LRRC10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LRRC10
Entrez Gene ID	376132
Full Name	leucine rich repeat containing 10
Synonyms	HRLRRP,LRRC10A
General protein information	Preferred Names leucine rich repeat containing 10 Names leucine-rich repeat-containing protein 10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q15
Disorder MIM:	610846

mRNA and Protein(s)

mRNA	Protein	Name
NM_201550.3	NP_963844.2	leucine-rich repeat-containing protein 10
NM_201550.4	NP_963844.2	leucine-rich repeat-containing protein 10

Pathways from BioSystems

Homologies

	LRRC10	XP_001117377.1
Rattus norvegicus (Norway rat)	Lrrc10	NP_001101566.1
Xenopus tropicalis (tropical clawed frog)	lrrc10	XP_002938552.2
Canis lupus familiaris (dog)	LRRC10	XP_005625671.1
Mus musculus (house mouse)	Lrrc10	NP_666354.1
Homo sapiens (human)	LRRC10	NP_963844.2
Rattus norvegicus (Norway rat)	LOC100911101	XP_003750370.1
Danio rerio (zebrafish)	lrrc10	NP_001009559.1
Pan troglodytes (chimpanzee)	LRRC10	XP_522465.1
Bos taurus (cattle)	LRRC10	NP_001069225.1
Gallus gallus (chicken)	LRRC10	XP_004937622.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular pathological study on LRRC10 in sudden unexplained nocturnal death syndrome in the Chinese Han population.
Huang L, Tang S, Chen Y, Zhang L, Yin K, Wu Y, Zheng J, Wu Q, Makielski JC, Cheng J
International journal of legal medicine131(3)621-628(2017 May)

LRRC10 is required to maintain cardiac function in response to pressure overload.
Brody MJ, Feng L, Grimes AC, Hacker TA, Olson TM, Kamp TJ, Balijepalli RC, Lee Y
American journal of physiology. Heart and circulatory physiology310(2)H269-78(2016 Jan)

Prevalence and spectrum of LRRC10 mutations associated with idiopathic dilated cardiomyopathy.
Qu XK, Yuan F, Li RG, Xu L, Jing WF, Liu H, Xu YJ, Zhang M, Liu X, Fang WY, Yang YQ, Qiu XB
Molecular medicine reports12(3)3718-24(2015 Sep)

Many sequence variants affecting diversity of adult human height.
Gudbjartsson DF, Walters GB, Thorleifsson G, Stefansson H, Halldorsson BV, Zusmanovich P, Sulem P, Thorlacius S, Gylfason A, Steinberg S, Helgadottir A, Ingason A, Steinthorsdottir V, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Pedersen O, Aben KK, Witjes JA, Swinkels DW, den Heijer M, Franke B, Verbeek AL, Becker DM, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Gulcher J, Kiemeney LA, Kong A, Thorsteinsdottir U, Stefansson K
Nature genetics40(5)609-15(2008 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LRRC10 may be a new susceptible gene for Sudden unexplained nocturnal death syndrome, and LRRC10 variant was initially and genetically linked to Brugada syndrome associated arrhythmia.
Title: Molecular pathological study on LRRC10 in sudden unexplained nocturnal death syndrome in the Chinese Han population.

This study firstly reports the association of LRRC10 mutations with enhanced susceptibility to dilated cardiomyopathy in humans.
Title: Prevalence and spectrum of LRRC10 mutations associated with idiopathic dilated cardiomyopathy.

The following LRRC10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LRRC10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29778	NM_201550.4 Latest version!	Homo sapiens leucine rich repeat containing 10 (LRRC10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
View Old Accession Versions >>
OHu29778	NM_201550.3	Homo sapiens leucine rich repeat containing 10 (LRRC10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LRRC10 ( NM_201550.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_963844.2 Homo sapiens leucine rich repeat containing 10 (LRRC10), mRNA.

