MOS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MOS
Entrez Gene ID	4342
Full Name	MOS proto-oncogene, serine/threonine kinase
Synonyms	MSV
General protein information	Preferred Names MOS proto-oncogene, serine/threonine kinase Names proto-oncogene serine/threonine-protein kinase mos c-mos oncogene MOS, Moloney murine sarcoma virus oocyte maturation factor mos proto-oncogene c-Mos v-mos Moloney murine sarcoma viral oncogene homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q12.1
Summary	MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009].
Disorder MIM:	190060

mRNA and Protein(s)

mRNA	Protein	Name
NM_005372.1	NP_005363.1	proto-oncogene serine/threonine-protein kinase mos

Pathways from BioSystems

Homologies

Bos taurus (cattle)	MOS	XP_002692700.1
Mus musculus (house mouse)	Mos	NP_064405.2
Rattus norvegicus (Norway rat)	Mos	NP_064487.3
Xenopus tropicalis (tropical clawed frog)	LOC100489962	XP_004915249.1
Homo sapiens (human)	MOS	NP_005363.1
	MOS	XP_001087400.2
Canis lupus familiaris (dog)	MOS	XP_544088.4
Gallus gallus (chicken)	MOS	NP_001026687.1
Pan troglodytes (chimpanzee)	MOS	XP_528144.2
Danio rerio (zebrafish)	mos	NP_991143.1

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Genetic modifiers of EGFR dependence in non-small cell lung cancer.
Sharifnia T, Rusu V, Piccioni F, Bagul M, Imielinski M, Cherniack AD, Pedamallu CS, Wong B, Wilson FH, Garraway LA, Altshuler D, Golub TR, Root DE, Subramanian A, Meyerson M
Proceedings of the National Academy of Sciences of the United States of America111(52)18661-6(2014 Dec)

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Taipale M, Tucker G, Peng J, Krykbaeva I, Lin ZY, Larsen B, Choi H, Berger B, Gingras AC, Lindquist S
Cell158(2)434-448(2014 Jul)

Changes in aberrant DNA methylation after Helicobacter pylori eradication: a long-term follow-up study.
Shin CM, Kim N, Lee HS, Park JH, Ahn S, Kang GH, Kim JM, Kim JS, Lee DH, Jung HC
International journal of cancer133(9)2034-42(2013 Nov)

Prediction of the risk for gastric cancer using candidate methylation markers in the non-neoplastic gastric mucosae.
Shin CM, Kim N, Park JH, Kang GH, Kim JS, Jung HC, Song IS
The Journal of pathology226(4)654-65(2012 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

approach identified 18 kinase and kinase-related genes whose overexpression can substitute for EGFR in EGFR-dependent PC9 cells, and these genes include seven of nine Src family kinase genes, FGFR1, FGFR2, ITK, NTRK1, NTRK2, MOS, MST1R, and RAF1.
Title: Genetic modifiers of EGFR dependence in non-small cell lung cancer.

High methylation level in MOS is associated with intestinal metaplasia.
Title: Changes in aberrant DNA methylation after Helicobacter pylori eradication: a long-term follow-up study.

among the candidate genes, DNA methylation of MOS may reflect the duration of H. pylori exposure and may be a marker for the development of gastric cancer.
Title: Prediction of the risk for gastric cancer using candidate methylation markers in the non-neoplastic gastric mucosae.

Observational study of gene-disease association. (HuGE Navigator)
Title: The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.

In the absence of p53, Mos knockdown prevents multipolar mitoses and exerts genome-stabilizing effects.
Title: Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos.

The following MOS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MOS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu29810	NM_005372.1 Latest version!	Homo sapiens MOS proto-oncogene, serine/threonine kinase (MOS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MOS ( NM_005372.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_005363.1 Homo sapiens MOS proto-oncogene, serine/threonine kinase (MOS), mRNA.

Price & Availability↑

CloneID	OHu29810
Clone ID Related Accession (Same CDS sequence)	NM_005372.1
Accession Version	NM_005372.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	proto-oncogene serine/threonine-protein kinase mos
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC107376.7. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC106737.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000311923.1/ ENSP00000310722.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCCCTCGC CCCTGGCCCT ACGCCCCTAC CTCCGGAGCG AGTTTTCCCC ATCGGTGGAC 
GCGCGGCCCT GCAGCAGTCC CTCAGAGCTA CCTGCGAAGC TGCTTCTGGG GGCCACTCTT 
CCTCGGGCCC CGCGGCTGCC GCGCCGGCTG GCCTGGTGCT CCATTGACTG GGAGCAGGTG 
TGCTTGCTGC AGAGGCTGGG AGCTGGAGGG TTTGGCTCGG TGTACAAGGC GACTTACCGC 
GGTGTTCCTG TGGCCATAAA GCAAGTGAAC AAGTGCACCA AGAACCGACT AGCATCTCGG 
CGGAGTTTCT GGGCTGAGCT CAACGTAGCA AGGCTGCGCC ACGATAACAT CGTGCGCGTG 
GTGGCTGCCA GCACGCGCAC GCCCGCAGGG TCCAATAGCC TAGGGACCAT CATCATGGAG 
TTCGGTGGCA ACGTCACTTT ACACCAAGTC ATCTATGGCG CCGCCGGCCA CCCTGAGGGG 
GACGCAGGGG AGCCTCACTG CCGCACTGGA GGACAGTTAA GTTTGGGAAA GTGTCTCAAG 
TACTCACTAG ATGTTGTGAA CGGCCTGCTC TTCCTCCACT CGCAAAGCAT TGTGCACTTG 
GACCTGAAGC CCGCGAACAT CTTGATCAGT GAGCAGGATG TCTGTAAAAT TAGTGACTTC 
GGTTGCTCTG AGAAGTTGGA AGATCTGCTG TGCTTCCAGA CACCCTCTTA CCCTCTAGGA 
GGCACATACA CCCACCGCGC CCCGGAGCTC CTGAAAGGAG AGGGCGTGAC GCCTAAAGCC 
GACATTTATT CCTTTGCCAT CACTCTCTGG CAAATGACTA CCAAGCAGGC GCCGTATTCG 
GGGGAGCGGC AGCACATACT GTACGCGGTG GTGGCCTACG ACCTGCGCCC GTCCCTCTCC 
GCTGCCGTCT TCGAGGACTC GCTCCCCGGG CAGCGCCTTG GGGACGTCAT CCAGCGCTGC 
TGGAGACCCA GCGCGGCGCA GAGGCCGAGC GCGCGGCTGC TTTTGGTGGA TCTCACCTCT 
TTGAAAGCTG AACTCGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005363.1
CDS	1..1041
Translation	MPSPLALRPYLRSEFSPSVDARPCSSPSELPAKLLLGATLPRAPRLPRRLAWCSIDWEQVCLLQRLGAGGFGSVYKATYRGVPVAIKQVNKCTKNRLASRRSFWAELNVARLRHDNIVRVVAASTRTPAGSNSLGTIIMEFGGNVTLHQVIYGAAGHPEGDAGEPHCRTGGQLSLGKCLKYSLDVVNGLLFLHSQSIVHLDLKPANILISEQDVCKISDFGCSEKLEDLLCFQTPSYPLGGTYTHRAPELLKGEGVTPKADIYSFAITLWQMTTKQAPYSGERQHILYAVVAYDLRPSLSAAVFEDSLPGQRLGDVIQRCWRPSAAQRPSARLLLVDLTSLKAELG

