CEACAM16 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CEACAM16
Entrez Gene ID	388551
Full Name	carcinoembryonic antigen related cell adhesion molecule 16
Synonyms	CEAL2,DFNA4B
General protein information	Preferred Names carcinoembryonic antigen related cell adhesion molecule 16 Names carcinoembryonic antigen-related cell adhesion molecule 16 carcinoembryonic antigen like-2 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.31-q13.32
Summary	The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012].
Disorder MIM:	614591
Disorder Html:	Deafness, autosomal dominant 4B, 614614 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001039213.4	NP_001034302.2	carcinoembryonic antigen-related cell adhesion molecule 16 precursor
NM_001039213.3	NP_001034302.2	carcinoembryonic antigen-related cell adhesion molecule 16 precursor
XM_017026795.1	XP_016882284.1	carcinoembryonic antigen-related cell adhesion molecule 16 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	CEACAM16	NP_001034302.2
Canis lupus familiaris (dog)	CEACAM16	XP_541572.2
Pan troglodytes (chimpanzee)	CEACAM16	XP_003316491.1
Bos taurus (cattle)	CEACAM16	XP_003587343.2
Mus musculus (house mouse)	Ceacam16	NP_001028591.2
Rattus norvegicus (Norway rat)	Ceacam16	NP_001163050.1

Gene Ontology
Bibliography

Related articles in PubMed

Cell motility and spreading promoted by CEACAM6 through cyclin D1/CDK4 in human pancreatic carcinoma.
Yan L, Wang Y, Wang ZZ, Rong YT, Chen LL, Li Q, Liu T, Chen YH, Li YD, Huang ZH, Peng J
Oncology reports35(1)418-26(2016 Jan)

Exome sequencing identifies a novel CEACAM16 mutation associated with autosomal dominant nonsyndromic hearing loss DFNA4B in a Chinese family.
Wang H, Wang X, He C, Li H, Qing J, Grati M, Hu Z, Li J, Hu Y, Xia K, Mei L, Wang X, Yu J, Chen H, Jiang L, Liu Y, Men M, Zhang H, Guan L, Xiao J, Zhang J, Liu X, Feng Y
Journal of human genetics60(3)119-126(2015 Mar)

SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Morihara T, Moriaha T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Ki CS, Won HH, Na DL, Seo SW, Mook-Jung I, , St George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R
PloS one8(4)e58618(2013)

Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.
Kammerer R, R?ttiger L, Riesenberg R, Sch?uble C, Krupar R, Kamp A, Sunami K, Eisenried A, Hennenberg M, Grunert F, Bress A, Battaglia S, Schrewe H, Knipper M, Schneider MR, Zimmermann W
The Journal of biological chemistry287(26)21584-98(2012 Jun)

Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4).
Zheng J, Miller KK, Yang T, Hildebrand MS, Shearer AE, DeLuca AP, Scheetz TE, Drummond J, Scherer SE, Legan PK, Goodyear RJ, Richardson GP, Cheatham MA, Smith RJ, Dallos P
Proceedings of the National Academy of Sciences of the United States of America108(10)4218-23(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results confirm that CEACAM6 promoted cell proliferation mediated by cyclin D1/CDK4.
Title: Cell motility and spreading promoted by CEACAM6 through cyclin D1/CDK4 in human pancreatic carcinoma.

Data indicate that a heterozygous missense mutation, c.505G>A (p.G169R) in exon 3 of the CEACAM16 gene (carcinoembryonic antigen-related cell adhesion molecule 16) was identified in autosomal dominant nonsyndromic hearing loss family.
Title: Exome sequencing identifies a novel CEACAM16 mutation associated with autosomal dominant nonsyndromic hearing loss DFNA4B in a Chinese family.

CEACAM16 can probably form higher order structures with other tectorial membrane proteins such as alpha-tectorin and beta-tectorin and influences the physical properties of the tectorial membrane
Title: Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.

data identify CEACAM16 as an alpha-tectorin-interacting protein that concentrates at the point of attachment of the TM to the stereocilia and, when mutated, results in ADNSHL at the DFNA4 locus
Title: Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4).

