Lrrc10 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Lrrc10
Entrez Gene ID	237560
Full Name	leucine rich repeat containing 10
Synonyms	D330003I11Rik,Hrlrrp,Serdin1
General protein information	Preferred Names leucine rich repeat containing 10 Names leucine-rich repeat-containing protein 10 heart-restricted leucine-rich repeat protein leucine-rich containing 10 leucine-rich repeat protein
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 10 Map Location: 10\|10 D2

mRNA and Protein(s)

mRNA	Protein	Name
NM_146242.2	NP_666354.1	leucine-rich repeat-containing protein 10

Pathways from BioSystems

Homologies

	LRRC10	XP_001117377.1
Rattus norvegicus (Norway rat)	Lrrc10	NP_001101566.1
Xenopus tropicalis (tropical clawed frog)	lrrc10	XP_002938552.2
Canis lupus familiaris (dog)	LRRC10	XP_005625671.1
Mus musculus (house mouse)	Lrrc10	NP_666354.1
Homo sapiens (human)	LRRC10	NP_963844.2
Rattus norvegicus (Norway rat)	LOC100911101	XP_003750370.1
Danio rerio (zebrafish)	lrrc10	NP_001009559.1
Pan troglodytes (chimpanzee)	LRRC10	XP_522465.1
Bos taurus (cattle)	LRRC10	NP_001069225.1
Gallus gallus (chicken)	LRRC10	XP_004937622.1

Gene Ontology
Bibliography

Related articles in PubMed

LRRC10 is required to maintain cardiac function in response to pressure overload.
Brody MJ, Feng L, Grimes AC, Hacker TA, Olson TM, Kamp TJ, Balijepalli RC, Lee Y
American journal of physiology. Heart and circulatory physiology310(2)H269-78(2016 Jan)

Lrrc10 is a novel cardiac-specific target gene of Nkx2-5 and GATA4.
Brody MJ, Cho E, Mysliwiec MR, Kim TG, Carlson CD, Lee KH, Lee Y
Journal of molecular and cellular cardiology62237-46(2013 Sep)

Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.
Brody MJ, Hacker TA, Patel JR, Feng L, Sadoshima J, Tevosian SG, Balijepalli RC, Moss RL, Lee Y
PloS one7(12)e51621(2012)

Cloning and characterization of the cardiac-specific Lrrc10 promoter.
Fan X, Yang Q, Wang Y, Zhang Y, Wang J, Yuan J, Li Y, Wang Y, Deng Y, Yuan W, Mo X, Wan Y, Ocorr K, Yang X, Wu X
BMB reports44(2)123-8(2011 Feb)

Serdin1/Lrrc10 is dispensable for mouse development.
Manuylov NL, Manuylova E, Avdoshina V, Tevosian S
Genesis (New York, N.Y. : 2000)46(9)441-6(2008 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

LRRC10 is required to maintain cardiac performance in response to pressure overload and suggest that dysregulated expression or mutation of LRRC10
Title: LRRC10 is required to maintain cardiac function in response to pressure overload.

Data demonstrate that the transcription factors Nkx2-5 and GATA4 cooperatively regulate cardiac-specific expression of Lrrc10.
Title: Lrrc10 is a novel cardiac-specific target gene of Nkx2-5 and GATA4.

Lrrc10 is a novel dilated cardiomyopathy candidate gene and the Lrrc10-/- mouse model is a unique system to investigate pediatric cardiomyopathy.
Title: Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.

GATA4 and MEF2C can both increase transcriptional activity of Lrrc10 promoter but that they do not work together in a synergistic fashion.
Title: Cloning and characterization of the cardiac-specific Lrrc10 promoter.

Lrrc10-null mice develop normally and exhibit no discernable phenotype
Title: Serdin1/Lrrc10 is dispensable for mouse development.

The following Lrrc10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lrrc10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu14800	NM_146242.2 Latest version!	Mus musculus leucine rich repeat containing 10 (Lrrc10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Lrrc10 ( NM_146242.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_666354.1 Mus musculus leucine rich repeat containing 10 (Lrrc10), mRNA.

Price & Availability↑

CloneID	OMu14800
Clone ID Related Accession (Same CDS sequence)	NM_146242.2
Accession Version	NM_146242.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Mus musculus(house mouse)
Product	leucine-rich repeat-containing protein 10
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC086911.1 and AK142167.1. On Sep 2, 2006 this sequence version replaced NM_146242.1. ##Evidence-Data-START## Transcript is intronless :: AK142167.1 [ECO:0000345] ##Evidence-Data-END##

