ARMS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ARMS2
Entrez Gene ID	387715
Full Name	age-related maculopathy susceptibility 2
Synonyms	ARMD8
General protein information	Preferred Names age-related maculopathy susceptibility 2 Names age-related maculopathy susceptibility protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q26.13
Summary	This gene encodes a small secreted protein specific to primates. This protein is a component of the choroidal extracellular matrix of the eye. Mutations in this gene are associated with age-related macular degeneration. [provided by RefSeq, Sep 2017].
Disorder MIM:	611313
Disorder Html:	{Macular degeneration, age-related, 8}, 613778 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001099667.1	NP_001093137.1	age-related maculopathy susceptibility protein 2
NM_001099667.2	NP_001093137.1	age-related maculopathy susceptibility protein 2
NM_001099667.3	NP_001093137.1	age-related maculopathy susceptibility protein 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ARMS2	XP_529353.1
Homo sapiens (human)	ARMS2	NP_001093137.1

Gene Ontology
Bibliography

Related articles in PubMed

Vavvas DG, Small KW, Awh CC, Zanke BW, Tibshirani RJ, Kustra R
Proceedings of the National Academy of Sciences of the United States of America(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In polypoidal choroidal vasculopathy patients, ARMS2 rs10490924 showed association with anatomic therapeutic response to anti-VEGF, suggesting pharmacogenetic relationship.
Title: Association of ARMS2 genotype with response to anti-vascular endothelial growth factor treatment in polypoidal choroidal vasculopathy.

The ARMS2 A69S polymorphism was associated with CNV recurrence rate in our patient cohort. Prediction of a greater risk of recurrence could help to design more appropriate follow-up treatment strategies for patients with neovascular AMD.
Title: ARMS2 A69S polymorphism is associated with the number of ranibizumab injections needed for exudative age-related macular degeneration in a pro re nata regimen during 4 years of follow-up.

This analysis revealed the synergistic effect of these two factors indicating that there is a common pathway of ARMS2/LOC387715 and smoking in AMD pathogenesis which may be the complement system pathway.
Title: Association of combined cigarette smoking and ARMS2/LOC387715 A69S polymorphisms with age-related macular degeneration: A meta-analysis.

we speculate that up-regulation of leptin and ARMS2 forms part of an important survival mechanism to compensate for placental growth discordance in monochorionic diamniotic twin pregnancies
Title: Placental Up-Regulation of Leptin and ARMS2 is Associated with Growth Discordance in Monochorionic Diamniotic Twin Pregnancies.

OCT scans revealed lower retinal thickness in patients homozygous for CFH or ARMS2, which was caused by a significantly reduced photoreceptor layer. The number and ultrastructure of drusen were also significantly different.
Title: Genetic Polymorphisms and the Phenotypic Characterization of Individuals with Early Age-Related Macular Degeneration.

The following ARMS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARMS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19862	NM_001099667.3 Latest version!	Homo sapiens age-related maculopathy susceptibility 2 (ARMS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19862	NM_001099667.1	Homo sapiens age-related maculopathy susceptibility 2 (ARMS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu19862	NM_001099667.2	Homo sapiens age-related maculopathy susceptibility 2 (ARMS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ARMS2 ( NM_001099667.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001093137.1 Homo sapiens age-related maculopathy susceptibility 2 (ARMS2), mRNA.

Price & Availability↑

CloneID	OHu19862
Clone ID Related Accession (Same CDS sequence)	NM_001099667.1 , NM_001099667.2 , NM_001099667.3
Accession Version	NM_001099667.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-05-06
Organism	Homo sapiens(Human)
Product	age-related maculopathy susceptibility protein 2
Comment	REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC066349.1 and BC090924.1. This sequence is a reference standard in the RefSeqGene project. On or before Jul 26, 2007 this sequence version replaced XM_001131282.1, XM_001131263.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC066349.1, CB998303.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCGCC TATACCCAGG ACCGATGGTA ACTGAGGCGG AGGGGAAAGG AGGGCCTGAG 
ATGGCAAGTC TGTCCTCCTC GGTGGTTCCT GTGTCCTTCA TTTCCACTCT GCGAGAGTCT 
GTGCTGGACC CTGGAGTTGG TGGAGAAGGA GCCAGTGACA AGCAGAGGAG CAAACTGTCT 
TTATCACACT CCATGATCCC AGCTGCTAAA ATCCACACTG AGCTCTGCTT ACCAGCCTTC 
TTCTCTCCTG CTGGAACCCA GAGGAGGTTC CAGCAGCCTC AGCACCACCT GACACTGTCT 
ATCATCCACA CTGCAGCAAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001093137.1
CDS	66..389
Translation	MLRLYPGPMVTEAEGKGGPEMASLSSSVVPVSFISTLRESVLDPGVGGEGASDKQRSKLSLSHSMIPAAKIHTELCLPAFFSPAGTQRRFQQPQHHLTLSIIHTAAR

Target ORF information:

RefSeq Version	NM_001099667.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens age-related maculopathy susceptibility 2 (ARMS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001099667.1

ORF Insert Sequence:

ATGCTGCGCC TATACCCAGG ACCGATGGTA ACTGAGGCGG AGGGGAAAGG AGGGCCTGAG 
ATGGCAAGTC TGTCCTCCTC GGTGGTTCCT GTGTCCTTCA TTTCCACTCT GCGAGAGTCT 
GTGCTGGACC CTGGAGTTGG TGGAGAAGGA GCCAGTGACA AGCAGAGGAG CAAACTGTCT 
TTATCACACT CCATGATCCC AGCTGCTAAA ATCCACACTG AGCTCTGCTT ACCAGCCTTC 
TTCTCTCCTG CTGGAACCCA GAGGAGGTTC CAGCAGCCTC AGCACCACCT GACACTGTCT 
ATCATCCACA CTGCAGCAAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARMS2 ( NM_001099667.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001093137.1 Homo sapiens age-related maculopathy susceptibility 2 (ARMS2), mRNA.