The following CEACAM16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CEACAM16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21838	NM_001039213.4 Latest version!	Homo sapiens CEA cell adhesion molecule 16, tectorial membrane component (CEACAM16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu88459	XM_017026795.1 Latest version!	Homo sapiens CEA cell adhesion molecule 16, tectorial membrane component (CEACAM16), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu21838	NM_001039213.3	Homo sapiens carcinoembryonic antigen related cell adhesion molecule 16 (CEACAM16), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CEACAM16 ( NM_001039213.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001034302.2 Homo sapiens CEA cell adhesion molecule 16, tectorial membrane component (CEACAM16), mRNA.

Price & Availability↑

CloneID	OHu21838
Clone ID Related Accession (Same CDS sequence)	NM_001039213.4 , NM_001039213.3
Accession Version	NM_001039213.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1278bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	carcinoembryonic antigen-related cell adhesion molecule 16 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC144608.1, AC243964.3 and BF589367.1. This sequence is a reference standard in the RefSeqGene project. On Sep 21, 2018 this sequence version replaced NM_001039213.3. ##Evidence-Data-START## Transcript exon combination :: BC144608.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000587331.7/ ENSP00000466561.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END##

ATGGCGCTGA CTGGGTACAG CTGGCTGCTC CTCAGTGCCA CATTCCTGAA TGTGGGGGCC 
GAGATCTCTA TCACCCTGGA GCCTGCCCAG CCGAGCGAAG GGGACAACGT CACGCTGGTC 
GTCCATGGGC TTTCGGGGGA ACTGCTCGCC TACAGCTGGT ATGCGGGGCC CACACTCAGC 
GTGTCATACC TGGTGGCCAG CTACATCGTG AGCACAGGCG ATGAGACTCC TGGCCCGGCC 
CACACGGGGC GGGAGGCTGT GCGCCCCGAT GGCAGCCTGG ACATCCAGGG CATCCTGCCC 
CGGCACTCAG GCACCTACAT CCTGCAGACC TTCAACAGGC AGTTGCAGAC CGAGGTGGGC 
TACGGACACG TGCAGGTCCA TGAGATCCTG GCCCAGCCCA CAGTCTTGGC CAACAGCACA 
GCGCTGGTGG AACGTCGAGA CACCCTGCGC CTTATGTGCA GCAGCCCCAG CCCCACCGCC 
GAGGTCCGCT GGTTCTTCAA CGGTGGGGCC CTGCCCGTCG CTCTCCGCCT GGGCCTGTCC 
CCTGACGGCC GGGTGCTGGC CAGGCATGGC ATCCGCCGGG AGGAGGCCGG CGCCTATCAG 
TGTGAGGTGT GGAACCCGGT CAGTGTCAGC CGCAGCGAGC CCATCAACCT GACCGTGTAC 
TTTGGCCCAG AGCGTGTGGC CATCCTCCAG GATTCCACCA CCCGCACAGG CTGCACCATC 
AAAGTTGACT TCAACACGTC CCTCACCCTG TGGTGCGTGT CCAGGTCCTG CCCAGAGCCC 
GAGTATGTGT GGACCTTCAA CGGGCAGGCC CTAAAGAACG GCCAAGACCA CCTCAACATC 
AGCAGCATGA CAGCCGCCCA GGAGGGGACG TACACATGTA TTGCGAAGAA CACCAAGACC 
CTGCTATCTG GATCTGCCTC AGTCGTGGTC AAGCTCTCTG CTGCAGCAGT TGCCACGATG 
ATCGTGCCCG TGCCCACCAA GCCAACGGAG GGCCAGGACG TAACACTGAC CGTGCAGGGC 
TACCCCAAGG ACCTGCTGGT CTACGCCTGG TACCGCGGGC CTGCCTCCGA GCCCAACCGG 
CTGCTCAGCC AGCTGCCGTC AGGAACCTGG ATTGCAGGCC CCGCGCACAC AGGCCGGGAG 
GTGGGCTTCC CCAACTGCTC GCTGTTGGTG CAGAAGCTGA ACCTCACAGA CACTGGCCGC 
TACACACTCA AGACTGTCAC AGTGCAGGGC AAGACTGAGA CACTGGAAGT GGAGCTGCAG 
GTGGCCCCCC TGGGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034302.2
CDS	207..1484
Translation	MALTGYSWLLLSATFLNVGAEISITLEPAQPSEGDNVTLVVHGLSGELLAYSWYAGPTLSVSYLVASYIVSTGDETPGPAHTGREAVRPDGSLDIQGILPRHSGTYILQTFNRQLQTEVGYGHVQVHEILAQPTVLANSTALVERRDTLRLMCSSPSPTAEVRWFFNGGALPVALRLGLSPDGRVLARHGIRREEAGAYQCEVWNPVSVSRSEPINLTVYFGPERVAILQDSTTRTGCTIKVDFNTSLTLWCVSRSCPEPEYVWTFNGQALKNGQDHLNISSMTAAQEGTYTCIAKNTKTLLSGSASVVVKLSAAAVATMIVPVPTKPTEGQDVTLTVQGYPKDLLVYAWYRGPASEPNRLLSQLPSGTWIAGPAHTGREVGFPNCSLLVQKLNLTDTGRYTLKTVTVQGKTETLEVELQVAPLG