ATGGGAAACA CCATCCGGGC CTTCGTGGCT TTCATCCCCA CCGACCGCTG CCAGAGTTAT 
GTGGTGGGAG ACCTCCGGGA GATGCCCCTG GACAGGATGG TGGATCTGAG CGGGAGCCAG 
CTGCGTCGCT TCCCACTGCA CGTGTGCTCC TTCACGGAGC TGGTGAAGCT CTACCTCAGC 
GACAACCACC TTCACAGCCT GCCTCCCGAC CTGGCACAGC TGCAGAACCT GCAGATCCTG 
GCCTTGGATT TCAACAACTT CAAAGCTCTC CCCCGGGTGG TGTGTACCTT GAAACAGCTC 
TGCATCCTCT ACCTGGGCAA TAACAAACTC TGTGACCTCC CGGATGAGCT CAGCCTGCTC 
CAGAACCTAC GGACCCTGTG GCTCGAATCC AACTGCCTCA CCCGGCTGCC CGATGTGGTG 
TGTGAGCTGA GTCTCCTTAA AACCCTGCAT GCCGGTTCCA ACGCCCTACG TCTGCTACCC 
GGCCAGCTCC GGCGCCTGCG CGAGCTCAGG ACCATCTGGC TCTCCGGCAA TCAGCTAGCT 
GACTTCCCCT CGGTACTGCT TCGCATGCCC TTTCTGGAGG TGATCGACGT GGATCGGAAC 
AGTATCCGCT ACTTCCCCAG CCTGGCCCAC TTGACAAATC TGAAGCTGGT CATCTATGAC 
CACAATCCTT GCAGAAATGC CCCCAAGGTG GGCAAAGGGG TTCGCCGTGT TGGGAGATGG 
GCAGAGGAGA CACCAGAGCC TGACCCCAGA AAAGCTAGGC GGTACGCACT GGCCAAGGAA 
GAGAATCAAG AGCCACCTCC TCCCCTTCTT CCTTCCAGCT CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_666354.1
CDS	83..907
Translation	MGNTIRAFVAFIPTDRCQSYVVGDLREMPLDRMVDLSGSQLRRFPLHVCSFTELVKLYLSDNHLHSLPPDLAQLQNLQILALDFNNFKALPRVVCTLKQLCILYLGNNKLCDLPDELSLLQNLRTLWLESNCLTRLPDVVCELSLLKTLHAGSNALRLLPGQLRRLRELRTIWLSGNQLADFPSVLLRMPFLEVIDVDRNSIRYFPSLAHLTNLKLVIYDHNPCRNAPKVGKGVRRVGRWAEETPEPDPRKARRYALAKEENQEPPPPLLPSSS

Target ORF information:

RefSeq Version	NM_146242.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus leucine rich repeat containing 10 (Lrrc10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_146242.2

ORF Insert Sequence:

ATGGGAAACA CCATCCGGGC CTTCGTGGCT TTCATCCCCA CCGACCGCTG CCAGAGTTAT 
GTGGTGGGAG ACCTCCGGGA GATGCCCCTG GACAGGATGG TGGATCTGAG CGGGAGCCAG 
CTGCGTCGCT TCCCACTGCA CGTGTGCTCC TTCACGGAGC TGGTGAAGCT CTACCTCAGC 
GACAACCACC TTCACAGCCT GCCTCCCGAC CTGGCACAGC TGCAGAACCT GCAGATCCTG 
GCCTTGGATT TCAACAACTT CAAAGCTCTC CCCCGGGTGG TGTGTACCTT GAAACAGCTC 
TGCATCCTCT ACCTGGGCAA TAACAAACTC TGTGACCTCC CGGATGAGCT CAGCCTGCTC 
CAGAACCTAC GGACCCTGTG GCTCGAATCC AACTGCCTCA CCCGGCTGCC CGATGTGGTG 
TGTGAGCTGA GTCTCCTTAA AACCCTGCAT GCCGGTTCCA ACGCCCTACG TCTGCTACCC 
GGCCAGCTCC GGCGCCTGCG CGAGCTCAGG ACCATCTGGC TCTCCGGCAA TCAGCTAGCT 
GACTTCCCCT CGGTACTGCT TCGCATGCCC TTTCTGGAGG TGATCGACGT GGATCGGAAC 
AGTATCCGCT ACTTCCCCAG CCTGGCCCAC TTGACAAATC TGAAGCTGGT CATCTATGAC 
CACAATCCTT GCAGAAATGC CCCCAAGGTG GGCAAAGGGG TTCGCCGTGT TGGGAGATGG 
GCAGAGGAGA CACCAGAGCC TGACCCCAGA AAAGCTAGGC GGTACGCACT GGCCAAGGAA 
GAGAATCAAG AGCCACCTCC TCCCCTTCTT CCTTCCAGCT CTTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

LRRC10 is required to maintain cardiac function in response to pressure overload.
American journal of physiology. Heart and circulatory physiology310(2)H269-78(2016 Jan)
Brody MJ,Feng L,Grimes AC,Hacker TA,Olson TM,Kamp TJ,Balijepalli RC,Lee Y

Lrrc10 is a novel cardiac-specific target gene of Nkx2-5 and GATA4.
Journal of molecular and cellular cardiology62237-46(2013 Sep)
Brody MJ,Cho E,Mysliwiec MR,Kim TG,Carlson CD,Lee KH,Lee Y

Ablation of the cardiac-specific gene leucine-rich repeat containing 10 (Lrrc10) results in dilated cardiomyopathy.
PloS one7(12)e51621(2012)
Brody MJ,Hacker TA,Patel JR,Feng L,Sadoshima J,Tevosian SG,Balijepalli RC,Moss RL,Lee Y

Cloning and characterization of the cardiac-specific Lrrc10 promoter.
BMB reports44(2)123-8(2011 Feb)
Fan X,Yang Q,Wang Y,Zhang Y,Wang J,Yuan J,Li Y,Wang Y,Deng Y,Yuan W,Mo X,Wan Y,Ocorr K,Yang X,Wu X

Serdin1/Lrrc10 is dispensable for mouse development.
Genesis (New York, N.Y. : 2000)46(9)441-6(2008 Sep)
Manuylov NL,Manuylova E,Avdoshina V,Tevosian S

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Lrrc10 cDNA ORF clone, Mus musculus(house mouse)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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