MSMB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MSMB
Entrez Gene ID	4477
Full Name	microseminoprotein beta
Synonyms	HPC13,IGBF,MSP,MSPB,PN44,PRPS,PSP,PSP-94,PSP57,PSP94
General protein information	Preferred Names microseminoprotein beta Names beta-microseminoprotein immunoglobulin binding factor prostate secreted seminal plasma protein prostate secretory protein of 94 amino acids seminal plasma beta-inhibin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q11.22
Summary	The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:	157145
Disorder Html:	{Prostate cancer, hereditary, 13}, 611928 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002443.3	NP_002434.1	beta-microseminoprotein isoform a precursor
NM_138634.2	NP_619540.1	beta-microseminoprotein isoform b precursor
NM_002443.4	NP_002434.1	beta-microseminoprotein isoform a precursor

Pathways from BioSystems

Homologies

	MSMB	NP_001040596.1
Mus musculus (house mouse)	Msmb	NP_065622.1
Rattus norvegicus (Norway rat)	Msmb	NP_062061.1
Homo sapiens (human)	MSMB	NP_002434.1
Pan troglodytes (chimpanzee)	MSMB	XP_003312607.1

Gene Ontology
Bibliography

Related articles in PubMed

Prostate tumors downregulate microseminoprotein-beta (MSMB) in the surrounding benign prostate epithelium and this response is associated with tumor aggressiveness.
Bergstr?m SH, J?remo H, Nilsson M, Adamo HH, Bergh A
The Prostate78(4)257-265(2018 Mar)

Structural and molecular biology of PSP94: Its significance in prostate pathophysiology.
Anklesaria JH, Mhatre DR, Mahale SD
Frontiers in bioscience (Landmark edition)23535-562(2018 Jan)

MSMB gene rs10993994 polymorphism increases the risk of prostate cancer.
Peng T, Zhang L, Zhu L, Mi YY
Oncotarget8(17)28494-28501(2017 Apr)

Prognostic significance of surfactant protein A, surfactant protein D, Clara cell protein 16, S100 protein, trefoil factor 3, and prostatic secretory protein 94 in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease.
Doubkov? M, Karp??ek M, Mazoch J, Sk?i?kov? J, Doubek M
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG33(3)224-234(2016 Oct)

Identification of CRISP2 from human sperm as PSP94-binding protein and generation of CRISP2-specific anti-peptide antibodies.
Anklesaria JH, Kulkarni BJ, Pathak BR, Mahale SD
Journal of peptide science : an official publication of the European Peptide Society22(6)383-90(2016 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PSP94 levels differed among idiopathic pulmonary fibrosis, pulmonary sarcoidosis and chronic pulmonary obstructive disease.
Title: Prognostic significance of surfactant protein A, surfactant protein D, Clara cell protein 16, S100 protein, trefoil factor 3, and prostatic secretory protein 94 in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease.

Results identified CRISP2 as a potential binding protein of PSP94 from human sperm.
Title: Identification of CRISP2 from human sperm as PSP94-binding protein and generation of CRISP2-specific anti-peptide antibodies.

decreased expression of MSMB parallels the clinical progression of PC and adjusted serum MSMB levels are associated with PC risk
Title: Microseminoprotein-Beta Expression in Different Stages of Prostate Cancer.

Based on nasopharyngeal MSP gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants.
Title: Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection.

PSP94 regulate the Lin28/Let-7 loop in ovarian cancer cells.
Title: PSP94, an upstream signaling mediator of prostasin found highly elevated in ovarian cancer.

The following MSMB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MSMB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18600	NM_002443.4 Latest version!	Homo sapiens microseminoprotein beta (MSMB), transcript variant PSP94, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu26795	NM_138634.2 Latest version!	Homo sapiens microseminoprotein beta (MSMB), transcript variant PSP57, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18600	NM_002443.3	Homo sapiens microseminoprotein beta (MSMB), transcript variant PSP94, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MSMB ( NM_002443.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002434.1 Homo sapiens microseminoprotein beta (MSMB), transcript variant PSP94, mRNA.