Price & Availability↑

CloneID	OHu19862
Clone ID Related Accession (Same CDS sequence)	NM_001099667.1 , NM_001099667.2 , NM_001099667.3
Accession Version	NM_001099667.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-25
Organism	Homo sapiens(human)
Product	age-related maculopathy susceptibility protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB997927.1, BC090924.1 and BC066349.1. This sequence is a reference standard in the RefSeqGene project. On Sep 16, 2017 this sequence version replaced NM_001099667.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC066349.1, CB998303.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCGCC TATACCCAGG ACCGATGGTA ACTGAGGCGG AGGGGAAAGG AGGGCCTGAG 
ATGGCAAGTC TGTCCTCCTC GGTGGTTCCT GTGTCCTTCA TTTCCACTCT GCGAGAGTCT 
GTGCTGGACC CTGGAGTTGG TGGAGAAGGA GCCAGTGACA AGCAGAGGAG CAAACTGTCT 
TTATCACACT CCATGATCCC AGCTGCTAAA ATCCACACTG AGCTCTGCTT ACCAGCCTTC 
TTCTCTCCTG CTGGAACCCA GAGGAGGTTC CAGCAGCCTC AGCACCACCT GACACTGTCT 
ATCATCCACA CTGCAGCAAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001093137.1
CDS	76..399
Translation	MLRLYPGPMVTEAEGKGGPEMASLSSSVVPVSFISTLRESVLDPGVGGEGASDKQRSKLSLSHSMIPAAKIHTELCLPAFFSPAGTQRRFQQPQHHLTLSIIHTAAR

Target ORF information:

RefSeq Version	NM_001099667.2
Organism	Homo sapiens(human)
Definition	Homo sapiens age-related maculopathy susceptibility 2 (ARMS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001099667.2

ORF Insert Sequence:

ATGCTGCGCC TATACCCAGG ACCGATGGTA ACTGAGGCGG AGGGGAAAGG AGGGCCTGAG 
ATGGCAAGTC TGTCCTCCTC GGTGGTTCCT GTGTCCTTCA TTTCCACTCT GCGAGAGTCT 
GTGCTGGACC CTGGAGTTGG TGGAGAAGGA GCCAGTGACA AGCAGAGGAG CAAACTGTCT 
TTATCACACT CCATGATCCC AGCTGCTAAA ATCCACACTG AGCTCTGCTT ACCAGCCTTC 
TTCTCTCCTG CTGGAACCCA GAGGAGGTTC CAGCAGCCTC AGCACCACCT GACACTGTCT 
ATCATCCACA CTGCAGCAAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ARMS2 ( NM_001099667.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001093137.1 Homo sapiens age-related maculopathy susceptibility 2 (ARMS2), mRNA.

Price & Availability↑

CloneID	OHu19862
Clone ID Related Accession (Same CDS sequence)	NM_001099667.1 , NM_001099667.2 , NM_001099667.3
Accession Version	NM_001099667.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 324bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	age-related maculopathy susceptibility protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB997927.1, BC090924.1 and BC066349.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_001099667.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC090924.1, CB997927.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology MANE Ensembl match :: ENST00000528446.1/ ENSP00000436682.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGCGCC TATACCCAGG ACCGATGGTA ACTGAGGCGG AGGGGAAAGG AGGGCCTGAG 
ATGGCAAGTC TGTCCTCCTC GGTGGTTCCT GTGTCCTTCA TTTCCACTCT GCGAGAGTCT 
GTGCTGGACC CTGGAGTTGG TGGAGAAGGA GCCAGTGACA AGCAGAGGAG CAAACTGTCT 
TTATCACACT CCATGATCCC AGCTGCTAAA ATCCACACTG AGCTCTGCTT ACCAGCCTTC 
TTCTCTCCTG CTGGAACCCA GAGGAGGTTC CAGCAGCCTC AGCACCACCT GACACTGTCT 
ATCATCCACA CTGCAGCAAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001093137.1
CDS	76..399
Translation	MLRLYPGPMVTEAEGKGGPEMASLSSSVVPVSFISTLRESVLDPGVGGEGASDKQRSKLSLSHSMIPAAKIHTELCLPAFFSPAGTQRRFQQPQHHLTLSIIHTAAR

Target ORF information:

RefSeq Version	NM_001099667.3
Organism	Homo sapiens(human)
Definition	Homo sapiens age-related maculopathy susceptibility 2 (ARMS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001099667.3

ORF Insert Sequence:

ATGCTGCGCC TATACCCAGG ACCGATGGTA ACTGAGGCGG AGGGGAAAGG AGGGCCTGAG 
ATGGCAAGTC TGTCCTCCTC GGTGGTTCCT GTGTCCTTCA TTTCCACTCT GCGAGAGTCT 
GTGCTGGACC CTGGAGTTGG TGGAGAAGGA GCCAGTGACA AGCAGAGGAG CAAACTGTCT 
TTATCACACT CCATGATCCC AGCTGCTAAA ATCCACACTG AGCTCTGCTT ACCAGCCTTC 
TTCTCTCCTG CTGGAACCCA GAGGAGGTTC CAGCAGCCTC AGCACCACCT GACACTGTCT 
ATCATCCACA CTGCAGCAAG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proceedings of the National Academy of Sciences of the United States of America(2018 Jan)
Vavvas DG,Small KW,Awh CC,Zanke BW,Tibshirani RJ,Kustra R

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ARMS2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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