RTL1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RTL1
Entrez Gene ID	388015
Full Name	retrotransposon Gag like 1
Synonyms	HUR1,MART1,Mar1,PEG11,SIRH2
General protein information	Preferred Names retrotransposon Gag like 1 Names retrotransposon-like protein 1 Sushi-Ichi retrotransposon homolog 2 mammalian retrotransposon derived protein 1 mammalian retrotransposon-derived 1 paternally expressed 11 paternally expressed gene 11 protein retrotransposon-derived protein PEG11 retrotransposon-like 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 14 Map Location: 14q32.2
Summary	This gene is a retrotransposon-derived, paternally expressed imprinted gene that is highly expressed at the late fetal stage in both the fetus and placenta. It has an overlapping maternally expressed antisense transcript, which contains several microRNAs targeting the transcripts of this gene through an RNA interference (RNAi) mechanism. This gene is essential for maintenance of the fetal capillaries. [provided by RefSeq, Jul 2009].
Disorder MIM:	611896

mRNA and Protein(s)

mRNA	Protein	Name
NM_001134888.2	NP_001128360.1	retrotransposon-like protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	RTL1	NP_001128360.1
Pan troglodytes (chimpanzee)	RTL1	XP_520846.3
Bos taurus (cattle)	RTL1	NP_001181949.1
Mus musculus (house mouse)	Rtl1	NP_908998.1
	RTL1	XP_001110319.1
Canis lupus familiaris (dog)	RTL1	XP_003639272.1

Gene Ontology
Bibliography

Related articles in PubMed

The placental imprinted DLK1-DIO3 domain: a new link to prenatal and postnatal growth in humans.
Prats-Puig A, Carreras-Badosa G, Bassols J, Cavelier P, Magret A, Sabench C, de Zegher F, Ib??ez L, Feil R, L?pez-Bermejo A
American journal of obstetrics and gynecology217(3)350.e1-350.e13(2017 09)

Role of DNA methylation at the placental RTL1 gene locus in type 1 diabetes.
Belot MP, Nad?ri K, Mille C, Bo?lle PY, Benachi A, Bougn?res P, Fradin D
Pediatric diabetes18(3)178-187(2017 May)

Increased l1 retrotransposition in the neuronal genome in schizophrenia.
Bundo M, Toyoshima M, Okada Y, Akamatsu W, Ueda J, Nemoto-Miyauchi T, Sunaga F, Toritsuka M, Ikawa D, Kakita A, Kato M, Kasai K, Kishimoto T, Nawa H, Okano H, Yoshikawa T, Kato T, Iwamoto K
Neuron81(2)306-13(2014 Jan)

Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis.
Riordan JD, Keng VW, Tschida BR, Scheetz TE, Bell JB, Podetz-Pedersen KM, Moser CD, Copeland NG, Jenkins NA, Roberts LR, Largaespada DA, Dupuy AJ
PLoS genetics9(4)e1003441(2013 Apr)

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.
Wallace C, Smyth DJ, Maisuria-Armer M, Walker NM, Todd JA, Clayton DG
Nature genetics42(1)68-71(2010 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We find that placental expression of DIO3 and RTL1) correlates with prenatal growth. Combined, these findings suggest that epigenetic programming and gene expression within the DLK1-DIO3 imprinted domain influence both prenatal and postnatal growth.
Title: The placental imprinted DLK1-DIO3 domain: a new link to prenatal and postnatal growth in humans.

Data suggest that DNA is differentially methylated (hypomethylated) at a gene locus associated with regulation of expression of RTL1 and miR136 in type 1 diabetes; these studies were conducted using tissue bank placentas and whole blood cell DNA from children with type 1 diabetes. (RTL1 = retrotransposon-like protein 1; miR136 = microRNA 136)
Title: Role of DNA methylation at the placental RTL1 gene locus in type 1 diabetes.

The results of this study suggest that hyperactive retrotransposition of L1 in neurons triggered by environmental and/or genetic risk factors may contribute to the susceptibility and pathophysiology of schizophrenia.
Title: Increased l1 retrotransposition in the neuronal genome in schizophrenia.

In addition to identifying Rtl1 as a novel driver of HCC, our study represents one of the first direct in vivo demonstrations of a role for such a co-opted genetic element in promoting carcinogenesis.
Title: Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis.

