NUCB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NUCB1
Entrez Gene ID	4924
Full Name	nucleobindin 1
Synonyms	CALNUC,NUC
General protein information	Preferred Names nucleobindin 1 Names nucleobindin-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33
Summary	This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and Ca(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010].
Disorder MIM:	601323

mRNA and Protein(s)

mRNA	Protein	Name
NM_006184.5	NP_006175.2	nucleobindin-1 precursor
NM_006184.6	NP_006175.2	nucleobindin-1 precursor
XM_017026845.1	XP_016882334.1	nucleobindin-1 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	NUCB1	NP_006175.2
Canis lupus familiaris (dog)	NUCB1	XP_541506.2
Danio rerio (zebrafish)	nucb1	NP_001038928.1
Xenopus tropicalis (tropical clawed frog)	nucb1	NP_998854.1
Mus musculus (house mouse)	Nucb1	NP_001157134.1
Rattus norvegicus (Norway rat)	Nucb1	NP_445915.1
Pan troglodytes (chimpanzee)	NUCB1	XP_512807.3
Bos taurus (cattle)	NUCB1	NP_001068667.1

Gene Ontology
Bibliography

Related articles in PubMed

Chaperone-like Activity of Calnuc Prevents Amyloid Aggregation.
Kanuru M, Aradhyam GK
Biochemistry56(1)149-159(2017 Jan)

Calnuc Function in Endosomal Sorting of Lysosomal Receptors.
Larkin H, Costantino S, Seaman MN, Lavoie C
Traffic (Copenhagen, Denmark)17(4)416-32(2016 Apr)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that calnuc (nucleobindin 1) is possibly involved in controlling protein unfolding diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), prion disease, and type II diabetes.
Title: Chaperone-like Activity of Calnuc Prevents Amyloid Aggregation.

Calnuc depletion causes the misdelivery to and degradation in lysosomes of cationic-independent mannose-6-phosphate receptor and Sortilin .
Title: Calnuc Function in Endosomal Sorting of Lysosomal Receptors.

nesfatin-1 has a role in thyroid dysfunction in patients with T2DM
Title: Decreased plasma nesfatin-1 level is related to the thyroid dysfunction in patients with type 2 diabetes mellitus.

The serine protease activity of calnuc is allosterically regulated by Zn2+ binding and its interaction with G protein alpha subunit.
Title: Serine protease activity of calnuc: regulation by Zn2+ and G proteins.

postulate that the engineered forms of NUCB1 prevent hIAPP fibril formation by a mechanism where protofibril-like species are "capped" to prevent further fibril assembly and maturation
Title: Nucleobindin 1 caps human islet amyloid polypeptide protofibrils to prevent amyloid fibril formation.

The following NUCB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NUCB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu07805	NM_006184.6 Latest version!	Homo sapiens nucleobindin 1 (NUCB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu07805	XM_017026845.1 Latest version!	Homo sapiens nucleobindin 1 (NUCB1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu07805	NM_006184.5	Homo sapiens nucleobindin 1 (NUCB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NUCB1 ( NM_006184.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_006175.2 Homo sapiens nucleobindin 1 (NUCB1), mRNA.