Target ORF information:

RefSeq Version	NM_001039213.4
Organism	Homo sapiens(human)
Definition	Homo sapiens CEA cell adhesion molecule 16, tectorial membrane component (CEACAM16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039213.4

ORF Insert Sequence:

ATGGCGCTGA CTGGGTACAG CTGGCTGCTC CTCAGTGCCA CATTCCTGAA TGTGGGGGCC 
GAGATCTCTA TCACCCTGGA GCCTGCCCAG CCGAGCGAAG GGGACAACGT CACGCTGGTC 
GTCCATGGGC TTTCGGGGGA ACTGCTCGCC TACAGCTGGT ATGCGGGGCC CACACTCAGC 
GTGTCATACC TGGTGGCCAG CTACATCGTG AGCACAGGCG ATGAGACTCC TGGCCCGGCC 
CACACGGGGC GGGAGGCTGT GCGCCCCGAT GGCAGCCTGG ACATCCAGGG CATCCTGCCC 
CGGCACTCAG GCACCTACAT CCTGCAGACC TTCAACAGGC AGTTGCAGAC CGAGGTGGGC 
TACGGACACG TGCAGGTCCA TGAGATCCTG GCCCAGCCCA CAGTCTTGGC CAACAGCACA 
GCGCTGGTGG AACGTCGAGA CACCCTGCGC CTTATGTGCA GCAGCCCCAG CCCCACCGCC 
GAGGTCCGCT GGTTCTTCAA CGGTGGGGCC CTGCCCGTCG CTCTCCGCCT GGGCCTGTCC 
CCTGACGGCC GGGTGCTGGC CAGGCATGGC ATCCGCCGGG AGGAGGCCGG CGCCTATCAG 
TGTGAGGTGT GGAACCCGGT CAGTGTCAGC CGCAGCGAGC CCATCAACCT GACCGTGTAC 
TTTGGCCCAG AGCGTGTGGC CATCCTCCAG GATTCCACCA CCCGCACAGG CTGCACCATC 
AAAGTTGACT TCAACACGTC CCTCACCCTG TGGTGCGTGT CCAGGTCCTG CCCAGAGCCC 
GAGTATGTGT GGACCTTCAA CGGGCAGGCC CTAAAGAACG GCCAAGACCA CCTCAACATC 
AGCAGCATGA CAGCCGCCCA GGAGGGGACG TACACATGTA TTGCGAAGAA CACCAAGACC 
CTGCTATCTG GATCTGCCTC AGTCGTGGTC AAGCTCTCTG CTGCAGCAGT TGCCACGATG 
ATCGTGCCCG TGCCCACCAA GCCAACGGAG GGCCAGGACG TAACACTGAC CGTGCAGGGC 
TACCCCAAGG ACCTGCTGGT CTACGCCTGG TACCGCGGGC CTGCCTCCGA GCCCAACCGG 
CTGCTCAGCC AGCTGCCGTC AGGAACCTGG ATTGCAGGCC CCGCGCACAC AGGCCGGGAG 
GTGGGCTTCC CCAACTGCTC GCTGTTGGTG CAGAAGCTGA ACCTCACAGA CACTGGCCGC 
TACACACTCA AGACTGTCAC AGTGCAGGGC AAGACTGAGA CACTGGAAGT GGAGCTGCAG 
GTGGCCCCCC TGGGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CEACAM16 ( NM_001039213.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001034302.2 Homo sapiens carcinoembryonic antigen related cell adhesion molecule 16 (CEACAM16), mRNA.