RTL1, a paternally expressed gene in a cluster of imprinted genes on chromosome 14q32.2, is associated with upd(14)pat-like and upd(14)mat-like phenotypes.
Title: Deletions and epimutations affecting the human 14q32.2 imprinted region in individuals with paternal and maternal upd(14)-like phenotypes.

The following RTL1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RTL1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu14905	NM_001134888.2 Latest version!	Homo sapiens retrotransposon Gag like 1 (RTL1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	25	$384.30 $549.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RTL1 ( NM_001134888.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001128360.1 Homo sapiens retrotransposon Gag like 1 (RTL1), mRNA.

Price & Availability↑

CloneID	OHu14905
Clone ID Related Accession (Same CDS sequence)	NM_001134888.2
Accession Version	NM_001134888.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 4077bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	retrotransposon-like protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC150617.1 and AL117190.6. This sequence is a reference standard in the RefSeqGene project. On Jul 15, 2009 this sequence version replaced NM_001134888.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript is intronless :: BC150617.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## imprinted gene :: PMID: 18176563 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGATAGAAC CCTCTGAAGA CTCATTTGAG ACGATGATGG AGCATAAGAA TCCATCATCA 
AAACAAATGG AGTCCTCCGA GGGCTCATCC AACACCACCG AGGCGACGTC GGGCAGTGGA 
GTGCGGGGAG AGGCAGGGCC AGCCAGCGGC CCAGCCCAGG AAAAGAAGGA GCCCCCCAGT 
GGCCCACTCC AGGAAATGGA AGAGCTGCCC ACTGATCTAC TCCAAGACAT GGAGGAGCCA 
TCCAGTGGCC CACGTAAGGA AATAGAGGAT CCACCCAATG ACCTACTCCA AGACCTGGAG 
GAGTCATGCA ACGGTTCACA CCAGGCAAGG GGGGATCCAC TCAGTGGAGC ATCTGATAGG 
ATGAAAGAAG CATCAGTCAA CCCATCGGGA GCCCGAGAAG AACAAGAGGC TCACACTGAC 
CTGAAGGAAT CGGGAAGGGA GGAGACTCCT CAAGAGCAAA ACCAGACCGA GCACTCAACC 
GCAGAACTTA TGGCCATGGT GAGGTCCATC ATCTCGCTGT ACTTCCGAAT GCAAGACCTC 
AAAGAGCAAC AGAGAGTAGC AGAAGAGATC TTGATCAAAG GGATCAATGC AGGCCAACTG 
CCCGCCCCAA AGCACTTCTC TGGCGATCGC AGAGAATTCC ACGAGTTCAT CGTACTCTGC 
CAACTGACCT TACAGAGCTA CCCAAGAATG TTCTATAACG ACCGTCTGAG AGTTGGCTAT 
GTCATCAATC ACCTGTCCGG CTTGGCATTA GAATGGGCCA AAGCTCTACT GCAGGAAAAC 
AGCCCCCTGA TCGGAGACTT CCCAGCCTTC CTGGAGGCCA TGTCCGAAGT GTTTGAGTAC 
CGCCAGGCAC TGCGTGTGGC AGAAGAGGCC ATGTTCACCA TCAGGCAGGG CGGCCGCTCT 
