGACT GTGAAGGACC AGCCTGATGA GAAGTCAAAT 
GGAAAAAAAG CTAAAGGTCT TCAGTTTCTT TACTCTCCAT GGTGGTGCCT GGCTGCTGCG 
ACTCTAGGGG TCCTTTGCCT GGGATTAGTA GTGACCATTA TGGTGCTGGG CATGCAATTA 
TCCCAGGTGT CTGACCTCCT AACACAAGAG CAAGCAAACC TAACTCACCA GAAAAAGAAA 
CTGGAGGGAC AGATCTCAGC CCGGCAACAA GCAGAAGAAG CTTCACAGGA GTCAGAAAAC 
GAACTCAAGG AAATGATAGA AACCCTTGCT CGGAAGCTGA ATGAGAAATC CAAAGAGCAA 
ATGGAACTTC ACCACCAGAA TCTGAATCTC CAAGAAACAC TGAAGAGAGT AGCAAATTGT 
TCAGCTCCTT GTCCGCAAGA CTGGATCTGG CATGGAGAAA ACTGTTACCT ATTTTCCTCG 
GGCTCATTTA ACTGGGAAAA GAGCCAAGAG AAGTGCTTGT CTTTGGATGC CAAGTTGCTG 
AAAATTAATA GCACAGCTGA TCTGGACTTC ATCCAGCAAG CAATTTCCTA TTCCAGTTTT 
CCATTCTGGA TGGGGCTGTC TCGGAGGAAC CCCAGCTACC CATGGCTCTG GGAGGACGGT 
TCTCCTTTGA TGCCCCACTT ATTTAGAGTC CGAGGCGCTG TCTCCCAGAC ATACCCTTCA 
GGTACCTGTG CATATATACA ACGAGGAGCT GTTTATGCGG AAAACTGCAT TTTAGCTGCC 
TTCAGTATAT GTCAGAAGAA GGCAAACCTA AGAGCACAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002534.1
CDS	115..936
Translation	MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ

Target ORF information:

RefSeq Version	NM_002543.3
Organism	Homo sapiens(human)
Definition	Homo sapiens oxidized low density lipoprotein receptor 1 (OLR1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002543.3

ORF Insert Sequence:

ATGACTTTTG ATGACCTAAA GATCCAGACT GTGAAGGACC AGCCTGATGA GAAGTCAAAT 
GGAAAAAAAG CTAAAGGTCT TCAGTTTCTT TACTCTCCAT GGTGGTGCCT GGCTGCTGCG 
ACTCTAGGGG TCCTTTGCCT GGGATTAGTA GTGACCATTA TGGTGCTGGG CATGCAATTA 
TCCCAGGTGT CTGACCTCCT AACACAAGAG CAAGCAAACC TAACTCACCA GAAAAAGAAA 
CTGGAGGGAC AGATCTCAGC CCGGCAACAA GCAGAAGAAG CTTCACAGGA GTCAGAAAAC 
GAACTCAAGG AAATGATAGA AACCCTTGCT CGGAAGCTGA ATGAGAAATC CAAAGAGCAA 
ATGGAACTTC ACCACCAGAA TCTGAATCTC CAAGAAACAC TGAAGAGAGT AGCAAATTGT 
TCAGCTCCTT GTCCGCAAGA CTGGATCTGG CATGGAGAAA ACTGTTACCT ATTTTCCTCG 
GGCTCATTTA ACTGGGAAAA GAGCCAAGAG AAGTGCTTGT CTTTGGATGC CAAGTTGCTG 
AAAATTAATA GCACAGCTGA TCTGGACTTC ATCCAGCAAG CAATTTCCTA TTCCAGTTTT 
CCATTCTGGA TGGGGCTGTC TCGGAGGAAC CCCAGCTACC CATGGCTCTG GGAGGACGGT 
TCTCCTTTGA TGCCCCACTT ATTTAGAGTC CGAGGCGCTG TCTCCCAGAC ATACCCTTCA 
GGTACCTGTG CATATATACA ACGAGGAGCT GTTTATGCGG AAAACTGCAT TTTAGCTGCC 
TTCAGTATAT GTCAGAAGAA GGCAAACCTA AGAGCACAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OLR1 ( NM_002543.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002534.1 Homo sapiens oxidized low density lipoprotein receptor 1 (OLR1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21845
Clone ID Related Accession (Same CDS sequence)	NM_002543.3 , XM_011520682.1 , NM_002543.4
Accession Version	NM_002543.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	oxidized low-density lipoprotein receptor 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC024224.33. On Nov 24, 2018 this sequence version replaced NM_002543.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.59189.1, AB010710.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000309539.8/ ENSP00000309124.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACTTTTG ATGACCTAAA GATCCAGACT GTGAAGGACC AGCCTGATGA GAAGTCAAAT 
GGAAAAAAAG CTAAAGGTCT TCAGTTTCTT TACTCTCCAT GGTGGTGCCT GGCTGCTGCG 
ACTCTAGGGG TCCTTTGCCT GGGATTAGTA GTGACCATTA TGGTGCTGGG CATGCAATTA 
TCCCAGGTGT CTGACCTCCT AACACAAGAG CAAGCAAACC TAACTCACCA GAAAAAGAAA 
CTGGAGGGAC AGATCTCAGC CCGGCAACAA GCAGAAGAAG CTTCACAGGA GTCAGAAAAC 
GAACTCAAGG AAATGATAGA AACCCTTGCT CGGAAGCTGA ATGAGAAATC CAAAGAGCAA 
ATGGAACTTC ACCACCAGAA TCTGAATCTC CAAGAAACAC TGAAGAGAGT AGCAAATTGT 
TCAGCTCCTT GTCCGCAAGA CTGGATCTGG CATGGAGAAA ACTGTTACCT ATTTTCCTCG 
GGCTCATTTA ACTGGGAAAA GAGCCAAGAG AAGTGCTTGT CTTTGGATGC CAAGTTGCTG 
AAAATTAATA GCACAGCTGA TCTGGACTTC ATCCAGCAAG CAATTTCCTA TTCCAGTTTT 
CCATTCTGGA TGGGGCTGTC TCGGAGGAAC CCCAGCTACC CATGGCTCTG GGAGGACGGT 
TCTCCTTTGA TGCCCCACTT ATTTAGAGTC CGAGGCGCTG TCTCCCAGAC ATACCCTTCA 
GGTACCTGTG CATATATACA ACGAGGAGCT GTTTATGCGG AAAACTGCAT TTTAGCTGCC 
TTCAGTATAT GTCAGAAGAA GGCAAACCTA AGAGCACAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002534.1
CDS	56..877
Translation	MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ

Target ORF information:

RefSeq Version	NM_002543.4
Organism	Homo sapiens(human)
Definition	Homo sapiens oxidized low density lipoprotein receptor 1 (OLR1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002543.4

ORF Insert Sequence:

ATGACTTTTG ATGACCTAAA GATCCAGACT GTGAAGGACC AGCCTGATGA GAAGTCAAAT 
GGAAAAAAAG CTAAAGGTCT TCAGTTTCTT TACTCTCCAT GGTGGTGCCT GGCTGCTGCG 
ACTCTAGGGG TCCTTTGCCT GGGATTAGTA GTGACCATTA TGGTGCTGGG CATGCAATTA 
TCCCAGGTGT CTGACCTCCT AACACAAGAG CAAGCAAACC TAACTCACCA GAAAAAGAAA 
CTGGAGGGAC AGATCTCAGC CCGGCAACAA GCAGAAGAAG CTTCACAGGA GTCAGAAAAC 
GAACTCAAGG AAATGATAGA AACCCTTGCT CGGAAGCTGA ATGAGAAATC CAAAGAGCAA 
ATGGAACTTC ACCACCAGAA TCTGAATCTC CAAGAAACAC TGAAGAGAGT AGCAAATTGT 
TCAGCTCCTT GTCCGCAAGA CTGGATCTGG CATGGAGAAA ACTGTTACCT ATTTTCCTCG 
GGCTCATTTA ACTGGGAAAA GAGCCAAGAG AAGTGCTTGT CTTTGGATGC CAAGTTGCTG 
AAAATTAATA GCACAGCTGA TCTGGACTTC ATCCAGCAAG CAATTTCCTA TTCCAGTTTT 
CCATTCTGGA TGGGGCTGTC TCGGAGGAAC CCCAGCTACC CATGGCTCTG GGAGGACGGT 
TCTCCTTTGA TGCCCCACTT ATTTAGAGTC CGAGGCGCTG TCTCCCAGAC ATACCCTTCA 
GGTACCTGTG CATATATACA ACGAGGAGCT GTTTATGCGG AAAACTGCAT TTTAGCTGCC 
TTCAGTATAT GTCAGAAGAA GGCAAACCTA AGAGCACAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OLR1 ( XM_011520682.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011518984.1 Homo sapiens oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu21845
Clone ID Related Accession (Same CDS sequence)	NM_002543.3 , XM_011520682.1 , NM_002543.4
Accession Version	XM_011520682.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	oxidized low-density lipoprotein receptor 1 isoform X1
Comment