Price & Availability↑

CloneID	OHu21838
Clone ID Related Accession (Same CDS sequence)	NM_001039213.4 , NM_001039213.3
Accession Version	NM_001039213.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1278bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	carcinoembryonic antigen-related cell adhesion molecule 16 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC243964.3, BC144608.1 and BF589367.1. This sequence is a reference standard in the RefSeqGene project. On Jan 17, 2014 this sequence version replaced NM_001039213.2. ##Evidence-Data-START## Transcript exon combination :: BC144608.1 [ECO:0000332] ##Evidence-Data-END##

ATGGCGCTGA CTGGGTACAG CTGGCTGCTC CTCAGTGCCA CATTCCTGAA TGTGGGGGCC 
GAGATCTCTA TCACCCTGGA GCCTGCCCAG CCGAGCGAAG GGGACAACGT CACGCTGGTC 
GTCCATGGGC TTTCGGGGGA ACTGCTCGCC TACAGCTGGT ATGCGGGGCC CACACTCAGC 
GTGTCATACC TGGTGGCCAG CTACATCGTG AGCACAGGCG ATGAGACTCC TGGCCCGGCC 
CACACGGGGC GGGAGGCTGT GCGCCCCGAT GGCAGCCTGG ACATCCAGGG CATCCTGCCC 
CGGCACTCAG GCACCTACAT CCTGCAGACC TTCAACAGGC AGTTGCAGAC CGAGGTGGGC 
TACGGACACG TGCAGGTCCA TGAGATCCTG GCCCAGCCCA CAGTCTTGGC CAACAGCACA 
GCGCTGGTGG AACGTCGAGA CACCCTGCGC CTTATGTGCA GCAGCCCCAG CCCCACCGCC 
GAGGTCCGCT GGTTCTTCAA CGGTGGGGCC CTGCCCGTCG CTCTCCGCCT GGGCCTGTCC 
CCTGACGGCC GGGTGCTGGC CAGGCATGGC ATCCGCCGGG AGGAGGCCGG CGCCTATCAG 
TGTGAGGTGT GGAACCCGGT CAGTGTCAGC CGCAGCGAGC CCATCAACCT GACCGTGTAC 
TTTGGCCCAG AGCGTGTGGC CATCCTCCAG GATTCCACCA CCCGCACAGG CTGCACCATC 
AAAGTTGACT TCAACACGTC CCTCACCCTG TGGTGCGTGT CCAGGTCCTG CCCAGAGCCC 
GAGTATGTGT GGACCTTCAA CGGGCAGGCC CTAAAGAACG GCCAAGACCA CCTCAACATC 
AGCAGCATGA CAGCCGCCCA GGAGGGGACG TACACATGTA TTGCGAAGAA CACCAAGACC 
CTGCTATCTG GATCTGCCTC AGTCGTGGTC AAGCTCTCTG CTGCAGCAGT TGCCACGATG 
ATCGTGCCCG TGCCCACCAA GCCAACGGAG GGCCAGGACG TAACACTGAC CGTGCAGGGC 
TACCCCAAGG ACCTGCTGGT CTACGCCTGG TACCGCGGGC CTGCCTCCGA GCCCAACCGG 
CTGCTCAGCC AGCTGCCGTC AGGAACCTGG ATTGCAGGCC CCGCGCACAC AGGCCGGGAG 
GTGGGCTTCC CCAACTGCTC GCTGTTGGTG CAGAAGCTGA ACCTCACAGA CACTGGCCGC 
TACACACTCA AGACTGTCAC AGTGCAGGGC AAGACTGAGA CACTGGAAGT GGAGCTGCAG 
GTGGCCCCCC TGGGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001034302.2
CDS	207..1484
Translation	MALTGYSWLLLSATFLNVGAEISITLEPAQPSEGDNVTLVVHGLSGELLAYSWYAGPTLSVSYLVASYIVSTGDETPGPAHTGREAVRPDGSLDIQGILPRHSGTYILQTFNRQLQTEVGYGHVQVHEILAQPTVLANSTALVERRDTLRLMCSSPSPTAEVRWFFNGGALPVALRLGLSPDGRVLARHGIRREEAGAYQCEVWNPVSVSRSEPINLTVYFGPERVAILQDSTTRTGCTIKVDFNTSLTLWCVSRSCPEPEYVWTFNGQALKNGQDHLNISSMTAAQEGTYTCIAKNTKTLLSGSASVVVKLSAAAVATMIVPVPTKPTEGQDVTLTVQGYPKDLLVYAWYRGPASEPNRLLSQLPSGTWIAGPAHTGREVGFPNCSLLVQKLNLTDTGRYTLKTVTVQGKTETLEVELQVAPLG