GCCACTGAGT ACATCGATGA GTTCCAGAGC CTGGTACCCA TCTTGGGCTG GCCAGATGAA 
GTCCTGCAGG CCCACTTGTG CCAGGGGCTC AACGAGGAGA TCAGGCACTA TCTATTCCGG 
GTCCCTCAGC CGGATTCCCT AGACAGTCTG ATTGTGCTCA TCCTGCAAAT AGAAGAGAAG 
CTGGCAGAGA GAAGAGCTAT GCTCAGGCTG CCCCCCGAGG CCCGCCCCCG GAACCTGACC 
TGGATCGACT CACCTGCTCC AGAGAGGTGG ATGGTCAGCA GCTGGTTGCC CAGCGAAGTC 
CATCCGGACA TCAATCGCGC CCACCTCTTC CTGCTGCTCA TGGTGAGAGT GAACCCCTAC 
CACAGCGTCG CGGTCCAGGC CCTGGTGGAT TCGGGAGCTG ACGGCAACTT CATGGATGAG 
AAGTTCGCCC AAGAGCACTA CGTCGAGCTC TACGAGAAGC CGTACCCACA GCCGGTCCAA 
TCCGTGGACG GCTCGCTGAT TGGCAACGAG CCTGTCTGGC TCTACACGGA GCCCCTGGTG 
TGTATCCACC AGAACCACCA GGAGTCCATC GAATTTGACA TCGTACCTTC ACCGAACTTC 
TCTGTGGTCC TAGGCATCCG CTGGCTCCGA GTCCACGCCC CCGAAGTCGA CTGGATCAAA 
GGCCGCTGCA CCTTCCACTC TCCCTACTGC CTGAAGAACT GCTTCCGCCC GCCCCCGCCA 
TGCATTGCCC TAGAGAGGCA CGGCATGAGC CTGCTACCCG GACTGCCACA CCCATACTCA 
GACCTGGCCG ACGTGTTTAA CCCGAAGGAA GCAGATGATG AGACTTCCGA CCAGCCAAGC 
TCAGACGGAT CCGATGATCT TTCTGAATCA GAGCCCTCTG AGCTTCAGCA GGCTGGAGAC 
AGTGATCACA GCGAGACCTT TTACGAGTGT CCCTCCACCG CGCCTTGGGA ACCTGTGGGT 
GCCAGGATGC AAGAAAGAGC CAGGCTACAG GAGGAATACT GGGACCTGCA GGACATGCTG 
ACCAACAGAC AGGACTACAT ACAGATGATT CCGGAACTGT TTGACCAGTT ACACGGAGCC 
GAGTGGTTCA CAAAACTGGA GCTGCGTGGG ACCATTGTGG AGGAAAGCGT GAACGGGCAC 
CGCACCGAAG ATGTGTGGAA AGCAGCGTTT GGTTTGGAGC TTGAAGAGAT GAAGAGCTAC 
CAGCCGTTTG CGCTCTCCCC AGACCCTATC ATACCTCAGA ACGTGATTCA CTTCATCCTA 
AAGGACATGC TAGGGTTCTT TGTGCTTTCT TATGGCCAGG AAGTCCTGAT CTACTCAATG 
AGTCAGGAGG AGCACCTCCA CCACGTCCGC CAAGTCCTGG TCCGCTTCCG CCATCACAAC 
GTCTACTGCT CCCTGGACAA GAGCCAGTTC CACCGCCAAA CCGTGGAATT CCTGGGCTTC 
GTCGTCACCC CCAAAGGGGT GAAACTGAAC AAGAACGTCA TGACCATCAT AACAGGGTAC 
CCTACCCCTG GCTCCAAGCT ATCTCTGCGA AACTTCATCG AATTCGTCTT CCCCTACCGC 
CACTTCGTGG AGCGCTTCAG CATCATCGCA GAGCCCCTGG TGCGGCAGCT GCTGAGCTCC 
TACCAGTTCT ACTGGGGAGT CGAGGAGCAA GAGGCCTTCG AGTGCCTGAA GAGGGCTTTC 
CGCAAGGCGC CTCTCCTCCA CCACCCCAAG CCCCAGAACC CATTCTACTT GGAAACCGGC 
GTCACCGGCA CGGCCCTGCA CGCCTCCCTG ATCCAAATCG ACGACCAAAC CGGCAAGAGA 
GCCTGCTGCG CTTTCTACTC CCGCAACATC TCCCCTATCG AGGTTGAGTA CTCTCAAGCG 
GAGATGAAGA TTCTTCCAAT ACGGGCTGCC TTCATGGTGT GGTGCCGCTA CCTGGAGAAC 
ACCGAGGAGC CCATCATGAT CCTTCTCAAC ACAGAGGATC TAGCCTCTCT GAATAATGAC 
AGGCTCACCG TACTTCTCCC CGGGCATTGG GTCTTCTTCT TCTCCCACTT CAACTTTGAC 
GTCATGGAGC TGCCAGAACA AGACGGCGGC CGAGCTCTGC CACCTGTGAG AAACCTCCGG 
TGGAGGAGAG CCTTCCAGAG GAACACTGCC GCCAGGCAAA CCCTGCTGCT GGCCTCAAGG 
GGATTCCCCA GGGATCCATC GACGGAATCC GGGGAAGAAG AGAATGAAGA ACAGGATGAG 