Price & Availability↑

CloneID	OHu07805
Clone ID Related Accession (Same CDS sequence)	NM_006184.5 , NM_006184.6 , XM_017026845.1
Accession Version	NM_006184.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	nucleobindin-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK292066.1, AK315422.1, AC026803.7 and AI208532.1. On Jun 3, 2010 this sequence version replaced NM_006184.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292066.1, SRR1803611.253404.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTCCCT CTGGGCCCCG AGGAACCCTC CTTCTGTTGC CGCTGCTGCT GCTGCTCCTG 
CTTCGCGCCG TGCTGGCTGT CCCCCTGGAG CGAGGGGCGC CCAACAAGGA GGAGACCCCT 
GCGACTGAGA GTCCCGACAC AGGCCTGTAC TACCACCGGT ACCTCCAGGA GGTCATCGAT 
GTACTGGAGA CGGATGGGCA TTTCCGAGAG AAGCTGCAGG CTGCCAATGC GGAGGACATC 
AAGAGCGGGA AGCTGAGCCG AGAGCTGGAC TTTGTCAGCC ACCACGTCCG CACCAAGCTG 
GATGAGCTCA AGCGACAGGA GGTGTCACGG CTGCGGATGC TGCTCAAGGC CAAGATGGAC 
GCCGAGCAGG ATCCCAATGT ACAGGTGGAT CATCTGAATC TCCTGAAACA GTTTGAACAC 
CTGGACCCTC AGAACCAGCA TACATTCGAG GCCCGCGACC TGGAGCTGCT GATCCAGACG 
GCCACCCGGG ACCTTGCCCA GTACGACGCA GCCCATCATG AAGAGTTCAA GCGCTACGAG 
ATGCTTAAGG AACACGAGAG ACGGCGTTAT CTGGAGTCAC TGGGAGAGGA GCAGAGAAAG 
GAGGCGGAGA GGAAGCTGGA AGAGCAACAG CGCCGGCACC GCGAGCACCC TAAAGTCAAC 
GTGCCTGGCA GCCAAGCCCA GTTGAAGGAG GTGTGGGAGG AGCTGGATGG ACTGGACCCC 
AACAGGTTTA ACCCCAAGAC CTTCTTCATA CTGCATGATA TCAACAGTGA TGGTGTCCTG 
GATGAGCAGG AGCTGGAGGC ACTCTTCACC AAGGAGCTGG AGAAAGTGTA CGACCCAAAG 
AATGAGGAGG ACGACATGCG GGAGATGGAG GAGGAGCGAC TGCGCATGCG GGAGCATGTG 
ATGAAGAATG TGGACACCAA CCAGGACCGC CTCGTGACCC TGGAGGAGTT CCTCGCATCC 
ACTCAGAGGA AGGAGTTTGG GGACACCGGG GAGGGCTGGG AGACAGTGGA GATGCACCCT 
GCCTACACCG AGGAAGAGCT GAGGCGCTTT GAAGAGGAGC TGGCTGCCCG GGAGGCAGAG 
CTGAATGCCA AGGCCCAGCG CCTCAGCCAG GAGACAGAGG CTCTAGGGCG GTCCCAGGGC 
CGCCTGGAGG CCCAGAAGAG AGAGCTGCAG CAGGCTGTGC TGCACATGGA GCAGCGGAAG 
CAGCAGCAGC AGCAGCAGCA AGGCCACAAG GCCCCGGCTG CCCACCCTGA GGGGCAGCTC 
AAGTTCCACC CAGACACAGA CGATGTACCT GTCCCAGCTC CAGCCGGTGA CCAGAAGGAG 
GTGGACACTT CAGAAAAGAA ACTTCTCGAG CGGCTCCCTG AGGTTGAGGT GCCCCAGCAT 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006175.2
CDS	335..1720
Translation	MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHPDTDDVPVPAPAGDQKEVDTSEKKLLERLPEVEVPQHL

Target ORF information:

RefSeq Version	NM_006184.5
Organism	Homo sapiens(human)
Definition	Homo sapiens nucleobindin 1 (NUCB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006184.5

ORF Insert Sequence:

ATGCCTCCCT CTGGGCCCCG AGGAACCCTC CTTCTGTTGC CGCTGCTGCT GCTGCTCCTG 
CTTCGCGCCG TGCTGGCTGT CCCCCTGGAG CGAGGGGCGC CCAACAAGGA GGAGACCCCT 
GCGACTGAGA GTCCCGACAC AGGCCTGTAC TACCACCGGT ACCTCCAGGA GGTCATCGAT 
GTACTGGAGA CGGATGGGCA TTTCCGAGAG AAGCTGCAGG CTGCCAATGC GGAGGACATC 
AAGAGCGGGA AGCTGAGCCG AGAGCTGGAC TTTGTCAGCC ACCACGTCCG CACCAAGCTG 
GATGAGCTCA AGCGACAGGA GGTGTCACGG CTGCGGATGC TGCTCAAGGC CAAGATGGAC 
GCCGAGCAGG ATCCCAATGT ACAGGTGGAT CATCTGAATC TCCTGAAACA GTTTGAACAC 
CTGGACCCTC AGAACCAGCA TACATTCGAG GCCCGCGACC TGGAGCTGCT GATCCAGACG 
GCCACCCGGG ACCTTGCCCA GTACGACGCA GCCCATCATG AAGAGTTCAA GCGCTACGAG 
ATGCTTAAGG AACACGAGAG ACGGCGTTAT CTGGAGTCAC TGGGAGAGGA GCAGAGAAAG 
GAGGCGGAGA GGAAGCTGGA AGAGCAACAG CGCCGGCACC GCGAGCACCC TAAAGTCAAC 
GTGCCTGGCA GCCAAGCCCA GTTGAAGGAG GTGTGGGAGG AGCTGGATGG ACTGGACCCC 
AACAGGTTTA ACCCCAAGAC CTTCTTCATA CTGCATGATA TCAACAGTGA TGGTGTCCTG 
GATGAGCAGG AGCTGGAGGC ACTCTTCACC AAGGAGCTGG AGAAAGTGTA CGACCCAAAG 
AATGAGGAGG ACGACATGCG GGAGATGGAG GAGGAGCGAC TGCGCATGCG GGAGCATGTG 
ATGAAGAATG TGGACACCAA CCAGGACCGC CTCGTGACCC TGGAGGAGTT CCTCGCATCC 
ACTCAGAGGA AGGAGTTTGG GGACACCGGG GAGGGCTGGG AGACAGTGGA GATGCACCCT 
GCCTACACCG AGGAAGAGCT GAGGCGCTTT GAAGAGGAGC TGGCTGCCCG GGAGGCAGAG 
CTGAATGCCA AGGCCCAGCG CCTCAGCCAG GAGACAGAGG CTCTAGGGCG GTCCCAGGGC 
CGCCTGGAGG CCCAGAAGAG AGAGCTGCAG CAGGCTGTGC TGCACATGGA GCAGCGGAAG 
CAGCAGCAGC AGCAGCAGCA AGGCCACAAG GCCCCGGCTG CCCACCCTGA GGGGCAGCTC 
AAGTTCCACC CAGACACAGA CGATGTACCT GTCCCAGCTC CAGCCGGTGA CCAGAAGGAG 
GTGGACACTT CAGAAAAGAA ACTTCTCGAG CGGCTCCCTG AGGTTGAGGT GCCCCAGCAT 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUCB1 ( NM_006184.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_006175.2 Homo sapiens nucleobindin 1 (NUCB1), mRNA.

Price & Availability↑

CloneID	OHu07805
Clone ID Related Accession (Same CDS sequence)	NM_006184.5 , NM_006184.6 , XM_017026845.1