Target ORF information:

RefSeq Version	NM_001039213.3
Organism	Homo sapiens(human)
Definition	Homo sapiens carcinoembryonic antigen related cell adhesion molecule 16 (CEACAM16), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001039213.3

ORF Insert Sequence:

ATGGCGCTGA CTGGGTACAG CTGGCTGCTC CTCAGTGCCA CATTCCTGAA TGTGGGGGCC 
GAGATCTCTA TCACCCTGGA GCCTGCCCAG CCGAGCGAAG GGGACAACGT CACGCTGGTC 
GTCCATGGGC TTTCGGGGGA ACTGCTCGCC TACAGCTGGT ATGCGGGGCC CACACTCAGC 
GTGTCATACC TGGTGGCCAG CTACATCGTG AGCACAGGCG ATGAGACTCC TGGCCCGGCC 
CACACGGGGC GGGAGGCTGT GCGCCCCGAT GGCAGCCTGG ACATCCAGGG CATCCTGCCC 
CGGCACTCAG GCACCTACAT CCTGCAGACC TTCAACAGGC AGTTGCAGAC CGAGGTGGGC 
TACGGACACG TGCAGGTCCA TGAGATCCTG GCCCAGCCCA CAGTCTTGGC CAACAGCACA 
GCGCTGGTGG AACGTCGAGA CACCCTGCGC CTTATGTGCA GCAGCCCCAG CCCCACCGCC 
GAGGTCCGCT GGTTCTTCAA CGGTGGGGCC CTGCCCGTCG CTCTCCGCCT GGGCCTGTCC 
CCTGACGGCC GGGTGCTGGC CAGGCATGGC ATCCGCCGGG AGGAGGCCGG CGCCTATCAG 
TGTGAGGTGT GGAACCCGGT CAGTGTCAGC CGCAGCGAGC CCATCAACCT GACCGTGTAC 
TTTGGCCCAG AGCGTGTGGC CATCCTCCAG GATTCCACCA CCCGCACAGG CTGCACCATC 
AAAGTTGACT TCAACACGTC CCTCACCCTG TGGTGCGTGT CCAGGTCCTG CCCAGAGCCC 
GAGTATGTGT GGACCTTCAA CGGGCAGGCC CTAAAGAACG GCCAAGACCA CCTCAACATC 
AGCAGCATGA CAGCCGCCCA GGAGGGGACG TACACATGTA TTGCGAAGAA CACCAAGACC 
CTGCTATCTG GATCTGCCTC AGTCGTGGTC AAGCTCTCTG CTGCAGCAGT TGCCACGATG 
ATCGTGCCCG TGCCCACCAA GCCAACGGAG GGCCAGGACG TAACACTGAC CGTGCAGGGC 
TACCCCAAGG ACCTGCTGGT CTACGCCTGG TACCGCGGGC CTGCCTCCGA GCCCAACCGG 
CTGCTCAGCC AGCTGCCGTC AGGAACCTGG ATTGCAGGCC CCGCGCACAC AGGCCGGGAG 
GTGGGCTTCC CCAACTGCTC GCTGTTGGTG CAGAAGCTGA ACCTCACAGA CACTGGCCGC 
TACACACTCA AGACTGTCAC AGTGCAGGGC AAGACTGAGA CACTGGAAGT GGAGCTGCAG 
GTGGCCCCCC TGGGGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CEACAM16 ( XM_017026795.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016882284.1 Homo sapiens CEA cell adhesion molecule 16, tectorial membrane component (CEACAM16), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu88459
Clone ID Related Accession (Same CDS sequence)	XM_017026795.1
Accession Version	XM_017026795.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1422bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	carcinoembryonic antigen-related cell adhesion molecule 16 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCTGA CTGGGTACAG CTGGCTGCTC CTCAGTGCCA CATTCCTGAA TGTGGGGGCC 
