Olr1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Olr1
Entrez Gene ID	140914
Full Name	oxidized low density lipoprotein receptor 1
Synonyms	LOX-1,Oldlr1,Oldr1
General protein information	Preferred Names oxidized low density lipoprotein receptor 1 Names oxidized low-density lipoprotein receptor 1 Lectin-like oxidized low-density lipoprotein receptor-1 lectin-like oxLDL receptor 1 lectin-like oxidized LDL receptor 1 lectin-like oxidized low-density lipoprotein receptor lectin-type oxidized LDL receptor 1 ox-LDL receptor 1 oxidised low density lipoprotein (lectin-like) receptor 1 oxidized low density lipoprotein (lectin-like) receptor 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	receptor for oxidized low-density lipoprotein that may be involved in pathogenesis of hypertension as well as atherosclerosis [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_133306.2	NP_579840.2	oxidized low-density lipoprotein receptor 1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	OLR1	NP_776557.1
Mus musculus (house mouse)	Olr1	NP_619589.2
Rattus norvegicus (Norway rat)	Olr1	NP_579840.2
Pan troglodytes (chimpanzee)	OLR1	XP_001145768.1
Homo sapiens (human)	OLR1	NP_002534.1
	OLR1	XP_001115025.1
Canis lupus familiaris (dog)	OLR1	XP_543821.3

Gene Ontology
Bibliography

Related articles in PubMed

LOX-1 mediated phenotypic switching of pulmonary arterial smooth muscle cells contributes to hypoxic pulmonary hypertension.
Zhang W, Zhu T, Wu W, Ge X, Xiong X, Zhang Z, Hu C
European journal of pharmacology81884-95(2018 Jan)

LOX-1 promotes right ventricular hypertrophy in hypoxia-exposed rats.
Zhu TT, Zhang WF, Luo P, Qian ZX, Li F, Zhang Z, Hu CP
Life sciences17435-42(2017 Apr)

Syncytiotrophoblast extracellular vesicles impair rat uterine vascular function via the lectin-like oxidized LDL receptor-1.
Spaans F, Kao CK, Morton JS, Quon AL, Sawamura T, Tannetta DS, Sargent IL, Davidge ST
PloS one12(7)e0180364(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Negative feedback regulation between let-7g and LOX-1 mediated hypoxia-induced proliferation of in pulmonary artery smooth muscle cells (PASMCs).
Title: Negative feedback regulation between microRNA let-7g and LOX-1 mediated hypoxia-induced PASMCs proliferation.

LOX-1 promotes right ventricular hypertrophy in hypoxia-exposed rats
Title: LOX-1 promotes right ventricular hypertrophy in hypoxia-exposed rats.

data support an important role for STBEVs in impairment of vascular function via activation of LOX-1 and reduced nitric oxide mediated vasodilation. Moreover, we postulate that the LOX-1 pathway could be a potential therapeutic target in pathologies associated with vascular dysfunction during pregnancy
Title: Syncytiotrophoblast extracellular vesicles impair rat uterine vascular function via the lectin-like oxidized LDL receptor-1.

The in vitro and in vivo models revealed that lipid metabolism disorder and FK506 caused oxidative stress and a fibrogenic response. In addition, decreased levels of LOX1 markedly reduced the levels of TGFb1 in the in vitro model.
Title: Mechanism of tacrolimus-induced chronic renal fibrosis following transplantation is regulated by ox-LDL and its receptor, LOX-1.

The inhibition of LOX-1 by RNA interference LOX-1 lentivirus resulted in the loss of PI3K/Akt activation and GATA4 protein expression. GATA4 may play an important role in the LOX-1 and PI3K/Akt regulation of cardiac fibroblast proliferation.
Title: Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 reduces cardiac fibroblast proliferation by suppressing GATA Binding Protein 4.

The following Olr1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Olr1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12251	NM_133306.2 Latest version!	Rattus norvegicus oxidized low density lipoprotein receptor 1 (Olr1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$188.30 $269.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Olr1 ( NM_133306.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_579840.2 Rattus norvegicus oxidized low density lipoprotein receptor 1 (Olr1), mRNA.

Price & Availability↑

CloneID	ORa12251
Clone ID Related Accession (Same CDS sequence)	NM_133306.2
Accession Version	NM_133306.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-20
Organism	Rattus norvegicus(Norway rat)
Product	oxidized low-density lipoprotein receptor 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC115156.5, BC097290.1 and AABR07073062.1. On Sep 11, 2012 this sequence version replaced NM_133306.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB005900.1, BC097290.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689594, SAMEA2689599 [ECO:0000348] ##Evidence-Data-END##