ATGACTTTTG ATGACCTAAA GATCCAGACT GTGAAGGACC AGCCTGATGA GAAGTCAAAT 
GGAAAAAAAG CTAAAGGTCT TCAGTTTCTT TACTCTCCAT GGTGGTGCCT GGCTGCTGCG 
ACTCTAGGGG TCCTTTGCCT GGGATTAGTA GTGACCATTA TGGTGCTGGG CATGCAATTA 
TCCCAGGTGT CTGACCTCCT AACACAAGAG CAAGCAAACC TAACTCACCA GAAAAAGAAA 
CTGGAGGGAC AGATCTCAGC CCGGCAACAA GCAGAAGAAG CTTCACAGGA GTCAGAAAAC 
GAACTCAAGG AAATGATAGA AACCCTTGCT CGGAAGCTGA ATGAGAAATC CAAAGAGCAA 
ATGGAACTTC ACCACCAGAA TCTGAATCTC CAAGAAACAC TGAAGAGAGT AGCAAATTGT 
TCAGCTCCTT GTCCGCAAGA CTGGATCTGG CATGGAGAAA ACTGTTACCT ATTTTCCTCG 
GGCTCATTTA ACTGGGAAAA GAGCCAAGAG AAGTGCTTGT CTTTGGATGC CAAGTTGCTG 
AAAATTAATA GCACAGCTGA TCTGGACTTC ATCCAGCAAG CAATTTCCTA TTCCAGTTTT 
CCATTCTGGA TGGGGCTGTC TCGGAGGAAC CCCAGCTACC CATGGCTCTG GGAGGACGGT 
TCTCCTTTGA TGCCCCACTT ATTTAGAGTC CGAGGCGCTG TCTCCCAGAC ATACCCTTCA 
GGTACCTGTG CATATATACA ACGAGGAGCT GTTTATGCGG AAAACTGCAT TTTAGCTGCC 
TTCAGTATAT GTCAGAAGAA GGCAAACCTA AGAGCACAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011518984.1
Translation	MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSAPCPQDWIWHGENCYLFSSGSFNWEKSQEKCLSLDAKLLKINSTADLDFIQQAISYSSFPFWMGLSRRNPSYPWLWEDGSPLMPHLFRVRGAVSQTYPSGTCAYIQRGAVYAENCILAAFSICQKKANLRAQ

Target ORF information:

RefSeq Version	XM_011520682.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011520682.1

ORF Insert Sequence:

ATGACTTTTG ATGACCTAAA GATCCAGACT GTGAAGGACC AGCCTGATGA GAAGTCAAAT 
GGAAAAAAAG CTAAAGGTCT TCAGTTTCTT TACTCTCCAT GGTGGTGCCT GGCTGCTGCG 
ACTCTAGGGG TCCTTTGCCT GGGATTAGTA GTGACCATTA TGGTGCTGGG CATGCAATTA 
TCCCAGGTGT CTGACCTCCT AACACAAGAG CAAGCAAACC TAACTCACCA GAAAAAGAAA 
CTGGAGGGAC AGATCTCAGC CCGGCAACAA GCAGAAGAAG CTTCACAGGA GTCAGAAAAC 
GAACTCAAGG AAATGATAGA AACCCTTGCT CGGAAGCTGA ATGAGAAATC CAAAGAGCAA 
ATGGAACTTC ACCACCAGAA TCTGAATCTC CAAGAAACAC TGAAGAGAGT AGCAAATTGT 
TCAGCTCCTT GTCCGCAAGA CTGGATCTGG CATGGAGAAA ACTGTTACCT ATTTTCCTCG 
GGCTCATTTA ACTGGGAAAA GAGCCAAGAG AAGTGCTTGT CTTTGGATGC CAAGTTGCTG 
AAAATTAATA GCACAGCTGA TCTGGACTTC ATCCAGCAAG CAATTTCCTA TTCCAGTTTT 
CCATTCTGGA TGGGGCTGTC TCGGAGGAAC CCCAGCTACC CATGGCTCTG GGAGGACGGT 
TCTCCTTTGA TGCCCCACTT ATTTAGAGTC CGAGGCGCTG TCTCCCAGAC ATACCCTTCA 
GGTACCTGTG CATATATACA ACGAGGAGCT GTTTATGCGG AAAACTGCAT TTTAGCTGCC 
TTCAGTATAT GTCAGAAGAA GGCAAACCTA AGAGCACAGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OLR1 ( NM_001172632.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001166103.1 Homo sapiens oxidized low density lipoprotein receptor 1 (OLR1), transcript variant 2, mRNA.