GAGATCTCTA TCACCCTGGA GCCTGCCCAG CCGAGCGAAG GGGACAACGT CACGCTGGTC 
GTCCATGGGC TTTCGGGGGA ACTGCTCGCC TACAGCTGGT ATGCGGGGCC CACACTCAGC 
GTGTCATACC TGGTGGCCAG CTACATCGTG AGCACAGGCG ATGAGACTCC TGGCCCGGCC 
CACACGGGGC GGGAGGCTGT GCGCCCCGAT GGCAGCCTGG ACATCCAGGG CATCCTGCCC 
CGGCACTCAG GCACCTACAT CCTGCAGACC TTCAACAGGC AGTTGCAGAC CGAGGTGGGC 
TACGGACACG TGCAGGTCCA TGAGATCCTG GCCCAGCCCA CAGTCTTGGC CAACAGCACA 
GCGCTGGTGG AACGTCGAGA CACCCTGCGC CTTATGTGCA GCAGCCCCAG CCCCACCGCC 
GAGGTCCGCT GGTTCTTCAA CGGTGGGGCC CTGCCCGTCG CTCTCCGCCT GGGCCTGTCC 
CCTGACGGCC GGGTGCTGGC CAGGCATGGC ATCCGCCGGG AGGAGGCCGG CGCCTATCAG 
TGTGAGGTGT GGAACCCGGT CAGTGTCAGC CGCAGCGAGC CCATCAACCT GACCGTGTAC 
TTTGGCCCAG AGCGTGTGGC CATCCTCCAG GATTCCACCA CCCGCACAGG CTGCACCATC 
AAAGTTGACT TCAACACGTC CCTCACCCTG TGGTGCGTGT CCAGGTCCTG CCCAGAGCCC 
GAGTATGTGT GGACCTTCAA CGGGCAGGCC CTAAAGAACG GCCAAGACCA CCTCAACATC 
AGCAGCATGA CAGCCGCCCA GGAGGGGACG TACACATGTA TTGCGAAGAA CACCAAGACC 
CTGCTATCTG GATCTGCCTC AGTCGTGGTC AAGCTCTCTG CTGCAGCAGT TGCCACGATG 
ATCGTGCCCG TGCCCACCAA GCCAACGGAG GGCCAGGACG TAACACTGAC CGTGCAGGGC 
TACCCCAAGG ACCTGCTGGT CTACGCCTGG TACCGCGGGC CTGCCTCCGA GCCCAACCGG 
CTGCTCAGCC AGCTGCCGTC AGGAACCTGG ATTGCAGGCC CCGCGCACAC AGGCCGGGAG 
GTGGGCTTCC CCAACTGCTC GCTGTTGGTG CAGAAGCTGA ACCTCACAGA CACTGGCCGC 
TACACACTCA AGACTGTCAC AGTGCAGGGC AAGACTGAGA CACTGGAAGT GGAGCTGCAG 
GTGGCCCGTG AGTGTGTGGG AAGGGGCAAG GCGTGCCCCT TTTTAGACAA GGGCTCCCAA 
AAGGAGCCTT TGCTTCCTCC ATCAGGCTGG GGGGACATAG ACCAAAGATG GATACCCATC 
CCCCATCAGG CTGAAGGAAG CAGCCTTGTC TCCTCCGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016882284.1
CDS	902..2323
Translation	MALTGYSWLLLSATFLNVGAEISITLEPAQPSEGDNVTLVVHGLSGELLAYSWYAGPTLSVSYLVASYIVSTGDETPGPAHTGREAVRPDGSLDIQGILPRHSGTYILQTFNRQLQTEVGYGHVQVHEILAQPTVLANSTALVERRDTLRLMCSSPSPTAEVRWFFNGGALPVALRLGLSPDGRVLARHGIRREEAGAYQCEVWNPVSVSRSEPINLTVYFGPERVAILQDSTTRTGCTIKVDFNTSLTLWCVSRSCPEPEYVWTFNGQALKNGQDHLNISSMTAAQEGTYTCIAKNTKTLLSGSASVVVKLSAAAVATMIVPVPTKPTEGQDVTLTVQGYPKDLLVYAWYRGPASEPNRLLSQLPSGTWIAGPAHTGREVGFPNCSLLVQKLNLTDTGRYTLKTVTVQGKTETLEVELQVARECVGRGKACPFLDKGSQKEPLLPPSGWGDIDQRWIPIPHQAEGSSLVSSA