Accession Version	NM_006184.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	nucleobindin-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK315422.1, AC026803.7 and AI208532.1. On Nov 23, 2018 this sequence version replaced NM_006184.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK315422.1, SRR1803612.40534.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000405315.9/ ENSP00000385923.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCTCCCT CTGGGCCCCG AGGAACCCTC CTTCTGTTGC CGCTGCTGCT GCTGCTCCTG 
CTTCGCGCCG TGCTGGCTGT CCCCCTGGAG CGAGGGGCGC CCAACAAGGA GGAGACCCCT 
GCGACTGAGA GTCCCGACAC AGGCCTGTAC TACCACCGGT ACCTCCAGGA GGTCATCGAT 
GTACTGGAGA CGGATGGGCA TTTCCGAGAG AAGCTGCAGG CTGCCAATGC GGAGGACATC 
AAGAGCGGGA AGCTGAGCCG AGAGCTGGAC TTTGTCAGCC ACCACGTCCG CACCAAGCTG 
GATGAGCTCA AGCGACAGGA GGTGTCACGG CTGCGGATGC TGCTCAAGGC CAAGATGGAC 
GCCGAGCAGG ATCCCAATGT ACAGGTGGAT CATCTGAATC TCCTGAAACA GTTTGAACAC 
CTGGACCCTC AGAACCAGCA TACATTCGAG GCCCGCGACC TGGAGCTGCT GATCCAGACG 
GCCACCCGGG ACCTTGCCCA GTACGACGCA GCCCATCATG AAGAGTTCAA GCGCTACGAG 
ATGCTTAAGG AACACGAGAG ACGGCGTTAT CTGGAGTCAC TGGGAGAGGA GCAGAGAAAG 
GAGGCGGAGA GGAAGCTGGA AGAGCAACAG CGCCGGCACC GCGAGCACCC TAAAGTCAAC 
GTGCCTGGCA GCCAAGCCCA GTTGAAGGAG GTGTGGGAGG AGCTGGATGG ACTGGACCCC 
AACAGGTTTA ACCCCAAGAC CTTCTTCATA CTGCATGATA TCAACAGTGA TGGTGTCCTG 
GATGAGCAGG AGCTGGAGGC ACTCTTCACC AAGGAGCTGG AGAAAGTGTA CGACCCAAAG 
AATGAGGAGG ACGACATGCG GGAGATGGAG GAGGAGCGAC TGCGCATGCG GGAGCATGTG 
ATGAAGAATG TGGACACCAA CCAGGACCGC CTCGTGACCC TGGAGGAGTT CCTCGCATCC 
ACTCAGAGGA AGGAGTTTGG GGACACCGGG GAGGGCTGGG AGACAGTGGA GATGCACCCT 
GCCTACACCG AGGAAGAGCT GAGGCGCTTT GAAGAGGAGC TGGCTGCCCG GGAGGCAGAG 
CTGAATGCCA AGGCCCAGCG CCTCAGCCAG GAGACAGAGG CTCTAGGGCG GTCCCAGGGC 
CGCCTGGAGG CCCAGAAGAG AGAGCTGCAG CAGGCTGTGC TGCACATGGA GCAGCGGAAG 
CAGCAGCAGC AGCAGCAGCA AGGCCACAAG GCCCCGGCTG CCCACCCTGA GGGGCAGCTC 
AAGTTCCACC CAGACACAGA CGATGTACCT GTCCCAGCTC CAGCCGGTGA CCAGAAGGAG 
GTGGACACTT CAGAAAAGAA ACTTCTCGAG CGGCTCCCTG AGGTTGAGGT GCCCCAGCAT 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006175.2
CDS	73..1458
Translation	MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHPDTDDVPVPAPAGDQKEVDTSEKKLLERLPEVEVPQHL

