UFSP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	UFSP1
Entrez Gene ID	402682
Full Name	UFM1 specific peptidase 1 (inactive)
Synonyms	UFSP
General protein information	Preferred Names UFM1 specific peptidase 1 (inactive) Names inactive Ufm1-specific protease 1 UFM1-specific peptidase 1 (non-functional)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q22.1
Summary	This gene encodes a protein that is similar to other Ufm1-specific proteases. Studies in mouse determined that Ufsp1 releases Ufm1 (ubiquitin-fold modifier 1) from its bound conjugated complexes which also makes it into an active form. Because the human UFSP1 protein is shorter on the N-terminus and lacks a conserved Cys active site, it is predicted to be non-functional.[provided by RefSeq, Nov 2009]. COMPLETENESS: complete on the 3' end.
Disorder MIM:	611481

mRNA and Protein(s)

mRNA	Protein	Name
NM_001015072.4	NP_001015072.2	inactive Ufm1-specific protease 1
NM_001015072.3	NP_001015072.2	inactive Ufm1-specific protease 1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	UFSP1	XP_005621081.1
Pan troglodytes (chimpanzee)	UFSP1	XP_001152833.1
Homo sapiens (human)	UFSP1	NP_001015072.2
	UFSP1	XP_001106761.1
Bos taurus (cattle)	UFSP1	XP_002698248.1
Mus musculus (house mouse)	Ufsp1	NP_081632.1
Rattus norvegicus (Norway rat)	LOC102550903	XP_006249260.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
Huang J, Sabater-Lleal M, Asselbergs FW, Tregouet D, Shin SY, Ding J, Baumert J, Oudot-Mellakh T, Folkersen L, Johnson AD, Smith NL, Williams SM, Ikram MA, Kleber ME, Becker DM, Truong V, Mychaleckyj JC, Tang W, Yang Q, Sennblad B, Moore JH, Williams FM, Dehghan A, Silbernagel G, Schrijvers EM, Smith S, Karakas M, Tofler GH, Silveira A, Navis GJ, Lohman K, Chen MH, Peters A, Goel A, Hopewell JC, Chambers JC, Saleheen D, Lundmark P, Psaty BM, Strawbridge RJ, Boehm BO, Carter AM, Meisinger C, Peden JF, Bis JC, McKnight B, ?hrvik J, Taylor K, Franzosi MG, Seedorf U, Collins R, Franco-Cereceda A, Syv?nen AC, Goodall AH, Yanek LR, Cushman M, M?ller-Nurasyid M, Folsom AR, Basu S, Matijevic N, van Gilst WH, Kooner JS, Hofman A, Danesh J, Clarke R, Meigs JB, , Kathiresan S, Reilly MP, , Klopp N, Harris TB, Winkelmann BR, Grant PJ, Hillege HL, Watkins H, , Spector TD, Becker LC, Tracy RP, M?rz W, Uitterlinden AG, Eriksson P, Cambien F, , Morange PE, Koenig W, Soranzo N, van der Harst P, Liu Y, O'Donnell CJ, Hamsten A
Blood120(24)4873-81(2012 Dec)

Genome-wide association analysis identifies multiple loci related to resting heart rate.
Eijgelsheim M, Newton-Cheh C, Sotoodehnia N, de Bakker PI, M?ller M, Morrison AC, Smith AV, Isaacs A, Sanna S, D?rr M, Navarro P, Fuchsberger C, Nolte IM, de Geus EJ, Estrada K, Hwang SJ, Bis JC, R?ckert IM, Alonso A, Launer LJ, Hottenga JJ, Rivadeneira F, Noseworthy PA, Rice KM, Perz S, Arking DE, Spector TD, Kors JA, Aulchenko YS, Tarasov KV, Homuth G, Wild SH, Marroni F, Gieger C, Licht CM, Prineas RJ, Hofman A, Rotter JI, Hicks AA, Ernst F, Najjar SS, Wright AF, Peters A, Fox ER, Oostra BA, Kroemer HK, Couper D, V?lzke H, Campbell H, Meitinger T, Uda M, Witteman JC, Psaty BM, Wichmann HE, Harris TB, K??b S, Siscovick DS, Jamshidi Y, Uitterlinden AG, Folsom AR, Larson MG, Wilson JF, Penninx BW, Snieder H, Pramstaller PP, van Duijn CM, Lakatta EG, Felix SB, Gudnason V, Pfeufer A, Heckbert SR, Stricker BH, Boerwinkle E, O'Donnell CJ
Human molecular genetics19(19)3885-94(2010 Oct)