Price & Availability↑

CloneID	OHu29778
Clone ID Related Accession (Same CDS sequence)	NM_201550.3 , NM_201550.4
Accession Version	NM_201550.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-11-22
Organism	Homo sapiens(human)
Product	leucine-rich repeat-containing protein 10
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC090881.1 and AC018921.22. On Jan 16, 2015 this sequence version replaced NM_201550.2. ##Evidence-Data-START## Transcript is intronless :: BC090881.1 [ECO:0000345] ##Evidence-Data-END##

ATGGGGAACA CCATCAGGGC CCTCGTGGCC TTCATCCCTG CTGACCGTTG CCAGAACTAT 
GTGGTCAGGG ACCTCCGTGA GATGCCGCTG GACAAGATGG TGGATCTGAG TGGGAGCCAG 
TTACGCCGCT TCCCCCTGCA CGTGTGCTCC TTCAGGGAGC TGGTCAAGCT CTACCTGAGC 
GACAACCACC TCAATAGCCT GCCTCCGGAG CTGGGGCAGC TACAGAACCT GCAGATTCTG 
GCCTTGGATT TCAACAACTT CAAGGCTCTG CCCCAGGTGG TGTGCACCTT GAAACAGCTC 
TGCATCCTCT ACCTGGGCAA CAACAAACTC TGCGACCTCC CCAGTGAGCT GAGCCTGCTC 
CAGAACCTCA GGACCCTGTG GATCGAGGCC AACTGCCTCA CCCAGCTGCC GGATGTGGTC 
TGTGAGCTGA GTCTCCTTAA GACTCTGCAT GCCGGCTCCA ACGCCCTGCG TTTGCTGCCA 
GGCCAGCTCC GGCGCCTCCA GGAGCTGAGG ACCATCTGGC TCTCGGGCAA CCGGCTAACT 
GACTTTCCCA CTGTGCTGCT TCACATGCCC TTCCTGGAGG TGATTGATGT GGACTGGAAC 
AGCATCCGTT ACTTCCCCAG CCTGGCGCAC CTGTCAAGTC TGAAGCTGGT CATCTATGAC 
CACAATCCTT GCAGGAACGC ACCCAAGGTG GCCAAAGGTG TGCGCCGTGT GGGGAGATGG 
GCAGAGGAGA CGCCAGAGCC CGACCCTAGA AAAGCCAGGC GCTATGCGTT GGTCAGAGAG 
GAAAGCCAGG AGCTACAGGC ACCAGTCCCT CTACTTCCTC CTACCAACTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_963844.2
CDS	325..1158
Translation	MGNTIRALVAFIPADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSSLKLVIYDHNPCRNAPKVAKGVRRVGRWAEETPEPDPRKARRYALVREESQELQAPVPLLPPTNS

Target ORF information:

RefSeq Version	NM_201550.3
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine rich repeat containing 10 (LRRC10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_201550.3

ORF Insert Sequence:

ATGGGGAACA CCATCAGGGC CCTCGTGGCC TTCATCCCTG CTGACCGTTG CCAGAACTAT 
GTGGTCAGGG ACCTCCGTGA GATGCCGCTG GACAAGATGG TGGATCTGAG TGGGAGCCAG 
TTACGCCGCT TCCCCCTGCA CGTGTGCTCC TTCAGGGAGC TGGTCAAGCT CTACCTGAGC 
GACAACCACC TCAATAGCCT GCCTCCGGAG CTGGGGCAGC TACAGAACCT GCAGATTCTG 
GCCTTGGATT TCAACAACTT CAAGGCTCTG CCCCAGGTGG TGTGCACCTT GAAACAGCTC 
TGCATCCTCT ACCTGGGCAA CAACAAACTC TGCGACCTCC CCAGTGAGCT GAGCCTGCTC 
CAGAACCTCA GGACCCTGTG GATCGAGGCC AACTGCCTCA CCCAGCTGCC GGATGTGGTC 
TGTGAGCTGA GTCTCCTTAA GACTCTGCAT GCCGGCTCCA ACGCCCTGCG TTTGCTGCCA 
GGCCAGCTCC GGCGCCTCCA GGAGCTGAGG ACCATCTGGC TCTCGGGCAA CCGGCTAACT 
GACTTTCCCA CTGTGCTGCT TCACATGCCC TTCCTGGAGG TGATTGATGT GGACTGGAAC 
AGCATCCGTT ACTTCCCCAG CCTGGCGCAC CTGTCAAGTC TGAAGCTGGT CATCTATGAC 
CACAATCCTT GCAGGAACGC ACCCAAGGTG GCCAAAGGTG TGCGCCGTGT GGGGAGATGG 
GCAGAGGAGA CGCCAGAGCC CGACCCTAGA AAAGCCAGGC GCTATGCGTT GGTCAGAGAG 
GAAAGCCAGG AGCTACAGGC ACCAGTCCCT CTACTTCCTC CTACCAACTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LRRC10 ( NM_201550.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_963844.2 Homo sapiens leucine rich repeat containing 10 (LRRC10), mRNA.

Price & Availability↑

CloneID	OHu29778
Clone ID Related Accession (Same CDS sequence)	NM_201550.3 , NM_201550.4
Accession Version	NM_201550.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 834bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	leucine-rich repeat-containing protein 10
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC090881.1 and AC018921.22. On May 17, 2019 this sequence version replaced NM_201550.3. ##Evidence-Data-START## Transcript is intronless :: BC090881.1, AK123908.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361484.5/ ENSP00000355166.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGGGAACA CCATCAGGGC CCTCGTGGCC TTCATCCCTG CTGACCGTTG CCAGAACTAT 
GTGGTCAGGG ACCTCCGTGA GATGCCGCTG GACAAGATGG TGGATCTGAG TGGGAGCCAG 
TTACGCCGCT TCCCCCTGCA CGTGTGCTCC TTCAGGGAGC TGGTCAAGCT CTACCTGAGC 
GACAACCACC TCAATAGCCT GCCTCCGGAG CTGGGGCAGC TACAGAACCT GCAGATTCTG 
GCCTTGGATT TCAACAACTT CAAGGCTCTG CCCCAGGTGG TGTGCACCTT GAAACAGCTC 
TGCATCCTCT ACCTGGGCAA CAACAAACTC TGCGACCTCC CCAGTGAGCT GAGCCTGCTC 
CAGAACCTCA GGACCCTGTG GATCGAGGCC AACTGCCTCA CCCAGCTGCC GGATGTGGTC 
TGTGAGCTGA GTCTCCTTAA GACTCTGCAT GCCGGCTCCA ACGCCCTGCG TTTGCTGCCA 
GGCCAGCTCC GGCGCCTCCA GGAGCTGAGG ACCATCTGGC TCTCGGGCAA CCGGCTAACT 
GACTTTCCCA CTGTGCTGCT TCACATGCCC TTCCTGGAGG TGATTGATGT GGACTGGAAC 
AGCATCCGTT ACTTCCCCAG CCTGGCGCAC CTGTCAAGTC TGAAGCTGGT CATCTATGAC 
CACAATCCTT GCAGGAACGC ACCCAAGGTG GCCAAAGGTG TGCGCCGTGT GGGGAGATGG 
GCAGAGGAGA CGCCAGAGCC CGACCCTAGA AAAGCCAGGC GCTATGCGTT GGTCAGAGAG 
GAAAGCCAGG AGCTACAGGC ACCAGTCCCT CTACTTCCTC CTACCAACTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_963844.2
CDS	70..903
Translation	MGNTIRALVAFIPADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSSLKLVIYDHNPCRNAPKVAKGVRRVGRWAEETPEPDPRKARRYALVREESQELQAPVPLLPPTNS

Target ORF information:

RefSeq Version	NM_201550.4
Organism	Homo sapiens(human)
Definition	Homo sapiens leucine rich repeat containing 10 (LRRC10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_201550.4