ATGAATTTGG AAATGGCTTT TGATGACAAG ATGAAGCCTG TGAATGGCCA GCCTGATCAG 
AAGTCATGTG GCAAGAAGCC TAAAGGGCTG CATTTGCTTT CTTCCACATG GTGGTGCCCT 
GCTGCTGTGA CTCTGGCCAT CCTTTGCCTA GTGTTATCAG TGACCCTTAT TGTACAGCAG 
ACACAGTTAC TCCAGGTATC TGACCTCCTA AAGCAATACC AAGCAAACCT TACTCAGCAG 
GATCATATCC TGGAGGGGCA GATGTCAGCC CAGAAGAAAG CAGAAAATGC TTCACAAGAA 
TCAAAGAGGG AACTGAAGGA ACAGATAGAC ACCCTCACCT GGAAGCTAAA CGAGAAATCC 
AAAGAGCAGG AGAAGCTTCT GCAGCAGAAT CAGAACCTCC AAGAAGCCCT GCAGAGAGCT 
GTGAACGCTT CAGAGGAGTC CAAGTGGGAA CTGAAGGAAC AAATAGACAT TCTCAACTGG 
AAGCTGAATG GGATATCCAA AGAGCAGAAG GAGCTTCTGC AGCAGAATCA GAACCTCCAA 
GAAGCCCTGC AGAAAGCTGA GAAATATTCA GAGGAGTCCC AGAGAGAACT GAAGGAACAG 
ATAGACACCC TCAGCTGGAA GCTAAACGAG AAATCCAAAG AGCAGGAGGA GCTTCTGCAG 
CAGAATCAGA ATCTTCAAGA AGCCCTGCAG AGAGCTGCAA ACTCTTCAGG TCCTTGTCCA 
CAAGACTGGA TCTGGCATAA AGAAAACTGT TACCTCTTCC ATGGGCCCTT TAACTGGGAA 
AAAAGTCGGG AGAATTGCCT ATCTTTAGAT GCCCAGTTAC TACAAATTAG TACCACAGAT 
GATCTGAACT TCGTCTTACA AGCAACTTCC CATTCCACCT CCCCATTTTG GATGGGATTA 
CATCGGAAAA ATCCCAACCA CCCATGGCTA TGGGAGAACG GCTCTCCTTT GAGTTTTCAA 
TTCTTTAGGA CCAGGGGCGT TTCTTTACAG ATGTACTCAT CAGGCACCTG TGCATATATT 
CAAGGAGGAG TTGTGTTTGC TGAAAACTGC ATTTTAACTG CATTCAGCAT ATGTCAGAAG 
AAGGCAAATT TATTGCTAAC TCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_579840.2
CDS	80..1186
Translation	MNLEMAFDDKMKPVNGQPDQKSCGKKPKGLHLLSSTWWCPAAVTLAILCLVLSVTLIVQQTQLLQVSDLLKQYQANLTQQDHILEGQMSAQKKAENASQESKRELKEQIDTLTWKLNEKSKEQEKLLQQNQNLQEALQRAVNASEESKWELKEQIDILNWKLNGISKEQKELLQQNQNLQEALQKAEKYSEESQRELKEQIDTLSWKLNEKSKEQEELLQQNQNLQEALQRAANSSGPCPQDWIWHKENCYLFHGPFNWEKSRENCLSLDAQLLQISTTDDLNFVLQATSHSTSPFWMGLHRKNPNHPWLWENGSPLSFQFFRTRGVSLQMYSSGTCAYIQGGVVFAENCILTAFSICQKKANLLLTQ

Target ORF information:

RefSeq Version	NM_133306.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus oxidized low density lipoprotein receptor 1 (Olr1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133306.2

ORF Insert Sequence:

ATGAATTTGG AAATGGCTTT TGATGACAAG ATGAAGCCTG TGAATGGCCA GCCTGATCAG 
AAGTCATGTG GCAAGAAGCC TAAAGGGCTG CATTTGCTTT CTTCCACATG GTGGTGCCCT 
GCTGCTGTGA CTCTGGCCAT CCTTTGCCTA GTGTTATCAG TGACCCTTAT TGTACAGCAG 
ACACAGTTAC TCCAGGTATC TGACCTCCTA AAGCAATACC AAGCAAACCT TACTCAGCAG 
GATCATATCC TGGAGGGGCA GATGTCAGCC CAGAAGAAAG CAGAAAATGC TTCACAAGAA 
TCAAAGAGGG AACTGAAGGA ACAGATAGAC ACCCTCACCT GGAAGCTAAA CGAGAAATCC 
AAAGAGCAGG AGAAGCTTCT GCAGCAGAAT CAGAACCTCC AAGAAGCCCT GCAGAGAGCT 
GTGAACGCTT CAGAGGAGTC CAAGTGGGAA CTGAAGGAAC AAATAGACAT TCTCAACTGG 
AAGCTGAATG GGATATCCAA AGAGCAGAAG GAGCTTCTGC AGCAGAATCA GAACCTCCAA 
GAAGCCCTGC AGAAAGCTGA GAAATATTCA GAGGAGTCCC AGAGAGAACT GAAGGAACAG 
ATAGACACCC TCAGCTGGAA GCTAAACGAG AAATCCAAAG AGCAGGAGGA GCTTCTGCAG 
CAGAATCAGA ATCTTCAAGA AGCCCTGCAG AGAGCTGCAA ACTCTTCAGG TCCTTGTCCA 
CAAGACTGGA TCTGGCATAA AGAAAACTGT TACCTCTTCC ATGGGCCCTT TAACTGGGAA 
AAAAGTCGGG AGAATTGCCT ATCTTTAGAT GCCCAGTTAC TACAAATTAG TACCACAGAT 
GATCTGAACT TCGTCTTACA AGCAACTTCC CATTCCACCT CCCCATTTTG GATGGGATTA 
CATCGGAAAA ATCCCAACCA CCCATGGCTA TGGGAGAACG GCTCTCCTTT GAGTTTTCAA 
TTCTTTAGGA CCAGGGGCGT TTCTTTACAG ATGTACTCAT CAGGCACCTG TGCATATATT 
CAAGGAGGAG TTGTGTTTGC TGAAAACTGC ATTTTAACTG CATTCAGCAT ATGTCAGAAG 
AAGGCAAATT TATTGCTAAC TCAGTGA