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CloneID	OHu12227
Clone ID Related Accession (Same CDS sequence)	NM_001172632.1
Accession Version	NM_001172632.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 546bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-02
Organism	Homo sapiens(human)
Product	oxidized low-density lipoprotein receptor 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP219342.1, AK295409.1, AC024224.33 and CA309323.1. Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.30175.1, SRR1803617.12691.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTTTG ATGACCTAAA GATCCAGACT GTGAAGGACC AGCCTGATGA GAAGTCAAAT 
GGAAAAAAAG CTAAAGGTCT TCAGTTTCTT TACTCTCCAT GGTGGTGCCT GGCTGCTGCG 
ACTCTAGGGG TCCTTTGCCT GGGATTAGTA GTGACCATTA TGGTGCTGGG CATGCAATTA 
TCCCAGGTGT CTGACCTCCT AACACAAGAG CAAGCAAACC TAACTCACCA GAAAAAGAAA 
CTGGAGGGAC AGATCTCAGC CCGGCAACAA GCAGAAGAAG CTTCACAGGA GTCAGAAAAC 
GAACTCAAGG AAATGATAGA AACCCTTGCT CGGAAGCTGA ATGAGAAATC CAAAGAGCAA 
ATGGAACTTC ACCACCAGAA TCTGAATCTC CAAGAAACAC TGAAGAGAGT AGCAAATTGT 
TCAGGACTTC ATCCAGCAAG CAATTTCCTA TTCCAGTTTT CCATTCTGGA TGGGGCTGTC 
TCGGAGGAAC CCCAGCTACC CATGGCTCTG GGAGGACGGT TCTCCTTTGA TGCCCCACTT 
ATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001166103.1
CDS	115..660
Translation	MTFDDLKIQTVKDQPDEKSNGKKAKGLQFLYSPWWCLAAATLGVLCLGLVVTIMVLGMQLSQVSDLLTQEQANLTHQKKKLEGQISARQQAEEASQESENELKEMIETLARKLNEKSKEQMELHHQNLNLQETLKRVANCSGLHPASNFLFQFSILDGAVSEEPQLPMALGGRFSFDAPLI

Target ORF information:

RefSeq Version	NM_001172632.1
Organism	Homo sapiens(human)
Definition	Homo sapiens oxidized low density lipoprotein receptor 1 (OLR1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001172632.1

ORF Insert Sequence:

ATGACTTTTG ATGACCTAAA GATCCAGACT GTGAAGGACC AGCCTGATGA GAAGTCAAAT 
GGAAAAAAAG CTAAAGGTCT TCAGTTTCTT TACTCTCCAT GGTGGTGCCT GGCTGCTGCG 
ACTCTAGGGG TCCTTTGCCT GGGATTAGTA GTGACCATTA TGGTGCTGGG CATGCAATTA 
TCCCAGGTGT CTGACCTCCT AACACAAGAG CAAGCAAACC TAACTCACCA GAAAAAGAAA 
CTGGAGGGAC AGATCTCAGC CCGGCAACAA GCAGAAGAAG CTTCACAGGA GTCAGAAAAC 
GAACTCAAGG AAATGATAGA AACCCTTGCT CGGAAGCTGA ATGAGAAATC CAAAGAGCAA 
ATGGAACTTC ACCACCAGAA TCTGAATCTC CAAGAAACAC TGAAGAGAGT AGCAAATTGT 
TCAGGACTTC ATCCAGCAAG CAATTTCCTA TTCCAGTTTT CCATTCTGGA TGGGGCTGTC 
TCGGAGGAAC CCCAGCTACC CATGGCTCTG GGAGGACGGT TCTCCTTTGA TGCCCCACTT 
ATTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Scavenger Receptor LOX1 Genotype Predicts Coronary Artery Disease in Patients With Familial Hypercholesterolemia.
The Canadian journal of cardiology33(10)1312-1318(2017 Oct)
Paquette M,Dufour R,Baass A

LOX-1: A potential target for therapy in atherosclerosis; an in vitro study.
The international journal of biochemistry & cell biology91(Pt A)65-80(2017 Oct)
Arjuman A,Chandra NC

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OLR1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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