CTCAATGAAC AGATCCTACG GCAAGAGCTG CTGGCCATGA TACCCATCGA CCAGATCCTC 
AACAGCTTCC TCGCCCACTT CAGCATGGCC CAGATCAGGG CCGTCATTCT GCACTTCTTC 
CGAGGCCTCC TGTACTGGAA GAACACCCTA GCCCTGGCAG CCATCCTCGT GCTACTGCGC 
GTGAGGCAAT GCCTCTCGCT GCGGCCGGCA CCCGCCATGC GGGTGGCTCG GCCCCAGCCC 
CAGCGCTCCC TACGACTCAT CCTGGATTCG TCCCTCATCG CAGGCAGCAG CATCACGACA 
GCCATCACCC AGCTGCTCAC CCAGATGCCC GCTCTCGTAG GTGCAAACAC CATCCCAGCC 
CAGGAGCTGG CTGAGCTGTT CCTGGGCCCT GGCCGCTGGC AGCGAAATGC TCTGCACTCC 
CAGGCCCACC GAGGCCTGCA GTTCACCCCT GGCTTCTGGC TGACGCTGTG TGAGTTCTTC 
GGTGTCAGAG TCACCCCCCA GGAGGGCCAC CTCCCTGCCC TGCGTCAGAA CCGCTACCTG 
GAGCTGCACG TCGTTGGTGA TGAGGATGTC GTCTTGCGAG AAGCCCTGCA AGACGACCTG 
CAACGTTACC GTCAGTGTGG CCTGCATGAC GGCCTGCAAG ACACCTCGCA GGACAAGCAG 
GACAACGACG TGCAGGAGGC CCCACCCAGC CACACAGCAG CCACCCACCC ACCCCGCCCA 
CGCCACCTGA TGGATCCCCA GGTCCTGGAA TTCCTTGGTA GCCGCCTGCT CCACATCCAC 
AGTGCAGATG GCCAGCTGCA CCTGCTCAGC CGGGAGCAGG CAGCCAGGGC CCTGAGCCAG 
TTCCTGACCC TGATCTACAG GCGGGCCCTG CCCATCCCCG CCTGGGAGAG CCAGCCCAGG 
GAGCAGGCAA GGCTAGAAGA GCTGCCTGAT GAGGACGAAG ATGCTAACCT CGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001128360.1
CDS	60..4136
Translation	MIEPSEDSFETMMEHKNPSSKQMESSEGSSNTTEATSGSGVRGEAGPASGPAQEKKEPPSGPLQEMEELPTDLLQDMEEPSSGPRKEIEDPPNDLLQDLEESCNGSHQARGDPLSGASDRMKEASVNPSGAREEQEAHTDLKESGREETPQEQNQTEHSTAELMAMVRSIISLYFRMQDLKEQQRVAEEILIKGINAGQLPAPKHFSGDRREFHEFIVLCQLTLQSYPRMFYNDRLRVGYVINHLSGLALEWAKALLQENSPLIGDFPAFLEAMSEVFEYRQALRVAEEAMFTIRQGGRSATEYIDEFQSLVPILGWPDEVLQAHLCQGLNEEIRHYLFRVPQPDSLDSLIVLILQIEEKLAERRAMLRLPPEARPRNLTWIDSPAPERWMVSSWLPSEVHPDINRAHLFLLLMVRVNPYHSVAVQALVDSGADGNFMDEKFAQEHYVELYEKPYPQPVQSVDGSLIGNEPVWLYTEPLVCIHQNHQESIEFDIVPSPNFSVVLGIRWLRVHAPEVDWIKGRCTFHSPYCLKNCFRPPPPCIALERHGMSLLPGLPHPYSDLADVFNPKEADDETSDQPSSDGSDDLSESEPSELQQAGDSDHSETFYECPSTAPWEPVGARMQERARLQEEYWDLQDMLTNRQDYIQMIPELFDQLHGAEWFTKLELRGTIVEESVNGHRTEDVWKAAFGLELEEMKSYQPFALSPDPIIPQNVIHFILKDMLGFFVLSYGQEVLIYSMSQEEHLHHVRQVLVRFRHHNVYCSLDKSQFHRQTVEFLGFVVTPKGVKLNKNVMTIITGYPTPGSKLSLRNFIEFVFPYRHFVERFSIIAEPLVRQLLSSYQFYWGVEEQEAFECLKRAFRKAPLLHHPKPQNPFYLETGVTGTALHASLIQIDDQTGKRACCAFYSRNISPIEVEYSQAEMKILPIRAAFMVWCRYLENTEEPIMILLNTEDLASLNNDRLTVLLPGHWVFFFSHFNFDVMELPEQDGGRALPPVRNLRWRRAFQRNTAARQTLLLASRGFPRDPSTESGEEENEEQDELNEQILRQELLAMIPIDQILNSFLAHFSMAQIRAVILHFFRGLLYWKNTLALAAILVLLRVRQCLSLRPAPAMRVARPQPQRSLRLILDSSLIAGSSITTAITQLLTQMPALVGANTIPAQELAELFLGPGRWQRNALHSQAHRGLQFTPGFWLTLCEFFGVRVTPQEGHLPALRQNRYLELHVVGDEDVVLREALQDDLQRYRQCGLHDGLQDTSQDKQDNDVQEAPPSHTAATHPPRPRHLMDPQVLEFLGSRLLHIHSADGQLHLLSREQAARALSQFLTLIYRRALPIPAWESQPREQARLEELPDEDEDANLD