Target ORF information:

RefSeq Version	NM_006184.6
Organism	Homo sapiens(human)
Definition	Homo sapiens nucleobindin 1 (NUCB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006184.6

ORF Insert Sequence:

ATGCCTCCCT CTGGGCCCCG AGGAACCCTC CTTCTGTTGC CGCTGCTGCT GCTGCTCCTG 
CTTCGCGCCG TGCTGGCTGT CCCCCTGGAG CGAGGGGCGC CCAACAAGGA GGAGACCCCT 
GCGACTGAGA GTCCCGACAC AGGCCTGTAC TACCACCGGT ACCTCCAGGA GGTCATCGAT 
GTACTGGAGA CGGATGGGCA TTTCCGAGAG AAGCTGCAGG CTGCCAATGC GGAGGACATC 
AAGAGCGGGA AGCTGAGCCG AGAGCTGGAC TTTGTCAGCC ACCACGTCCG CACCAAGCTG 
GATGAGCTCA AGCGACAGGA GGTGTCACGG CTGCGGATGC TGCTCAAGGC CAAGATGGAC 
GCCGAGCAGG ATCCCAATGT ACAGGTGGAT CATCTGAATC TCCTGAAACA GTTTGAACAC 
CTGGACCCTC AGAACCAGCA TACATTCGAG GCCCGCGACC TGGAGCTGCT GATCCAGACG 
GCCACCCGGG ACCTTGCCCA GTACGACGCA GCCCATCATG AAGAGTTCAA GCGCTACGAG 
ATGCTTAAGG AACACGAGAG ACGGCGTTAT CTGGAGTCAC TGGGAGAGGA GCAGAGAAAG 
GAGGCGGAGA GGAAGCTGGA AGAGCAACAG CGCCGGCACC GCGAGCACCC TAAAGTCAAC 
GTGCCTGGCA GCCAAGCCCA GTTGAAGGAG GTGTGGGAGG AGCTGGATGG ACTGGACCCC 
AACAGGTTTA ACCCCAAGAC CTTCTTCATA CTGCATGATA TCAACAGTGA TGGTGTCCTG 
GATGAGCAGG AGCTGGAGGC ACTCTTCACC AAGGAGCTGG AGAAAGTGTA CGACCCAAAG 
AATGAGGAGG ACGACATGCG GGAGATGGAG GAGGAGCGAC TGCGCATGCG GGAGCATGTG 
ATGAAGAATG TGGACACCAA CCAGGACCGC CTCGTGACCC TGGAGGAGTT CCTCGCATCC 
ACTCAGAGGA AGGAGTTTGG GGACACCGGG GAGGGCTGGG AGACAGTGGA GATGCACCCT 
GCCTACACCG AGGAAGAGCT GAGGCGCTTT GAAGAGGAGC TGGCTGCCCG GGAGGCAGAG 
CTGAATGCCA AGGCCCAGCG CCTCAGCCAG GAGACAGAGG CTCTAGGGCG GTCCCAGGGC 
CGCCTGGAGG CCCAGAAGAG AGAGCTGCAG CAGGCTGTGC TGCACATGGA GCAGCGGAAG 
CAGCAGCAGC AGCAGCAGCA AGGCCACAAG GCCCCGGCTG CCCACCCTGA GGGGCAGCTC 
AAGTTCCACC CAGACACAGA CGATGTACCT GTCCCAGCTC CAGCCGGTGA CCAGAAGGAG 
GTGGACACTT CAGAAAAGAA ACTTCTCGAG CGGCTCCCTG AGGTTGAGGT GCCCCAGCAT 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NUCB1 ( XM_017026845.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882334.1 Homo sapiens nucleobindin 1 (NUCB1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu07805
Clone ID Related Accession (Same CDS sequence)	NM_006184.5 , NM_006184.6 , XM_017026845.1
Accession Version	XM_017026845.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	nucleobindin-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTCCCT CTGGGCCCCG AGGAACCCTC CTTCTGTTGC CGCTGCTGCT GCTGCTCCTG 
CTTCGCGCCG TGCTGGCTGT CCCCCTGGAG CGAGGGGCGC CCAACAAGGA GGAGACCCCT 
GCGACTGAGA GTCCCGACAC AGGCCTGTAC TACCACCGGT ACCTCCAGGA GGTCATCGAT 
GTACTGGAGA CGGATGGGCA TTTCCGAGAG AAGCTGCAGG CTGCCAATGC GGAGGACATC 
AAGAGCGGGA AGCTGAGCCG AGAGCTGGAC TTTGTCAGCC ACCACGTCCG CACCAAGCTG 
GATGAGCTCA AGCGACAGGA GGTGTCACGG CTGCGGATGC TGCTCAAGGC CAAGATGGAC 
GCCGAGCAGG ATCCCAATGT ACAGGTGGAT CATCTGAATC TCCTGAAACA GTTTGAACAC 
CTGGACCCTC AGAACCAGCA TACATTCGAG GCCCGCGACC TGGAGCTGCT GATCCAGACG 
GCCACCCGGG ACCTTGCCCA GTACGACGCA GCCCATCATG AAGAGTTCAA GCGCTACGAG 
ATGCTTAAGG AACACGAGAG ACGGCGTTAT CTGGAGTCAC TGGGAGAGGA GCAGAGAAAG 
GAGGCGGAGA GGAAGCTGGA AGAGCAACAG CGCCGGCACC GCGAGCACCC TAAAGTCAAC 
GTGCCTGGCA GCCAAGCCCA GTTGAAGGAG GTGTGGGAGG AGCTGGATGG ACTGGACCCC 
AACAGGTTTA ACCCCAAGAC CTTCTTCATA CTGCATGATA TCAACAGTGA TGGTGTCCTG 
GATGAGCAGG AGCTGGAGGC ACTCTTCACC AAGGAGCTGG AGAAAGTGTA CGACCCAAAG 
AATGAGGAGG ACGACATGCG GGAGATGGAG GAGGAGCGAC TGCGCATGCG GGAGCATGTG 
ATGAAGAATG TGGACACCAA CCAGGACCGC CTCGTGACCC TGGAGGAGTT CCTCGCATCC 
ACTCAGAGGA AGGAGTTTGG GGACACCGGG GAGGGCTGGG AGACAGTGGA GATGCACCCT 
GCCTACACCG AGGAAGAGCT GAGGCGCTTT GAAGAGGAGC TGGCTGCCCG GGAGGCAGAG 
CTGAATGCCA AGGCCCAGCG CCTCAGCCAG GAGACAGAGG CTCTAGGGCG GTCCCAGGGC 
CGCCTGGAGG CCCAGAAGAG AGAGCTGCAG CAGGCTGTGC TGCACATGGA GCAGCGGAAG 
CAGCAGCAGC AGCAGCAGCA AGGCCACAAG GCCCCGGCTG CCCACCCTGA GGGGCAGCTC 
AAGTTCCACC CAGACACAGA CGATGTACCT GTCCCAGCTC CAGCCGGTGA CCAGAAGGAG 
GTGGACACTT CAGAAAAGAA ACTTCTCGAG CGGCTCCCTG AGGTTGAGGT GCCCCAGCAT 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882334.1
CDS	302..1687
Translation	MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHPDTDDVPVPAPAGDQKEVDTSEKKLLERLPEVEVPQHL