ORF Insert Sequence:

ATGGGGAACA CCATCAGGGC CCTCGTGGCC TTCATCCCTG CTGACCGTTG CCAGAACTAT 
GTGGTCAGGG ACCTCCGTGA GATGCCGCTG GACAAGATGG TGGATCTGAG TGGGAGCCAG 
TTACGCCGCT TCCCCCTGCA CGTGTGCTCC TTCAGGGAGC TGGTCAAGCT CTACCTGAGC 
GACAACCACC TCAATAGCCT GCCTCCGGAG CTGGGGCAGC TACAGAACCT GCAGATTCTG 
GCCTTGGATT TCAACAACTT CAAGGCTCTG CCCCAGGTGG TGTGCACCTT GAAACAGCTC 
TGCATCCTCT ACCTGGGCAA CAACAAACTC TGCGACCTCC CCAGTGAGCT GAGCCTGCTC 
CAGAACCTCA GGACCCTGTG GATCGAGGCC AACTGCCTCA CCCAGCTGCC GGATGTGGTC 
TGTGAGCTGA GTCTCCTTAA GACTCTGCAT GCCGGCTCCA ACGCCCTGCG TTTGCTGCCA 
GGCCAGCTCC GGCGCCTCCA GGAGCTGAGG ACCATCTGGC TCTCGGGCAA CCGGCTAACT 
GACTTTCCCA CTGTGCTGCT TCACATGCCC TTCCTGGAGG TGATTGATGT GGACTGGAAC 
AGCATCCGTT ACTTCCCCAG CCTGGCGCAC CTGTCAAGTC TGAAGCTGGT CATCTATGAC 
CACAATCCTT GCAGGAACGC ACCCAAGGTG GCCAAAGGTG TGCGCCGTGT GGGGAGATGG 
GCAGAGGAGA CGCCAGAGCC CGACCCTAGA AAAGCCAGGC GCTATGCGTT GGTCAGAGAG 
GAAAGCCAGG AGCTACAGGC ACCAGTCCCT CTACTTCCTC CTACCAACTC CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular pathological study on LRRC10 in sudden unexplained nocturnal death syndrome in the Chinese Han population.
International journal of legal medicine131(3)621-628(2017 May)
Huang L,Tang S,Chen Y,Zhang L,Yin K,Wu Y,Zheng J,Wu Q,Makielski JC,Cheng J

LRRC10 is required to maintain cardiac function in response to pressure overload.
American journal of physiology. Heart and circulatory physiology310(2)H269-78(2016 Jan)
Brody MJ,Feng L,Grimes AC,Hacker TA,Olson TM,Kamp TJ,Balijepalli RC,Lee Y

Prevalence and spectrum of LRRC10 mutations associated with idiopathic dilated cardiomyopathy.
Molecular medicine reports12(3)3718-24(2015 Sep)
Qu XK,Yuan F,Li RG,Xu L,Jing WF,Liu H,Xu YJ,Zhang M,Liu X,Fang WY,Yang YQ,Qiu XB

Many sequence variants affecting diversity of adult human height.
Nature genetics40(5)609-15(2008 May)
Gudbjartsson DF,Walters GB,Thorleifsson G,Stefansson H,Halldorsson BV,Zusmanovich P,Sulem P,Thorlacius S,Gylfason A,Steinberg S,Helgadottir A,Ingason A,Steinthorsdottir V,Olafsdottir EJ,Olafsdottir GH,Jonsson T,Borch-Johnsen K,Hansen T,Andersen G,Jorgensen T,Pedersen O,Aben KK,Witjes JA,Swinkels DW,den Heijer M,Franke B,Verbeek AL,Becker DM,Yanek LR,Becker LC,Tryggvadottir L,Rafnar T,Gulcher J,Kiemeney LA,Kong A,Thorsteinsdottir U,Stefansson K

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LRRC10 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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