Target ORF information:

RefSeq Version	NM_001134888.2
Organism	Homo sapiens(human)
Definition	Homo sapiens retrotransposon Gag like 1 (RTL1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001134888.2

ORF Insert Sequence:

ATGATAGAAC CCTCTGAAGA CTCATTTGAG ACGATGATGG AGCATAAGAA TCCATCATCA 
AAACAAATGG AGTCCTCCGA GGGCTCATCC AACACCACCG AGGCGACGTC GGGCAGTGGA 
GTGCGGGGAG AGGCAGGGCC AGCCAGCGGC CCAGCCCAGG AAAAGAAGGA GCCCCCCAGT 
GGCCCACTCC AGGAAATGGA AGAGCTGCCC ACTGATCTAC TCCAAGACAT GGAGGAGCCA 
TCCAGTGGCC CACGTAAGGA AATAGAGGAT CCACCCAATG ACCTACTCCA AGACCTGGAG 
GAGTCATGCA ACGGTTCACA CCAGGCAAGG GGGGATCCAC TCAGTGGAGC ATCTGATAGG 
ATGAAAGAAG CATCAGTCAA CCCATCGGGA GCCCGAGAAG AACAAGAGGC TCACACTGAC 
CTGAAGGAAT CGGGAAGGGA GGAGACTCCT CAAGAGCAAA ACCAGACCGA GCACTCAACC 
GCAGAACTTA TGGCCATGGT GAGGTCCATC ATCTCGCTGT ACTTCCGAAT GCAAGACCTC 
AAAGAGCAAC AGAGAGTAGC AGAAGAGATC TTGATCAAAG GGATCAATGC AGGCCAACTG 
CCCGCCCCAA AGCACTTCTC TGGCGATCGC AGAGAATTCC ACGAGTTCAT CGTACTCTGC 
CAACTGACCT TACAGAGCTA CCCAAGAATG TTCTATAACG ACCGTCTGAG AGTTGGCTAT 
GTCATCAATC ACCTGTCCGG CTTGGCATTA GAATGGGCCA AAGCTCTACT GCAGGAAAAC 
AGCCCCCTGA TCGGAGACTT CCCAGCCTTC CTGGAGGCCA TGTCCGAAGT GTTTGAGTAC 
CGCCAGGCAC TGCGTGTGGC AGAAGAGGCC ATGTTCACCA TCAGGCAGGG CGGCCGCTCT 
GCCACTGAGT ACATCGATGA GTTCCAGAGC CTGGTACCCA TCTTGGGCTG GCCAGATGAA 
GTCCTGCAGG CCCACTTGTG CCAGGGGCTC AACGAGGAGA TCAGGCACTA TCTATTCCGG 
GTCCCTCAGC CGGATTCCCT AGACAGTCTG ATTGTGCTCA TCCTGCAAAT AGAAGAGAAG 
CTGGCAGAGA GAAGAGCTAT GCTCAGGCTG CCCCCCGAGG CCCGCCCCCG GAACCTGACC 
TGGATCGACT CACCTGCTCC AGAGAGGTGG ATGGTCAGCA GCTGGTTGCC CAGCGAAGTC 
CATCCGGACA TCAATCGCGC CCACCTCTTC CTGCTGCTCA TGGTGAGAGT GAACCCCTAC 
CACAGCGTCG CGGTCCAGGC CCTGGTGGAT TCGGGAGCTG ACGGCAACTT CATGGATGAG 
AAGTTCGCCC AAGAGCACTA CGTCGAGCTC TACGAGAAGC CGTACCCACA GCCGGTCCAA 
TCCGTGGACG GCTCGCTGAT TGGCAACGAG CCTGTCTGGC TCTACACGGA GCCCCTGGTG 
TGTATCCACC AGAACCACCA GGAGTCCATC GAATTTGACA TCGTACCTTC ACCGAACTTC 
TCTGTGGTCC TAGGCATCCG CTGGCTCCGA GTCCACGCCC CCGAAGTCGA CTGGATCAAA 
GGCCGCTGCA CCTTCCACTC TCCCTACTGC CTGAAGAACT GCTTCCGCCC GCCCCCGCCA 
TGCATTGCCC TAGAGAGGCA CGGCATGAGC CTGCTACCCG GACTGCCACA CCCATACTCA 
GACCTGGCCG ACGTGTTTAA CCCGAAGGAA GCAGATGATG AGACTTCCGA CCAGCCAAGC 
TCAGACGGAT CCGATGATCT TTCTGAATCA GAGCCCTCTG AGCTTCAGCA GGCTGGAGAC 
AGTGATCACA GCGAGACCTT TTACGAGTGT CCCTCCACCG CGCCTTGGGA ACCTGTGGGT 
GCCAGGATGC AAGAAAGAGC CAGGCTACAG GAGGAATACT GGGACCTGCA GGACATGCTG 
ACCAACAGAC AGGACTACAT ACAGATGATT CCGGAACTGT TTGACCAGTT ACACGGAGCC 
GAGTGGTTCA CAAAACTGGA GCTGCGTGGG ACCATTGTGG AGGAAAGCGT GAACGGGCAC 
CGCACCGAAG ATGTGTGGAA AGCAGCGTTT GGTTTGGAGC TTGAAGAGAT GAAGAGCTAC 