Structural basis for Ufm1 processing by UfSP1.
Ha BH, Ahn HC, Kang SH, Tanaka K, Chung CH, Kim EE
The Journal of biological chemistry283(21)14893-900(2008 May)

Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2.
Kang SH, Kim GR, Seong M, Baek SH, Seol JH, Bang OS, Ovaa H, Tatsumi K, Komatsu M, Tanaka K, Chung CH
The Journal of biological chemistry282(8)5256-62(2007 Feb)

Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.
Wilson MD, Riemer C, Martindale DW, Schnupf P, Boright AP, Cheung TL, Hardy DM, Schwartz S, Scherer SW, Tsui LC, Miller W, Koop BF
Nucleic acids research29(6)1352-65(2001 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association analysis identifies multiple loci related to resting heart rate.

The following UFSP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UFSP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31222	NM_001015072.4 Latest version!	Homo sapiens UFM1 specific peptidase 1 (inactive) (UFSP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu31222	NM_001015072.3	Homo sapiens UFM1 specific peptidase 1 (inactive) (UFSP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

UFSP1 ( NM_001015072.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001015072.2 Homo sapiens UFM1 specific peptidase 1 (inactive) (UFSP1), mRNA.

Price & Availability↑

CloneID	OHu31222
Clone ID Related Accession (Same CDS sequence)	NM_001015072.4 , NM_001015072.3
Accession Version	NM_001015072.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	inactive Ufm1-specific protease 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB073745.1, BC067904.1, BC017456.2 and AC011895.4. On Nov 22, 2018 this sequence version replaced NM_001015072.3. ##Evidence-Data-START## Transcript is intronless :: SRR1163657.100801.1, SRR7346977.102642.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000388761.4/ ENSP00000373413.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCGACA AGCCCCCCGG CTTCCGGGGC TCCCGGGACT GGATCGGCTG CGTGGAGGCC 
AGCCTCTGCC TCGCTCACTT CGGAGGGCCC CAGGGACGCC TCTGCCACGT ACCCCGGGGA 
GTGGGGCTGC ACGGGGAGCT GGAGAGGCTT TACTCGCACT TCGCAGGGGG TGGGGGCCCA 
GTCATGGTTG GGGGGGACGC AGATGCCAGG TCCAAGGCCT TGCTGGGAGT CTGCGTAGGG 
TCAGGCACGG AAGCCTATGT CCTGGTATTG GACCCTCACT ACTGGGGCAC TCCAAAAAGC 
CCCAGTGAAC TACAGGCTGC TGGGTGGGTG GGCTGGCAAG AGGTGAGTGC AGCCTTTGAC 
CCCAACTCCT TCTACAACCT GTGCTTGACC AGCCTTAGCT CCCAACAGCA GCAGCGCACC 
TTGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001015072.2
CDS	445..873
Translation	MGDKPPGFRGSRDWIGCVEASLCLAHFGGPQGRLCHVPRGVGLHGELERLYSHFAGGGGPVMVGGDADARSKALLGVCVGSGTEAYVLVLDPHYWGTPKSPSELQAAGWVGWQEVSAAFDPNSFYNLCLTSLSSQQQQRTLD

Target ORF information:

RefSeq Version	NM_001015072.4
Organism	Homo sapiens(human)
Definition	Homo sapiens UFM1 specific peptidase 1 (inactive) (UFSP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001015072.4

ORF Insert Sequence:

ATGGGCGACA AGCCCCCCGG CTTCCGGGGC TCCCGGGACT GGATCGGCTG CGTGGAGGCC 
AGCCTCTGCC TCGCTCACTT CGGAGGGCCC CAGGGACGCC TCTGCCACGT ACCCCGGGGA 
GTGGGGCTGC ACGGGGAGCT GGAGAGGCTT TACTCGCACT TCGCAGGGGG TGGGGGCCCA 
GTCATGGTTG GGGGGGACGC AGATGCCAGG TCCAAGGCCT TGCTGGGAGT CTGCGTAGGG 
TCAGGCACGG AAGCCTATGT CCTGGTATTG GACCCTCACT ACTGGGGCAC TCCAAAAAGC 
CCCAGTGAAC TACAGGCTGC TGGGTGGGTG GGCTGGCAAG AGGTGAGTGC AGCCTTTGAC 
CCCAACTCCT TCTACAACCT GTGCTTGACC AGCCTTAGCT CCCAACAGCA GCAGCGCACC 
TTGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

UFSP1 ( NM_001015072.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001015072.2 Homo sapiens UFM1 specific peptidase 1 (inactive) (UFSP1), mRNA.

Price & Availability↑

CloneID	OHu31222
Clone ID Related Accession (Same CDS sequence)	NM_001015072.4 , NM_001015072.3
Accession Version	NM_001015072.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	inactive Ufm1-specific protease 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB073745.1, BC067904.1 and BC017456.2. On May 4, 2007 this sequence version replaced NM_001015072.2. COMPLETENESS: complete on the 3' end.

ATGGGCGACA AGCCCCCCGG CTTCCGGGGC TCCCGGGACT GGATCGGCTG CGTGGAGGCC 
AGCCTCTGCC TCGCTCACTT CGGAGGGCCC CAGGGACGCC TCTGCCACGT ACCCCGGGGA 
GTGGGGCTGC ACGGGGAGCT GGAGAGGCTT TACTCGCACT TCGCAGGGGG TGGGGGCCCA 
GTCATGGTTG GGGGGGACGC AGATGCCAGG TCCAAGGCCT TGCTGGGAGT CTGCGTAGGG 
TCAGGCACGG AAGCCTATGT CCTGGTATTG GACCCTCACT ACTGGGGCAC TCCAAAAAGC 
CCCAGTGAAC TACAGGCTGC TGGGTGGGTG GGCTGGCAAG AGGTGAGTGC AGCCTTTGAC 
CCCAACTCCT TCTACAACCT GTGCTTGACC AGCCTTAGCT CCCAACAGCA GCAGCGCACC 
TTGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001015072.2
CDS	448..876
Translation	MGDKPPGFRGSRDWIGCVEASLCLAHFGGPQGRLCHVPRGVGLHGELERLYSHFAGGGGPVMVGGDADARSKALLGVCVGSGTEAYVLVLDPHYWGTPKSPSELQAAGWVGWQEVSAAFDPNSFYNLCLTSLSSQQQQRTLD

Target ORF information:

RefSeq Version	NM_001015072.3
Organism	Homo sapiens(human)
Definition	Homo sapiens UFM1 specific peptidase 1 (inactive) (UFSP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001015072.3

ORF Insert Sequence:

ATGGGCGACA AGCCCCCCGG CTTCCGGGGC TCCCGGGACT GGATCGGCTG CGTGGAGGCC 
AGCCTCTGCC TCGCTCACTT CGGAGGGCCC CAGGGACGCC TCTGCCACGT ACCCCGGGGA 
GTGGGGCTGC ACGGGGAGCT GGAGAGGCTT TACTCGCACT TCGCAGGGGG TGGGGGCCCA 
GTCATGGTTG GGGGGGACGC AGATGCCAGG TCCAAGGCCT TGCTGGGAGT CTGCGTAGGG 
TCAGGCACGG AAGCCTATGT CCTGGTATTG GACCCTCACT ACTGGGGCAC TCCAAAAAGC 
CCCAGTGAAC TACAGGCTGC TGGGTGGGTG GGCTGGCAAG AGGTGAGTGC AGCCTTTGAC 
CCCAACTCCT TCTACAACCT GTGCTTGACC AGCCTTAGCT CCCAACAGCA GCAGCGCACC 
TTGGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
Blood120(24)4873-81(2012 Dec)
Huang J,Sabater-Lleal M,Asselbergs FW,Tregouet D,Shin SY,Ding J,Baumert J,Oudot-Mellakh T,Folkersen L,Johnson AD,Smith NL,Williams SM,Ikram MA,Kleber ME,Becker DM,Truong V,Mychaleckyj JC,Tang W,Yang Q,Sennblad B,Moore JH,Williams FM,Dehghan A,Silbernagel G,Schrijvers EM,Smith S,Karakas M,Tofler GH,Silveira A,Navis GJ,Lohman K,Chen MH,Peters A,Goel A,Hopewell JC,Chambers JC,Saleheen D,Lundmark P,Psaty BM,Strawbridge RJ,Boehm BO,Carter AM,Meisinger C,Peden JF,Bis JC,McKnight B,?hrvik J,Taylor K,Franzosi MG,Seedorf U,Collins R,Franco-Cereceda A,Syv?nen AC,Goodall AH,Yanek LR,Cushman M,M?ller-Nurasyid M,Folsom AR,Basu S,Matijevic N,van Gilst WH,Kooner JS,Hofman A,Danesh J,Clarke R,Meigs JB,,Kathiresan S,Reilly MP,,Klopp N,Harris TB,Winkelmann BR,Grant PJ,Hillege HL,Watkins H,,Spector TD,Becker LC,Tracy RP,M?rz W,Uitterlinden AG,Eriksson P,Cambien F,,Morange PE,Koenig W,Soranzo N,van der Harst P,Liu Y,O'Donnell CJ,Hamsten A

Genome-wide association analysis identifies multiple loci related to resting heart rate.
Human molecular genetics19(19)3885-94(2010 Oct)
Eijgelsheim M,Newton-Cheh C,Sotoodehnia N,de Bakker PI,M?ller M,Morrison AC,Smith AV,Isaacs A,Sanna S,D?rr M,Navarro P,Fuchsberger C,Nolte IM,de Geus EJ,Estrada K,Hwang SJ,Bis JC,R?ckert IM,Alonso A,Launer LJ,Hottenga JJ,Rivadeneira F,Noseworthy PA,Rice KM,Perz S,Arking DE,Spector TD,Kors JA,Aulchenko YS,Tarasov KV,Homuth G,Wild SH,Marroni F,Gieger C,Licht CM,Prineas RJ,Hofman A,Rotter JI,Hicks AA,Ernst F,Najjar SS,Wright AF,Peters A,Fox ER,Oostra BA,Kroemer HK,Couper D,V?lzke H,Campbell H,Meitinger T,Uda M,Witteman JC,Psaty BM,Wichmann HE,Harris TB,K??b S,Siscovick DS,Jamshidi Y,Uitterlinden AG,Folsom AR,Larson MG,Wilson JF,Penninx BW,Snieder H,Pramstaller PP,van Duijn CM,Lakatta EG,Felix SB,Gudnason V,Pfeufer A,Heckbert SR,Stricker BH,Boerwinkle E,O'Donnell CJ

Structural basis for Ufm1 processing by UfSP1.
The Journal of biological chemistry283(21)14893-900(2008 May)
Ha BH,Ahn HC,Kang SH,Tanaka K,Chung CH,Kim EE

Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2.
The Journal of biological chemistry282(8)5256-62(2007 Feb)
Kang SH,Kim GR,Seong M,Baek SH,Seol JH,Bang OS,Ovaa H,Tatsumi K,Komatsu M,Tanaka K,Chung CH

Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.
Nucleic acids research29(6)1352-65(2001 Mar)
Wilson MD,Riemer C,Martindale DW,Schnupf P,Boright AP,Cheung TL,Hardy DM,Schwartz S,Scherer SW,Tsui LC,Miller W,Koop BF

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UFSP1 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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