Price & Availability↑

CloneID	OHu18600
Clone ID Related Accession (Same CDS sequence)	NM_002443.3 , NM_002443.4
Accession Version	NM_002443.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	beta-microseminoprotein isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005257.1 and BM856408.1. This sequence is a reference standard in the RefSeqGene project. On Mar 11, 2011 this sequence version replaced NM_002443.2. Transcript Variant: This variant (PSP94) encodes the full length isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA874002.1, BF675692.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2153427 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATGTTC TCCTGGGCAG CGTTGTGATC TTTGCCACCT TCGTGACTTT ATGCAATGCA 
TCATGCTATT TCATACCTAA TGAGGGAGTT CCAGGAGATT CAACCAGGAA ATGCATGGAT 
CTCAAAGGAA ACAAACACCC AATAAACTCG GAGTGGCAGA CTGACAACTG TGAGACATGC 
ACTTGCTACG AAACAGAAAT TTCATGTTGC ACCCTTGTTT CTACACCTGT GGGTTATGAC 
AAAGACAACT GCCAAAGAAT CTTCAAGAAG GAGGACTGCA AGTATATCGT GGTGGAGAAG 
AAGGACCCAA AAAAGACCTG TTCTGTCAGT GAATGGATAA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002434.1
CDS	33..377
Translation	MNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVSTPVGYDKDNCQRIFKKEDCKYIVVEKKDPKKTCSVSEWII

Target ORF information:

RefSeq Version	NM_002443.3
Organism	Homo sapiens(human)
Definition	Homo sapiens microseminoprotein beta (MSMB), transcript variant PSP94, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002443.3

ORF Insert Sequence:

ATGAATGTTC TCCTGGGCAG CGTTGTGATC TTTGCCACCT TCGTGACTTT ATGCAATGCA 
TCATGCTATT TCATACCTAA TGAGGGAGTT CCAGGAGATT CAACCAGGAA ATGCATGGAT 
CTCAAAGGAA ACAAACACCC AATAAACTCG GAGTGGCAGA CTGACAACTG TGAGACATGC 
ACTTGCTACG AAACAGAAAT TTCATGTTGC ACCCTTGTTT CTACACCTGT GGGTTATGAC 
AAAGACAACT GCCAAAGAAT CTTCAAGAAG GAGGACTGCA AGTATATCGT GGTGGAGAAG 
AAGGACCCAA AAAAGACCTG TTCTGTCAGT GAATGGATAA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MSMB ( NM_002443.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002434.1 Homo sapiens microseminoprotein beta (MSMB), transcript variant PSP94, mRNA.

Price & Availability↑

CloneID	OHu18600
Clone ID Related Accession (Same CDS sequence)	NM_002443.3 , NM_002443.4
Accession Version	NM_002443.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	beta-microseminoprotein isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC005257.1 and BM856408.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_002443.3. Transcript Variant: This variant (PSP94) encodes the full length isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF964983.1, BF965280.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2153427 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000582163.3/ ENSP00000463092.1 RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAATGTTC TCCTGGGCAG CGTTGTGATC TTTGCCACCT TCGTGACTTT ATGCAATGCA 
TCATGCTATT TCATACCTAA TGAGGGAGTT CCAGGAGATT CAACCAGGAA ATGCATGGAT 
CTCAAAGGAA ACAAACACCC AATAAACTCG GAGTGGCAGA CTGACAACTG TGAGACATGC 
ACTTGCTACG AAACAGAAAT TTCATGTTGC ACCCTTGTTT CTACACCTGT GGGTTATGAC 
AAAGACAACT GCCAAAGAAT CTTCAAGAAG GAGGACTGCA AGTATATCGT GGTGGAGAAG 
AAGGACCCAA AAAAGACCTG TTCTGTCAGT GAATGGATAA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002434.1
CDS	33..377
Translation	MNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRKCMDLKGNKHPINSEWQTDNCETCTCYETEISCCTLVSTPVGYDKDNCQRIFKKEDCKYIVVEKKDPKKTCSVSEWII

Target ORF information:

RefSeq Version	NM_002443.4
Organism	Homo sapiens(human)
Definition	Homo sapiens microseminoprotein beta (MSMB), transcript variant PSP94, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002443.4

ORF Insert Sequence:

ATGAATGTTC TCCTGGGCAG CGTTGTGATC TTTGCCACCT TCGTGACTTT ATGCAATGCA 
TCATGCTATT TCATACCTAA TGAGGGAGTT CCAGGAGATT CAACCAGGAA ATGCATGGAT 
CTCAAAGGAA ACAAACACCC AATAAACTCG GAGTGGCAGA CTGACAACTG TGAGACATGC 
ACTTGCTACG AAACAGAAAT TTCATGTTGC ACCCTTGTTT CTACACCTGT GGGTTATGAC 
AAAGACAACT GCCAAAGAAT CTTCAAGAAG GAGGACTGCA AGTATATCGT GGTGGAGAAG 
AAGGACCCAA AAAAGACCTG TTCTGTCAGT GAATGGATAA TCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MSMB ( NM_138634.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_619540.1 Homo sapiens microseminoprotein beta (MSMB), transcript variant PSP57, mRNA.

Price & Availability↑

CloneID	OHu26795
Clone ID Related Accession (Same CDS sequence)	NM_138634.2
Accession Version	NM_138634.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 234bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-21
Organism	Homo sapiens(human)
Product	beta-microseminoprotein isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF680662.1 and BM856408.1. On Mar 11, 2011 this sequence version replaced NM_138634.1. Transcript Variant: This variant (PSP57) lacks an alternate coding exon compared to variant PSP94, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM855253.1, BF680662.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153427, SAMEA2159368 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATGTTC TCCTGGGCAG CGTTGTGATC TTTGCCACCT TCGTGACTTT ATGCAATGCA 
TCATGCTATT TCATACCTAA TGAGGGAGTT CCAGGAGATT CAACCAGGAT GTTTCTACAC 
CTGTGGGTTA TGACAAAGAC AACTGCCAAA GAATCTTCAA GAAGGAGGAC TGCAAGTATA 
TCGTGGTGGA GAAGAAGGAC CCAAAAAAGA CCTGTTCTGT CAGTGAATGG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_619540.1
CDS	33..266
Translation	MNVLLGSVVIFATFVTLCNASCYFIPNEGVPGDSTRMFLHLWVMTKTTAKESSRRRTASISWWRRRTQKRPVLSVNG

Target ORF information:

RefSeq Version	NM_138634.2
Organism	Homo sapiens(human)
Definition	Homo sapiens microseminoprotein beta (MSMB), transcript variant PSP57, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_138634.2

ORF Insert Sequence:

ATGAATGTTC TCCTGGGCAG CGTTGTGATC TTTGCCACCT TCGTGACTTT ATGCAATGCA 
TCATGCTATT TCATACCTAA TGAGGGAGTT CCAGGAGATT CAACCAGGAT GTTTCTACAC 
CTGTGGGTTA TGACAAAGAC AACTGCCAAA GAATCTTCAA GAAGGAGGAC TGCAAGTATA 
TCGTGGTGGA GAAGAAGGAC CCAAAAAAGA CCTGTTCTGT CAGTGAATGG ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prostate tumors downregulate microseminoprotein-beta (MSMB) in the surrounding benign prostate epithelium and this response is associated with tumor aggressiveness.
The Prostate78(4)257-265(2018 Mar)
Bergstr?m SH,J?remo H,Nilsson M,Adamo HH,Bergh A

Structural and molecular biology of PSP94: Its significance in prostate pathophysiology.
Frontiers in bioscience (Landmark edition)23535-562(2018 Jan)
Anklesaria JH,Mhatre DR,Mahale SD

MSMB gene rs10993994 polymorphism increases the risk of prostate cancer.
Oncotarget8(17)28494-28501(2017 Apr)
Peng T,Zhang L,Zhu L,Mi YY

Prognostic significance of surfactant protein A, surfactant protein D, Clara cell protein 16, S100 protein, trefoil factor 3, and prostatic secretory protein 94 in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG33(3)224-234(2016 Oct)
Doubkov? M,Karp??ek M,Mazoch J,Sk?i?kov? J,Doubek M

Identification of CRISP2 from human sperm as PSP94-binding protein and generation of CRISP2-specific anti-peptide antibodies.
Journal of peptide science : an official publication of the European Peptide Society22(6)383-90(2016 Jun)
Anklesaria JH,Kulkarni BJ,Pathak BR,Mahale SD

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MSMB cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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