CAGCCGTTTG CGCTCTCCCC AGACCCTATC ATACCTCAGA ACGTGATTCA CTTCATCCTA 
AAGGACATGC TAGGGTTCTT TGTGCTTTCT TATGGCCAGG AAGTCCTGAT CTACTCAATG 
AGTCAGGAGG AGCACCTCCA CCACGTCCGC CAAGTCCTGG TCCGCTTCCG CCATCACAAC 
GTCTACTGCT CCCTGGACAA GAGCCAGTTC CACCGCCAAA CCGTGGAATT CCTGGGCTTC 
GTCGTCACCC CCAAAGGGGT GAAACTGAAC AAGAACGTCA TGACCATCAT AACAGGGTAC 
CCTACCCCTG GCTCCAAGCT ATCTCTGCGA AACTTCATCG AATTCGTCTT CCCCTACCGC 
CACTTCGTGG AGCGCTTCAG CATCATCGCA GAGCCCCTGG TGCGGCAGCT GCTGAGCTCC 
TACCAGTTCT ACTGGGGAGT CGAGGAGCAA GAGGCCTTCG AGTGCCTGAA GAGGGCTTTC 
CGCAAGGCGC CTCTCCTCCA CCACCCCAAG CCCCAGAACC CATTCTACTT GGAAACCGGC 
GTCACCGGCA CGGCCCTGCA CGCCTCCCTG ATCCAAATCG ACGACCAAAC CGGCAAGAGA 
GCCTGCTGCG CTTTCTACTC CCGCAACATC TCCCCTATCG AGGTTGAGTA CTCTCAAGCG 
GAGATGAAGA TTCTTCCAAT ACGGGCTGCC TTCATGGTGT GGTGCCGCTA CCTGGAGAAC 
ACCGAGGAGC CCATCATGAT CCTTCTCAAC ACAGAGGATC TAGCCTCTCT GAATAATGAC 
AGGCTCACCG TACTTCTCCC CGGGCATTGG GTCTTCTTCT TCTCCCACTT CAACTTTGAC 
GTCATGGAGC TGCCAGAACA AGACGGCGGC CGAGCTCTGC CACCTGTGAG AAACCTCCGG 
TGGAGGAGAG CCTTCCAGAG GAACACTGCC GCCAGGCAAA CCCTGCTGCT GGCCTCAAGG 
GGATTCCCCA GGGATCCATC GACGGAATCC GGGGAAGAAG AGAATGAAGA ACAGGATGAG 
CTCAATGAAC AGATCCTACG GCAAGAGCTG CTGGCCATGA TACCCATCGA CCAGATCCTC 
AACAGCTTCC TCGCCCACTT CAGCATGGCC CAGATCAGGG CCGTCATTCT GCACTTCTTC 
CGAGGCCTCC TGTACTGGAA GAACACCCTA GCCCTGGCAG CCATCCTCGT GCTACTGCGC 
GTGAGGCAAT GCCTCTCGCT GCGGCCGGCA CCCGCCATGC GGGTGGCTCG GCCCCAGCCC 
CAGCGCTCCC TACGACTCAT CCTGGATTCG TCCCTCATCG CAGGCAGCAG CATCACGACA 
GCCATCACCC AGCTGCTCAC CCAGATGCCC GCTCTCGTAG GTGCAAACAC CATCCCAGCC 
CAGGAGCTGG CTGAGCTGTT CCTGGGCCCT GGCCGCTGGC AGCGAAATGC TCTGCACTCC 
CAGGCCCACC GAGGCCTGCA GTTCACCCCT GGCTTCTGGC TGACGCTGTG TGAGTTCTTC 
GGTGTCAGAG TCACCCCCCA GGAGGGCCAC CTCCCTGCCC TGCGTCAGAA CCGCTACCTG 
GAGCTGCACG TCGTTGGTGA TGAGGATGTC GTCTTGCGAG AAGCCCTGCA AGACGACCTG 
CAACGTTACC GTCAGTGTGG CCTGCATGAC GGCCTGCAAG ACACCTCGCA GGACAAGCAG 
GACAACGACG TGCAGGAGGC CCCACCCAGC CACACAGCAG CCACCCACCC ACCCCGCCCA 
CGCCACCTGA TGGATCCCCA GGTCCTGGAA TTCCTTGGTA GCCGCCTGCT CCACATCCAC 
AGTGCAGATG GCCAGCTGCA CCTGCTCAGC CGGGAGCAGG CAGCCAGGGC CCTGAGCCAG 
TTCCTGACCC TGATCTACAG GCGGGCCCTG CCCATCCCCG CCTGGGAGAG CCAGCCCAGG 
GAGCAGGCAA GGCTAGAAGA GCTGCCTGAT GAGGACGAAG ATGCTAACCT CGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The placental imprinted DLK1-DIO3 domain: a new link to prenatal and postnatal growth in humans.
American journal of obstetrics and gynecology217(3)350.e1-350.e13(2017 09)
Prats-Puig A,Carreras-Badosa G,Bassols J,Cavelier P,Magret A,Sabench C,de Zegher F,Ib??ez L,Feil R,L?pez-Bermejo A