Target ORF information:

RefSeq Version	XM_017026845.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nucleobindin 1 (NUCB1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026845.1

ORF Insert Sequence:

ATGCCTCCCT CTGGGCCCCG AGGAACCCTC CTTCTGTTGC CGCTGCTGCT GCTGCTCCTG 
CTTCGCGCCG TGCTGGCTGT CCCCCTGGAG CGAGGGGCGC CCAACAAGGA GGAGACCCCT 
GCGACTGAGA GTCCCGACAC AGGCCTGTAC TACCACCGGT ACCTCCAGGA GGTCATCGAT 
GTACTGGAGA CGGATGGGCA TTTCCGAGAG AAGCTGCAGG CTGCCAATGC GGAGGACATC 
AAGAGCGGGA AGCTGAGCCG AGAGCTGGAC TTTGTCAGCC ACCACGTCCG CACCAAGCTG 
GATGAGCTCA AGCGACAGGA GGTGTCACGG CTGCGGATGC TGCTCAAGGC CAAGATGGAC 
GCCGAGCAGG ATCCCAATGT ACAGGTGGAT CATCTGAATC TCCTGAAACA GTTTGAACAC 
CTGGACCCTC AGAACCAGCA TACATTCGAG GCCCGCGACC TGGAGCTGCT GATCCAGACG 
GCCACCCGGG ACCTTGCCCA GTACGACGCA GCCCATCATG AAGAGTTCAA GCGCTACGAG 
ATGCTTAAGG AACACGAGAG ACGGCGTTAT CTGGAGTCAC TGGGAGAGGA GCAGAGAAAG 
GAGGCGGAGA GGAAGCTGGA AGAGCAACAG CGCCGGCACC GCGAGCACCC TAAAGTCAAC 
GTGCCTGGCA GCCAAGCCCA GTTGAAGGAG GTGTGGGAGG AGCTGGATGG ACTGGACCCC 
AACAGGTTTA ACCCCAAGAC CTTCTTCATA CTGCATGATA TCAACAGTGA TGGTGTCCTG 
GATGAGCAGG AGCTGGAGGC ACTCTTCACC AAGGAGCTGG AGAAAGTGTA CGACCCAAAG 
AATGAGGAGG ACGACATGCG GGAGATGGAG GAGGAGCGAC TGCGCATGCG GGAGCATGTG 
ATGAAGAATG TGGACACCAA CCAGGACCGC CTCGTGACCC TGGAGGAGTT CCTCGCATCC 
ACTCAGAGGA AGGAGTTTGG GGACACCGGG GAGGGCTGGG AGACAGTGGA GATGCACCCT 
GCCTACACCG AGGAAGAGCT GAGGCGCTTT GAAGAGGAGC TGGCTGCCCG GGAGGCAGAG 
CTGAATGCCA AGGCCCAGCG CCTCAGCCAG GAGACAGAGG CTCTAGGGCG GTCCCAGGGC 
CGCCTGGAGG CCCAGAAGAG AGAGCTGCAG CAGGCTGTGC TGCACATGGA GCAGCGGAAG 
CAGCAGCAGC AGCAGCAGCA AGGCCACAAG GCCCCGGCTG CCCACCCTGA GGGGCAGCTC 
AAGTTCCACC CAGACACAGA CGATGTACCT GTCCCAGCTC CAGCCGGTGA CCAGAAGGAG 
GTGGACACTT CAGAAAAGAA ACTTCTCGAG CGGCTCCCTG AGGTTGAGGT GCCCCAGCAT 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Chaperone-like Activity of Calnuc Prevents Amyloid Aggregation.
Biochemistry56(1)149-159(2017 Jan)
Kanuru M,Aradhyam GK

Calnuc Function in Endosomal Sorting of Lysosomal Receptors.
Traffic (Copenhagen, Denmark)17(4)416-32(2016 Apr)
Larkin H,Costantino S,Seaman MN,Lavoie C

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

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NUCB1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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