Target ORF information:

RefSeq Version	NM_005372.1
Organism	Homo sapiens(human)
Definition	Homo sapiens MOS proto-oncogene, serine/threonine kinase (MOS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005372.1

ORF Insert Sequence:

ATGCCCTCGC CCCTGGCCCT ACGCCCCTAC CTCCGGAGCG AGTTTTCCCC ATCGGTGGAC 
GCGCGGCCCT GCAGCAGTCC CTCAGAGCTA CCTGCGAAGC TGCTTCTGGG GGCCACTCTT 
CCTCGGGCCC CGCGGCTGCC GCGCCGGCTG GCCTGGTGCT CCATTGACTG GGAGCAGGTG 
TGCTTGCTGC AGAGGCTGGG AGCTGGAGGG TTTGGCTCGG TGTACAAGGC GACTTACCGC 
GGTGTTCCTG TGGCCATAAA GCAAGTGAAC AAGTGCACCA AGAACCGACT AGCATCTCGG 
CGGAGTTTCT GGGCTGAGCT CAACGTAGCA AGGCTGCGCC ACGATAACAT CGTGCGCGTG 
GTGGCTGCCA GCACGCGCAC GCCCGCAGGG TCCAATAGCC TAGGGACCAT CATCATGGAG 
TTCGGTGGCA ACGTCACTTT ACACCAAGTC ATCTATGGCG CCGCCGGCCA CCCTGAGGGG 
GACGCAGGGG AGCCTCACTG CCGCACTGGA GGACAGTTAA GTTTGGGAAA GTGTCTCAAG 
TACTCACTAG ATGTTGTGAA CGGCCTGCTC TTCCTCCACT CGCAAAGCAT TGTGCACTTG 
GACCTGAAGC CCGCGAACAT CTTGATCAGT GAGCAGGATG TCTGTAAAAT TAGTGACTTC 
GGTTGCTCTG AGAAGTTGGA AGATCTGCTG TGCTTCCAGA CACCCTCTTA CCCTCTAGGA 
GGCACATACA CCCACCGCGC CCCGGAGCTC CTGAAAGGAG AGGGCGTGAC GCCTAAAGCC 
GACATTTATT CCTTTGCCAT CACTCTCTGG CAAATGACTA CCAAGCAGGC GCCGTATTCG 
GGGGAGCGGC AGCACATACT GTACGCGGTG GTGGCCTACG ACCTGCGCCC GTCCCTCTCC 
GCTGCCGTCT TCGAGGACTC GCTCCCCGGG CAGCGCCTTG GGGACGTCAT CCAGCGCTGC 
TGGAGACCCA GCGCGGCGCA GAGGCCGAGC GCGCGGCTGC TTTTGGTGGA TCTCACCTCT 
TTGAAAGCTG AACTCGGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Genetic modifiers of EGFR dependence in non-small cell lung cancer.
Proceedings of the National Academy of Sciences of the United States of America111(52)18661-6(2014 Dec)
Sharifnia T,Rusu V,Piccioni F,Bagul M,Imielinski M,Cherniack AD,Pedamallu CS,Wong B,Wilson FH,Garraway LA,Altshuler D,Golub TR,Root DE,Subramanian A,Meyerson M

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Cell158(2)434-448(2014 Jul)
Taipale M,Tucker G,Peng J,Krykbaeva I,Lin ZY,Larsen B,Choi H,Berger B,Gingras AC,Lindquist S

Changes in aberrant DNA methylation after Helicobacter pylori eradication: a long-term follow-up study.
International journal of cancer133(9)2034-42(2013 Nov)
Shin CM,Kim N,Lee HS,Park JH,Ahn S,Kang GH,Kim JM,Kim JS,Lee DH,Jung HC

Prediction of the risk for gastric cancer using candidate methylation markers in the non-neoplastic gastric mucosae.
The Journal of pathology226(4)654-65(2012 Mar)
Shin CM,Kim N,Park JH,Kang GH,Kim JS,Jung HC,Song IS