Role of DNA methylation at the placental RTL1 gene locus in type 1 diabetes.
Pediatric diabetes18(3)178-187(2017 May)
Belot MP,Nad?ri K,Mille C,Bo?lle PY,Benachi A,Bougn?res P,Fradin D

Increased l1 retrotransposition in the neuronal genome in schizophrenia.
Neuron81(2)306-13(2014 Jan)
Bundo M,Toyoshima M,Okada Y,Akamatsu W,Ueda J,Nemoto-Miyauchi T,Sunaga F,Toritsuka M,Ikawa D,Kakita A,Kato M,Kasai K,Kishimoto T,Nawa H,Okano H,Yoshikawa T,Kato T,Iwamoto K

Identification of rtl1, a retrotransposon-derived imprinted gene, as a novel driver of hepatocarcinogenesis.
PLoS genetics9(4)e1003441(2013 Apr)
Riordan JD,Keng VW,Tschida BR,Scheetz TE,Bell JB,Podetz-Pedersen KM,Moser CD,Copeland NG,Jenkins NA,Roberts LR,Largaespada DA,Dupuy AJ

The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.
Nature genetics42(1)68-71(2010 Jan)
Wallace C,Smyth DJ,Maisuria-Armer M,Walker NM,Todd JA,Clayton DG

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RTL1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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