Target ORF information:

RefSeq Version	XM_017026795.1
Organism	Homo sapiens(human)
Definition	Homo sapiens CEA cell adhesion molecule 16, tectorial membrane component (CEACAM16), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026795.1

ORF Insert Sequence:

ATGGCGCTGA CTGGGTACAG CTGGCTGCTC CTCAGTGCCA CATTCCTGAA TGTGGGGGCC 
GAGATCTCTA TCACCCTGGA GCCTGCCCAG CCGAGCGAAG GGGACAACGT CACGCTGGTC 
GTCCATGGGC TTTCGGGGGA ACTGCTCGCC TACAGCTGGT ATGCGGGGCC CACACTCAGC 
GTGTCATACC TGGTGGCCAG CTACATCGTG AGCACAGGCG ATGAGACTCC TGGCCCGGCC 
CACACGGGGC GGGAGGCTGT GCGCCCCGAT GGCAGCCTGG ACATCCAGGG CATCCTGCCC 
CGGCACTCAG GCACCTACAT CCTGCAGACC TTCAACAGGC AGTTGCAGAC CGAGGTGGGC 
TACGGACACG TGCAGGTCCA TGAGATCCTG GCCCAGCCCA CAGTCTTGGC CAACAGCACA 
GCGCTGGTGG AACGTCGAGA CACCCTGCGC CTTATGTGCA GCAGCCCCAG CCCCACCGCC 
GAGGTCCGCT GGTTCTTCAA CGGTGGGGCC CTGCCCGTCG CTCTCCGCCT GGGCCTGTCC 
CCTGACGGCC GGGTGCTGGC CAGGCATGGC ATCCGCCGGG AGGAGGCCGG CGCCTATCAG 
TGTGAGGTGT GGAACCCGGT CAGTGTCAGC CGCAGCGAGC CCATCAACCT GACCGTGTAC 
TTTGGCCCAG AGCGTGTGGC CATCCTCCAG GATTCCACCA CCCGCACAGG CTGCACCATC 
AAAGTTGACT TCAACACGTC CCTCACCCTG TGGTGCGTGT CCAGGTCCTG CCCAGAGCCC 
GAGTATGTGT GGACCTTCAA CGGGCAGGCC CTAAAGAACG GCCAAGACCA CCTCAACATC 
AGCAGCATGA CAGCCGCCCA GGAGGGGACG TACACATGTA TTGCGAAGAA CACCAAGACC 
CTGCTATCTG GATCTGCCTC AGTCGTGGTC AAGCTCTCTG CTGCAGCAGT TGCCACGATG 
ATCGTGCCCG TGCCCACCAA GCCAACGGAG GGCCAGGACG TAACACTGAC CGTGCAGGGC 
TACCCCAAGG ACCTGCTGGT CTACGCCTGG TACCGCGGGC CTGCCTCCGA GCCCAACCGG 
CTGCTCAGCC AGCTGCCGTC AGGAACCTGG ATTGCAGGCC CCGCGCACAC AGGCCGGGAG 
GTGGGCTTCC CCAACTGCTC GCTGTTGGTG CAGAAGCTGA ACCTCACAGA CACTGGCCGC 
TACACACTCA AGACTGTCAC AGTGCAGGGC AAGACTGAGA CACTGGAAGT GGAGCTGCAG 
GTGGCCCGTG AGTGTGTGGG AAGGGGCAAG GCGTGCCCCT TTTTAGACAA GGGCTCCCAA 
AAGGAGCCTT TGCTTCCTCC ATCAGGCTGG GGGGACATAG ACCAAAGATG GATACCCATC 
CCCCATCAGG CTGAAGGAAG CAGCCTTGTC TCCTCCGCCT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cell motility and spreading promoted by CEACAM6 through cyclin D1/CDK4 in human pancreatic carcinoma.
Oncology reports35(1)418-26(2016 Jan)
Yan L,Wang Y,Wang ZZ,Rong YT,Chen LL,Li Q,Liu T,Chen YH,Li YD,Huang ZH,Peng J

Exome sequencing identifies a novel CEACAM16 mutation associated with autosomal dominant nonsyndromic hearing loss DFNA4B in a Chinese family.
Journal of human genetics60(3)119-126(2015 Mar)
Wang H,Wang X,He C,Li H,Qing J,Grati M,Hu Z,Li J,Hu Y,Xia K,Mei L,Wang X,Yu J,Chen H,Jiang L,Liu Y,Men M,Zhang H,Guan L,Xiao J,Zhang J,Liu X,Feng Y

SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
PloS one8(4)e58618(2013)
Miyashita A,Koike A,Jun G,Wang LS,Takahashi S,Matsubara E,Kawarabayashi T,Shoji M,Tomita N,Arai H,Asada T,Harigaya Y,Ikeda M,Amari M,Hanyu H,Higuchi S,Ikeuchi T,Nishizawa M,Suga M,Kawase Y,Akatsu H,Kosaka K,Yamamoto T,Imagawa M,Hamaguchi T,Yamada M,Morihara T,Moriaha T,Takeda M,Takao T,Nakata K,Fujisawa Y,Sasaki K,Watanabe K,Nakashima K,Urakami K,Ooya T,Takahashi M,Yuzuriha T,Serikawa K,Yoshimoto S,Nakagawa R,Kim JW,Ki CS,Won HH,Na DL,Seo SW,Mook-Jung I,,St George-Hyslop P,Mayeux R,Haines JL,Pericak-Vance MA,Yoshida M,Nishida N,Tokunaga K,Yamamoto K,Tsuji S,Kanazawa I,Ihara Y,Schellenberg GD,Farrer LA,Kuwano R

Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.
The Journal of biological chemistry287(26)21584-98(2012 Jun)
Kammerer R,R?ttiger L,Riesenberg R,Sch?uble C,Krupar R,Kamp A,Sunami K,Eisenried A,Hennenberg M,Grunert F,Bress A,Battaglia S,Schrewe H,Knipper M,Schneider MR,Zimmermann W

Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4).
Proceedings of the National Academy of Sciences of the United States of America108(10)4218-23(2011 Mar)
Zheng J,Miller KK,Yang T,Hildebrand MS,Shearer AE,DeLuca AP,Scheetz TE,Drummond J,Scherer SE,Legan PK,Goodyear RJ,Richardson GP,Cheatham MA,Smith RJ,Dallos P

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CEACAM16 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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